| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Eun Young Kim, Nils Schrader, Birthe Smolinsky, Cécile Bedet, Christian Vannier, Günter Schwarz, Hermann Schindeli. Deciphering the structural framework of glycine receptor anchoring by gephyrin. The EMBO journal. vol 25. issue 6. 2006-04-25. PMID:16511563. |
gephyrin is required to achieve a high concentration of glycine receptors (glyrs) in the postsynaptic membrane, which is crucial for efficient glycinergic signal transduction. |
2006-04-25 |
2023-08-12 |
Not clear |
| Nadia Hejazi, Chunyi Zhou, Murat Oz, Hui Sun, Jiang Hong Ye, Li Zhan. Delta9-tetrahydrocannabinol and endogenous cannabinoid anandamide directly potentiate the function of glycine receptors. Molecular pharmacology. vol 69. issue 3. 2006-04-19. PMID:16332990. |
here, we report that thc and aea, in a cb1 receptor-independent manner, cause a significant potentiation of the amplitudes of glycine-activated currents (i(gly)) in acutely isolated neurons from rat ventral tegmental area (vta) and in xenopus laevis oocytes expressing human homomeric (alpha1) and heteromeric (alpha1beta1) subunits of glycine receptors (glyrs). |
2006-04-19 |
2023-08-12 |
human |
| Nadia Hejazi, Chunyi Zhou, Murat Oz, Hui Sun, Jiang Hong Ye, Li Zhan. Delta9-tetrahydrocannabinol and endogenous cannabinoid anandamide directly potentiate the function of glycine receptors. Molecular pharmacology. vol 69. issue 3. 2006-04-19. PMID:16332990. |
the potentiation of i(gly) by thc and aea is concentration-dependent, with respective ec50 values of 86 +/- 9 and 319 +/- 31 nm for alpha1 homomeric receptors, 73 +/- 8 and 318 +/- 24 nm for alpha1beta1 heteromeric receptors, and 115 +/- 13 and 230 +/- 29 nm for native glyrs in vta neurons. |
2006-04-19 |
2023-08-12 |
human |
| Ingrid A Lobo, James R Trudell, R Adron Harri. Accessibility to residues in transmembrane segment four of the glycine receptor. Neuropharmacology. vol 50. issue 2. 2006-04-12. PMID:16225893. |
glycine receptors (glyrs) are members of the ligand-gated ion channel superfamily. |
2006-04-12 |
2023-08-12 |
Not clear |
| Michael T Roberts, Rachel Phelan, Beth S Erlichman, Rathi N Pillai, Lan Ma, Gregory F Lopreato, S John Mihi. Occupancy of a single anesthetic binding pocket is sufficient to enhance glycine receptor function. The Journal of biological chemistry. vol 281. issue 6. 2006-04-11. PMID:16361257. |
alcohols and volatile anesthetics enhance the function of inhibitory glycine receptors (glyrs). |
2006-04-11 |
2023-08-12 |
xenopus_laevis |
| Elena L Kondratskaya, Heinrich Betz, Oleg A Krishtal, Bodo Laub. The beta subunit increases the ginkgolide B sensitivity of inhibitory glycine receptors. Neuropharmacology. vol 49. issue 6. 2006-03-10. PMID:16125206. |
we investigated the effect of ginkgolide b (gb), a component of the extract from the leaves of the ginkgo biloba tree, on recombinant glycine receptors (glyrs) expressed in xenopus oocytes by using voltage-clamp recording. |
2006-03-10 |
2023-08-12 |
xenopus_laevis |
| Elena L Kondratskaya, Heinrich Betz, Oleg A Krishtal, Bodo Laub. The beta subunit increases the ginkgolide B sensitivity of inhibitory glycine receptors. Neuropharmacology. vol 49. issue 6. 2006-03-10. PMID:16125206. |
as hetero-oligomeric glyrs are known to be synaptically localized, gb represents a channel blocker that may be employed to separate extrasynaptic from synaptic glycine currents. |
2006-03-10 |
2023-08-12 |
xenopus_laevis |
| Joseph W Lynch, Robert J Calliste. Glycine receptors: a new therapeutic target in pain pathways. Current opinion in investigational drugs (London, England : 2000). vol 7. issue 1. 2006-02-03. PMID:16425671. |
although glycine receptor cl- channels (glyrs) have long been known to mediate inhibitory neurotransmission onto spinal nociceptive neurons, their therapeutic potential for peripheral analgesia has received little attention. |
2006-02-03 |
2023-08-12 |
Not clear |
| Fushun Wang, Cheng Xiao, Jiang Hong Y. Taurine activates excitatory non-synaptic glycine receptors on dopamine neurones in ventral tegmental area of young rats. The Journal of physiology. vol 565. issue Pt 2. 2005-08-31. PMID:15817633. |
thus, taurine is a full agonist of the glycine receptors (glyrs) in the vta. |
2005-08-31 |
2023-08-12 |
rat |
| Jochen C Meier, Christian Henneberger, Igor Melnick, Claudia Racca, Robert J Harvey, Uwe Heinemann, Volker Schmieden, Rosemarie Granty. RNA editing produces glycine receptor alpha3(P185L), resulting in high agonist potency. Nature neuroscience. vol 8. issue 6. 2005-08-02. PMID:15895087. |
