| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| b' A R Baer, J Dupr\\xc3\\xa. Suppression of insulin receptor binding by prolonged enteral or parenteral nutrient infusion in the rat: role of gastric inhibitory polypeptide. Canadian journal of physiology and pharmacology. vol 67. issue 9. 1990-02-08. PMID:2513110.' |
an additional suppression of insulin receptor binding may in part be responsible for the insulin resistance elicited by prolonged exogenous gip administration. |
1990-02-08 |
2023-08-11 |
rat |
| K E Schwartz, T Sait. Suppression of alimentary lipemia in man by a prostaglandin analogue (enprostil). Atherosclerosis. vol 79. issue 2-3. 1990-01-12. PMID:2512938. |
oral administration of gardrin (enprostil), a synthetic prostaglandin e2 structural analogue, is associated with a rapid reduction in serum lipoproteins as well as a reduction in meal-stimulated increments for glucose, insulin, and glucose-dependent insulinotropic peptide (gip). |
1990-01-12 |
2023-08-11 |
human |
| K E Schwartz, T Sait. Suppression of alimentary lipemia in man by a prostaglandin analogue (enprostil). Atherosclerosis. vol 79. issue 2-3. 1990-01-12. PMID:2512938. |
compared with placebo, enprostil resulted in significant or near significant reductions in insulin, total triglycerides (tg), chylomicron tgs, and gip while glucose was modestly elevated. |
1990-01-12 |
2023-08-11 |
human |
| K E Schwartz, T Sait. Suppression of alimentary lipemia in man by a prostaglandin analogue (enprostil). Atherosclerosis. vol 79. issue 2-3. 1990-01-12. PMID:2512938. |
the integrated areas under the insulin, gip, tg, and chylomicron curves were reduced by 59% for insulin and greater than 90% for the remainder, respectively. |
1990-01-12 |
2023-08-11 |
human |
| P Demol, W Wingende. Effects of rioprostil on the postprandial glucose, GIP, insulin and gastrin levels in volunteers. Scandinavian journal of gastroenterology. Supplement. vol 164. 1989-12-21. PMID:2510253. |
effects of rioprostil on the postprandial glucose, gip, insulin and gastrin levels in volunteers. |
1989-12-21 |
2023-08-11 |
human |
| C G Nicholl, G Carolan, H Sevelius, S R Bloo. Effect of enprostil on gastric emptying, intestinal transit time and post-prandial release of gastro-intestinal peptides. Digestion. vol 43. issue 1-2. 1989-12-19. PMID:2509267. |
enprostil markedly reduced the post-prandial rises in insulin and glucose-dependent insulinotropic peptide (gip) but plasma glucose remained unchanged. |
1989-12-19 |
2023-08-11 |
human |
| C G Nicholl, G Carolan, H Sevelius, S R Bloo. Effect of enprostil on gastric emptying, intestinal transit time and post-prandial release of gastro-intestinal peptides. Digestion. vol 43. issue 1-2. 1989-12-19. PMID:2509267. |
this delay was associated with a reduced and delayed post-prandial rise in gip and insulin and with other changes in the gut hormone profile. |
1989-12-19 |
2023-08-11 |
human |
| M Nauck, S Härter, R Ebert, W Creutzfeld. Effects of four orally administered analogues of prostaglandin E1 and E2 on glucose tolerance and on the secretion of pancreatic and gastrointestinal hormones in man. European journal of clinical investigation. vol 19. issue 3. 1989-12-08. PMID:2509214. |
nocloprost was without effect on gastric inhibitory polypeptide (gip) and did not influence insulin or c-peptide concentrations. |
1989-12-08 |
2023-08-11 |
human |
| M Nauck, S Härter, R Ebert, W Creutzfeld. Effects of four orally administered analogues of prostaglandin E1 and E2 on glucose tolerance and on the secretion of pancreatic and gastrointestinal hormones in man. European journal of clinical investigation. vol 19. issue 3. 1989-12-08. PMID:2509214. |
misoprostol and rioprostil reduced integrated incremental responses of gip by 57% (p less than or equal to 0.001) and 45% (p less than or equal to 0.01), respectively, and both gave rise to an initial (approximately 10 min) delay of insulin and c-peptide responses, without a significant overall reduction in integrated incremental responses. |
1989-12-08 |
2023-08-11 |
human |
| M Nauck, S Härter, R Ebert, W Creutzfeld. Effects of four orally administered analogues of prostaglandin E1 and E2 on glucose tolerance and on the secretion of pancreatic and gastrointestinal hormones in man. European journal of clinical investigation. vol 19. issue 3. 1989-12-08. PMID:2509214. |
enprostil almost totally inhibited the gip response (by 94%; p less than or equal to 0.001), delayed initial insulin and c-peptide responses, but reduced the integrated incremental c-peptide response (which corresponds to the overall release of insulin) by only 14% (p less than or equal to 0.05). |
1989-12-08 |
2023-08-11 |
human |
| M Nauck, S Härter, R Ebert, W Creutzfeld. Effects of four orally administered analogues of prostaglandin E1 and E2 on glucose tolerance and on the secretion of pancreatic and gastrointestinal hormones in man. European journal of clinical investigation. vol 19. issue 3. 1989-12-08. PMID:2509214. |
