| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Farnaz Keyhani-Nejad, Renate Luisa Barbosa Yanez, Margrit Kemper, Rita Schueler, Olga Pivovarova-Ramich, Natalia Rudovich, Andreas F H Pfeiffe. Endogenously released GIP reduces and GLP-1 increases hepatic insulin extraction. Peptides. vol 125. 2021-02-08. PMID:31870938. |
we compared effects of sucrose vs. isomaltulose on gip and glucagon-like peptide-1 (glp-1) secretion, hepatic insulin clearance (hic) and insulin sensitivity in normal (ngt), impaired glucose tolerant (igt) and type 2 diabetes mellitus (t2dm) participants. |
2021-02-08 |
2023-08-13 |
mouse |
| R Charlotte Moffett, Violetta Naughto. Emerging role of GIP and related gut hormones in fertility and PCOS. Peptides. vol 125. 2021-02-08. PMID:31935429. |
gastric inhibitory polypeptide (gip) is best known as an incretin hormone released by enteroendocrine k-cells in response to feeding and stimulates insulin release to regulate blood glucose and nutrient homeostasis. |
2021-02-08 |
2023-08-13 |
Not clear |
| R Charlotte Moffett, Violetta Naughto. Emerging role of GIP and related gut hormones in fertility and PCOS. Peptides. vol 125. 2021-02-08. PMID:31935429. |
this is considered to reflect indirect effects mediated by alleviation of insulin resistance together with possible direct effects of surgically induced changes of gip, glp-1 and related peptide hormones on ovaries and the hypothalamic-pituitary-adrenal axis. |
2021-02-08 |
2023-08-13 |
Not clear |
| Vincent Mark. The early history of GIP 1969-2000: From enterogastrone to major metabolic hormone. Peptides. vol 125. 2021-02-08. PMID:32081451. |
augmentation of glucose mediated insulin release, the incretin effect, was discovered soon after gip was first isolated and only much later was its important role in the pathogenesis of obesity, through mechanism other than its insulin secretion, appreciated. |
2021-02-08 |
2023-08-13 |
human |
| Jens Juul Holst, Mette Marie Rosenkild. GIP as a Therapeutic Target in Diabetes and Obesity: Insight From Incretin Co-agonists. The Journal of clinical endocrinology and metabolism. vol 105. issue 8. 2021-02-08. PMID:32459834. |
the 2 hormones responsible for the amplification of insulin secretion after oral as opposed to intravenous nutrient administration are the gut peptides, glucagon-like peptide-1 (glp-1) and glucose-dependent insulinotropic polypeptide (gip). |
2021-02-08 |
2023-08-13 |
Not clear |
| Colin G Nichols, Nathaniel W York, Maria S Remed. Preferential Gq signaling in diabetes: an electrical switch in incretin action and in diabetes progression? The Journal of clinical investigation. vol 130. issue 12. 2021-02-08. PMID:33196460. |
glucagon-like peptide-1 (glp-1) and glucose-dependent insulinotropic polypeptide (gip) are two incretins secreted from gastrointestinal cells that amplify insulin secretion when glucose is high. |
2021-02-08 |
2023-08-13 |
mouse |
| Dipak Sarnobat, Charlotte R Moffett, Neil Tanday, Frank Reimann, Fiona M Gribble, Peter R Flatt, Andrei I Taraso. Antidiabetic drug therapy alleviates type 1 diabetes in mice by promoting pancreatic α-cell transdifferentiation. Biochemical pharmacology. vol 182. 2021-01-21. PMID:32926875. |
gut incretins, glucagon-like peptide-1 (glp-1) and glucose-dependent insulinotropic peptide (gip), enhance secretion of insulin in a glucose-dependent manner, predominantly by elevating cytosolic levels of camp in pancreatic β-cells. |
2021-01-21 |
2023-08-13 |
mouse |
