| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Verena Tretter, Jayanta Mukherjee, Hans-Michael Maric, Hermann Schindelin, Werner Sieghart, Stephen J Mos. Gephyrin, the enigmatic organizer at GABAergic synapses. Frontiers in cellular neuroscience. vol 6. 2012-10-02. PMID:22615685. |
gephyrin-binding to gaba(a) receptors seems to be at least one order of magnitude weaker than to glycine receptors (glyrs) and most probably is regulated by phosphorylation. |
2012-10-02 |
2023-08-12 |
Not clear |
| Sébastien Dutertre, Malgorzata Drwal, Bodo Laube, Heinrich Bet. Probing the pharmacological properties of distinct subunit interfaces within heteromeric glycine receptors reveals a functional ββ agonist-binding site. Journal of neurochemistry. vol 122. issue 1. 2012-08-27. PMID:22486198. |
synaptic glycine receptors (glyrs) are hetero-pentameric chloride channels composed of α and β subunits, which are activated by agonist binding at subunit interfaces. |
2012-08-27 |
2023-08-12 |
xenopus_laevis |
| Daya I Perkins, James R Trudell, Liana Asatryan, Daryl L Davies, Ronald L Alkan. Charge and geometry of residues in the loop 2 β hairpin differentially affect agonist and ethanol sensitivity in glycine receptors. The Journal of pharmacology and experimental therapeutics. vol 341. issue 2. 2012-08-20. PMID:22357974. |
recent studies highlighted the importance of loop 2 of α1 glycine receptors (glyrs) in the propagation of ligand-binding energy to the channel gate. |
2012-08-20 |
2023-08-12 |
Not clear |
| Wei Xiong, Tanxing Cui, Kejun Cheng, Fei Yang, Shao-Rui Chen, Dan Willenbring, Yun Guan, Hui-Lin Pan, Ke Ren, Yan Xu, Li Zhan. Cannabinoids suppress inflammatory and neuropathic pain by targeting α3 glycine receptors. The Journal of experimental medicine. vol 209. issue 6. 2012-08-13. PMID:22585736. |
certain types of nonpsychoactive cannabinoids can potentiate glycine receptors (glyrs), an important target for nociceptive regulation at the spinal level. |
2012-08-13 |
2023-08-12 |
mouse |
| Zhihong Li, Shunnan Ge, Fuxing Zhang, Ting Zhang, Noboru Mizuno, Hiroyuki Hioki, Takeshi Kaneko, Guodong Gao, Jinlian L. Distribution of gephyrin-immunoreactivity in the trigeminal motor nucleus: an immunohistochemical study in rats. Anatomical record (Hoboken, N.J. : 2007). vol 295. issue 4. 2012-07-30. PMID:22290869. |
it has been established that a postsynaptic scaffolding protein, gephyrin, is essential for anchoring two main groups of inhibitory receptors, gaba(a) receptors (gaba(a) rs) and glycine receptors (glyrs), to the postsynaptic sites of neurons. |
2012-07-30 |
2023-08-12 |
rat |
| Wei Xiong, Xiongwu Wu, Fuying Li, Kejun Cheng, Kenner C Rice, David M Lovinger, Li Zhan. A common molecular basis for exogenous and endogenous cannabinoid potentiation of glycine receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 15. 2012-06-15. PMID:22496565. |
both exogenous and endogenous cannabinoids can allosterically modulate glycine receptors (glyrs). |
2012-06-15 |
2023-08-12 |
human |
| Stefanie Buerbank, Kristina Becker, Cord-Michael Becker, Niels Brandt, Jutta Engel, Marlies Knipper, Bernhard Schick, Julia Dlugaiczy. Developmental regulation of glycine receptors at efferent synapses of the murine cochlea. Histochemistry and cell biology. vol 136. issue 4. 2012-05-18. PMID:21850450. |
in our previous work, we gave a first description of glycine receptors (glyrs) in the rat cochlea indicating a possible localization at efferent cochlear synapses. |
2012-05-18 |
2023-08-12 |
rat |
| Rong-Qing Chen, Shan-Hui Wang, Wen Yao, Jing-Jing Wang, Fang Ji, Jing-Zhi Yan, Si-Qiang Ren, Zheng Chen, Su-Yi Liu, Wei L. Role of glycine receptors in glycine-induced LTD in hippocampal CA1 pyramidal neurons. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 36. issue 9. 2012-05-08. PMID:21593734. |
glycine in the hippocampus can exert its effect on both synaptic nmda receptors (nmdars) and extrasynaptic functional glycine receptors (glyrs) via distinct binding sites. |
2012-05-08 |
2023-08-12 |
Not clear |
| Jing Li, Hong Nie, Weiliang Bian, Vaidehi Dave, Patricia H Janak, Jiang-Hong Y. Microinjection of glycine into the ventral tegmental area selectively decreases ethanol consumption. The Journal of pharmacology and experimental therapeutics. vol 341. issue 1. 2012-05-04. PMID:22238211. |
our previous in vitro electrophysiological data indicate that glycine receptors (glyrs) exist on the gabaergic terminals, which make synapses on vta dopaminergic neurons, and activation of these glyrs reduces gabaergic transmission and increases the activity of vta dopaminergic neurons. |
2012-05-04 |
2023-08-12 |
rat |
| Jing Li, Hong Nie, Weiliang Bian, Vaidehi Dave, Patricia H Janak, Jiang-Hong Y. Microinjection of glycine into the ventral tegmental area selectively decreases ethanol consumption. The Journal of pharmacology and experimental therapeutics. vol 341. issue 1. 2012-05-04. PMID:22238211. |
