| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Paula-Peace James-Okoro, Jo Edward Lewis, Fiona Mary Gribble, Frank Reiman. The role of GIPR in food intake control. Frontiers in endocrinology. vol 16. 2025-04-01. PMID:40166681. |
glucose-dependent insulinotropic polypeptide (gip) is one of two incretin hormones playing key roles in the control of food intake, nutrient assimilation, insulin secretion and whole-body metabolism. |
2025-04-01 |
2025-04-03 |
Not clear |
| Kristine Henriksen, Anne Jørgensen, Simranjeet Kaur, Rebekka Gerwig, Cecilie Amalie Brøgger Svane, Filip K Knop, Joachim Størlin. Exploring the functional, protective, and transcriptomic effects of GIP on cytokine-exposed human pancreatic islets and EndoC-βH5 cells. Molecular and cellular endocrinology. 2025-03-23. PMID:40122442. |
gip dose-dependently augmented glucose-stimulated insulin secretion from endoc-βh5 cells and increased insulin and glucagon secretion from human islets at high and low glucose concentrations, respectively. |
2025-03-23 |
2025-03-26 |
human |
| Stefan Kabisch, Jasmin Hajir, Varvara Sukhobaevskaia, Martin O Weickert, Andreas F H Pfeiffe. Impact of Dietary Fiber on Inflammation in Humans. International journal of molecular sciences. vol 26. issue 5. 2025-03-13. PMID:40076626. |
hypotheses on putative mechanisms of anti-inflammatory fiber effects include a direct impact on immune cells (e.g., for pectin), fermentation to pleiotropic short-chain fatty acids (for fermentable fiber only), modulation of the gut microbiome towards higher levels of diversity, changes in bile acid metabolism, a differential release of gut hormones (such as the glucose-dependent insulinotropic peptide (gip)), and an improvement of insulin resistance via the mtor/s6k1 signaling cascade. |
2025-03-13 |
2025-03-15 |
human |
| Marco Infante, Francesca Silvestri, Nathalia Padilla, Francesca Pacifici, Donatella Pastore, Marcelo Maia Pinheiro, Massimiliano Caprio, Manfredi Tesauro, Andrea Fabbri, Giuseppe Novelli, Rodolfo Alejandro, Antonino De Lorenzo, Camillo Ricordi, David Della-Mort. Unveiling the Therapeutic Potential of the Second-Generation Incretin Analogs Semaglutide and Tirzepatide in Type 1 Diabetes and Latent Autoimmune Diabetes in Adults. Journal of clinical medicine. vol 14. issue 4. 2025-02-26. PMID:40004833. |
although the glucagon-like peptide-1 (glp-1) receptor agonists and the novel dual gip (glucose-dependent insulinotropic polypeptide)/glp-1 receptor agonist tirzepatide are currently not approved for the treatment of t1d, a growing body of evidence over the last few years has shown that these medications may serve as valid add-on treatments to insulin with substantial efficacy in improving glucose control, promoting weight loss, preserving residual beta-cell function and providing other beneficial metabolic effects in patients with t1d, double diabetes and latent autoimmune diabetes in adults (lada). |
2025-02-26 |
2025-02-28 |
Not clear |
| M Michael Wolfe, Michael O Boylan, Wiliam W Chi. Glucose-Dependent Insulinotropic Polypeptide in Incretin Physiology: Role in Health and Disease. Endocrine reviews. 2025-02-14. PMID:39951489. |
although originally named "gastric inhibitory polypeptide" on the basis of its ability to inhibit gastric acid secretion, gip accounts for 60%-80% of the postprandial insulin response, consistent with the notion that this regulatory peptide constitutes the principal physiological incretin. |
2025-02-14 |
2025-02-17 |
Not clear |
| M Michael Wolfe, Michael O Boylan, Wiliam W Chi. Glucose-Dependent Insulinotropic Polypeptide in Incretin Physiology: Role in Health and Disease. Endocrine reviews. 2025-02-14. PMID:39951489. |
under normal conditions, gip plays a major role in nutrient deposition and storage, both directly through its insulin mimetic properties and indirectly by enhancing insulin release. |
