| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| L M Morgan, J A Tredger, S M Hampton, A P French, J C Peake, V Mark. The effect of dietary modification and hyperglycaemia on gastric emptying and gastric inhibitory polypeptide (GIP) secretion. The British journal of nutrition. vol 60. issue 1. 1988-10-05. PMID:3408703. |
plasma gip, insulin, triglyceride and lsi levels were similar to those found in the first study. |
1988-10-05 |
2023-08-11 |
human |
| P Miralles, E Peiró, R A Silvestre, M L Villanueva, J Marc. Effects of galanin on islet cell secretory responses to VIP, GIP, 8-CCK, and glucagon by the perfused rat pancreas. Metabolism: clinical and experimental. vol 37. issue 8. 1988-09-12. PMID:2457142. |
to achieve further insight into the influence of galanin on the endocrine pancreas, we have investigated the effect of synthetic porcine galanin (a 200 ng bolus followed by constant infusion at a concentration of 16.8 ng/ml for 16 to 24 minutes) on unstimulated insulin, glucagon, and somatostatin release, as well as on the responses of these hormones to 1 nmol/l vasoactive intestinal peptide (vip), 1 nmol/l gastric inhibitory peptide (gip), 1 nmol/l 26 to 33 octapeptide form of cholecystokinin (8-cck) or 10 nmol/l glucagon in the perfused rat pancreas. |
1988-09-12 |
2023-08-11 |
rat |
| P Miralles, E Peiró, R A Silvestre, M L Villanueva, J Marc. Effects of galanin on islet cell secretory responses to VIP, GIP, 8-CCK, and glucagon by the perfused rat pancreas. Metabolism: clinical and experimental. vol 37. issue 8. 1988-09-12. PMID:2457142. |
galanin also blocked insulin release elicited by vip, gip, and 8-cck, it did not affect the glucagon responses to vip and gip, or the somatostatin responses to vip, gip, and 8-cck. |
1988-09-12 |
2023-08-11 |
rat |
| W S Zawalic. Synergistic impact of cholecystokinin and gastric inhibitory polypeptide on the regulation of insulin secretion. Metabolism: clinical and experimental. vol 37. issue 8. 1988-09-12. PMID:2841557. |
the modulation of insulin output from isolated perifused rat islets by the intestinal peptides cholecystokinin (cck) and gastric inhibitory polypeptide (gip) was assessed. |
1988-09-12 |
2023-08-11 |
rat |
| W S Zawalic. Synergistic impact of cholecystokinin and gastric inhibitory polypeptide on the regulation of insulin secretion. Metabolism: clinical and experimental. vol 37. issue 8. 1988-09-12. PMID:2841557. |
in the presence of 7 mmol/l (126 mg/dl) glucose, but not 2.75 mmol/l (50 mg/dl) glucose, cck (5 nmol/l) or gip (50 ng/ml) alone evoke small insulin secretory responses. |
1988-09-12 |
2023-08-11 |
rat |
| W S Zawalic. Synergistic impact of cholecystokinin and gastric inhibitory polypeptide on the regulation of insulin secretion. Metabolism: clinical and experimental. vol 37. issue 8. 1988-09-12. PMID:2841557. |
however, the combination of gip (50 ng/ml) plus cck (5 nmol/l) together with 7 mmol/l glucose results in a markedly amplified insulin secretory response. |
1988-09-12 |
2023-08-11 |
rat |
| L M Morgan, S M Hampton, J A Tredger, R Cramb, V Mark. Modifications of gastric inhibitory polypeptide (GIP) secretion in man by a high-fat diet. The British journal of nutrition. vol 59. issue 3. 1988-08-31. PMID:3293660. |
immunoreactive plasma insulin, c-peptide and gastric inhibitory polypeptide (gip) were measured. |
1988-08-31 |
2023-08-11 |
human |
| C K Lardinois, G H Starich, E L Mazzaferr. The postprandial response of gastric inhibitory polypeptide to various dietary fats in man. Journal of the American College of Nutrition. vol 7. issue 3. 1988-08-23. PMID:3392357. |
in the presence of hyperglycemia, gip augments nutrient stimulated insulin secretion. |
1988-08-23 |
2023-08-11 |
human |
| C K Lardinois, G H Starich, E L Mazzaferr. The postprandial response of gastric inhibitory polypeptide to various dietary fats in man. Journal of the American College of Nutrition. vol 7. issue 3. 1988-08-23. PMID:3392357. |
fifty grams of each triglyceride rich fat were ingested and serum cholesterol, triglyceride, glucose, insulin, and gip levels were determined over a 180-minute period. |
1988-08-23 |
2023-08-11 |
human |
| C K Lardinois, G H Starich, E L Mazzaferr. The postprandial response of gastric inhibitory polypeptide to various dietary fats in man. Journal of the American College of Nutrition. vol 7. issue 3. 1988-08-23. PMID:3392357. |
the reason for these differences in serum gip responses is uncertain, but is not readily explained by changes in serum glucose, insulin, or triglyceride concentrations. |
1988-08-23 |
2023-08-11 |
human |
| C K Lardinois, G H Starich, E L Mazzaferr. The postprandial response of gastric inhibitory polypeptide to various dietary fats in man. Journal of the American College of Nutrition. vol 7. issue 3. 1988-08-23. PMID:3392357. |
