| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Daya I Perkins, James R Trudell, Daniel K Crawford, Liana Asatryan, Ronald L Alkana, Daryl L Davie. Loop 2 structure in glycine and GABA(A) receptors plays a key role in determining ethanol sensitivity. The Journal of biological chemistry. vol 284. issue 40. 2009-10-21. PMID:19656948. |
the present study tests the hypothesis that the structure of extracellular domain loop 2 can markedly affect ethanol sensitivity in glycine receptors (glyrs) and gamma-aminobutyric acid type a receptors (gaba(a)rs). |
2009-10-21 |
2023-08-12 |
xenopus_laevis |
| Alexandre Charlet, François Lasbennes, Pascal Darbon, Pierrick Poisbea. Fast non-genomic effects of progesterone-derived neurosteroids on nociceptive thresholds and pain symptoms. Pain. vol 139. issue 3. 2009-09-28. PMID:18614289. |
fast inhibitory controls mediated by glycine (glyrs) and gabaa receptors (gabaars) play an important role to prevent the apparition of pathological pain symptoms of allodynia and hyperalgesia. |
2009-09-28 |
2023-08-12 |
Not clear |
| Diana Coomes Peterson, Kiran Nataraj, Jeffrey Wenstru. Glycinergic inhibition creates a form of auditory spectral integration in nuclei of the lateral lemniscus. Journal of neurophysiology. vol 102. issue 2. 2009-09-24. PMID:19515958. |
to understand the mechanisms underlying this suppression in nll neurons, we examined the roles of glycinergic and gabaergic input through local microiontophoretic application of strychnine, an antagonist to glycine receptors (glyrs), or bicuculline, an antagonist to gamma-aminobutyric acid type a receptors (gaba(a)rs). |
2009-09-24 |
2023-08-12 |
Not clear |
| Jiang H Ye, Kimberly A Sokol, Urvi Bhavsa. Glycine receptors contribute to hypnosis induced by ethanol. Alcoholism, clinical and experimental research. vol 33. issue 6. 2009-09-07. PMID:19382904. |
glycine is a major inhibitory neurotransmitter in the adult central nervous system (cns), and its receptors (glyrs) are well known for their effects in the spinal cord and the lower brainstem. |
2009-09-07 |
2023-08-12 |
Not clear |
| Yong Liu, Changping Hu, Yamei Tang, Jindong Chen, Min Dong, Tao Song, Xianghui Zhang, Jingping Zha. Clozapine inhibits strychnine-sensitive glycine receptors in rat hippocampal neurons. Brain research. vol 1278. 2009-08-18. PMID:19409375. |
strychnine-sensitive glycine receptors (glyrs) play an important role in regulating the excitability in the hippocampus. |
2009-08-18 |
2023-08-12 |
rat |
| H Wang, J G Turner, L Ling, J L Parrish, L F Hughes, D M Caspar. Age-related changes in glycine receptor subunit composition and binding in dorsal cochlear nucleus. Neuroscience. vol 160. issue 1. 2009-08-17. PMID:19217931. |
the present study assessed age-related behavioral gap detection changes and neurochemical changes of postsynaptic glycine receptor (glyrs) subunits and their anchoring protein gephyrin in fusiform cells of young (7-11 months) and aged (28-33 months) fischer brown norway (fbn) rats. |
2009-08-17 |
2023-08-12 |
rat |
| Tara Keck, John A Whit. Glycinergic inhibition in the hippocampus. Reviews in the neurosciences. vol 20. issue 1. 2009-07-29. PMID:19526731. |
while gaba receptors in the hippocampus have been studied in great detail, the role of glycine receptors (glyrs) in the hippocampus is less understood. |
2009-07-29 |
2023-08-12 |
Not clear |
| Tara Keck, John A Whit. Glycinergic inhibition in the hippocampus. Reviews in the neurosciences. vol 20. issue 1. 2009-07-29. PMID:19526731. |
extracellular glycine levels are controlled through a combination of release and transport mechanisms, both of which, along with the glyrs themselves, can be modulated by a number of factors. |
2009-07-29 |
2023-08-12 |
Not clear |
| Gábor Maksay, Bodo Laube, Rudolf Schemm, Joanna Grudzinska, Malgorzata Drwal, Heinrich Bet. Different binding modes of tropeines mediating inhibition and potentiation of alpha1 glycine receptors. Journal of neurochemistry. vol 109. issue 6. 2009-07-17. PMID:19383091. |
tropeines are bidirectional modulators of native and recombinant glycine receptors (glyrs) and promising leads for the development of novel modulatory agents. |
2009-07-17 |
2023-08-12 |
xenopus_laevis |
| Martino Calamai, Christian G Specht, Janosch Heller, Damien Alcor, Patricia Machado, Christian Vannier, Antoine Trille. Gephyrin oligomerization controls GlyR mobility and synaptic clustering. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 24. 2009-07-17. PMID:19535575. |
high local concentrations of glycine receptors (glyrs) at inhibitory postsynaptic sites are achieved through their binding to the scaffold protein gephyrin. |
2009-07-17 |
2023-08-12 |
Not clear |