the function of supramedullary glycine receptors (glyrs) is still unclear. |
2005-08-02 |
2023-08-12 |
rat |
| C Deleuze, G Alonso, I A Lefevre, A Duvoid-Guillou, N Huss. Extrasynaptic localization of glycine receptors in the rat supraoptic nucleus: further evidence for their involvement in glia-to-neuron communication. Neuroscience. vol 133. issue 1. 2005-08-01. PMID:15893641. |
neurons of the rat supraoptic nucleus (son) express glycine receptors (glyrs), which are implicated in the osmoregulation of neuronal activity. |
2005-08-01 |
2023-08-12 |
rat |
| Peiyuan Wang, Malcolm M Slaughte. Effects of GABA receptor antagonists on retinal glycine receptors and on homomeric glycine receptor alpha subunits. Journal of neurophysiology. vol 93. issue 6. 2005-07-15. PMID:15728760. |
interestingly, bicuculline was much more effective at alpha2 glyrs and might be used to separate glycine receptor subtypes. |
2005-07-15 |
2023-08-12 |
human |
| Maria Sola, Vassiliy N Bavro, Joanna Timmins, Thomas Franz, Sylvie Ricard-Blum, Guy Schoehn, Rob W H Ruigrok, Ingo Paarmann, Taslimarif Saiyed, Gregory A O'Sullivan, Bertram Schmitt, Heinrich Betz, Winfried Weissenhor. Structural basis of dynamic glycine receptor clustering by gephyrin. The EMBO journal. vol 23. issue 13. 2005-06-16. PMID:15201864. |
gephyrin is a bi-functional modular protein involved in molybdenum cofactor biosynthesis and in postsynaptic clustering of inhibitory glycine receptors (glyrs). |
2005-06-16 |
2023-08-12 |
Not clear |
| Anna Molander, Bo Söderpal. Accumbal strychnine-sensitive glycine receptors: an access point for ethanol to the brain reward system. Alcoholism, clinical and experimental research. vol 29. issue 1. 2005-05-25. PMID:15654288. |
we recently demonstrated that strychnine-sensitive glycine receptors (glyrs) are present in the nac and that they are involved in regulating extracellular da levels. |
2005-05-25 |
2023-08-12 |
Not clear |
| Anna Molander, Elin Löf, Rosita Stomberg, Mia Ericson, Bo Söderpal. Involvement of accumbal glycine receptors in the regulation of voluntary ethanol intake in the rat. Alcoholism, clinical and experimental research. vol 29. issue 1. 2005-05-25. PMID:15654289. |
the mechanisms underlying this da activation and how they relate to etoh reinforcement remain to be elucidated, but recent data indicate that glycine receptors (glyrs) in the nac may be involved. |
2005-05-25 |
2023-08-12 |
rat |
| Li Zhu, Jiang Hong Y. The role of G proteins in the activity and ethanol modulation of glycine-induced currents in rat neurons freshly isolated from the ventral tegmental area. Brain research. vol 1033. issue 1. 2005-04-25. PMID:15680345. |
gtp-gamma-s enhanced the amplitude of glycine-induced current (i(gly)), suggesting modulation of glyrs via a g protein-coupled pathway. |
2005-04-25 |
2023-08-12 |
rat |
| Li Zhu, Jiang Hong Y. The role of G proteins in the activity and ethanol modulation of glycine-induced currents in rat neurons freshly isolated from the ventral tegmental area. Brain research. vol 1033. issue 1. 2005-04-25. PMID:15680345. |
gdp-beta-s suppressed i(gly), suggesting that basal g protein activity positively modulates the glyrs. |
2005-04-25 |
2023-08-12 |
rat |
| Joanna Grudzinska, Rudolf Schemm, Svenja Haeger, Annette Nicke, Guenther Schmalzing, Heinrich Betz, Bodo Laub. The beta subunit determines the ligand binding properties of synaptic glycine receptors. Neuron. vol 45. issue 5. 2005-04-12. PMID:15748848. |
inhibitory glycine receptors (glyrs) regulate motor coordination and sensory signal processing in spinal cord and other brain regions. |
2005-04-12 |
2023-08-12 |
Not clear |
| Luis G Aguayo, Brigitte van Zundert, Juan C Tapia, Monica A Carrasco, Francisco J Alvare. Changes on the properties of glycine receptors during neuronal development. Brain research. Brain research reviews. vol 47. issue 1-3. 2005-03-15. PMID:15572161. |
glycine receptors (glyrs) play a major role in the excitability of spinal cord and brain stem neurons. |
2005-03-15 |
2023-08-12 |
Not clear |
| Koichi Inoue, Shinya Ueno, Junko Yamada, Atsuo Fukud. Characterization of newly cloned variant of rat glycine receptor alpha1 subunit. Biochemical and biophysical research communications. vol 327. issue 1. 2005-03-11. PMID:15629462. |
responses to glycine, a major inhibitory neurotransmitter within the nervous system, are mediated by glycine receptors (glyrs). |
2005-03-11 |
2023-08-12 |
rat |