| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ling-Yu Zhang, Qian-Qian Jin, Christian Hölscher, Lin L. Glucagon-like peptide-1/glucose-dependent insulinotropic polypeptide dual receptor agonist DA-CH5 is superior to exendin-4 in protecting neurons in the 6-hydroxydopamine rat Parkinson model. Neural regeneration research. vol 16. issue 8. 2021-08-12. PMID:33433498. |
incretin hormones, including glucagon-like peptide-1 (glp-1) and glucose-dependent insulinotropic polypeptide (gip), can re-sensitize insulin signaling. |
2021-08-12 |
2023-08-13 |
rat |
| Hannah L Notbohm, Joshua F Feuerbacher, Finn Papendorf, Nils Friese, Mats W Jacobs, Hans-Georg Predel, Jonas Zacher, Wilhelm Bloch, Moritz Schuman. Metabolic, hormonal and performance effects of isomaltulose ingestion before prolonged aerobic exercise: a double-blind, randomised, cross-over trial. Journal of the International Society of Sports Nutrition. vol 18. issue 1. 2021-07-05. PMID:34001166. |
therefore, we primarily aimed to investigate the effects of isomaltulose ingestion compared to glucose and maltodextrin on fat and carbohydrate oxidation rates, blood glucose levels and serum hormone concentrations of insulin and glucose-dependent insulinotropic polypeptide (gip). |
2021-07-05 |
2023-08-13 |
Not clear |
| Bhumi M Shah, Palmi Modi, Priti Trived. Recent Medicinal Chemistry Approach for the Development of Dipeptidyl Peptidase IV Inhibitors. Current medicinal chemistry. vol 28. issue 18. 2021-06-22. PMID:33045957. |
two major incretin hormones like glucose-dependent insulinotropic polypeptide (gip) and glucagonlike peptide - 1 (glp-1) stimulate insulin release after a meal, but their action is inhibited by enzyme dipeptidyl peptidase- iv. |
2021-06-22 |
2023-08-13 |
Not clear |
| Francis S Willard, Jonathan D Douros, Maria Bn Gabe, Aaron D Showalter, David B Wainscott, Todd M Suter, Megan E Capozzi, Wijnand Jc van der Velden, Cynthia Stutsman, Guemalli R Cardona, Shweta Urva, Paul J Emmerson, Jens J Holst, David A D'Alessio, Matthew P Coghlan, Mette M Rosenkilde, Jonathan E Campbell, Kyle W Sloo. Tirzepatide is an imbalanced and biased dual GIP and GLP-1 receptor agonist. JCI insight. vol 5. issue 17. 2021-06-16. PMID:32730231. |
experiments in primary islets reveal β-arrestin1 limits the insulin response to glp-1, but not gip or tirzepatide, suggesting that the biased agonism of tirzepatide enhances insulin secretion. |
2021-06-16 |
2023-08-13 |
Not clear |
| Yasutaka Takeda, Yukihiro Fujita, Tsuyoshi Yanagimachi, Nobuhiro Maruyama, Ryoichi Bessho, Hidemitsu Sakagami, Jun Honjo, Hiroki Yokoyama, Masakazu Haned. Establishment of novel specific assay for short-form glucose-dependent insulinotropic polypeptide and evaluation of its secretion in nondiabetic subjects. Physiological reports. vol 8. issue 11. 2021-06-07. PMID:32472669. |
the short-form glucose-dependent insulinotropic polypeptide (gip) (1-30) is released from islet alpha cells and promotes insulin secretion in a paracrine manner in vitro. |
2021-06-07 |
2023-08-13 |
human |
| Renata Luise de Araujo, Francisco A Tomás-Barberán, Rosa Ferreira Dos Santos, J Alberto Martinez-Blazquez, Maria Inés Genoves. Postprandial glucose-lowering effect of cagaita (Eugenia dysenterica DC) fruit juice in dysglycemic subjects with metabolic syndrome: An exploratory study. Food research international (Ottawa, Ont.). vol 142. 2021-05-27. PMID:33773684. |
the results showed that dysglycemic subjects with mets presented a 53% reduction of incremental area under the curve (iauc) of glucose, 38% reduction of insulin, 78% reduction of gip (glucose-dependent insulinotropic polypeptide), and 58% reduction of c-peptide (p < 0.05), after the consumption of cagaita juice along with bread, in comparison to control water. |
2021-05-27 |
2023-08-13 |
human |
