| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Maria Chiara Pelle, Michele Provenzano, Isabella Zaffina, Roberta Pujia, Federica Giofrè, Stefania Lucà, Michele Andreucci, Angela Sciacqua, Franco Artur. Role of a Dual Glucose-Dependent Insulinotropic Peptide (GIP)/Glucagon-like Peptide-1 Receptor Agonist (Twincretin) in Glycemic Control: From Pathophysiology to Treatment. Life (Basel, Switzerland). vol 12. issue 1. 2022-01-21. PMID:35054422. |
glucagon-like peptide-1 (glp-1) and glucose-dependent insulinotropic polypeptide (gip) are two gut hormones, defined incretins, responsible for the amplification of insulin secretion after oral glucose intake. |
2022-01-21 |
2023-08-13 |
Not clear |
| Maria Chiara Pelle, Michele Provenzano, Isabella Zaffina, Roberta Pujia, Federica Giofrè, Stefania Lucà, Michele Andreucci, Angela Sciacqua, Franco Artur. Role of a Dual Glucose-Dependent Insulinotropic Peptide (GIP)/Glucagon-like Peptide-1 Receptor Agonist (Twincretin) in Glycemic Control: From Pathophysiology to Treatment. Life (Basel, Switzerland). vol 12. issue 1. 2022-01-21. PMID:35054422. |
unlike glp-1, gip has little acute effect on insulin secretion and no effect on food intake; instead it seems that the gip may be an obesity-promoting hormone. |
2022-01-21 |
2023-08-13 |
Not clear |
| John R Ussher, Amanda A Greenwell, My-Anh Nguyen, Erin E Mulvihil. Cardiovascular Effects of Incretin-Based Therapies: Integrating Mechanisms With Cardiovascular Outcome Trials. Diabetes. vol 71. issue 2. 2022-01-20. PMID:35050311. |
incretin hormones, including glp-1 (glucagon-like peptide 1) and gip (glucose-dependent insulinotropic polypeptide), are gut hormones secreted in response to nutrient intake that maintain glycemic control by regulating insulin and glucagon release. |
2022-01-20 |
2023-08-13 |
Not clear |
| Jelena Osmanovic Barilar, Ana Knezovic, Jan Homolak, Ana Babic Perhoc, Melita Salkovic-Petrisi. Divergent Effect of Central Incretin Receptors Inhibition in a Rat Model of Sporadic Alzheimer's Disease. International journal of molecular sciences. vol 23. issue 1. 2022-01-11. PMID:35008973. |
this study aimed to explore the roles of central glucagon-like peptide-1 (glp-1) and gastric inhibitory polypeptide (gip) on cell metabolism and energy in the brain, as well as on the levels of these incretins, insulin, and glucose via inhibition of the central incretin receptors following intracerebroventricular administration of the respective antagonists in healthy rats and a streptozotocin-induced rat model of sporadic alzheimer's disease (sad). |
2022-01-11 |
2023-08-13 |
rat |
| Tomoyuki Hioki, Gen Kuroyanagi, Kazuhiko Fujita, Go Sakai, Tetsu Kawabata, Woo Kim, Junko Tachi, Rie Matsushima-Nishiwaki, Hiroki Iida, Osamu Kozawa, Haruhiko Tokud. Incretins Enhance PGF2α-Induced Synthesis of IL-6 and Osteoprotegerin in Osteoblasts. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 54. issue 1. 2022-01-05. PMID:34986499. |
incretins including glucose-dependent insulinotropic polypeptide (gip) and glucagon-like peptide-1 (glp-1), which are secreted from the small intestine after oral food ingestion, are currently well-known to stimulate insulin secretion from pancreatic β-cells and used for the treatment of type 2 diabetes mellitus. |
2022-01-05 |
2023-08-13 |
Not clear |
| Sebastian M N Heimburger, Chris N Nielsen, Salvatore Calanna, Jens J Holst, Tina Vilsbøll, Filip K Knop, Mikkel B Christense. Glucose-dependent insulinotropic polypeptide induces lipolysis during stable basal insulin substitution and hyperglycaemia in men with type 1 diabetes: A randomized, double-blind, placebo-controlled, crossover clinical trial. Diabetes, obesity & metabolism. vol 24. issue 1. 2021-12-09. PMID:34490741. |
we investigated the effects of exogenous gip on lipid metabolism during time of stable insulin levels. |
2021-12-09 |
2023-08-13 |
Not clear |
