| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| K Shima, M Hirota, C Ohbosh. Effect of glucagon-like peptide-1 on insulin secretion. Regulatory peptides. vol 22. issue 3. 1988-11-15. PMID:3051138. |
at the doses tested, neither glp-1s nor gip had any effect on insulin secretion induced by 3.3 mm d-glucose. |
1988-11-15 |
2023-08-11 |
rat |
| L M Morgan, J A Tredger, S M Hampton, A P French, J C Peake, V Mark. The effect of dietary modification and hyperglycaemia on gastric emptying and gastric inhibitory polypeptide (GIP) secretion. The British journal of nutrition. vol 60. issue 1. 1988-10-05. PMID:3408703. |
plasma gip, insulin, triglyceride and lsi levels were similar to those found in the first study. |
1988-10-05 |
2023-08-11 |
human |
| P Miralles, E Peiró, R A Silvestre, M L Villanueva, J Marc. Effects of galanin on islet cell secretory responses to VIP, GIP, 8-CCK, and glucagon by the perfused rat pancreas. Metabolism: clinical and experimental. vol 37. issue 8. 1988-09-12. PMID:2457142. |
to achieve further insight into the influence of galanin on the endocrine pancreas, we have investigated the effect of synthetic porcine galanin (a 200 ng bolus followed by constant infusion at a concentration of 16.8 ng/ml for 16 to 24 minutes) on unstimulated insulin, glucagon, and somatostatin release, as well as on the responses of these hormones to 1 nmol/l vasoactive intestinal peptide (vip), 1 nmol/l gastric inhibitory peptide (gip), 1 nmol/l 26 to 33 octapeptide form of cholecystokinin (8-cck) or 10 nmol/l glucagon in the perfused rat pancreas. |
1988-09-12 |
2023-08-11 |
rat |
| P Miralles, E Peiró, R A Silvestre, M L Villanueva, J Marc. Effects of galanin on islet cell secretory responses to VIP, GIP, 8-CCK, and glucagon by the perfused rat pancreas. Metabolism: clinical and experimental. vol 37. issue 8. 1988-09-12. PMID:2457142. |
galanin also blocked insulin release elicited by vip, gip, and 8-cck, it did not affect the glucagon responses to vip and gip, or the somatostatin responses to vip, gip, and 8-cck. |
1988-09-12 |
2023-08-11 |
rat |
| W S Zawalic. Synergistic impact of cholecystokinin and gastric inhibitory polypeptide on the regulation of insulin secretion. Metabolism: clinical and experimental. vol 37. issue 8. 1988-09-12. PMID:2841557. |
the modulation of insulin output from isolated perifused rat islets by the intestinal peptides cholecystokinin (cck) and gastric inhibitory polypeptide (gip) was assessed. |
1988-09-12 |
2023-08-11 |
rat |
| W S Zawalic. Synergistic impact of cholecystokinin and gastric inhibitory polypeptide on the regulation of insulin secretion. Metabolism: clinical and experimental. vol 37. issue 8. 1988-09-12. PMID:2841557. |
in the presence of 7 mmol/l (126 mg/dl) glucose, but not 2.75 mmol/l (50 mg/dl) glucose, cck (5 nmol/l) or gip (50 ng/ml) alone evoke small insulin secretory responses. |
1988-09-12 |
2023-08-11 |
rat |
| W S Zawalic. Synergistic impact of cholecystokinin and gastric inhibitory polypeptide on the regulation of insulin secretion. Metabolism: clinical and experimental. vol 37. issue 8. 1988-09-12. PMID:2841557. |
however, the combination of gip (50 ng/ml) plus cck (5 nmol/l) together with 7 mmol/l glucose results in a markedly amplified insulin secretory response. |
1988-09-12 |
2023-08-11 |
rat |
| L M Morgan, S M Hampton, J A Tredger, R Cramb, V Mark. Modifications of gastric inhibitory polypeptide (GIP) secretion in man by a high-fat diet. The British journal of nutrition. vol 59. issue 3. 1988-08-31. PMID:3293660. |
immunoreactive plasma insulin, c-peptide and gastric inhibitory polypeptide (gip) were measured. |
1988-08-31 |
2023-08-11 |
human |
| C K Lardinois, G H Starich, E L Mazzaferr. The postprandial response of gastric inhibitory polypeptide to various dietary fats in man. Journal of the American College of Nutrition. vol 7. issue 3. 1988-08-23. PMID:3392357. |
in the presence of hyperglycemia, gip augments nutrient stimulated insulin secretion. |
1988-08-23 |
2023-08-11 |
human |
| C K Lardinois, G H Starich, E L Mazzaferr. The postprandial response of gastric inhibitory polypeptide to various dietary fats in man. Journal of the American College of Nutrition. vol 7. issue 3. 1988-08-23. PMID:3392357. |
fifty grams of each triglyceride rich fat were ingested and serum cholesterol, triglyceride, glucose, insulin, and gip levels were determined over a 180-minute period. |
1988-08-23 |
2023-08-11 |
human |
| C K Lardinois, G H Starich, E L Mazzaferr. The postprandial response of gastric inhibitory polypeptide to various dietary fats in man. Journal of the American College of Nutrition. vol 7. issue 3. 1988-08-23. PMID:3392357. |