2025-02-14 |
2025-02-17 |
Not clear |
| M Michael Wolfe, Michael O Boylan, Wiliam W Chi. Glucose-Dependent Insulinotropic Polypeptide in Incretin Physiology: Role in Health and Disease. Endocrine reviews. 2025-02-14. PMID:39951489. |
gip is overexpressed in obese individuals, which may exacerbate insulin resistance manifested by many patients with type 2 diabetes mellitus. |
2025-02-14 |
2025-02-17 |
Not clear |
| M Michael Wolfe, Michael O Boylan, Wiliam W Chi. Glucose-Dependent Insulinotropic Polypeptide in Incretin Physiology: Role in Health and Disease. Endocrine reviews. 2025-02-14. PMID:39951489. |
enhanced postprandial secretion of gip also initiates a vicious cycle characterized by increased nutrient uptake and storage in adipocytes, leading to insulin resistance and hyperinsulinemia, which then further increases adipocyte nutrient uptake and storage. |
2025-02-14 |
2025-02-17 |
Not clear |
| Mayra Betancourt Ponce, Bridget E Shield. Dermatologic Implications of Glycemic Control Medications for Patients with Type 2 Diabetes Mellitus. Cutis. vol 115. issue 1. 2025-02-13. PMID:39946251. |
in patients with t2dm who are overweight or obese, glucagonlike peptide 1 (glp-1) and dual glp-1/gastric inhibitory peptide (gip) agonists are used as adjunct or alternative therapies given their dual benefits for insulin sensitivity and weight loss. |
2025-02-13 |
2025-02-16 |
Not clear |
| Yusman Manchanda, Ben Jones, Gaelle Carrat, Zenouska Ramchunder, Piero Marchetti, Isabelle Leclerc, Rajamannar Thennati, Vinod Burade, Muthukumaran Natarajan, Pradeep Shahi, Alejandra Tomas, Guy A Rutte. Binding Kinetics, Bias, Receptor Internalization and Effects on Insulin Secretion bioRxiv : the preprint server for biology. 2025-01-27. PMID:39868265. |
here, we describe the synthesis and properties of a molecule which binds to both glucagon-like peptide-1 (glp-1) and glucose-dependent insulinotropic polypeptide (gip) receptors (glp-1r and gipr) to enhance insulin secretion. |
2025-01-27 |
2025-01-29 |
Not clear |
| Vandana Zaman, Denise Matzelle, Naren L Banik, Azizul Haqu. Dysregulation of Metabolic Peptides Precedes Hyperinsulinemia and Inflammation Following Exposure to Rotenone in Rats. Cells. vol 14. issue 2. 2025-01-24. PMID:39851552. |
interestingly, levels of several hormonal peptides related to hyperinsulinemia, such as insulin, leptin, pancreatic peptide (pp), peptide yy (pyy), and gastric inhibitory polypeptide (gip), were significantly upregulated. |
2025-01-24 |
2025-01-27 |
rat |
| Rola Hammoud, Kiran Deep Kaur, Jacqueline A Koehler, Laurie L Baggio, Chi Kin Wong, Katie E Advani, Bernardo Yusta, Irina Efimova, Fiona M Gribble, Frank Reimann, Sigal Fishman, Chen Varol, Daniel J Drucke. Glucose-dependent insulinotropic polypeptide receptor signaling alleviates gut inflammation in mice. JCI insight. 2024-12-26. PMID:39723966. |
glucose-dependent insulinotropic polypeptide (gip) and glucagon-like peptide 1 (glp-1) are gut-derived peptide hormones that potentiate glucose-dependent insulin secretion. |
2024-12-26 |
2024-12-29 |
mouse |
| Franck Phan, Romane Bertrand, Chloé Amouyal, Fabrizio Andreell. [From the discovery of incretin hormones to GIP / GLP-1 / glucagon double and triple agonists]. Medecine sciences : M/S. vol 40. issue 11. 2024-12-10. PMID:39656981. |
the discovery of the incretin effect (potentiation of insulin secretion when glucose is taken orally compared to intravenously) led to the discovery of the two main gut hormones responsible for this effect: gip and glp-1. |
2024-12-10 |
2024-12-21 |
Not clear |
| b' Denise Tan, Yueying Yao, Yifan Zhou, Chin Meng Khoo, Ludovic Penseyres, Andreas Rytz, Leroy Sivappiragasam Pakkiri, Chester Lee Drum, Jung Eun Kim, Kim-Anne L\\xc3\\xa. Differently Processed Low Doses of \\xce\\xb2-Glucan from Oat Bran Similarly Attenuate Postprandial Glycemic Response. Foods (Basel, Switzerland). vol 13. issue 22. 2024-11-27. PMID:39594039.' |