| L M Rings, A M Kamr, H M Kinsella, L D Hostnik, J M Swink, T A Burns, K Christie, J B David, R E Toribi. The enteroinsular axis during hospitalization in newborn foals. Domestic animal endocrinology. vol 78. 2021-12-09. PMID:34649126. |
the goals of this study were to measure serum insulin and plasma incretin (glucose-dependent insulinotropic polypeptide [gip], glucagon-like peptide-1 [glp-1] and glucagon-like peptide-2 [glp-2]) concentrations, to determine the insulin and incretin association, as well as their link to disease severity and outcome in hospitalized foals. |
2021-12-09 |
2023-08-13 |
Not clear |
| L M Rings, A M Kamr, H M Kinsella, L D Hostnik, J M Swink, T A Burns, K Christie, J B David, R E Toribi. The enteroinsular axis during hospitalization in newborn foals. Domestic animal endocrinology. vol 78. 2021-12-09. PMID:34649126. |
blood samples were collected over 72 h to measure serum insulin and plasma gip, glp-1 and glp-2 concentrations using immunoassays. |
2021-12-09 |
2023-08-13 |
Not clear |
| L M Rings, A M Kamr, H M Kinsella, L D Hostnik, J M Swink, T A Burns, K Christie, J B David, R E Toribi. The enteroinsular axis during hospitalization in newborn foals. Domestic animal endocrinology. vol 78. 2021-12-09. PMID:34649126. |
at admission, serum glucose and insulin and plasma gip were significantly lower in hospitalized and septic compared to healthy foals (p < 0.01), while plasma glp-1 and glp-2 concentrations were higher in hospitalized and septic foals than healthy and sns foals, and decreased over time in septic foals (p < 0.05). |
2021-12-09 |
2023-08-13 |
Not clear |
| L M Rings, A M Kamr, H M Kinsella, L D Hostnik, J M Swink, T A Burns, K Christie, J B David, R E Toribi. The enteroinsular axis during hospitalization in newborn foals. Domestic animal endocrinology. vol 78. 2021-12-09. PMID:34649126. |
low gip together with increased glp-1 and glp-2 concentrations indicates that different mechanisms may be contributing to reduced insulin secretion in critically ill foals, including impaired intestinal production (gip, proximal intestine) and pancreatic endocrine resistance to enhanced incretin secretion (glp-1, glp-2; distal intestine). |
2021-12-09 |
2023-08-13 |
Not clear |
| Ji Yeon Park, Oh Kyoung Kwon, Jae-Han Jeon, Yeon-Kyung Choi, Ki Bum Par. Impact of the different biliopancreatic limb length on diabetes and incretin hormone secretion following distal gastrectomy in gastric cancer patients. Scientific reports. vol 11. issue 1. 2021-11-21. PMID:34789863. |
serum glucose, insulin, glucagon, glucagon-like peptide-1 (glp-1), and glucose-dependent insulinotropic polypeptide (gip) were serially measured. |
2021-11-21 |
2023-08-13 |
Not clear |
| Teng Ma, Weisheng Lu, Yongkang Wang, Peng Qian, Hong Tian, Xiangdong Gao, Wenbing Ya. An oral GLP-1 and GIP dual receptor agonist improves metabolic disorders in high fat-fed mice. European journal of pharmacology. 2021-11-20. PMID:34800466. |
in vitro studies were performed to reveal that 19w could stimulate insulin secretion from ins-1 cells in a dose-dependent manner, just like the native peptide gip and exendin-4 do. |
2021-11-20 |
2023-08-13 |
mouse |
| Tina Ovlund, Giovanni Pacini, Bo Ahré. Impact of Incretin Hormone Receptors on Insulin-Independent Glucose Disposal in Model Experiments in Mice. Frontiers in endocrinology. vol 12. 2021-11-18. PMID:34168617. |
we have previously shown that the two incretin hormones, glucose-dependent insulinotropic polypeptide (gip) and glucagon-like peptide-1 (glp-1) increase this process and, therefore, seem to contribute to glucose disposal both through this effect and through the classical incretin effect resulting in enhanced insulin levels. |
2021-11-18 |
2023-08-13 |
mouse |
| Haopeng Lin, Nancy Smith, Aliya F Spigelman, Kunimasa Suzuki, Mourad Ferdaoussi, Tamadher A Alghamdi, Sophie L Lewandowski, Yaxing Jin, Austin Bautista, Ying Wayne Wang, Jocelyn E Manning Fox, Matthew J Merrins, Jean Buteau, Patrick E MacDonal. β-Cell Knockout of SENP1 Reduces Responses to Incretins and Worsens Oral Glucose Tolerance in High-Fat Diet-Fed Mice. Diabetes. vol 70. issue 11. 2021-11-17. PMID:34462260. |
