| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Lu, M B Wheeler, X H Leng, A E Boy. The role of the free cytosolic calcium level in beta-cell signal transduction by gastric inhibitory polypeptide and glucagon-like peptide I(7-37). Endocrinology. vol 132. issue 1. 1993-02-05. PMID:8380389. |
this study establishes that gip and glp-i potentiate glucose-stimulated insulin secretion by increasing extracellular ca2+ influx through voltage-dependent ca2+ channels. |
1993-02-05 |
2023-08-12 |
Not clear |
| E C Opara, V L G. Dual effects of gastric inhibitory polypeptide on insulin secretion. Pancreas. vol 8. issue 1. 1993-02-05. PMID:8419907. |
the role of gastric inhibitory polypeptide (gip) on insulin secretion in the presence of different glucose concentrations has been studied in perifused microdissected murine islets. |
1993-02-05 |
2023-08-12 |
Not clear |
| E C Opara, V L G. Dual effects of gastric inhibitory polypeptide on insulin secretion. Pancreas. vol 8. issue 1. 1993-02-05. PMID:8419907. |
if 11.1 mm glucose perifusion in the presence of gip was preceded by 5.5 mm glucose alone, the integrated insulin secretion/20 min above basal level was attenuated (1.46 +/- 0.10 vs. 0.37 +/- 0.03 ng; p < 0.01, n = 6), and withdrawal of gip from the perifusion buffer resulted in the restoration of 11.1 mm glucose-stimulated insulin secretion (1.46 +/- 0.10 vs. 1.98 +/- 0.12 ng). |
1993-02-05 |
2023-08-12 |
Not clear |
| E C Opara, V L G. Dual effects of gastric inhibitory polypeptide on insulin secretion. Pancreas. vol 8. issue 1. 1993-02-05. PMID:8419907. |
if islets were continuously perifused with 11.1 mm glucose, the addition of gip did not alter insulin secretion. |
1993-02-05 |
2023-08-12 |
Not clear |
| E C Opara, V L G. Dual effects of gastric inhibitory polypeptide on insulin secretion. Pancreas. vol 8. issue 1. 1993-02-05. PMID:8419907. |
in contrast, the addition of gip to 22.2 mm glucose perifusion buffer further enhanced the high glucose-induced insulin secretion above basal (12.1 +/- 0.58 vs. 14.5 +/- 0.84 ng; p < 0.05, n = 6). |
1993-02-05 |
2023-08-12 |
Not clear |
| E C Opara, V L G. Dual effects of gastric inhibitory polypeptide on insulin secretion. Pancreas. vol 8. issue 1. 1993-02-05. PMID:8419907. |
these observations are consistent with a hypothesis that during a low glucose condition, gip prevents the risk of hypoglycemia by suppressing insulin secretion, while during a high glucose load, glucose-induced insulin stimulation is potentiated by gip, presumably to prevent hyperglycemia. |
1993-02-05 |
2023-08-12 |
Not clear |
| D P Nicholls, M Riley, J S Elborn, C F Stanford, C Shaw, J M McKillop, K D Buchana. Regulatory peptides in the plasma of patients with chronic cardiac failure at rest and during exercise. European heart journal. vol 13. issue 10. 1992-11-17. PMID:1396815. |
there were also no significant differences in the levels of vasoactive intestinal peptide (vip), glucose-dependent insulinotropic polypeptide (gip), insulin or glucagon in either experimental group both before and during exercise. |
1992-11-17 |
2023-08-11 |
Not clear |
| S B Curtis, A M Buchan, R A Pederson, J C Brow. Insulin response of cultured islets from diabetic and nondiabetic BB rats. Metabolism: clinical and experimental. vol 41. issue 10. 1992-11-05. PMID:1357529. |
after a 48-hour culture period, insulin release in response to glucose (17.8 mmol/l) either alone, with glucose-dependent insulinotropic polypeptide (gip) +/- somatostatin (ss), or with arg +/- ss was measured. |
1992-11-05 |
2023-08-11 |
rat |
| S B Curtis, A M Buchan, R A Pederson, J C Brow. Insulin response of cultured islets from diabetic and nondiabetic BB rats. Metabolism: clinical and experimental. vol 41. issue 10. 1992-11-05. PMID:1357529. |
the addition of gip (1 nmol/l) enhanced glucose-stimulated insulin secretion from bbn rat islets (2.9% +/- 0.42% tcc), but had no effect on bbd islets (2.04% +/- 0.57% tcc). |
1992-11-05 |
2023-08-11 |
rat |
| M A Nauck, M Büsing, C Orskov, E G Siegel, J Talartschik, A Baartz, T Baartz, H Hölzer, U T Hopt, R Eber. Basal and nutrient-stimulated pancreatic and gastrointestinal hormone concentrations in type-1-diabetic patients after successful combined pancreas and kidney transplantation. The Clinical investigator. vol 70. issue 1. 1992-07-13. PMID:1600330. |
in conclusion, the overall pattern of pancreatic and gastrointestinal hormone release is normal in patients after combined pancreas-kidney-transplantation, but there are some peculiarities due to (a) systemic venous drainage of the pancreas graft (elevated fasting ir insulin) and (b) impaired kidney function (negative correlation of fasting plasma values to endogenous creatinine clearance for c-peptide, gip, and gastrin). |
1992-07-13 |
2023-08-11 |
Not clear |