glycine and strychnine, the selective antagonist of glyrs, were injected, either alone or in combination, into the vta of rats. |
2012-05-04 |
2023-08-12 |
rat |
| Jing Li, Hong Nie, Weiliang Bian, Vaidehi Dave, Patricia H Janak, Jiang-Hong Y. Microinjection of glycine into the ventral tegmental area selectively decreases ethanol consumption. The Journal of pharmacology and experimental therapeutics. vol 341. issue 1. 2012-05-04. PMID:22238211. |
the effects of glycine probably were mediated by strychnine-sensitive glyrs, because the coinjection of glycine and strychnine reduced neither ethanol intake in the home cages nor lever-press responding for ethanol in the operant chambers. |
2012-05-04 |
2023-08-12 |
rat |
| Gonzalo E Yevenes, Hanns Ulrich Zeilhofe. Allosteric modulation of glycine receptors. British journal of pharmacology. vol 164. issue 2. 2012-04-16. PMID:21557733. |
inhibitory (or strychnine sensitive) glycine receptors (glyrs) are anion-selective transmitter-gated ion channels of the cys-loop superfamily, which includes among others also the inhibitory γ-aminobutyric acid receptors (gaba(a) receptors). |
2012-04-16 |
2023-08-12 |
Not clear |
| Gonzalo E Yévenes, Hanns Ulrich Zeilhofe. Molecular sites for the positive allosteric modulation of glycine receptors by endocannabinoids. PloS one. vol 6. issue 8. 2012-04-13. PMID:21901142. |
glycine receptors (glyrs) are transmitter-gated anion channels of the cys-loop superfamily which mediate synaptic inhibition at spinal and selected supraspinal sites. |
2012-04-13 |
2023-08-12 |
Not clear |
| Gonzalo E Yévenes, Hanns Ulrich Zeilhofe. Molecular sites for the positive allosteric modulation of glycine receptors by endocannabinoids. PloS one. vol 6. issue 8. 2012-04-13. PMID:21901142. |
we found that alanine 52 in extracellular loop 2, glycine 254 in transmembrane (tm) region 2 and intracellular lysine 385 determine the positive modulation of α(1) glyrs by na-gly. |
2012-04-13 |
2023-08-12 |
Not clear |
| Cecilia M Borghese, Yuri A Blednov, Yu Quan, Sangeetha V Iyer, Wei Xiong, S John Mihic, Li Zhang, David M Lovinger, James R Trudell, Gregg E Homanics, R Adron Harri. Characterization of two mutations, M287L and Q266I, in the α1 glycine receptor subunit that modify sensitivity to alcohols. The Journal of pharmacology and experimental therapeutics. vol 340. issue 2. 2012-04-06. PMID:22037201. |
glycine receptors (glyrs) are inhibitory ligand-gated ion channels. |
2012-04-06 |
2023-08-12 |
mouse |
| Cecilia M Borghese, Yuri A Blednov, Yu Quan, Sangeetha V Iyer, Wei Xiong, S John Mihic, Li Zhang, David M Lovinger, James R Trudell, Gregg E Homanics, R Adron Harri. Characterization of two mutations, M287L and Q266I, in the α1 glycine receptor subunit that modify sensitivity to alcohols. The Journal of pharmacology and experimental therapeutics. vol 340. issue 2. 2012-04-06. PMID:22037201. |
although zinc potentiation of glycine responses was unchanged in both mutants, zinc enhancement of ethanol potentiation of glycine responses was absent in m287l glyrs. |
2012-04-06 |
2023-08-12 |
mouse |
| PeiPei Chau, Bo Söderpalm, Mia Ericso. The mGluR5 antagonist MPEP elevates accumbal dopamine and glycine levels; interaction with strychnine-sensitive glycine receptors. Addiction biology. vol 16. issue 4. 2012-03-06. PMID:21790901. |
our previous research suggested that glycine receptors (glyrs) in the nucleus accumbens (nac) play a major part in mediating the dopamine-elevating properties of ethanol and are highly involved in the ethanol intake-reducing effect of acamprosate. |
2012-03-06 |
2023-08-12 |
Not clear |
| Gonzalo E Yévenes, Gustavo Moraga-Cid, Ximena Romo, Luis G Aguay. Activated G protein α s subunits increase the ethanol sensitivity of human glycine receptors. The Journal of pharmacology and experimental therapeutics. vol 339. issue 2. 2012-01-16. PMID:21821696. |
it is well known that ethanol modulates the function of the cys loop ligand-gated ion channels, which include the inhibitory glycine receptors (glyrs). |
2012-01-16 |
2023-08-12 |
human |
| Qing Chang, Lee J Marti. Motoneuron subtypes show specificity in glycine receptor channel abnormalities in a transgenic mouse model of amyotrophic lateral sclerosis. Channels (Austin, Tex.). vol 5. issue 4. 2012-01-10. PMID:21558795. |
recently we studied glycine receptors (glyrs) in motoneurons in an als mouse model expressing a mutant form of human superoxide dismutase-1 with a gly93→ala substitution (g93a-sod1). |
2012-01-10 |
2023-08-12 |
mouse |
| A Esmaeili, S R Zake. Differential expression of glycine receptor subunit messenger RNA in the rat following spinal cord injury. Spinal cord. vol 49. issue 2. 2012-01-09. PMID:20733588. |
the subtype expression mrna levels of glycine receptors (glyrs) after sci are unknown. |
2012-01-09 |
2023-08-12 |
rat |