| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Giuseppe Lisco, Anna De Tullio, Olga Disoteo, Vincenzo De Geronimo, Giuseppina Piazzolla, Giovanni De Pergola, Vito Angelo Giagulli, Emilio Jirillo, Edoardo Guastamacchia, Carlo Sabbà, Vincenzo Triggian. Basal insulin intensification with GLP-1RA and dual GIP and GLP-1RA in patients with uncontrolled type 2 diabetes mellitus: A rapid review of randomized controlled trials and meta-analysis. Frontiers in endocrinology. vol 13. 2022-09-26. PMID:36157450. |
herein, we overviewed the role of gip and glp-1 in the pathophysiology of type 2 diabetes and systematically reviewed the efficacy and safety of injectable incretin-based therapy added to basal insulin in light of the results of the surpass-5 trial. |
2022-09-26 |
2023-08-14 |
Not clear |
| Aleksey M Krasnyi, Alsu A Sadekova, Tatyana Y Smolnova, Vyacheslav V Chursin, Natalya A Buralkina, Vladimir D Chuprynin, Ekaterina Yarotskaya, Stanislav V Pavlovich, Gennadiy T Sukhik. The Levels of Ghrelin, Glucagon, Visfatin and Glp-1 Are Decreased in the Peritoneal Fluid of Women with Endometriosis along with the Increased Expression of the CD10 Protease by the Macrophages. International journal of molecular sciences. vol 23. issue 18. 2022-09-23. PMID:36142272. |
the aim of this study was to evaluate the levels of ten energy metabolism factors: c-peptide, ghrelin, gip, glp-1, glucagon, insulin, leptin, pai-1 (total), resistin, and visfatin, and to determine the expression of glp1r receptors, cd10, cd26 proteases, and pro-inflammatory marker cd86 by macrophages in the peritoneal fluid (pf) in patients with endometriosis. |
2022-09-23 |
2023-08-14 |
Not clear |
| Ananyaa Sridhar, Dawood Khan, Mahmoud Abdelaal, Jessie A Elliott, Violetta Naughton, Peter R Flatt, Carel W Le Roux, Neil G Docherty, Charlotte R Moffet. Differential effects of RYGB surgery and best medical treatment for obesity-diabetes on intestinal and islet adaptations in obese-diabetic ZDSD rats. PloS one. vol 17. issue 9. 2022-09-22. PMID:36137097. |
insulin, glucagon, somatostatin, pyy, glp-1 and gip expression patterns were assessed using immunocytochemistry and analyzed using imagej. |
2022-09-22 |
2023-08-14 |
rat |
| Wang Shin Lei, Marissa J Kilberg, Babette S Zemel, Ronald C Rubenstein, Clea Harris, Saba Sheikh, Andrea Kelly, Joseph M Kindle. Bone metabolism and incretin hormones following glucose ingestion in young adults with pancreatic insufficient cystic fibrosis. Journal of clinical & translational endocrinology. vol 30. 2022-09-16. PMID:36110921. |
gut-derived incretin hormones, including glucose-dependent insulinotropic peptide (gip) and glucagon-like peptide 1 (glp-1), regulate post-prandial glucose metabolism by promoting insulin production. |
2022-09-16 |
2023-08-14 |
Not clear |
| Wang Shin Lei, Marissa J Kilberg, Babette S Zemel, Ronald C Rubenstein, Clea Harris, Saba Sheikh, Andrea Kelly, Joseph M Kindle. Bone metabolism and incretin hormones following glucose ingestion in young adults with pancreatic insufficient cystic fibrosis. Journal of clinical & translational endocrinology. vol 30. 2022-09-16. PMID:36110921. |
gip, glp-1, and insulin contribute to the acute bone anti-resorptive effect of macronutrient ingestion by modifying bone turnover. |
2022-09-16 |
2023-08-14 |
Not clear |
| Federica Ferrari, Antonio Moretti, Roberto Federico Vill. Incretin-based drugs as potential therapy for neurodegenerative diseases: Current status and perspectives. Pharmacology & therapeutics. 2022-09-05. PMID:36064147. |
however, the adverse effects of chronic insulin prompted the research of alternative strategies, such as the novel antidiabetic drugs based on the incretin hormones glucagon-like protein-1 (glp-1) and glucose-dependent insulinotropic peptide (gip). |