in conclusion, prostaglandin e analogues which caused a reduction in gip responses, and thereby disrupting the enteroinsular axis to varying degrees, delayed the time-course of insulin secretion without a significant impact on glucose tolerance. |
1989-12-08 |
2023-08-11 |
human |
| A Siddhu, S Sud, R L Bijlani, M G Karmarkar, U Naya. Modulation of postprandial glycaemia and insulinaemia by cellulose in mixed nutrient combinations. The British journal of nutrition. vol 62. issue 1. 1989-11-08. PMID:2675962. |
the mechanism of the insulinotropic effect of cl cannot be deduced from the present study, but it is possible that like g, cl also stimulates gastric inhibitory peptide (gip) secretion from the duodenum, which in turn stimulates insulin secretion. |
1989-11-08 |
2023-08-11 |
human |
| H C Fehmann, B Göke, R Göke, M E Trautmann, R Arnol. Synergistic stimulatory effect of glucagon-like peptide-1 (7-36) amide and glucose-dependent insulin-releasing polypeptide on the endocrine rat pancreas. FEBS letters. vol 252. issue 1-2. 1989-09-21. PMID:2668027. |
the interaction of glucagon-like peptide-1 (7-36)amide (glp-1) and glucose-dependent insulin-releasing polypeptide (gip) on insulin release from the perfused rat pancreas was studied. |
1989-09-21 |
2023-08-11 |
rat |
| H C Fehmann, B Göke, R Göke, M E Trautmann, R Arnol. Synergistic stimulatory effect of glucagon-like peptide-1 (7-36) amide and glucose-dependent insulin-releasing polypeptide on the endocrine rat pancreas. FEBS letters. vol 252. issue 1-2. 1989-09-21. PMID:2668027. |
the glp-1 stimulated (0.5 nmol/l), glucose-induced (6.7 mmol/l) insulin secretory answer was enhanced by gip (0.1, 1.0 and 10.0 nmol/l) to the arterial perfusate. |
1989-09-21 |
2023-08-11 |
rat |
| H C Fehmann, B Göke, R Göke, M E Trautmann, R Arnol. Synergistic stimulatory effect of glucagon-like peptide-1 (7-36) amide and glucose-dependent insulin-releasing polypeptide on the endocrine rat pancreas. FEBS letters. vol 252. issue 1-2. 1989-09-21. PMID:2668027. |
the high gip concentration of 10 nmol/l gip did not further increase insulin secretion compared to the stimulation by 1 nmol/l gip. |
1989-09-21 |
2023-08-11 |
rat |
| H C Fehmann, B Göke, R Göke, M E Trautmann, R Arnol. Synergistic stimulatory effect of glucagon-like peptide-1 (7-36) amide and glucose-dependent insulin-releasing polypeptide on the endocrine rat pancreas. FEBS letters. vol 252. issue 1-2. 1989-09-21. PMID:2668027. |
our data demonstrate an additive synergistic effect of glp-1 and gip on the glucose-induced insulin release. |
1989-09-21 |
2023-08-11 |
rat |
| M Nauck, W E Schmidt, R Ebert, J Strietzel, P Cantor, G Hoffmann, W Creutzfeld. Insulinotropic properties of synthetic human gastric inhibitory polypeptide in man: interactions with glucose, phenylalanine, and cholecystokinin-8. The Journal of clinical endocrinology and metabolism. vol 69. issue 3. 1989-09-15. PMID:2668324. |
the quantitative contribution of glucose-dependent insulinotropic polypeptide [gastric inhibitory polypeptide (gip)] to the incretin effect after oral glucose (augmentation of insulin secretion over the degree that is explained by the glycemic rise) is not known. |
1989-09-15 |
2023-08-11 |
human |
| M Nauck, W E Schmidt, R Ebert, J Strietzel, P Cantor, G Hoffmann, W Creutzfeld. Insulinotropic properties of synthetic human gastric inhibitory polypeptide in man: interactions with glucose, phenylalanine, and cholecystokinin-8. The Journal of clinical endocrinology and metabolism. vol 69. issue 3. 1989-09-15. PMID:2668324. |
insulin secretion was stimulated by hyperglycemia alone, but was greatly (2.3-fold based on c-peptide) potentiated by gip infusions (p less than or equal to 0.001 for integrated incremental values). |
1989-09-15 |
2023-08-11 |
human |
| M Nauck, W E Schmidt, R Ebert, J Strietzel, P Cantor, G Hoffmann, W Creutzfeld. Insulinotropic properties of synthetic human gastric inhibitory polypeptide in man: interactions with glucose, phenylalanine, and cholecystokinin-8. The Journal of clinical endocrinology and metabolism. vol 69. issue 3. 1989-09-15. PMID:2668324. |
when integrated incremental responses over 120 min of gip, immunoreactive insulin, and immunoreactive c-peptide were compared after oral glucose and during gip infusions, no significant differences were found. |
1989-09-15 |
2023-08-11 |
human |
| M Nauck, W E Schmidt, R Ebert, J Strietzel, P Cantor, G Hoffmann, W Creutzfeld. Insulinotropic properties of synthetic human gastric inhibitory polypeptide in man: interactions with glucose, phenylalanine, and cholecystokinin-8. The Journal of clinical endocrinology and metabolism. vol 69. issue 3. 1989-09-15. PMID:2668324. |
additional infusion of sulfated cholecystokinin-8 (25 pmol/kg.h) or the amino acid phenylalanine (1.7 mumol/kg.min) did not further stimulate insulin secretion and had no influence on the pharmacokinetics of exogenous gip. |
1989-09-15 |
2023-08-11 |
human |