| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| H Takahashi, H Manaka, K Suda, N Fukase, A Sekikawa, H Eguchi, M Tominaga, H Sasak. Hyperglycaemia but not hyperinsulinaemia prevents the secretion of glucagon-like peptide-1 (7-36 amide) stimulated by fat ingestion. Scandinavian journal of clinical and laboratory investigation. vol 51. issue 6. 1992-02-18. PMID:1767243. |
the effect of insulin and glucose on fat-induced gastric inhibitory polypeptide (gip) and glucagon-like peptide-1 (7-36 amide) (glp-1 (7-36 amide)) was studied in five healthy subjects during continuous glucose infusion (protocol 1) and during hyperinsulinaemic euglycaemic blood glucose clamp (protocol 2). |
1992-02-18 |
2023-08-11 |
human |
| H Takahashi, H Manaka, K Suda, N Fukase, A Sekikawa, H Eguchi, M Tominaga, H Sasak. Hyperglycaemia but not hyperinsulinaemia prevents the secretion of glucagon-like peptide-1 (7-36 amide) stimulated by fat ingestion. Scandinavian journal of clinical and laboratory investigation. vol 51. issue 6. 1992-02-18. PMID:1767243. |
thus, it is concluded that insulin inhibits fat-induced gip, but not glp-1 (7-36 amide), secretion and that glucose is likely to inhibit glp-1 (7-36 amide) secretion. |
1992-02-18 |
2023-08-11 |
human |
| A A Ponter, D N Salter, L M Morgan, P R Flat. The effect of energy source and feeding level on the hormones of the entero-insular axis and plasma glucose in the growing pig. The British journal of nutrition. vol 66. issue 2. 1992-02-11. PMID:1760441. |
for acute test 1 the accustomed meal (diets cl, fl and fh) and for acute test 2 a standard high-fat meal (diet fl) were given; blood samples were taken during the next 5 h and analysed for gip, insulin and glucose. |
1992-02-11 |
2023-08-11 |
Not clear |
| J von Schönfeld, M K Müller, M Rünzi, H Goebel. Independence of GIP-induced insulin secretion from sympathetic and parasympathetic innervation in the isolated perfused rat pancreas. International journal of pancreatology : official journal of the International Association of Pancreatology. vol 10. issue 1. 1992-02-06. PMID:1757729. |
the incretin candidate gip (gastric inhibitory polypeptide) is released from the gut by nutrients and can stimulate insulin secretion. |
1992-02-06 |
2023-08-11 |
rat |
| J von Schönfeld, M K Müller, M Rünzi, H Goebel. Independence of GIP-induced insulin secretion from sympathetic and parasympathetic innervation in the isolated perfused rat pancreas. International journal of pancreatology : official journal of the International Association of Pancreatology. vol 10. issue 1. 1992-02-06. PMID:1757729. |
metabolic and hormonal factors have been shown to modulate insulin response to gip. |
1992-02-06 |
2023-08-11 |
rat |
| J von Schönfeld, M K Müller, M Rünzi, H Goebel. Independence of GIP-induced insulin secretion from sympathetic and parasympathetic innervation in the isolated perfused rat pancreas. International journal of pancreatology : official journal of the International Association of Pancreatology. vol 10. issue 1. 1992-02-06. PMID:1757729. |
it is unknown, however, whether the autonomic nervous system, which itself controls insulin secretion, can modulate the insulinotropic effect of gip. |
1992-02-06 |
2023-08-11 |
rat |
| J von Schönfeld, M K Müller, M Rünzi, H Goebel. Independence of GIP-induced insulin secretion from sympathetic and parasympathetic innervation in the isolated perfused rat pancreas. International journal of pancreatology : official journal of the International Association of Pancreatology. vol 10. issue 1. 1992-02-06. PMID:1757729. |
in the isolated perfused rat pancreas, we therefore investigated the influence of sympathetic and parasympathetic agonists and antagonists on the insulin response to gip. |
1992-02-06 |
2023-08-11 |
rat |