2022-09-05 |
2023-08-14 |
Not clear |
| Michael A Nauck, David A D'Alessi. Tirzepatide, a dual GIP/GLP-1 receptor co-agonist for the treatment of type 2 diabetes with unmatched effectiveness regrading glycaemic control and body weight reduction. Cardiovascular diabetology. vol 21. issue 1. 2022-09-01. PMID:36050763. |
tirzepatide is an acylated peptide engineered to activate the gip and glp-1 receptors, key mediators of insulin secretion that are also expressed in regions of the brain that regulate food intake. |
2022-09-01 |
2023-08-14 |
human |
| Joanna Goralska, Urszula Razny, Philip C Calder, Anna Gruca, Caroline E Childs, Piotr Zabielski, Aldona Dembinska-Kiec, Maciej Banach, Bogdan Solnica, Malgorzata Malczewska-Male. Glucose-Dependent Insulinotropic Polypeptide Plasma Level Influences the Effect of n-3 PUFA Supplementation. Diagnostics (Basel, Switzerland). vol 12. issue 8. 2022-08-26. PMID:36010335. |
blood analyses of glucose, insulin, non-esterified fatty acids (nefas), gip and triglycerides were performed at fasting, and during an oral glucose tolerance test and a high fat mixed-meal tolerance test. |
2022-08-26 |
2023-08-14 |
human |
| Harshit Sajal, Shashank M Patil, Ranjith Raj, Abdullah M Shbeer, Mohammed Ageel, Ramith Ram. Computer-Aided Screening of Phytoconstituents from Molecules (Basel, Switzerland). vol 27. issue 16. 2022-08-26. PMID:36014373. |
dpp4 targets and inactivates incretin hormones such as glucagon-like peptide-1 (glp-1) and gastric inhibitory polypeptide (gip) as physiological substrates, which are essential to regulate the amount of insulin that is secreted after eating. |
2022-08-26 |
2023-08-14 |
human |
| Huanqing Zhu, Kaixi Wang, Shuna Chen, Jiaxin Kang, Na Guo, Hongbo Chen, Junsheng Liu, Yuanyuan Wu, Puming He, Youying Tu, Bo L. Saponins from Nutrients. vol 14. issue 16. 2022-08-26. PMID:36014921. |
saponins from glucose-dependent insulinotropic polypeptide (gip) is one of the important incretins and possesses lots of physiological activities such as stimulating insulin secretion and maintaining glucose homeostasis. |
2022-08-26 |
2023-08-14 |
Not clear |
| Shizuka Kanek. Tirzepatide: A Novel, Once-weekly Dual GIP and GLP-1 Receptor Agonist for the Treatment of Type 2 Diabetes. TouchREVIEWS in endocrinology. vol 18. issue 1. 2022-08-11. PMID:35949358. |
however, recent studies have shown that gip has an important effect on glucagon and insulin secretion under normoglycaemic conditions. |
2022-08-11 |
2023-08-14 |
Not clear |
| Yahiya Y Sye. Tirzepatide: First Approval. Drugs. 2022-07-13. PMID:35830001. |
native gip and glp-1 are incretin hormones that stimulate insulin secretion and decrease glucagon secretion. |
2022-07-13 |
2023-08-14 |
Not clear |
| A M Pittaluga, M Y Ortiz-Fraguada, A J Parker, A E Rellin. Effects of calcium salts of palm oil inclusion and ad libitum feeding regimen on growth performance, carcass characteristics, and plasma glucose-dependent insulinotropic polypeptide concentration of feedlot steers. Journal of animal science. 2022-07-13. PMID:35830482. |
correlations between plasma gip and insulin concentrations and rq were analyzed. |
2022-07-13 |
2023-08-14 |
Not clear |
| A M Pittaluga, M Y Ortiz-Fraguada, A J Parker, A E Rellin. Effects of calcium salts of palm oil inclusion and ad libitum feeding regimen on growth performance, carcass characteristics, and plasma glucose-dependent insulinotropic polypeptide concentration of feedlot steers. Journal of animal science. 2022-07-13. PMID:35830482. |
there was no correlation (p = 0.96) of gip with rq, while insulin demonstrated marginal significance for a positive (p = 0.07) and negative (p = 0.08) correlation with plasma gip and rq, respectively. |
2022-07-13 |
2023-08-14 |
Not clear |