islet mass was not different, but insulin secretion and β-cell exocytotic responses to the glp-1 receptor agonist exendin-4 (ex4) and gip were impaired in islets lacking senp1. |
2021-11-17 |
2023-08-13 |
mouse |
| Haopeng Lin, Nancy Smith, Aliya F Spigelman, Kunimasa Suzuki, Mourad Ferdaoussi, Tamadher A Alghamdi, Sophie L Lewandowski, Yaxing Jin, Austin Bautista, Ying Wayne Wang, Jocelyn E Manning Fox, Matthew J Merrins, Jean Buteau, Patrick E MacDonal. β-Cell Knockout of SENP1 Reduces Responses to Incretins and Worsens Oral Glucose Tolerance in High-Fat Diet-Fed Mice. Diabetes. vol 70. issue 11. 2021-11-17. PMID:34462260. |
these phenocopied the psenp1-ko mice with selective impairment in oral glucose tolerance following hfd, preserved islet mass expansion, and impaired β-cell exocytosis and insulin secretion to ex4 and gip without changes in camp or ca |
2021-11-17 |
2023-08-13 |
mouse |
| Stefano Del Prato, Steven E Kahn, Imre Pavo, Govinda J Weerakkody, Zhengyu Yang, John Doupis, Diego Aizenberg, Alan G Wynne, Jeffrey S Riesmeyer, Robert J Heine, Russell J Wies. Tirzepatide versus insulin glargine in type 2 diabetes and increased cardiovascular risk (SURPASS-4): a randomised, open-label, parallel-group, multicentre, phase 3 trial. Lancet (London, England). vol 398. issue 10313. 2021-11-15. PMID:34672967. |
we aimed to assess efficacy and safety, with a special focus on cardiovascular safety, of the novel dual gip and glp-1 receptor agonist tirzepatide versus insulin glargine in adults with type 2 diabetes and high cardiovascular risk inadequately controlled on oral glucose-lowering medications. |
2021-11-15 |
2023-08-13 |
Not clear |
| Bo Ahrén, Yuichiro Yamada, Yutaka Sein. The Insulin Response to Oral Glucose in GIP and GLP-1 Receptor Knockout Mice: Review of the Literature and Stepwise Glucose Dose Response Studies in Female Mice. Frontiers in endocrinology. vol 12. 2021-11-10. PMID:34122340. |
the insulin response to oral glucose in gip and glp-1 receptor knockout mice: review of the literature and stepwise glucose dose response studies in female mice. |
2021-11-10 |
2023-08-13 |
mouse |
| Bo Ahrén, Yuichiro Yamada, Yutaka Sein. The Insulin Response to Oral Glucose in GIP and GLP-1 Receptor Knockout Mice: Review of the Literature and Stepwise Glucose Dose Response Studies in Female Mice. Frontiers in endocrinology. vol 12. 2021-11-10. PMID:34122340. |
a key factor for the insulin response to oral glucose is the pro-glucagon derived incretin hormone glucagon-like peptide-1 (glp-1), together with the companion incretin hormone, glucose-dependent insulinotropic polypeptide (gip). |
2021-11-10 |
2023-08-13 |
mouse |
| Bo Ahrén, Yuichiro Yamada, Yutaka Sein. The Insulin Response to Oral Glucose in GIP and GLP-1 Receptor Knockout Mice: Review of the Literature and Stepwise Glucose Dose Response Studies in Female Mice. Frontiers in endocrinology. vol 12. 2021-11-10. PMID:34122340. |
in a previous study in mice with genetic deletion of both glp-1 and gip receptors we showed that these mice have impaired insulin response to oral glucose after large but not small glucose loads, suggesting that the relevance of the incretin hormones may be dependent on the glucose load. |
2021-11-10 |
2023-08-13 |
mouse |
| Bo Ahrén, Yuichiro Yamada, Yutaka Sein. The Insulin Response to Oral Glucose in GIP and GLP-1 Receptor Knockout Mice: Review of the Literature and Stepwise Glucose Dose Response Studies in Female Mice. Frontiers in endocrinology. vol 12. 2021-11-10. PMID:34122340. |
we show that gip receptor ko mice exhibit glucose intolerance in the presence of impaired insulin response after 100 and 125 mg glucose, but not after lower doses of glucose. |
2021-11-10 |
2023-08-13 |
mouse |