| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| H C Fehmann, J F Habene. Homologous desensitization of the insulinotropic glucagon-like peptide-I (7-37) receptor on insulinoma (HIT-T15) cells. Endocrinology. vol 128. issue 6. 1991-07-02. PMID:1645253. |
prior exposure of cells to 100 nmol/liter glp-(7-37) (10 min) did not alter the gip-induced (10 nmol/liter) insulin release, but 100 nmol/liter gip (10 min) reduced the insulin secretion during stimulation with 10 nmol/liter gip by 56%. |
1991-07-02 |
2023-08-11 |
human |
| B K Chow, G W Morrow, M Ho, R A Pederson, C H McIntosh, J C Brown, R T MacGillivra. Expression of recombinant human glucose-dependent insulinotropic polypeptide in Escherichia coli by sequence-specific proteolysis of a protein A fusion protein. Peptides. vol 11. issue 6. 1991-05-23. PMID:2087431. |
glucose-dependent insulinotropic polypeptide (gip) is a forty-two amino acid hormone that stimulates the secretion of insulin from the pancreatic b-cells in the presence of elevated glucose concentrations. |
1991-05-23 |
2023-08-11 |
human |
| A Ohneda, T Tsuchiya, H Naito, I Sasaki, M Ohneda, T Kawamur. Increased plasma glucagon-like immunoreactivity in dogs with ileojejunal transposition. The Tohoku journal of experimental medicine. vol 162. issue 1. 1991-04-22. PMID:2077681. |
fasting levels of blood glucose, plasma insulin and gastric inhibitory polypeptide (gip) did not change significantly throughout 12 weeks. |
1991-04-22 |
2023-08-11 |
Not clear |
| A Ohneda, T Tsuchiya, H Naito, I Sasaki, M Ohneda, T Kawamur. Increased plasma glucagon-like immunoreactivity in dogs with ileojejunal transposition. The Tohoku journal of experimental medicine. vol 162. issue 1. 1991-04-22. PMID:2077681. |
the response of plasma insulin and gip to glucose in the transposed group did not differ from that of the sham operated group. |
1991-04-22 |
2023-08-11 |
Not clear |
| H C Fehmann, R Göke, B Göke, R Bächle, B Wagner, R Arnol. Priming effect of glucagon-like peptide-1 (7-36) amide, glucose-dependent insulinotropic polypeptide and cholecystokinin-8 at the isolated perfused rat pancreas. Biochimica et biophysica acta. vol 1091. issue 3. 1991-04-15. PMID:1705823. |
the priming effect of glucagon-like peptide-1 (7-36) amide (glp-1 (7-36) amide), glucose-dependent insulin-releasing polypeptide (gip) and cholecystokinin-8 (cck-8) on glucose-induced insulin secretion from rat pancreas was investigated. |
1991-04-15 |
2023-08-11 |
rat |
| H C Fehmann, R Göke, B Göke, R Bächle, B Wagner, R Arnol. Priming effect of glucagon-like peptide-1 (7-36) amide, glucose-dependent insulinotropic polypeptide and cholecystokinin-8 at the isolated perfused rat pancreas. Biochimica et biophysica acta. vol 1091. issue 3. 1991-04-15. PMID:1705823. |
pretreatment of the pancreas with gip augmented insulin secretion: 10 pmol/l gip enhanced only the first phase of the secretory response to 10 mmol/l glucose; 100 and 1000 pmol/l gip stimulated both phases of hormone secretion. |
1991-04-15 |
2023-08-11 |
rat |
| J Dupre, Y Caussignac, T J McDonald, S Van Vlie. Stimulation of glucagon secretion by gastric inhibitory polypeptide in patients with hepatic cirrhosis and hyperglucagonemia. The Journal of clinical endocrinology and metabolism. vol 72. issue 1. 1991-02-14. PMID:1986010. |
there were no significant effects of administration of gip or triglyceride on the blood levels of glucose or immunoreactive insulin. |
1991-02-14 |
2023-08-11 |
Not clear |
| H S Füessl, Y Yiangou, M A Ghatei, F D Goebel, S R Bloo. Effect of synthetic human glucose-dependent insulinotropic polypeptide (hGIP) on the release of insulin in man. European journal of clinical investigation. vol 20. issue 5. 1991-02-11. PMID:2124984. |
during an oral glucose tolerance test (ogtt) and an isoglycaemic intravenous glucose infusion, blood glucose and the responses of insulin and glucose-dependent insulinotropic polypeptide (gip) were measured in six healthy volunteers. |
1991-02-11 |
2023-08-11 |
human |
| H S Füessl, Y Yiangou, M A Ghatei, F D Goebel, S R Bloo. Effect of synthetic human glucose-dependent insulinotropic polypeptide (hGIP) on the release of insulin in man. European journal of clinical investigation. vol 20. issue 5. 1991-02-11. PMID:2124984. |
thus, in the presence of mild physiological hyperglycaemia, human gip is able to enhance the initial insulin response almost equivalently to the stimulus provided by oral glucose. |
1991-02-11 |
2023-08-11 |
human |
| H S Füessl, Y Yiangou, M A Ghatei, F D Goebel, S R Bloo. Effect of synthetic human glucose-dependent insulinotropic polypeptide (hGIP) on the release of insulin in man. European journal of clinical investigation. vol 20. issue 5. 1991-02-11. PMID:2124984. |