four-hour postprandial incremental areas under the curve (iauc) and peak incremental concentrations (icmax) of glucose, insulin, glucagon-like peptide 1 (glp-1), gastric inhibitory polypeptide (gip), and paracetamol were evaluated. |
2024-11-27 |
2024-11-29 |
human |
| Constanza Alcaino, Frank Reimann, Fiona M Gribbl. Incretin hormones and obesity. The Journal of physiology. 2024-11-22. PMID:39576749. |
the incretin hormones glucagon-like peptide-1 (glp-1) and glucose-dependent insulinotropic polypeptide (gip) play critical roles in co-ordinating postprandial metabolism, including modulation of insulin secretion and food intake. |
2024-11-22 |
2024-11-25 |
Not clear |
| Yukako Yamamoto, Osamu Sekine, Jun Ito-Kobayashi, Ayane Nishida, Takeshi Togawa, Yuki Ozamoto, Yasumitsu Oe, Akeo Hagiwara, Masaki Kobayashi, Tadahiro Kitamura, Masanori Iwanishi, Akira Shimatsu, Atsunori Kashiwag. Is glucose-induced hypersecretion of glicentin after the revision surgery using Roux-en-Y gastric bypass related to improved glycemic control due to insulin hypersecretion in a type 2 diabetes patient without diabetes remission after laparoscopic sleeve gastrectomy? Journal of diabetes investigation. 2024-11-18. PMID:39556486. |
interestingly, he showed improvements of insulin and a marked glicentin secretions with minor changes in glucagon related peptide 1 (glp-1) and glucose-dependent insulinotropic polypeptide (gip) secretions in the oral glucose tolerance test ogtt after the rygb surgery compared with post-lsg. |
2024-11-18 |
2024-11-22 |
Not clear |
| Junmin Jiang, Meifeng Shi, Shuduo Wu, Minling Ca. A Case of Severe Cholestatic Hepatitis Induced by a Novel Dual Agonist of Glucagon-like Peptide-1 and Glucose-dependent Insulinotropic Polypeptide Receptors. Journal of clinical and translational hepatology. vol 12. issue 11. 2024-11-15. PMID:39544242. |
glucagon-like peptide-1 (glp-1) and glucose-dependent insulinotropic polypeptide (gip) receptor agonists are increasingly used in the management of type 2 diabetes mellitus and obesity due to their ability to stimulate insulin secretion, delay gastric emptying, and suppress appetite. |
2024-11-15 |
2024-11-17 |
Not clear |
| Yuji Yamazaki, Yutaka Sein. Which is the real nature of glucose-dependent insulinotropic peptide?: Endogenous vs pharmacological. Journal of diabetes investigation. 2024-11-14. PMID:39540705. |
pharmacological gip receptor activation promotes weight loss and improves insulin sensitivity, contrasting sharply with the lipogenic and insulin-resistant effects of endogenous gip. |
2024-11-14 |
2024-11-17 |
Not clear |
| Antwi-Boasiako Oteng, Liu Liu, Yinghong Cui, Oksana Gavrilova, Huiyan Lu, Min Chen, Lee S Weinstein, Jonathan E Campbell, Jo E Lewis, Fiona M Gribble, Frank Reimann, Jürgen Wes. Activation of Gs signaling in mouse enteroendocrine K-cells greatly improves obesity- and diabetes-related metabolic deficits. The Journal of clinical investigation. 2024-10-22. PMID:39436694. |
following a meal, glucagon-like peptide-1 (glp1) and glucose-dependent insulinotropic polypeptide (gip), the two major incretins promoting insulin release, are secreted from specialized enteroendocrine cells (l- and k-cells, respectively). |
2024-10-22 |
2024-10-25 |
mouse |
| Hayrunisa Aksu, Ayşenur Demirbilek, Abdullahi Ibrahim Ub. Insights into the structure and activation mechanism of some class B1 GPCR family members. Molecular biology reports. vol 51. issue 1. 2024-09-06. PMID:39240462. |
for example, the insulinotropic polypeptide (gip) stimulates the glucose-dependent insulinotropic polypeptide receptor (gipr), while the glucagon receptor (gcgr) responds to glucagon by increasing blood glucose levels and promoting the breakdown of liver glycogen to induce the production of insulin. |
2024-09-06 |
2024-09-08 |
Not clear |