| Sarah Tosato, Chiara Bonetto, Simona Tomassi, Roberta Zanardini, Carlo Faravelli, Caterina Bruschi, Armando D'Agostino, Alessandra Minelli, Paolo Scocco, Antonio Lasalvia, Karin Furlato, Massimiliano Imbesi, Antonio Preti, Mirella Ruggeri, Massimo Gennarelli, Luisella Bocchio-Chiavett. Childhood trauma and glucose metabolism in patients with first-episode psychosis. Psychoneuroendocrinology. vol 113. 2021-01-19. PMID:31864124. |
in particular, in 148 fep patients we evaluated serum concentrations of c-peptide, insulin, plasminogen-activator-inhibitor-1 (pai-1), resistin, visfatin, glucagon, glucagon-like peptide-1 (glp-1), gastric-inhibitor-peptide (gip), leptin, and ghrelin. |
2021-01-19 |
2023-08-13 |
Not clear |
| Alexander S Christensen, Sofie Hædersdal, Heidi Storgaard, Kathrine Rose, Nina L Hansen, Jens J Holst, Torben Hansen, Filip K Knop, Tina Vilsbøl. GIP and GLP-1 Potentiate Sulfonylurea-Induced Insulin Secretion in Hepatocyte Nuclear Factor 1α Mutation Carriers. Diabetes. vol 69. issue 9. 2021-01-15. PMID:32518064. |
gip and glp-1 potentiate sulfonylurea-induced insulin secretion in hepatocyte nuclear factor 1α mutation carriers. |
2021-01-15 |
2023-08-13 |
Not clear |
| Alexander S Christensen, Sofie Hædersdal, Heidi Storgaard, Kathrine Rose, Nina L Hansen, Jens J Holst, Torben Hansen, Filip K Knop, Tina Vilsbøl. GIP and GLP-1 Potentiate Sulfonylurea-Induced Insulin Secretion in Hepatocyte Nuclear Factor 1α Mutation Carriers. Diabetes. vol 69. issue 9. 2021-01-15. PMID:32518064. |
the effect of sus together with gip or glp-1, respectively, on insulin and glucagon secretion in patients with hnf1a diabetes is currently unknown. |
2021-01-15 |
2023-08-13 |
Not clear |
| Geisa Nogueira Salles, Michele Longoni Calió, Christian Hölscher, Cristina Pacheco-Soares, Marimelia Porcionatto, Anderson Oliveira Lob. Neuroprotective and restorative properties of the GLP-1/GIP dual agonist DA-JC1 compared with a GLP-1 single agonist in Alzheimer's disease. Neuropharmacology. vol 162. 2021-01-06. PMID:31628935. |
the sister incretins glucagon-like peptide-1 (glp-1) and glucagon dependent insulinotropic polypeptide (gip) are growth factors responsible for re-sensitizing insulin signalling. |
2021-01-06 |
2023-08-13 |
human |
| Yukiko Fu, Kentaro Kaneko, Hsiao-Yun Lin, Qianxing Mo, Yong Xu, Takayoshi Suganami, Peter Ravn, Makoto Fukud. Gut Hormone GIP Induces Inflammation and Insulin Resistance in the Hypothalamus. Endocrinology. vol 161. issue 9. 2021-01-04. PMID:32603429. |
gut hormone gip induces inflammation and insulin resistance in the hypothalamus. |
2021-01-04 |
2023-08-13 |
mouse |
| Yukiko Fu, Kentaro Kaneko, Hsiao-Yun Lin, Qianxing Mo, Yong Xu, Takayoshi Suganami, Peter Ravn, Makoto Fukud. Gut Hormone GIP Induces Inflammation and Insulin Resistance in the Hypothalamus. Endocrinology. vol 161. issue 9. 2021-01-04. PMID:32603429. |
here, we show that a gut-derived hormone, glucose-dependent insulinotropic polypeptide (gip), whose levels are elevated during diet-induced obesity, promotes and mediates hypothalamic inflammation and insulin resistance during hfd-induced obesity. |
2021-01-04 |
2023-08-13 |
mouse |
| Yukiko Fu, Kentaro Kaneko, Hsiao-Yun Lin, Qianxing Mo, Yong Xu, Takayoshi Suganami, Peter Ravn, Makoto Fukud. Gut Hormone GIP Induces Inflammation and Insulin Resistance in the Hypothalamus. Endocrinology. vol 161. issue 9. 2021-01-04. PMID:32603429. |
additionally, centrally administered gip reduced anorectic actions of insulin in the brain and diminished insulin-induced phosphorylation of protein kinase b and glycogen synthase kinase 3β in the hypothalamus. |
2021-01-04 |
2023-08-13 |
mouse |
