| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J H Hays, E Silverman, B B Potter, K M Shaki. Normal gastric inhibitory polypeptide response to oral glucose in hypothyroidism. The Journal of endocrinology. vol 140. issue 2. 1994-06-01. PMID:8169563. |
we did not find significant differences in serum glucose or gip responses and postulate this as evidence of resistance to the effects of endogenous insulin. |
1994-06-01 |
2023-08-12 |
human |
| J F Habene. The incretin notion and its relevance to diabetes. Endocrinology and metabolism clinics of North America. vol 22. issue 4. 1994-04-08. PMID:8125072. |
glp-1 hormone is released into the circulation from intestinal l cells in response to meals and is the most potent incretin hormone known; glp-1 and gip appear to account for most, if not all, of the intestinal incretin effect in the augmentation of glucose-stimulated insulin secretion. |
1994-04-08 |
2023-08-12 |
rat |
| P Malfertheiner, M G Sarr, D K Nelson, E P DiMagn. Role of the duodenum in postprandial release of pancreatic and gastrointestinal hormones. Pancreas. vol 9. issue 1. 1994-03-18. PMID:8108366. |
in the current studies, we tested the hypothesis that an intact duodenopancreatic axis is necessary for normal postprandial release of pancreatic (pp, insulin) and gut peptides (gastric inhibitory peptide, gip; cholecystokinin octapeptides, cck-8; neurotensin; and gastrin). |
1994-03-18 |
2023-08-12 |
Not clear |
| B Gallwitz, M Witt, U R Fölsch, W Creutzfeldt, W E Schmid. Binding specificity and signal transduction of receptors for glucagon-like peptide-1(7-36)amide and gastric inhibitory polypeptide on RINm5F insulinoma cells. Journal of molecular endocrinology. vol 10. issue 3. 1993-10-21. PMID:8396943. |
glucagon-like peptide-1(7-36)amide (glp-1(7-36) amide) and gastric inhibitory polypeptide (gip), peptides of the glucagon family, stimulate insulin secretion in vitro and in vivo. |
1993-10-21 |
2023-08-12 |
Not clear |
| M A Nauck, M Büsing, C Orskov, E G Siegel, J Talartschik, A Baartz, T Baartz, U T Hopt, H D Becker, W Creutzfeld. Preserved incretin effect in type 1 diabetic patients with end-stage nephropathy treated by combined heterotopic pancreas and kidney transplantation. Acta diabetologica. vol 30. issue 1. 1993-08-16. PMID:8329730. |
the release of gastric inhibitory polypeptide (gip) and glucagon-like peptide 1 (glp-1) immunoreactivity and b cell secretory responses (ir insulin and c-peptide) to oral (50 g) and "isoglycaemic" intravenous glucose (identical glycaemic profile) were measured by radioimmunoassay. |
1993-08-16 |
2023-08-12 |
Not clear |
| R Mentlein, B Gallwitz, W E Schmid. Dipeptidyl-peptidase IV hydrolyses gastric inhibitory polypeptide, glucagon-like peptide-1(7-36)amide, peptide histidine methionine and is responsible for their degradation in human serum. European journal of biochemistry. vol 214. issue 3. 1993-08-03. PMID:8100523. |
since an intact n-terminus is obligate for the biological activity of the members of the glucagon/vip peptide family [e. g. gip(3-42) is known to be inactive to release insulin in the presence of glucose as does intact gip], dipeptidyl-peptidase-iv action inactivates these peptide hormones. |
1993-08-03 |
2023-08-12 |
human |
| P J Jones, C A Leitch, R A Pederso. Meal-frequency effects on plasma hormone concentrations and cholesterol synthesis in humans. The American journal of clinical nutrition. vol 57. issue 6. 1993-06-29. PMID:8503355. |
to examine meal-frequency effects on circulating hormone concentrations and cholesterol synthesis, male subjects consumed liquid diets given as either six evenly spaced (es) or three diurnal (di) meals over 3 d. deuterium oxide was given on day 2 and blood sampled every 4 h over days 2 and 3 to measure plasma cholesterol, glucose, insulin, and glucose-dependent insulinotropic polypeptide (gip) concentrations and cholesterol synthesis. |
1993-06-29 |
2023-08-12 |
human |
| P J Jones, C A Leitch, R A Pederso. Meal-frequency effects on plasma hormone concentrations and cholesterol synthesis in humans. The American journal of clinical nutrition. vol 57. issue 6. 1993-06-29. PMID:8503355. |
the es group had lower insulin (p < 0.05) and gip (p < 0.001) concentrations compared with the di group. |
1993-06-29 |
2023-08-12 |
human |
| M A Wahl, R J Plehn, E A Landsbeck, E J Verspohl, H P Ammo. Are ionic fluxes of pancreatic beta cells a target for gastric inhibitory polypeptide? Molecular and cellular endocrinology. vol 90. issue 1. 1993-05-28. PMID:1284494. |
gastric inhibitory polypeptide (gip), an incretin candidate, is suggested to amplify the glucose-induced insulin secretion. |
1993-05-28 |
2023-08-11 |
mouse |
| M A Wahl, R J Plehn, E A Landsbeck, E J Verspohl, H P Ammo. Are ionic fluxes of pancreatic beta cells a target for gastric inhibitory polypeptide? Molecular and cellular endocrinology. vol 90. issue 1. 1993-05-28. PMID:1284494. |
it is concluded that the amplification of insulin release by gip is based on the effect of gip on ca2+ uptake. |