| Emma Rose McGlone, Khalefah Malallah, Joyceline Cuenco, Nicolai J Wewer Albrechtsen, Jens J Holst, Royce P Vincent, Charlotte Ling, Omar A Khan, Surabhi Verma, Ahmed R Ahmed, Julian R F Walters, Bernard Khoo, Stephen R Bloom, Tricia M M Ta. Differential effects of bile acids on the postprandial secretion of gut hormones: a randomized crossover study. American journal of physiology. Endocrinology and metabolism. vol 320. issue 4. 2021-05-24. PMID:33459181. |
glucose, insulin, glp-1, oxm, pyy, gip, glucagon, ghrelin, and fibroblast growth factor 19 were measured prior to ba administration at -60 and 0 min (just prior to mixed meal) and 15, 30, 60, 120, 180, and 240 min after the meal. |
2021-05-24 |
2023-08-13 |
human |
| Emma Rose McGlone, Khalefah Malallah, Joyceline Cuenco, Nicolai J Wewer Albrechtsen, Jens J Holst, Royce P Vincent, Charlotte Ling, Omar A Khan, Surabhi Verma, Ahmed R Ahmed, Julian R F Walters, Bernard Khoo, Stephen R Bloom, Tricia M M Ta. Differential effects of bile acids on the postprandial secretion of gut hormones: a randomized crossover study. American journal of physiology. Endocrinology and metabolism. vol 320. issue 4. 2021-05-24. PMID:33459181. |
on the other hand, cdca reduced postprandial secretion of gip, with an associated reduction in postprandial insulin secretion. |
2021-05-24 |
2023-08-13 |
human |
| Eileen J Daley, Philip C Trackma. β-Catenin mediates glucose-dependent insulinotropic polypeptide increases in lysyl oxidase expression in osteoblasts. Bone reports. vol 14. 2021-05-14. PMID:33981809. |
gip is a gastric hormone released by the gut upon consumption of nutrients, which then stimulates insulin release from β-cells in the pancreas. |
2021-05-14 |
2023-08-13 |
mouse |
| Shumin Jiang, Xueli Wu, Yi Wang, Jingtao Zou, Xiaoping Zha. The potential DPP-4 inhibitors from Xiao-Ke-An improve the glucolipid metabolism via the activation of AKT/GSK-3β pathway. European journal of pharmacology. vol 882. 2021-05-13. PMID:32535096. |
dipeptidyl peptidase-4 (dpp-4) is a specific enzyme hydrolyzing the incretin hormone glucagon like peptide-1 (glp-1) and glucose-dependent insulinotropic polypeptide (gip) to reduce insulin secretion, meanwhile dpp-4 inhibitors play an important role in diabetic therapy. |
2021-05-13 |
2023-08-13 |
Not clear |
| Katarzyna Szkudelska, Marzanna Deniziak, Maciej Sassek, Ignacy Szkudelski, Wojciech Noskowiak, Tomasz Szkudelsk. Resveratrol Affects Insulin Signaling in Type 2 Diabetic Goto-Kakizaki Rats. International journal of molecular sciences. vol 22. issue 5. 2021-05-12. PMID:33671110. |
blood levels of insulin and gip were elevated, whereas proinsulin and glp-1 diminished in gk rats. |
2021-05-12 |
2023-08-13 |
rat |
| Anne Christin Meyer-Gerspach, Jürgen Drewe, Wout Verbeure, Carel W le Roux, Ludmilla Dellatorre-Teixeira, Jens F Rehfeld, Jens J Holst, Bolette Hartmann, Jan Tack, Ralph Peterli, Christoph Beglinger, Bettina K Wölnerhansse. Effect of the Natural Sweetener Xylitol on Gut Hormone Secretion and Gastric Emptying in Humans: A Pilot Dose-Ranging Study. Nutrients. vol 13. issue 1. 2021-04-12. PMID:33429977. |
we found: (i) a dose-dependent stimulation of cholecystokinin (cck), active glucagon-like peptide-1 (aglp-1), peptide tyrosine tyrosine (pyy)-release, and decelerated gastric emptying rates, (ii) a dose-dependent increase in blood glucose and insulin, (iii) no effect on motilin, glucagon, or glucose-dependent insulinotropic peptide (gip)-release, (iv) no effect on blood lipids, but a rise in uric acid, and (v) increased bowel sounds as only side effects. |
2021-04-12 |
2023-08-13 |
human |
| Ian Rollo, Javier T Gonzalez, Cas J Fuchs, Luc J C van Loon, Clyde William. Primary, Secondary, and Tertiary Effects of Carbohydrate Ingestion During Exercise. Sports medicine (Auckland, N.Z.). vol 50. issue 11. 2021-04-05. PMID:32936440. |
