| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Emily Pusch, Małgorzata Krążek, Tatiana Wojciechowicz, Maciej Sassek, Paweł A Kołodziejski, Mathias Z Strowski, Krzysztof W Nowak, Marek Skrzypsk. GIP_HUMAN [22-51] Peptide Encoded by the Glucose-Dependent Insulinotropic Polypeptide (GIP) Gene Suppresses Insulin Expression and Secretion in INS-1E Cells and Rat Pancreatic Islets. Genes. vol 14. issue 10. 2023-10-30. PMID:37895259. |
gip_human [22-51] peptide encoded by the glucose-dependent insulinotropic polypeptide (gip) gene suppresses insulin expression and secretion in ins-1e cells and rat pancreatic islets. |
2023-10-30 |
2023-11-08 |
mouse |
| Mona Mashayekhi, Hui Nian, Dustin Mayfield, Jessica K Devin, Jorge L Gamboa, Chang Yu, Heidi J Silver, Kevin Niswender, James M Luther, Nancy J Brow. Weight Loss-Independent Effect of Liraglutide on Insulin Sensitivity in Individuals with Obesity and Pre-Diabetes. Diabetes. 2023-10-24. PMID:37874653. |
sitagliptin increased endogenous glp-1 and gip without altering insulin sensitivity or fasting glucose, but decreased post-prandial glucose and glucagon. |
2023-10-24 |
2023-11-08 |
Not clear |
| Jing Xu, Peng Chen, Dongzhi Wu, Qiang Zhou, Sijie Chen, Xiang Ding, Hongping Xion. The novel GLP-1/GIP dual agonist DA3-CH improves rat type 2 diabetes through activating AMPK/ACC signaling pathway. Aging. vol 15. 2023-10-18. PMID:37851373. |
da3-ch is a novel dual receptor agonist of glucagon like peptide-1 (glp-1) and glucose dependent insulin stimulating polypeptide (gip). |
2023-10-18 |
2023-11-08 |
rat |
| Christine B Christiansen, Per B Jeppesen, Kjeld Hermansen, Søren Gregerse. Aronia in the Type 2 Diabetes Treatment Regimen. Nutrients. vol 15. issue 19. 2023-10-14. PMID:37836472. |
pre- and post-treatment period, we did fasting blood samples, including hemoglobin a1c, fructosamine, insulin, glucose, glucagon-like peptide-1, glucose-dependent insulinotropic peptide (gip) and glucagon, oral glucose tolerance tests, and anthropometric measurements. |
2023-10-14 |
2023-10-15 |
human |
| Heba A Mubarak, Manal M Kamal, Yossra Mahmoud, Fatma S Abd-Elsamea, Eman Abdelbary, Marwa G Gamea, Reham I El-Mahd. The ameliorating effects of mesenchymal stem cells compared to α-tocopherol on apoptosis and autophagy in streptozotocin-induced diabetic rats: Implication of PI3K/Akt signaling pathway and entero-insular axis. Journal of cellular biochemistry. 2023-10-05. PMID:37796145. |
histopathological examination of the pancreas, the expression levels of insulin, cd44, caspase-3, autophagy markers, p13k/akt, and pancreas/duodenum homeobox protein 1, in pancreatic tissue, and glucose-dependent insulinotropic polypeptide (gip) in the duodenum were detected by hematoxylin and eosin staining, immunofluorescence labeling, and by quantitative real-time polymerase chain reaction. the diabetic rats showed reduced insulin, hyperglycemia, nitrosative stress (no, cat), augmented apoptosis (caspase 3), impaired autophagy (p62/sqstm1, lc3), downregulated pi3k/akt pathway and increased gip expression, and degeneration of pancreatic islets. |
2023-10-05 |
2023-10-07 |
rat |
| Heba A Mubarak, Manal M Kamal, Yossra Mahmoud, Fatma S Abd-Elsamea, Eman Abdelbary, Marwa G Gamea, Reham I El-Mahd. The ameliorating effects of mesenchymal stem cells compared to α-tocopherol on apoptosis and autophagy in streptozotocin-induced diabetic rats: Implication of PI3K/Akt signaling pathway and entero-insular axis. Journal of cellular biochemistry. 2023-10-05. PMID:37796145. |