1993-05-28 |
2023-08-11 |
mouse |
| M A Nauck, E Bartels, C Orskov, R Ebert, W Creutzfeld. Additive insulinotropic effects of exogenous synthetic human gastric inhibitory polypeptide and glucagon-like peptide-1-(7-36) amide infused at near-physiological insulinotropic hormone and glucose concentrations. The Journal of clinical endocrinology and metabolism. vol 76. issue 4. 1993-05-18. PMID:8473405. |
gastric inhibitory polypeptide (gip) and glucagon-like peptide-1-(7-36) amide (glp-1) are glucose-dependent insulinotropic gut hormones that may explain the greater insulin secretory response with oral compared to i.v. |
1993-05-18 |
2023-08-12 |
human |
| C C Tseng, L A Jarboe, S B Landau, E K Williams, M M Wolf. Glucose-dependent insulinotropic peptide: structure of the precursor and tissue-specific expression in rat. Proceedings of the National Academy of Sciences of the United States of America. vol 90. issue 5. 1993-04-08. PMID:8446620. |
glucose-dependent insulinotropic peptide (gip) is a 42-amino acid gastrointestinal regulatory peptide that stimulates insulin secretion from pancreatic beta cells in the presence of glucose. |
1993-04-08 |
2023-08-12 |
human |
| N Fukase, M Igarashi, H Takahashi, H Manaka, K Yamatani, M Daimon, M Tominaga, H Sasak. Hypersecretion of truncated glucagon-like peptide-1 and gastric inhibitory polypeptide in obese patients. Diabetic medicine : a journal of the British Diabetic Association. vol 10. issue 1. 1993-03-22. PMID:8435987. |
these results suggest that the combined augmentation of plasma gip and tglp-1 responses were involved in the delayed and considerable increases in plasma insulin after glucose ingestion in obese diabetic patients. |
1993-03-22 |
2023-08-12 |
human |
| C B Verchere, Y N Kwok, J C Brow. Inhibitory actions of a somatostatin analog SMS 201-995 on endocrine secretion from the isolated perfused stomach and pancreas of the rat. Pharmacology. vol 46. issue 1. 1993-03-12. PMID:8094569. |
in the perfused pancreas both ss-14 (6.1 x 10(-9) mol/l) and sms (9.4 x 10(-9) mol/l) inhibited the gip (2 x 10(-9) mol/l) or acetylcholine (1 x 10(-6) mol/l), but not 17.8 x 10(-9) mol/l glucose-stimulated insulin secretion. |
1993-03-12 |
2023-08-12 |
rat |
| M A Nauck, M M Heimesaat, C Orskov, J J Holst, R Ebert, W Creutzfeld. Preserved incretin activity of glucagon-like peptide 1 [7-36 amide] but not of synthetic human gastric inhibitory polypeptide in patients with type-2 diabetes mellitus. The Journal of clinical investigation. vol 91. issue 1. 1993-02-24. PMID:8423228. |
both gip and glp-1 [7-36 amide] dose-dependently augmented insulin secretion (insulin, c-peptide) in both groups (p < 0.05). |
1993-02-24 |
2023-08-12 |
human |
| W T Phillips, J G Schwartz, C A McMaha. Reduced postprandial blood glucose levels in recently diagnosed non-insulin-dependent diabetics secondary to pharmacologically induced delayed gastric emptying. Digestive diseases and sciences. vol 38. issue 1. 1993-02-18. PMID:8420760. |
blood samples were obtained at 15-min intervals for measurement of glucose, insulin, cck-8, and gastric inhibitory polypeptide (gip) concentrations. |
1993-02-18 |
2023-08-12 |
Not clear |
| S K Sharma, C Austin, A Howard, G Lo, C G Nicholl, S Lego. Characterization of rat gastric inhibitory peptide cDNA. Journal of molecular endocrinology. vol 9. issue 3. 1993-02-05. PMID:1476614. |
gastric inhibitory peptide (gip) is a 42 amino acid gastrointestinal peptide which inhibits gastric acid secretion and stimulates pancreatic insulin secretion in the presence of glucose. |
1993-02-05 |
2023-08-11 |
rat |
| M Lu, M B Wheeler, X H Leng, A E Boy. The role of the free cytosolic calcium level in beta-cell signal transduction by gastric inhibitory polypeptide and glucagon-like peptide I(7-37). Endocrinology. vol 132. issue 1. 1993-02-05. PMID:8380389. |
using the glucose-responsive hamster beta-cell line (hamster insulin tumor cells), we examined the cellular mechanisms by which gastric inhibitory polypeptide (gip) and glucagon-like peptide i(7-37) (glp-i) potentiate glucose-stimulated insulin secretion. |
1993-02-05 |
2023-08-12 |
Not clear |
| M Lu, M B Wheeler, X H Leng, A E Boy. The role of the free cytosolic calcium level in beta-cell signal transduction by gastric inhibitory polypeptide and glucagon-like peptide I(7-37). Endocrinology. vol 132. issue 1. 1993-02-05. PMID:8380389. |
when added to glucose-stimulated cells, gip and glp-i increased camp levels and further increased insulin secretion. |
1993-02-05 |
2023-08-12 |
Not clear |
| M Lu, M B Wheeler, X H Leng, A E Boy. The role of the free cytosolic calcium level in beta-cell signal transduction by gastric inhibitory polypeptide and glucagon-like peptide I(7-37). Endocrinology. vol 132. issue 1. 1993-02-05. PMID:8380389. |
nimodipine also inhibited the potentiation of glucose-stimulated insulin secretion by gip and glp-i without inhibition of the stimulatory effect of these two peptides on camp accumulation. |
1993-02-05 |
2023-08-12 |
Not clear |