decreased insulin concentrations during porcine gip infusions in previous experiments might be due to sequence differences between human and porcine gip. |
1991-02-11 |
2023-08-11 |
human |
| S Pradines, A Joannard, C Boujet, S Halimi, A Beaudoin. [Familial form of hypoglycemia due to leucine hypersensitivity]. Pediatrie. vol 45. issue 9. 1991-01-31. PMID:2175419. |
the clinical picture, outcome of the disease dietary and medical treatment with diazoxide, and the role of gip in insulin secretion is discussed. |
1991-01-31 |
2023-08-11 |
Not clear |
| T K Nordt, I Besenthal, M Eggstein, B Jakobe. Influence of breakfasts with different nutrient contents on glucose, C peptide, insulin, glucagon, triglycerides, and GIP in non-insulin-dependent diabetics. The American journal of clinical nutrition. vol 53. issue 1. 1991-01-23. PMID:1984341. |
influence of breakfasts with different nutrient contents on glucose, c peptide, insulin, glucagon, triglycerides, and gip in non-insulin-dependent diabetics. |
1991-01-23 |
2023-08-11 |
human |
| T K Nordt, I Besenthal, M Eggstein, B Jakobe. Influence of breakfasts with different nutrient contents on glucose, C peptide, insulin, glucagon, triglycerides, and GIP in non-insulin-dependent diabetics. The American journal of clinical nutrition. vol 53. issue 1. 1991-01-23. PMID:1984341. |
thus, in niddm subjects, glucose and insulin responses to different mixed meals do not appear to be exclusively mediated by gip. |
1991-01-23 |
2023-08-11 |
human |
| R Schmid, V Schusdziarra, R Aulehner, N Weigert, M Classe. Comparison of GLP-1 (7-36amide) and GIP on release of somatostatin-like immunoreactivity and insulin from the isolated rat pancreas. Zeitschrift fur Gastroenterologie. vol 28. issue 6. 1990-12-27. PMID:2238756. |
comparison of glp-1 (7-36amide) and gip on release of somatostatin-like immunoreactivity and insulin from the isolated rat pancreas. |
1990-12-27 |
2023-08-11 |
rat |
| R Schmid, V Schusdziarra, R Aulehner, N Weigert, M Classe. Comparison of GLP-1 (7-36amide) and GIP on release of somatostatin-like immunoreactivity and insulin from the isolated rat pancreas. Zeitschrift fur Gastroenterologie. vol 28. issue 6. 1990-12-27. PMID:2238756. |
the effect of equimolar doses of gip and glp-1 (7-36amide) on insulin and somatostatin secretion in the isolated perfused rat pancreas was compared. |
1990-12-27 |
2023-08-11 |
rat |
| R Schmid, V Schusdziarra, R Aulehner, N Weigert, M Classe. Comparison of GLP-1 (7-36amide) and GIP on release of somatostatin-like immunoreactivity and insulin from the isolated rat pancreas. Zeitschrift fur Gastroenterologie. vol 28. issue 6. 1990-12-27. PMID:2238756. |
at a perfusate glucose concentration of 70 mg/dl glp-1 (7-36amide) 10(-9) and 10(-8) m and gip 10(-9) m elicited a significant stimulation of insulin while gip 10(-8) m and lower doses of both peptides (10(-11) and 10(-10) m) were ineffective. |
1990-12-27 |
2023-08-11 |
rat |
| C K Lardinois, R B Richeson, G H Starich, D Mazzu, E L Mazzaferr. Gastric inhibitory polypeptide mechanisms of augmenting insulin secretion. Life sciences. vol 47. issue 12. 1990-12-04. PMID:2122145. |
the cellular mechanisms whereby gastric inhibitory polypeptide (gip) augments glucose-dependent insulin secretion remains poorly defined. |
1990-12-04 |
2023-08-11 |
rat |
| C K Lardinois, R B Richeson, G H Starich, D Mazzu, E L Mazzaferr. Gastric inhibitory polypeptide mechanisms of augmenting insulin secretion. Life sciences. vol 47. issue 12. 1990-12-04. PMID:2122145. |
since glucose-dependent insulin secretion is modulated by membrane associated phospholipase a2 (pla2) and intracellular lipoxygenase (lpx) and cyclooxygenase (co) we hypothesize that gip's augmentation of insulin secretion involves these enzyme systems. |
1990-12-04 |
2023-08-11 |
rat |
| C K Lardinois, R B Richeson, G H Starich, D Mazzu, E L Mazzaferr. Gastric inhibitory polypeptide mechanisms of augmenting insulin secretion. Life sciences. vol 47. issue 12. 1990-12-04. PMID:2122145. |
insulin secretion significantly increased (p less than 0.05) when the glucose concentration was raised from 5.6 to 16mm glucose and this was further augmented by the addition of gip (p less than 0.05). |
1990-12-04 |
2023-08-11 |
rat |
| C K Lardinois, R B Richeson, G H Starich, D Mazzu, E L Mazzaferr. Gastric inhibitory polypeptide mechanisms of augmenting insulin secretion. Life sciences. vol 47. issue 12. 1990-12-04. PMID:2122145. |
pla2 inhibitors significantly (p less than 0.025) decreased 16mm glucose insulin secretion but this was restored by the simultaneous addition of gip. |
1990-12-04 |
2023-08-11 |
rat |