treatment with either bm-mscs or α-toc suppressed the nitrosative stress, reduced apoptosis, recovered autophagy, upregulated pi3k/akt pathway, and subsequently increased insulin levels, decreased blood glucose, and downregulated gip expression with partial restoration of pancreatic islets. based on our findings, the cytoprotective effects of bm-mscs and α-toc in type 1-induced diabetes appeared to be related to repaired autophagy and recovered pi3k/akt signaling. |
2023-10-05 |
2023-10-07 |
rat |
| Dina Medina-Vera, Emma N Zambrana-Infantes, Antonio J López-Gambero, Julia Verheul-Campos, Luis J Santín, Elena Baixeras, Juan Suarez, Francisco J Pavon, Cristina Rosell-Valle, Fernando Rodríguez de Fonsec. Transcending the amyloid-beta dominance paradigm in Alzheimer's disease: An exploration of behavioural, metabolic, and gut microbiota phenotypes in 5xFAD mice. Neurobiology of disease. 2023-09-17. PMID:37717663. |
dysregulation of both insulin and insulin secretion-regulating gip peptide were observed at 5 months of age, disappearing later. |
2023-09-17 |
2023-10-07 |
mouse |
| Nan Wu, Guohua A. A Quantitative Systems Pharmacology Model of the Incretin Hormones GIP and GLP1, Glucagon, Glucose, Insulin, and the Small Molecule DPP-4 Inhibitor, Linagliptin. Journal of pharmaceutical sciences. 2023-09-16. PMID:37716531. |
a quantitative systems pharmacology model of the incretin hormones gip and glp1, glucagon, glucose, insulin, and the small molecule dpp-4 inhibitor, linagliptin. |
2023-09-16 |
2023-10-07 |
human |
| Nan Wu, Guohua A. A Quantitative Systems Pharmacology Model of the Incretin Hormones GIP and GLP1, Glucagon, Glucose, Insulin, and the Small Molecule DPP-4 Inhibitor, Linagliptin. Journal of pharmaceutical sciences. 2023-09-16. PMID:37716531. |
in the current study, we established a comprehensive quantitative systems pharmacology (qsp) model using linagliptin as the model drug, where drug disposition, drug intervention on dipeptidyl peptidase-4 (dpp-4), glucose-dependent insulinotropic peptide (gip), glucagon-like peptide-1 (glp-1), glucagon, glucose, and insulin are integrated together with the cross talk and feedback loops incorporated among the whole glycemic control system. |
2023-09-16 |
2023-10-07 |
human |
| Pamela Bowman, Kashyap A Patel, Timothy J McDonald, Jens J Holst, Bolette Hartmann, Maria Leveridge, Beverley M Shields, Suzie Hammersley, Steve R Spaull, Bridget A Knight, Sarah E Flanagan, Maggie H Shepherd, Rob C Andrews, Andrew T Hattersle. Incretin hormone responses to carbohydrate and protein/fat are preserved in adults with sulfonylurea-treated KCNJ11 neonatal diabetes. Journal of diabetes investigation. 2023-08-21. PMID:37602910. |
the incretin hormones glucagon-like peptide-1 (glp-1) and glucose-dependent insulinotropic polypeptide (gip), are thought to be the main drivers of insulin secretion in individuals with sulfonylurea (su)-treated kcnj11 permanent neonatal diabetes. |
2023-08-21 |
2023-09-07 |
human |
| Philip N Newsome, Phil Amber. Incretins (GLP1 r agonists and dual, triple agonists) and the liver. Journal of hepatology. 2023-08-10. PMID:37562748. |
alongside glp-1ra, newer combinations with glucagon agonism and/or with glucose-dependent insulinotropic peptide (gip) agonism have been explored in related patient groups with evidence of improvements in weight loss, insulin resistance and non-invasive liver parameters. |
2023-08-10 |
2023-08-16 |
Not clear |
| Stine Smedegaard, Ulla Kampmann, Per G Ovesen, Henrik Støvring, Nikolaj Ritti. Whey Protein Premeal Lowers Postprandial Glucose Concentrations in Adults Compared with Water-The Effect of Timing, Dose, and Metabolic Status: a Systematic Review and Meta-analysis. The American journal of clinical nutrition. vol 118. issue 2. 2023-08-03. PMID:37536867. |