| Yukiko Fu, Kentaro Kaneko, Hsiao-Yun Lin, Qianxing Mo, Yong Xu, Takayoshi Suganami, Peter Ravn, Makoto Fukud. Gut Hormone GIP Induces Inflammation and Insulin Resistance in the Hypothalamus. Endocrinology. vol 161. issue 9. 2021-01-04. PMID:32603429. |
collectively, these findings reveal a previously unrecognized role for brain gip signaling in diet-induced inflammation and insulin resistance in the hypothalamus. |
2021-01-04 |
2023-08-13 |
mouse |
| Fernanda Dana Mantelmacher, Isabel Zvibel, Keren Cohen, Alona Epshtein, Metsada Pasmanik-Chor, Thomas Vogl, Yael Kuperman, Shai Weiss, Daniel J Drucker, Chen Varol, Sigal Fishma. GIP regulates inflammation and body weight by restraining myeloid-cell-derived S100A8/A9. Nature metabolism. vol 1. issue 1. 2020-12-21. PMID:32694806. |
here we show that high-fat diet (hfd)-fed mice with immune cell-targeted gip receptor (gipr) deficiency exhibit greater weight gain, insulin resistance, hepatic steatosis and significant myelopoiesis concomitantly with impaired energy expenditure and inguinal white adipose tissue (wat) beiging. |
2020-12-21 |
2023-08-13 |
mouse |
| Joanna Góralska, Urszula Raźny, Anna Polus, Agnieszka Dziewońska, Anna Gruca, Anna Zdzienicka, Aldona Dembińska-Kieć, Bogdan Solnica, Agnieszka Micek, Maria Kapusta, Krystyna Słowińska-Solnica, Małgorzata Malczewska-Male. Enhanced GIP Secretion in Obesity Is Associated with Biochemical Alteration and miRNA Contribution to the Development of Liver Steatosis. Nutrients. vol 12. issue 2. 2020-11-19. PMID:32069846. |
fasting and postprandial gip, glucose, insulin, and lipids, as well as fasting alanine aminotransferase (alt), γ-glutamyltransferase (ggt), cytokeratin-18, fibroblast growth factor (fgf)-19, and fgf-21 were determined. |
2020-11-19 |
2023-08-13 |
human |
| Mikkel B Christensen, Asger B Lund, Niklas R Jørgensen, Jens J Holst, Tina Vilsbøll, Filip K Kno. Glucose-Dependent Insulinotropic Polypeptide (GIP) Reduces Bone Resorption in Patients With Type 2 Diabetes. Journal of the Endocrine Society. vol 4. issue 9. 2020-11-05. PMID:32904711. |
in healthy individuals, glucose-dependent insulinotropic polypeptide (gip) enhances insulin secretion and reduces bone resorption by up to 25% estimated by absolute placebo-corrected changes in carboxy-terminal type 1 collagen crosslinks (ctx) during gip and glucose administration. |
2020-11-05 |
2023-08-13 |
Not clear |
| Alexandra Camara, Adronie Verbrugghe, Cara Cargo-Froom, Kylie Hogan, Trevor J DeVries, Andrea Sanchez, Lindsay E Robinson, Anna K Shovelle. The daytime feeding frequency affects appetite-regulating hormones, amino acids, physical activity, and respiratory quotient, but not energy expenditure, in adult cats fed regimens for 21 days. PloS one. vol 15. issue 9. 2020-10-29. PMID:32946478. |
on day 14, two fasted and 11 postprandial blood samples were collected over 24 hours to measure plasma concentrations of ghrelin, glp-1, gip, leptin, pyy, insulin and amino acids, and whole blood glucose. |
2020-10-29 |
2023-08-13 |
cat |
| Vikram Singh Shekhawat, Shobhit Bhansali, Pinaki Dutta, Kanchan Kumar Mukherjee, Kim Vaiphei, Rakesh Kochhar, Saroj K Sinha, Naresh Sachdeva, Anura V Kurpad, Kishor Bhat, Sunder Mudaliar, Anil Bhansal. Glucose-dependent Insulinotropic Polypeptide (GIP) Resistance and β-cell Dysfunction Contribute to Hyperglycaemia in Acromegaly. Scientific reports. vol 9. issue 1. 2020-10-27. PMID:30948746. |
patients of acromegaly, irrespective of presence or absence of hyperglycaemia, had similar degree of insulin resistance, however patients with diabetes exhibited hyperglucagonemia, and compromised β-cell function despite significantly higher gip levels. |
2020-10-27 |
2023-08-13 |
Not clear |