since gip augments nutrient stimulated insulin release 1-3 hours postprandially, the source of dietary fat consumed as part of a mixed meal could ultimately influence pancreatic beta cell insulin secretion. |
1988-08-23 |
2023-08-11 |
human |
| E Sandberg, B Ahrén, D Tendler, S Efendi. Cholecystokinin-33 potentiates and vasoactive intestinal polypeptide inhibits gastric inhibitory polypeptide--induced insulin secretion in the perfused rat pancreas. Acta endocrinologica. vol 117. issue 4. 1988-07-29. PMID:3291528. |
gastric inhibitory polypeptide (gip), cholecystokinin (cck), and vasoactive intestinal polypeptide (vip) stimulate insulin secretion. |
1988-07-29 |
2023-08-11 |
rat |
| E Sandberg, B Ahrén, D Tendler, S Efendi. Cholecystokinin-33 potentiates and vasoactive intestinal polypeptide inhibits gastric inhibitory polypeptide--induced insulin secretion in the perfused rat pancreas. Acta endocrinologica. vol 117. issue 4. 1988-07-29. PMID:3291528. |
we found that at 0.1 nmol/l, gip markedly potentiated glucose-induced insulin release whereas cck-33 and vip had a weak stimulatory effect and only during the late phase. |
1988-07-29 |
2023-08-11 |
rat |
| E Sandberg, B Ahrén, D Tendler, S Efendi. Cholecystokinin-33 potentiates and vasoactive intestinal polypeptide inhibits gastric inhibitory polypeptide--induced insulin secretion in the perfused rat pancreas. Acta endocrinologica. vol 117. issue 4. 1988-07-29. PMID:3291528. |
at this low dose level, cck-33 potentiated but vip inhibited the late phase of insulin release stimulated by glucose and gip. |
1988-07-29 |
2023-08-11 |
rat |
| E Sandberg, B Ahrén, D Tendler, S Efendi. Cholecystokinin-33 potentiates and vasoactive intestinal polypeptide inhibits gastric inhibitory polypeptide--induced insulin secretion in the perfused rat pancreas. Acta endocrinologica. vol 117. issue 4. 1988-07-29. PMID:3291528. |
at 1.0 nmol/l, gip, cck-33, and vip markedly potentiated both phases of glucose-induced insulin secretion. |
1988-07-29 |
2023-08-11 |
rat |
| E Sandberg, B Ahrén, D Tendler, S Efendi. Cholecystokinin-33 potentiates and vasoactive intestinal polypeptide inhibits gastric inhibitory polypeptide--induced insulin secretion in the perfused rat pancreas. Acta endocrinologica. vol 117. issue 4. 1988-07-29. PMID:3291528. |
at this dose level cck-33 and gip exerted additive stimulatory effects on the late phase of insulin release triggered by glucose. |
1988-07-29 |
2023-08-11 |
rat |
| E Sandberg, B Ahrén, D Tendler, S Efendi. Cholecystokinin-33 potentiates and vasoactive intestinal polypeptide inhibits gastric inhibitory polypeptide--induced insulin secretion in the perfused rat pancreas. Acta endocrinologica. vol 117. issue 4. 1988-07-29. PMID:3291528. |
in contrast, 1.0 nmol/l vip inhibited insulin secretion augmented by glucose and gip. |
1988-07-29 |
2023-08-11 |
rat |
| E Sandberg, B Ahrén, D Tendler, S Efendi. Cholecystokinin-33 potentiates and vasoactive intestinal polypeptide inhibits gastric inhibitory polypeptide--induced insulin secretion in the perfused rat pancreas. Acta endocrinologica. vol 117. issue 4. 1988-07-29. PMID:3291528. |
in summary 1) gip, cck-33 and vip all potentiate glucose-induced insulin secretion from the perfused rat pancreas, and 2) cck-33 potentiates and vip inhibits gip-induced insulin secretion. |
1988-07-29 |
2023-08-11 |
rat |
| L R Roust, M Stesin, V L Go, P C O'Brien, R A Rizza, F J Servic. Role of gastric inhibitory polypeptide in postprandial hyperinsulinemia of obesity. The American journal of physiology. vol 254. issue 6 Pt 1. 1988-07-08. PMID:3287953. |
to assess the contribution of gastric inhibitory polypeptide (gip) to the postprandial hyperinsulinemia of obesity, secretion rates of gip (generated from kinetic analyses from infusions of porcine gip) and insulin (from c-peptide applied to a validated kinetic model) to meals of 3 sizes were determined in 10 obese (5 male and 5 female) and 10 lean, sex- and age-matched healthy subjects. |
1988-07-08 |
2023-08-11 |
human |
| L R Roust, M Stesin, V L Go, P C O'Brien, R A Rizza, F J Servic. Role of gastric inhibitory polypeptide in postprandial hyperinsulinemia of obesity. The American journal of physiology. vol 254. issue 6 Pt 1. 1988-07-08. PMID:3287953. |
we conclude that 1) although postprandial plasma gip concentrations are normal, gip secretion is increased in obesity, 2) the postprandial hyperinsulinemia of obesity is not due to excessive insulin secretion but is likely secondary to altered insulin clearance, and 3) gip cannot account for the hyperinsulinemia of obesity through its insulinotropic action. |
1988-07-08 |
2023-08-11 |
human |