| E G Siegel, A Schulze, W E Schmidt, W Creutzfeld. Comparison of the effect of GIP and GLP-1 (7-36amide) on insulin release from rat pancreatic islets. European journal of clinical investigation. vol 22. issue 3. 1992-06-16. PMID:1582439. |
comparison of the effect of gip and glp-1 (7-36amide) on insulin release from rat pancreatic islets. |
1992-06-16 |
2023-08-11 |
rat |
| E G Siegel, A Schulze, W E Schmidt, W Creutzfeld. Comparison of the effect of GIP and GLP-1 (7-36amide) on insulin release from rat pancreatic islets. European journal of clinical investigation. vol 22. issue 3. 1992-06-16. PMID:1582439. |
after ingestion of glucose both gip (gastric inhibitory polypeptide, glucose-dependent insulinotropic polypeptide) and glp-1(7-36amide) (glucagon-like polypeptide-1, 7-36amide) may play a physiological role in augmenting insulin release. |
1992-06-16 |
2023-08-11 |
rat |
| E G Siegel, A Schulze, W E Schmidt, W Creutzfeld. Comparison of the effect of GIP and GLP-1 (7-36amide) on insulin release from rat pancreatic islets. European journal of clinical investigation. vol 22. issue 3. 1992-06-16. PMID:1582439. |
at 16.7 mmol l-1 glucose both gip and glp-1(7-36amide) 2 x 10(-10) mol l-1 significantly increased insulin release; 10(-10) mol l-1 of either hormone had no significant effect. |
1992-06-16 |
2023-08-11 |
rat |
| E G Siegel, A Schulze, W E Schmidt, W Creutzfeld. Comparison of the effect of GIP and GLP-1 (7-36amide) on insulin release from rat pancreatic islets. European journal of clinical investigation. vol 22. issue 3. 1992-06-16. PMID:1582439. |
these data show comparable effects of high concentrations of gip and glp-1(7-36amide) on glucose-induced insulin release; at presumably physiological concentrations, however, glp-1(7-36amide) was clearly more effective. |
1992-06-16 |
2023-08-11 |
rat |
| W J Rossowski, S Zacharia, Z Mungan, V Ozmen, A Ertan, L M Baylor, N Y Jiang, D H Co. Reduced gastric acid inhibitory effect of a pGIP(1-30)NH2 fragment with potent pancreatic amylase inhibitory activity. Regulatory peptides. vol 39. issue 1. 1992-06-10. PMID:1374565. |
gastric inhibitory polypeptide (gip) strongly stimulates insulin secretion in the presence of glucose and also stimulates somatostatin release from gastric mucosa. |
1992-06-10 |
2023-08-11 |
rat |
| C Simões Nunes, K Malmlö. Glucose absorption, hormonal release and hepatic metabolism after guar gum ingestion. Reproduction, nutrition, development. vol 32. issue 1. 1992-06-09. PMID:1315555. |
the sampling was continued for 8 h. guar gum strongly reduced the glucose absorption as well as the insulin, gastric inhibitory polypeptide (gip) and insulin-like growth factor-1 (igf-1) production. |
1992-06-09 |
2023-08-11 |
Not clear |
| N Fukase, H Takahashi, H Manaka, M Igarashi, K Yamatani, M Daimon, K Sugiyama, M Tominaga, H Sasak. Differences in glucagon-like peptide-1 and GIP responses following sucrose ingestion. Diabetes research and clinical practice. vol 15. issue 3. 1992-06-05. PMID:1576919. |
after treatment with ao-128 (0.6 mg/day) for 1 week, increases in plasma glucose and insulin levels were attenuated and the increase in plasma gip levels was diminished, while the increase in tglp-1 levels was sustained much longer. |
1992-06-05 |
2023-08-11 |
Not clear |
| S Suzuki, K Kawai, S Ohashi, Y Watanabe, K Yamashit. Interaction of glucagon-like peptide-1(7-36) amide and gastric inhibitory polypeptide or cholecystokinin on insulin and glucagon secretion from the isolated perfused rat pancreas. Metabolism: clinical and experimental. vol 41. issue 4. 1992-05-01. PMID:1556941. |
the interaction of three incretin candidates, glucagon-like peptide-1(7-36)amide (t-glp-1), gastric inhibitory polypeptide (gip), and sulfated cooh-terminal octapeptide of cholecystokinin (cck-8-s), on insulin and glucagon release from the isolated perfused rat pancreas was studied. |
1992-05-01 |
2023-08-11 |
rat |
| S Suzuki, K Kawai, S Ohashi, Y Watanabe, K Yamashit. Interaction of glucagon-like peptide-1(7-36) amide and gastric inhibitory polypeptide or cholecystokinin on insulin and glucagon secretion from the isolated perfused rat pancreas. Metabolism: clinical and experimental. vol 41. issue 4. 1992-05-01. PMID:1556941. |
under the perfusate condition of 8.3 mmol/l glucose, coinfusion of 0.1 nmol/l t-glp-1 and 0.1 nmol/l gip resulted in an augmented insulin release greater than that obtained by the same dose of each peptide alone. |
1992-05-01 |
2023-08-11 |
rat |
| R A Pederson, S B Curtis, C B Chisholm, N R Gaba, R V Campos, J C Brow. Insulin secretion and islet endocrine cell content at onset and during the early stages of diabetes in the BB rat: effect of the level of glycemic control. Canadian journal of physiology and pharmacology. vol 69. issue 8. 1992-03-16. PMID:1782606. |
the insulin response from the isolated perfused pancreas to glucose and the glucose-dependent insulinotropic hormone, gastric inhibitory polypeptide (gip), was reduced by 95%. |
1992-03-16 |
2023-08-11 |
rat |