the reason for these differences in serum gip responses is uncertain, but is not readily explained by changes in serum glucose, insulin, or triglyceride concentrations. |
1988-08-23 |
2023-08-11 |
human |
| C K Lardinois, G H Starich, E L Mazzaferr. The postprandial response of gastric inhibitory polypeptide to various dietary fats in man. Journal of the American College of Nutrition. vol 7. issue 3. 1988-08-23. PMID:3392357. |
since gip augments nutrient stimulated insulin release 1-3 hours postprandially, the source of dietary fat consumed as part of a mixed meal could ultimately influence pancreatic beta cell insulin secretion. |
1988-08-23 |
2023-08-11 |
human |
| E Sandberg, B Ahrén, D Tendler, S Efendi. Cholecystokinin-33 potentiates and vasoactive intestinal polypeptide inhibits gastric inhibitory polypeptide--induced insulin secretion in the perfused rat pancreas. Acta endocrinologica. vol 117. issue 4. 1988-07-29. PMID:3291528. |
gastric inhibitory polypeptide (gip), cholecystokinin (cck), and vasoactive intestinal polypeptide (vip) stimulate insulin secretion. |
1988-07-29 |
2023-08-11 |
rat |
| E Sandberg, B Ahrén, D Tendler, S Efendi. Cholecystokinin-33 potentiates and vasoactive intestinal polypeptide inhibits gastric inhibitory polypeptide--induced insulin secretion in the perfused rat pancreas. Acta endocrinologica. vol 117. issue 4. 1988-07-29. PMID:3291528. |
we found that at 0.1 nmol/l, gip markedly potentiated glucose-induced insulin release whereas cck-33 and vip had a weak stimulatory effect and only during the late phase. |
1988-07-29 |
2023-08-11 |
rat |
| E Sandberg, B Ahrén, D Tendler, S Efendi. Cholecystokinin-33 potentiates and vasoactive intestinal polypeptide inhibits gastric inhibitory polypeptide--induced insulin secretion in the perfused rat pancreas. Acta endocrinologica. vol 117. issue 4. 1988-07-29. PMID:3291528. |
at this low dose level, cck-33 potentiated but vip inhibited the late phase of insulin release stimulated by glucose and gip. |
1988-07-29 |
2023-08-11 |
rat |
| E Sandberg, B Ahrén, D Tendler, S Efendi. Cholecystokinin-33 potentiates and vasoactive intestinal polypeptide inhibits gastric inhibitory polypeptide--induced insulin secretion in the perfused rat pancreas. Acta endocrinologica. vol 117. issue 4. 1988-07-29. PMID:3291528. |
at 1.0 nmol/l, gip, cck-33, and vip markedly potentiated both phases of glucose-induced insulin secretion. |
1988-07-29 |
2023-08-11 |
rat |
| E Sandberg, B Ahrén, D Tendler, S Efendi. Cholecystokinin-33 potentiates and vasoactive intestinal polypeptide inhibits gastric inhibitory polypeptide--induced insulin secretion in the perfused rat pancreas. Acta endocrinologica. vol 117. issue 4. 1988-07-29. PMID:3291528. |
at this dose level cck-33 and gip exerted additive stimulatory effects on the late phase of insulin release triggered by glucose. |
1988-07-29 |
2023-08-11 |
rat |
| E Sandberg, B Ahrén, D Tendler, S Efendi. Cholecystokinin-33 potentiates and vasoactive intestinal polypeptide inhibits gastric inhibitory polypeptide--induced insulin secretion in the perfused rat pancreas. Acta endocrinologica. vol 117. issue 4. 1988-07-29. PMID:3291528. |
in contrast, 1.0 nmol/l vip inhibited insulin secretion augmented by glucose and gip. |
1988-07-29 |
2023-08-11 |
rat |
| E Sandberg, B Ahrén, D Tendler, S Efendi. Cholecystokinin-33 potentiates and vasoactive intestinal polypeptide inhibits gastric inhibitory polypeptide--induced insulin secretion in the perfused rat pancreas. Acta endocrinologica. vol 117. issue 4. 1988-07-29. PMID:3291528. |
in summary 1) gip, cck-33 and vip all potentiate glucose-induced insulin secretion from the perfused rat pancreas, and 2) cck-33 potentiates and vip inhibits gip-induced insulin secretion. |
1988-07-29 |
2023-08-11 |
rat |
| L R Roust, M Stesin, V L Go, P C O'Brien, R A Rizza, F J Servic. Role of gastric inhibitory polypeptide in postprandial hyperinsulinemia of obesity. The American journal of physiology. vol 254. issue 6 Pt 1. 1988-07-08. PMID:3287953. |
to assess the contribution of gastric inhibitory polypeptide (gip) to the postprandial hyperinsulinemia of obesity, secretion rates of gip (generated from kinetic analyses from infusions of porcine gip) and insulin (from c-peptide applied to a validated kinetic model) to meals of 3 sizes were determined in 10 obese (5 male and 5 female) and 10 lean, sex- and age-matched healthy subjects. |
1988-07-08 |
2023-08-11 |
human |