the intestinal mucosa has carbohydrate sensors that stimulate the release of two 'incretin' hormones (gip and glp-1) whose actions range from the secretion of insulin to appetite regulation. |
2021-04-05 |
2023-08-13 |
Not clear |
| Matthew P Gilbert, Richard E Pratle. GLP-1 Analogs and DPP-4 Inhibitors in Type 2 Diabetes Therapy: Review of Head-to-Head Clinical Trials. Frontiers in endocrinology. vol 11. 2021-03-29. PMID:32308645. |
in patients with type 2 diabetes (t2dm), an impaired insulin response to glp-1 and gip contributes to hyperglycemia. |
2021-03-29 |
2023-08-13 |
human |
| K El, S M Gray, M E Capozzi, E R Knuth, E Jin, B Svendsen, A Clifford, J L Brown, S E Encisco, B M Chazotte, K W Sloop, D J Nunez, M J Merrins, D A D'Alessio, J E Campbel. GIP mediates the incretin effect and glucose tolerance by dual actions on α cells and β cells. Science advances. vol 7. issue 11. 2021-03-26. PMID:33712466. |
glucose-dependent insulinotropic polypeptide (gip) communicates nutrient intake from the gut to islets, enabling optimal levels of insulin secretion via the gip receptor (gipr) on β cells. |
2021-03-26 |
2023-08-13 |
Not clear |
| K El, S M Gray, M E Capozzi, E R Knuth, E Jin, B Svendsen, A Clifford, J L Brown, S E Encisco, B M Chazotte, K W Sloop, D J Nunez, M J Merrins, D A D'Alessio, J E Campbel. GIP mediates the incretin effect and glucose tolerance by dual actions on α cells and β cells. Science advances. vol 7. issue 11. 2021-03-26. PMID:33712466. |
moreover, we demonstrate that gip activity in α cells contributes to insulin secretion by invoking paracrine α to β cell communication. |
2021-03-26 |
2023-08-13 |
Not clear |
| Thinzar Min, Stephen C Bai. The Role of Tirzepatide, Dual GIP and GLP-1 Receptor Agonist, in the Management of Type 2 Diabetes: The SURPASS Clinical Trials. Diabetes therapy : research, treatment and education of diabetes and related disorders. vol 12. issue 1. 2021-03-23. PMID:33325008. |
however, emerging evidence has illustrated that co-infusion of glp-1 and gip has a synergetic effect, resulting in significantly increased insulin response and glucagonostatic response, compared with separate administration of each hormone. |
2021-03-23 |
2023-08-13 |
Not clear |
| Tetsu Kawabata, Haruhiko Tokuda, Gen Kuroyanagi, Kazuhiko Fujita, Go Sakai, Woo Kim, Rie Matsushima-Nishiwaki, Hiroki Iida, Ken-Ichiro Yata, Shujie Wang, Akira Mizoguchi, Takanobu Otsuka, Osamu Kozaw. Incretin accelerates platelet-derived growth factor-BB-induced osteoblast migration via protein kinase A: The upregulation of p38 MAP kinase. Scientific reports. vol 10. issue 1. 2021-03-12. PMID:32047216. |
incretins, including glucagon-like peptide-1 (glp-1) and glucose-dependent insulinotropic polypeptide (gip), secreted from enteroendocrine cells after food ingestion, are currently recognized to regulate glucose metabolism through insulin secretion. |
2021-03-12 |
2023-08-13 |
mouse |
| Domenico Tricò, Lorenzo Nesti, Silvia Frascerra, Simona Baldi, Alessandro Mengozzi, Andrea Natal. A Protein/Lipid Preload Attenuates Glucose-Induced Endothelial Dysfunction in Individuals with Abnormal Glucose Tolerance. Nutrients. vol 12. issue 7. 2021-03-08. PMID:32664350. |
plasma glucose, insulin, glucagon-like peptide-1 (glp-1), glucose-dependent insulinotropic polypeptide (gip), glucagon, free fatty acids, and amino acids were measured through each test. |
2021-03-08 |
2023-08-13 |
human |
| Daniela Regazzo, Mattia Barbot, Carla Scaroni, Nora Albiger, Gianluca Occh. The pathogenic role of the GIP/GIPR axis in human endocrine tumors: emerging clinical mechanisms beyond diabetes. Reviews in endocrine & metabolic disorders. vol 21. issue 1. 2021-02-16. PMID:31933128. |
gip has a variety of effects on different systems, including the potentiation of insulin secretion from pancreatic β-cells after food intake (i.e. |
2021-02-16 |
2023-08-13 |
human |