| A M Pittaluga, M Y Ortiz-Fraguada, A J Parker, A E Rellin. Effects of calcium salts of palm oil inclusion and ad libitum feeding regimen on growth performance, carcass characteristics, and plasma glucose-dependent insulinotropic polypeptide concentration of feedlot steers. Journal of animal science. 2022-07-13. PMID:35830482. |
these data indicate that gip secretion results from an interaction between cpo and energy intake depending on the time relative to feed intake, that gip might indirectly regulate energy metabolism through insulin secretion, and that gip does not appear to be associated with ms. |
2022-07-13 |
2023-08-14 |
Not clear |
| Vivek P Chavda, Jinal Ajabiya, Divya Teli, Joanna Bojarska, Vasso Apostolopoulo. Tirzepatide, a New Era of Dual-Targeted Treatment for Diabetes and Obesity: A Mini-Review. Molecules (Basel, Switzerland). vol 27. issue 13. 2022-07-09. PMID:35807558. |
tirzepatide, known as a 'twincretin', is a 'first-in-class' and the only dual glucagon-like peptide-1 (glp-1) and glucose-dependent insulinotropic peptide (gip) receptor agonist, that can significantly reduce glycemic levels and improve insulin sensitivity, as well as reducing body weight by more than 20% and improving lipid metabolism. |
2022-07-09 |
2023-08-14 |
human |
| Sarah C Nyirjesy, Amy J Peleckis, Jack N Eiel, Kathryn Gallagher, Andriana Doliba, Abigail Tami, Anneliese J Flatt, Diva D De Leon, Denis Hadjiliadis, Saba Sheikh, Darko Stefanovski, Robert Gallop, David A D'Alessio, Ronald C Rubenstein, Andrea Kelly, Michael R Rickel. Effects of GLP-1 and GIP on Islet Function in Glucose Intolerant, Pancreatic Insufficient Cystic Fibrosis. Diabetes. 2022-07-07. PMID:35796669. |
in pi-cf with agt, glp-1 substantially augmented second-phase insulin secretion, but without effect on the acute insulin response to gpa or the proinsulin secretory ratio (pisr), while gip infusion did not enhance second phase or gpa-induced insulin secretion but increased the pisr. |
2022-07-07 |
2023-08-14 |
Not clear |
| Sarah C Nyirjesy, Amy J Peleckis, Jack N Eiel, Kathryn Gallagher, Andriana Doliba, Abigail Tami, Anneliese J Flatt, Diva D De Leon, Denis Hadjiliadis, Saba Sheikh, Darko Stefanovski, Robert Gallop, David A D'Alessio, Ronald C Rubenstein, Andrea Kelly, Michael R Rickel. Effects of GLP-1 and GIP on Islet Function in Glucose Intolerant, Pancreatic Insufficient Cystic Fibrosis. Diabetes. 2022-07-07. PMID:35796669. |
gip also did not enhance second-phase insulin in pi-cf with ngt but did so markedly in non-cf controls. |
2022-07-07 |
2023-08-14 |
Not clear |
| Sarah C Nyirjesy, Amy J Peleckis, Jack N Eiel, Kathryn Gallagher, Andriana Doliba, Abigail Tami, Anneliese J Flatt, Diva D De Leon, Denis Hadjiliadis, Saba Sheikh, Darko Stefanovski, Robert Gallop, David A D'Alessio, Ronald C Rubenstein, Andrea Kelly, Michael R Rickel. Effects of GLP-1 and GIP on Islet Function in Glucose Intolerant, Pancreatic Insufficient Cystic Fibrosis. Diabetes. 2022-07-07. PMID:35796669. |
these data indicate that glp-1, but not gip, augments glucose-dependent insulin secretion in pi-cf, supporting the likelihood that glp-1 agonists could have therapeutic benefit in this population. |
2022-07-07 |
2023-08-14 |
Not clear |
| Manuel Blandino-Rosano, Joshua O Scheys, Joao Pedro Werneck-de-Castro, Ruy A Louzada, Joana Almaca, Gil Leibowitz, Markus A Ruegg, Michael N Hall, Ernesto Bernal-Mizrach. Novel roles of mTORC2 in regulation of insulin secretion by actin filament remodeling. American journal of physiology. Endocrinology and metabolism. 2022-06-20. PMID:35723227. |
mechanistically, glucagon-like peptide-1 (glp-1), but not gastric inhibitory polypeptide (gip), rescued insulin secretion in vivo and in vitro by improving actin polymerization in βricko islets. |
2022-06-20 |
2023-08-14 |
mouse |