| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Daniel K Crawford, Daya I Perkins, James R Trudell, Edward J Bertaccini, Daryl L Davies, Ronald L Alkan. Roles for loop 2 residues of alpha1 glycine receptors in agonist activation. The Journal of biological chemistry. vol 283. issue 41. 2008-11-10. PMID:18658152. |
exposing e53c glyrs to the negatively charged 2-sulfonatoethyl methanethiosulfonate, but not neutral 2-hydroxyethyl methanethiosulfonate, positively charged 2-aminoethyl methanethiosulfonate, or 2-trimethylammonioethyl methanethiosulfonate, decreased the glycine ec(50) to resemble wt glyr responses. |
2008-11-10 |
2023-08-12 |
xenopus_laevis |
| Daniel K Crawford, Daya I Perkins, James R Trudell, Edward J Bertaccini, Daryl L Davies, Ronald L Alkan. Roles for loop 2 residues of alpha1 glycine receptors in agonist activation. The Journal of biological chemistry. vol 283. issue 41. 2008-11-10. PMID:18658152. |
exposure to these reagents did not significantly alter the glycine ec(50) for wt glyrs. |
2008-11-10 |
2023-08-12 |
xenopus_laevis |
| Daya I Perkins, James R Trudell, Daniel K Crawford, Ronald L Alkana, Daryl L Davie. Targets for ethanol action and antagonism in loop 2 of the extracellular domain of glycine receptors. Journal of neurochemistry. vol 106. issue 3. 2008-09-15. PMID:18485105. |
the present studies used increased atmospheric pressure in place of a traditional pharmacological antagonist to probe the molecular sites and mechanisms of ethanol action in glycine receptors (glyrs). |
2008-09-15 |
2023-08-12 |
Not clear |
| Emilie Muller, Hervé Le Corronc, Anne-Laure Scain, Antoine Triller, Pascal Legendr. Despite GABAergic neurotransmission, GABAergic innervation does not compensate for the defect in glycine receptor postsynaptic aggregation in spastic mice. The European journal of neuroscience. vol 27. issue 10. 2008-08-20. PMID:18445051. |
in spastic mice (spa), a model of human hyperekplexic syndrome, an insertion into the gene of the glycine receptor (glyr) beta subunit results in a decreased accumulation of glyrs at postsynaptic sites and an impaired glycinergic neurotransmission. |
2008-08-20 |
2023-08-12 |
mouse |
| Tara Keck, Kyle P Lillis, Yu-Dong Zhou, John A Whit. Frequency-dependent glycinergic inhibition modulates plasticity in hippocampus. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 29. 2008-08-12. PMID:18632940. |
previous studies have demonstrated the presence of functional glycine receptors (glyrs) in hippocampus. |
2008-08-12 |
2023-08-12 |
Not clear |
| Tara Keck, Kyle P Lillis, Yu-Dong Zhou, John A Whit. Frequency-dependent glycinergic inhibition modulates plasticity in hippocampus. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 29. 2008-08-12. PMID:18632940. |
exogenous glyr agonists (glycine, taurine) block rde by preventing the closure of postsynaptic glyrs. |
2008-08-12 |
2023-08-12 |
Not clear |
| Tara Keck, Kyle P Lillis, Yu-Dong Zhou, John A Whit. Frequency-dependent glycinergic inhibition modulates plasticity in hippocampus. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 29. 2008-08-12. PMID:18632940. |
during rde, glyrs are less responsive to local glycine application, suggesting that a reduction in the number or sensitivity of membrane-inserted glyrs underlies rde. |
2008-08-12 |
2023-08-12 |
Not clear |
| Joseph W Lynch, Xuebin Che. Subunit-specific potentiation of recombinant glycine receptors by NV-31, a bilobalide-derived compound. Neuroscience letters. vol 435. issue 2. 2008-07-30. PMID:18329806. |
however, although bilobalide inhibits recombinant glycine receptor cl channels (glyrs), nv-31 potentiates hippocampal neuron glyrs. |
2008-07-30 |
2023-08-12 |
Not clear |
| Gábor Maksay, Tímea Bíró, Bodo Laube, Péter Neme. Hyperekplexia mutation R271L of alpha1 glycine receptors potentiates allosteric interactions of nortropeines, propofol and glycine with [3H]strychnine binding. Neurochemistry international. vol 52. issue 1-2. 2008-05-05. PMID:17655979. |
human alpha1 and hyperekplexia mutant alpha1(r271l) glycine receptors (glyrs) were transiently expressed in human embryonic kidney 293 cells for [3h]strychnine binding. |
2008-05-05 |
2023-08-12 |
human |
| Gábor Maksay, Tímea Bíró, Bodo Laube, Péter Neme. Hyperekplexia mutation R271L of alpha1 glycine receptors potentiates allosteric interactions of nortropeines, propofol and glycine with [3H]strychnine binding. Neurochemistry international. vol 52. issue 1-2. 2008-05-05. PMID:17655979. |
the hyperekplexia mutation increased the positive cooperativity of 0.3 mm propofol and glycine binding by about six times: the cooperativity factor beta was 0.26 for alpha1 glyrs and 0.04 for alpha1(r271l) glyrs. |