the underlying mechanisms are only partly understood but may involve stimulation of glucagon-like peptide-1 (glp-1), glucose-dependent insulinotropic polypeptide (gip), and insulin secretion together with a slower gastric emptying rate. |
2023-08-03 |
2023-08-14 |
Not clear |
| Eleonora Grespan, Andrea Mar. Does glucose lowering restore GIP effects on insulin secretion? - Reply to Sten Madsbad, Filip K Knop and Jens J Holst. Nutrition, metabolism, and cardiovascular diseases : NMCD. 2023-07-24. PMID:37487785. |
does glucose lowering restore gip effects on insulin secretion? |
2023-07-24 |
2023-08-14 |
Not clear |
| Danielle L Jones, Clive J Petry, Keith Burling, Peter Barker, Elizabeth H Turner, Laura C Kusinski, Claire L Mee. Pregnancy glucagon-like peptide 1 predicts insulin but not glucose concentrations. Acta diabetologica. 2023-07-13. PMID:37439859. |
incretin hormones glucagon-like peptide 1 (glp-1) and gastric inhibitory peptide (gip) cause increased insulin secretion in non-pregnant adults, but their role in pregnancy, where there are additional metabolically-active hormones from the placenta, is less clear. |
2023-07-13 |
2023-08-14 |
Not clear |
| Michael A Nauck, Timo D Mülle. Incretin hormones and type 2 diabetes. Diabetologia. 2023-07-10. PMID:37430117. |
this appears to be because of a reduced ability of gip to stimulate insulin secretion, related either to an overall impairment of beta cell function or to specific defects in the gip signalling pathway. |
2023-07-10 |
2023-08-14 |
Not clear |
| Akira Mima, Atsuo Nomura, Takeshi Fuji. Current findings on the efficacy of incretin-based drugs for diabetic kidney disease: A narrative review. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 165. 2023-06-18. PMID:37331253. |
however, the insulin action after gip secretion is known to be drastically reduced in patients with type 2 diabetes. |
2023-06-18 |
2023-08-14 |
Not clear |
| Kimberley El, Jonathan D Douros, Francis S Willard, Aaron Novikoff, Ashot Sargsyan, Diego Perez-Tilve, David B Wainscott, Bin Yang, Alex Chen, Donald Wothe, Callum Coupland, Mattias H Tschöp, Brian Finan, David A D'Alessio, Kyle W Sloop, Timo D Müller, Jonathan E Campbel. The incretin co-agonist tirzepatide requires GIPR for hormone secretion from human islets. Nature metabolism. 2023-06-05. PMID:37277609. |
the incretins glucose-dependent insulinotropic polypeptide (gip) and glucagon-like peptide 1 (glp-1) mediate insulin responses that are proportionate to nutrient intake to facilitate glucose tolerance |
2023-06-05 |
2023-08-14 |
human |
| Gaber El-Saber Batiha, Hayder M Al-Kuraishy, Ali I Al-Gareeb, Nada A Ashour, Walaa A Neg. Potential role of tirzepatide towards Covid-19 infection in diabetic patients: a perspective approach. Inflammopharmacology. 2023-05-19. PMID:37208555. |
the beneficial effect of tzt in t2dm and obesity is related to direct activation of gip and glp-1 receptors with subsequent improvement of insulin sensitivity and reduction of body weight. |
2023-05-19 |
2023-08-14 |
Not clear |
| Sten Madsbad, Filip K Knop, Jens J Hols. Does glucose lowering restore GIP's effect on insulin secretion? Nutrition, metabolism, and cardiovascular diseases : NMCD. 2023-05-07. PMID:37150733. |
does glucose lowering restore gip's effect on insulin secretion? |
2023-05-07 |
2023-08-14 |
Not clear |
| Daniel J Drucker, Jens J Hols. The expanding incretin universe: from basic biology to clinical translation. Diabetologia. 2023-03-28. PMID:36976349. |
incretin hormones, principally glucose-dependent insulinotropic polypeptide (gip) and glucagon-like peptide-1(glp-1), potentiate meal-stimulated insulin secretion through direct (gip + glp-1) and indirect (glp-1) actions on islet β-cells. |
2023-03-28 |
2023-08-14 |
Not clear |