| J von Schönfeld, M K Müller, M Rünzi, H Goebel. Independence of GIP-induced insulin secretion from sympathetic and parasympathetic innervation in the isolated perfused rat pancreas. International journal of pancreatology : official journal of the International Association of Pancreatology. vol 10. issue 1. 1992-02-06. PMID:1757729. |
as compared to control (6990 +/- 890 microu/10 min), the effect of either acetylcholine (29030 +/- 4600 microu/10 min), atropine (5880 +/- 1740 microu/10 min), norepinephrine (2520 +/- 750 microu/10 min), phentolamine (11380 +/- 1910 microu/10 min), isoproterenol (12740 +/- 2090 microu/10 min), propranolol (5600 +/- 880 microu/10 min), or gip (29660 +/- 4490 microu/10 min) on insulin secretion was consistent with previous reports. |
1992-02-06 |
2023-08-11 |
rat |
| J von Schönfeld, M K Müller, M Rünzi, H Goebel. Independence of GIP-induced insulin secretion from sympathetic and parasympathetic innervation in the isolated perfused rat pancreas. International journal of pancreatology : official journal of the International Association of Pancreatology. vol 10. issue 1. 1992-02-06. PMID:1757729. |
the effects of the combined administration of gip and either acetylcholine (48140 +/- 7540 microu/10 min), phentolamine (43930 +/- 4490 microu/10 min), norepinephrine (9000 +/- 1740 microu/10 min), or isoproterenol (36280 +/- 5210 microu/10 min) on insulin release were additive. |
1992-02-06 |
2023-08-11 |
rat |
| J von Schönfeld, M K Müller, M Rünzi, H Goebel. Independence of GIP-induced insulin secretion from sympathetic and parasympathetic innervation in the isolated perfused rat pancreas. International journal of pancreatology : official journal of the International Association of Pancreatology. vol 10. issue 1. 1992-02-06. PMID:1757729. |
insulin response to gip was resistant to atropine (24210 +/- 9470 microu/10 min) and propranolol (26450 +/- 4930 mu/10 min). |
1992-02-06 |
2023-08-11 |
rat |
| J von Schönfeld, M K Müller, M Rünzi, H Goebel. Independence of GIP-induced insulin secretion from sympathetic and parasympathetic innervation in the isolated perfused rat pancreas. International journal of pancreatology : official journal of the International Association of Pancreatology. vol 10. issue 1. 1992-02-06. PMID:1757729. |
we conclude that both gip and the autonomic nervous system influence insulin secretion, but that they do so independently from each other. |
1992-02-06 |
2023-08-11 |
rat |
| W E Schmidt, W Creutzfeldt, M Höcker, R Nustede, A R Choudhury, A Schleser, L C Rovati, U R Fölsc. Cholecystokinin receptor antagonist loxiglumide modulates plasma levels of gastro-entero-pancreatic hormones in man. Feedback control of cholecystokinin and gastrin secretion. European journal of clinical investigation. vol 21. issue 5. 1992-01-27. PMID:1752290. |
the effect of the potent specific cholecystokinin (cck) receptor antagonist loxiglumide on meal-stimulated plasma concentrations of cck, gastrin, pancreatic polypeptide (pp), neurotensin, glucose-dependent insulinotropic polypeptide (gip), insulin and c peptide was investigated in a placebo-controlled study in 10 healthy male volunteers. |
1992-01-27 |
2023-08-11 |
human |
| W E Schmidt, W Creutzfeldt, M Höcker, R Nustede, A R Choudhury, A Schleser, L C Rovati, U R Fölsc. Cholecystokinin receptor antagonist loxiglumide modulates plasma levels of gastro-entero-pancreatic hormones in man. Feedback control of cholecystokinin and gastrin secretion. European journal of clinical investigation. vol 21. issue 5. 1992-01-27. PMID:1752290. |
infusion of the cck receptor antagonist only slightly increased postprandial peak plasma glucose, insulin and c-peptide levels, whereas gip and neurotensin levels were not significantly influenced. |
1992-01-27 |
2023-08-11 |
human |
| B Ahrén, M Pettersson, K Uvnäs-Moberg, M Gutniak, S Efendi. Effects of cholecystokinin (CCK)-8, CCK-33, and gastric inhibitory polypeptide (GIP) on basal and meal-stimulated pancreatic hormone secretion in man. Diabetes research and clinical practice. vol 13. issue 3. 1992-01-03. PMID:1683622. |