| Peng Jiang, Yan Kong, Xiao-Bing Zhang, Wei Wang, Chun-Feng Liu, Tian-Le X. Glycine receptor in rat hippocampal and spinal cord neurons as a molecular target for rapid actions of 17-beta-estradiol. Molecular pain. vol 5. 2009-04-13. PMID:19138413. |
glycine receptors (glyrs) play important roles in regulating hippocampal neural network activity and spinal nociception. |
2009-04-13 |
2023-08-12 |
rat |
| Xuebin Chen, Brett Cromer, Timothy I Webb, Zhe Yang, Janina Hantke, Robert J Harvey, Michael W Parker, Joseph W Lync. Dihydropyridine inhibition of the glycine receptor: subunit selectivity and a molecular determinant of inhibition. Neuropharmacology. vol 56. issue 1. 2009-04-02. PMID:18657556. |
the dihydropyridines (dhps), nifedipine and nicardipine, modulate native glycine receptors (glyrs) at micromolar concentrations. |
2009-04-02 |
2023-08-12 |
Not clear |
| Veeramuthu Balakrishnan, Sidney P Kuo, Patrick D Roberts, Laurence O Trussel. Slow glycinergic transmission mediated by transmitter pooling. Nature neuroscience. vol 12. issue 3. 2009-03-16. PMID:19198604. |
increasing the stimulus number or frequency, or blocking glycine uptake, slowed synaptic decays, whereas a low-affinity competitive antagonist of glycine receptors (glyrs) accelerated ipsc decay. |
2009-03-16 |
2023-08-12 |
rat |
| Veeramuthu Balakrishnan, Sidney P Kuo, Patrick D Roberts, Laurence O Trussel. Slow glycinergic transmission mediated by transmitter pooling. Nature neuroscience. vol 12. issue 3. 2009-03-16. PMID:19198604. |
these effects could be explained by unique features of glyrs that are activated by pooling of glycine across synapses. |
2009-03-16 |
2023-08-12 |
rat |
| Gonzalo E Yevenes, Gustavo Moraga-Cid, Robert W Peoples, Günther Schmalzing, Luis G Aguay. A selective G betagamma-linked intracellular mechanism for modulation of a ligand-gated ion channel by ethanol. Proceedings of the National Academy of Sciences of the United States of America. vol 105. issue 51. 2009-01-27. PMID:19074265. |
here, we demonstrate a key role of the tm3-4 intracellular loop and g betagamma signaling for potentiation of glycine receptors (glyrs) by ethanol. |
2009-01-27 |
2023-08-12 |
Not clear |
| Zhe Yang, Karin R Aubrey, Iris Alroy, Robert J Harvey, Robert J Vandenberg, Joseph W Lync. Subunit-specific modulation of glycine receptors by cannabinoids and N-arachidonyl-glycine. Biochemical pharmacology. vol 76. issue 8. 2008-11-18. PMID:18755158. |
glycine receptors (glyrs) mediate inhibitory neurotransmission in spinal cord motor and pain sensory neurons. |
2008-11-18 |
2023-08-12 |
Not clear |
| Shirley W Y Tsang, Harry V Vinters, Jeffrey L Cummings, Peter T-H Wong, Christopher P L-H Chen, Mitchell K P La. Alterations in NMDA receptor subunit densities and ligand binding to glycine recognition sites are associated with chronic anxiety in Alzheimer's disease. Neurobiology of aging. vol 29. issue 10. 2008-11-17. PMID:17433503. |
there is considerable preclinical evidence for the importance of glycine recognition sites (glyrs) of n-methyl-d-aspartate (nmda) receptors in the regulation of anxiety behaviors. |
2008-11-17 |
2023-08-12 |
Not clear |
| Joanna Grudzinska, Tanja Schumann, Rudolf Schemm, Heinrich Betz, Bodo Laub. Mutations within the agonist-binding site convert the homomeric alpha1 glycine receptor into a Zn2+-activated chloride channel. Channels (Austin, Tex.). vol 2. issue 1. 2008-11-12. PMID:18690053. |
in spinal neurons and cells expressing recombinant glyrs, low micromolar (<10 microm) concentrations of zn2+ enhance glycine currents, whereas higher concentrations (>10 microm) have an inhibitory effect. |
2008-11-12 |
2023-08-12 |
xenopus_laevis |
| Daniel K Crawford, Daya I Perkins, James R Trudell, Edward J Bertaccini, Daryl L Davies, Ronald L Alkan. Roles for loop 2 residues of alpha1 glycine receptors in agonist activation. The Journal of biological chemistry. vol 283. issue 41. 2008-11-10. PMID:18658152. |
the present study tested the hypothesis that several residues in loop 2 of alpha1 glycine receptors (glyrs) play important roles in mediating the transduction of agonist activation to channel gating. |
2008-11-10 |
2023-08-12 |
xenopus_laevis |
| Daniel K Crawford, Daya I Perkins, James R Trudell, Edward J Bertaccini, Daryl L Davies, Ronald L Alkan. Roles for loop 2 residues of alpha1 glycine receptors in agonist activation. The Journal of biological chemistry. vol 283. issue 41. 2008-11-10. PMID:18658152. |
we also tested the hypothesis that the charge at position 53 is important for agonist activation by measuring the glycine response of wild type (wt) and e53c glyrs exposed to methanethiosulfonate reagents. |
2008-11-10 |
2023-08-12 |
xenopus_laevis |