2008-05-05 |
2023-08-12 |
human |
| Long-Hua Zhang, Neng Gong, Da Fei, Lin Xu, Tian-Le X. Glycine uptake regulates hippocampal network activity via glycine receptor-mediated tonic inhibition. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 33. issue 3. 2008-04-23. PMID:17522628. |
functional glycine receptors (glyrs) are enriched in the hippocampus, but their role in hippocampal function remains unclear. |
2008-04-23 |
2023-08-12 |
Not clear |
| Long-Hua Zhang, Neng Gong, Da Fei, Lin Xu, Tian-Le X. Glycine uptake regulates hippocampal network activity via glycine receptor-mediated tonic inhibition. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 33. issue 3. 2008-04-23. PMID:17522628. |
since the concentration of ambient glycine is determined by the presence of powerful glycine transporter (glyt), we blocked the reuptake of glycine in hippocampal slices to examine the role of glyrs. |
2008-04-23 |
2023-08-12 |
Not clear |
| J Weiss, G A O'Sullivan, L Heinze, H-X Chen, H Betz, H Wässl. Glycinergic input of small-field amacrine cells in the retinas of wildtype and glycine receptor deficient mice. Molecular and cellular neurosciences. vol 37. issue 1. 2008-04-04. PMID:17920294. |
amacrine cells are known to express strychnine-sensitive glycine receptors (glyrs), however, it is not known which of the four glyralpha subunits (alpha1-4) are expressed in this diverse group of cells. |
2008-04-04 |
2023-08-12 |
mouse |
| Xiao-Bing Zhang, Guang-Chun Sun, Lu-Ying Liu, Fang Yu, Tian-Le X. Alpha2 subunit specificity of cyclothiazide inhibition on glycine receptors. Molecular pharmacology. vol 73. issue 4. 2008-04-03. PMID:18162605. |
in the mammalian cortex, alpha2 subunit-containing glycine receptors (glyrs) mediate tonic inhibition, but the precise functional role of this type of glyrs is difficult to establish because of the lack of subtype-selective antagonist. |
2008-04-03 |
2023-08-12 |
human |
| C Förster, M Mankowska, J P Fürste, M Perbandt, Ch Betzel, V A Erdman. Crystal structure of a human tRNA(Gly) microhelix at 1.2A resolution. Biochemical and biophysical research communications. vol 368. issue 4. 2008-03-31. PMID:18279665. |
the trna(gly)/glycyl-trna synthetase (glyrs) system belongs to the so-called 'class ii aminoacyl-trna synthetase system' in which trna identity elements are assured by rather few and simple determinants mostly located in the trna acceptor stem. |
2008-03-31 |
2023-08-12 |
human |
| Hai Xia Zhang, Liu Lin Thi. Zinc enhances the inhibitory effects of strychnine-sensitive glycine receptors in mouse hippocampal neurons. Journal of neurophysiology. vol 98. issue 6. 2008-03-05. PMID:17913992. |
although extracellular zn(2+) is an endogenous biphasic modulator of strychnine-sensitive glycine receptors (glyrs), the physiological significance of this modulation remains poorly understood. |
2008-03-05 |
2023-08-12 |
mouse |
| Hai Xia Zhang, Liu Lin Thi. Zinc enhances the inhibitory effects of strychnine-sensitive glycine receptors in mouse hippocampal neurons. Journal of neurophysiology. vol 98. issue 6. 2008-03-05. PMID:17913992. |
using cultured embryonic mouse hippocampal neurons, we examined whether 1 microm zn(2+), a potentiating concentration, enhances the inhibitory effects of glyrs activated by sustained glycine applications. |
2008-03-05 |
2023-08-12 |
mouse |
| Jason Tait Sanchez, Donald Gans, Jeffrey J Wenstru. Glycinergic "inhibition" mediates selective excitatory responses to combinations of sounds. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 1. 2008-02-07. PMID:18171925. |
here we compare roles of ionotropic receptors to glutamate (iglurs), glycine (glyrs), and gaba (gaba(a)rs) in facilitatory combination-sensitive interactions. |
2008-02-07 |
2023-08-12 |
Not clear |
| Hao Sun, Xin-Ping Cheng, Zeng You-Ye, Peng Jiang, Jiang-Ning Zho. Quercetin subunit specifically reduces GlyR-mediated current in rat hippocampal neurons. Neuroscience. vol 148. issue 2. 2008-01-25. PMID:17664043. |
in the present study, the effects of quercetin on native glycine receptors (glyrs) in cultured rat hippocampal neurons were investigated using a whole-cell patch-clamp technique. |
2008-01-25 |
2023-08-12 |
rat |
| Hao Sun, Xin-Ping Cheng, Zeng You-Ye, Peng Jiang, Jiang-Ning Zho. Quercetin subunit specifically reduces GlyR-mediated current in rat hippocampal neurons. Neuroscience. vol 148. issue 2. 2008-01-25. PMID:17664043. |
taken together, our results suggest that quercetin has possible effects in information processing within a neuronal network by inhibition of i(gly) and may be useful as a pharmacological probe for identifying the subunit types of glyrs. |
2008-01-25 |
2023-08-12 |
rat |