we therefore examined the effects of intravenous injection of pharmacological dose levels of cck-8 (100 and 300 pmol/kg), cck-33 (100 pmol/kg), gip (100 pmol/kg), and cck-8 plus gip (100 pmol/kg of each) on plasma levels of glucose, insulin, somatostatin, glucagon, and pancreatic polypeptide (pp) in healthy human volunteers. |
1992-01-03 |
2023-08-11 |
human |
| B Ahrén, M Pettersson, K Uvnäs-Moberg, M Gutniak, S Efendi. Effects of cholecystokinin (CCK)-8, CCK-33, and gastric inhibitory polypeptide (GIP) on basal and meal-stimulated pancreatic hormone secretion in man. Diabetes research and clinical practice. vol 13. issue 3. 1992-01-03. PMID:1683622. |
cck-8, cck-33, and gip were all found to increase the basal plasma levels of insulin, somatostatin, and pp; the increases were observed already in samples taken at 2 min after the injection. |
1992-01-03 |
2023-08-11 |
human |
| B Ahrén, M Pettersson, K Uvnäs-Moberg, M Gutniak, S Efendi. Effects of cholecystokinin (CCK)-8, CCK-33, and gastric inhibitory polypeptide (GIP) on basal and meal-stimulated pancreatic hormone secretion in man. Diabetes research and clinical practice. vol 13. issue 3. 1992-01-03. PMID:1683622. |
cck-8, cck-33, and gip (100 pmol/kg) all potentiated the meal-induced plasma responses of insulin and pp, whereas plasma levels of glucagon after the meal were not affected. |
1992-01-03 |
2023-08-11 |
human |
| B Ahrén, M Pettersson, K Uvnäs-Moberg, M Gutniak, S Efendi. Effects of cholecystokinin (CCK)-8, CCK-33, and gastric inhibitory polypeptide (GIP) on basal and meal-stimulated pancreatic hormone secretion in man. Diabetes research and clinical practice. vol 13. issue 3. 1992-01-03. PMID:1683622. |
cck-8 and gip together (100 pmol/kg for both) increased plasma levels of insulin, pp and somatostatin as much as each of the peptides given alone, both under basal conditions and after the meal intake. |
1992-01-03 |
2023-08-11 |
human |
| B Ahrén, M Pettersson, K Uvnäs-Moberg, M Gutniak, S Efendi. Effects of cholecystokinin (CCK)-8, CCK-33, and gastric inhibitory polypeptide (GIP) on basal and meal-stimulated pancreatic hormone secretion in man. Diabetes research and clinical practice. vol 13. issue 3. 1992-01-03. PMID:1683622. |
we conclude that in man, both cck-8, cck-33, and gip moderately stimulate basal and meal related insulin release without any synergistic effects and that the peptides do not inhibit the secretion of glucagon. |
1992-01-03 |
2023-08-11 |
human |
| J Oben, L Morgan, J Fletcher, V Mark. Effect of the entero-pancreatic hormones, gastric inhibitory polypeptide and glucagon-like polypeptide-1(7-36) amide, on fatty acid synthesis in explants of rat adipose tissue. The Journal of endocrinology. vol 130. issue 2. 1991-11-01. PMID:1919397. |
the effect of gastric inhibitory polypeptide (gip), glucagon-like peptide-1(7-36) amide, (glp-1(7-36) amide), glucagon-like peptide-2 (glp-2), glucagon and insulin on fatty acid synthesis in explants of rat adipose tissue from various sites was investigated. |
1991-11-01 |
2023-08-11 |
rat |
| J Oben, L Morgan, J Fletcher, V Mark. Effect of the entero-pancreatic hormones, gastric inhibitory polypeptide and glucagon-like polypeptide-1(7-36) amide, on fatty acid synthesis in explants of rat adipose tissue. The Journal of endocrinology. vol 130. issue 2. 1991-11-01. PMID:1919397. |
gip, glp-1(7-36) amide and insulin stimulated fatty acid synthesis, as determined by measuring the incorporation of [14c]acetate into saponifiable fat, in a dose-dependent manner, over the concentration range 5-15 ng/ml (0.87-2.61 nmol/l) for insulin and 0.5-7.5 ng/ml for gip (0.10-1.50 nmol/l) and glp-1(7-36) amide (0.15-2.27 nmol/l). |
1991-11-01 |
2023-08-11 |
rat |