| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Su-Jin Kim, Cuilan Nian, Subashini Karunakaran, Susanne M Clee, Carlos M Isales, Christopher H S McIntos. GIP-overexpressing mice demonstrate reduced diet-induced obesity and steatosis, and improved glucose homeostasis. PloS one. vol 7. issue 7. 2012-12-03. PMID:22802954. |
glucose-dependent insulinotropic polypeptide (gip) is a gastrointestinal hormone that potentiates glucose-stimulated insulin secretion during a meal. |
2012-12-03 |
2023-08-12 |
mouse |
| Su-Jin Kim, Cuilan Nian, Subashini Karunakaran, Susanne M Clee, Carlos M Isales, Christopher H S McIntos. GIP-overexpressing mice demonstrate reduced diet-induced obesity and steatosis, and improved glucose homeostasis. PloS one. vol 7. issue 7. 2012-12-03. PMID:22802954. |
in contrast, although gip tg mice demonstrated enhanced β-cell function, resulting in improved glucose tolerance and insulin sensitivity, they exhibited reduced diet-induced obesity. |
2012-12-03 |
2023-08-12 |
mouse |
| Nigel Irwin, Ian A Montgomery, Peter R Flat. Evaluation of the long-term effects of gastric inhibitory polypeptide-ovalbumin conjugates on insulin resistance, metabolic dysfunction, energy balance and cognition in high-fat-fed mice. The British journal of nutrition. vol 108. issue 1. 2012-10-30. PMID:22260799. |
the effects of active immunisation with gastric inhibitory polypeptide (gip) or (proline3)gip-ovalbumin conjugates on insulin resistance, metabolic dysfunction, energy expenditure and cognition were examined in high-fat-fed mice. |
2012-10-30 |
2023-08-12 |
mouse |
| Nigel Irwin, Ian A Montgomery, Peter R Flat. Evaluation of the long-term effects of gastric inhibitory polypeptide-ovalbumin conjugates on insulin resistance, metabolic dysfunction, energy balance and cognition in high-fat-fed mice. The British journal of nutrition. vol 108. issue 1. 2012-10-30. PMID:22260799. |
active immunisation resulted in gip antibody generation and significantly (p < 0·01 to p < 0·001) reduced circulating non-fasting plasma insulin concentrations compared to high-fat control mice from day 70 onwards. |
2012-10-30 |
2023-08-12 |
mouse |
| Akira Shimotoyodome, Noriko Osaki, Koji Onizawa, Tomohito Mizuno, Chika Suzukamo, Fumiaki Okahara, Daisuke Fukuoka, Tadashi Has. Dietary 1-monoolein decreases postprandial GIP release by reducing jejunal transport of glucose and fatty acid in rodents. American journal of physiology. Gastrointestinal and liver physiology. vol 303. issue 3. 2012-10-11. PMID:22651926. |
postprandial secretion of insulin and glucose-dependent insulinotropic polypeptide (gip) is differentially regulated by not only dietary carbohydrate but also fat. |
2012-10-11 |
2023-08-12 |
mouse |
| Akira Shimotoyodome, Noriko Osaki, Koji Onizawa, Tomohito Mizuno, Chika Suzukamo, Fumiaki Okahara, Daisuke Fukuoka, Tadashi Has. Dietary 1-monoolein decreases postprandial GIP release by reducing jejunal transport of glucose and fatty acid in rodents. American journal of physiology. Gastrointestinal and liver physiology. vol 303. issue 3. 2012-10-11. PMID:22651926. |
recent studies have shown that the ingestion of diacylglycerol (dag) results in lower postprandial insulin and gip release than that of triacylglycerol (tag), suggesting a possible mechanism for the antiobesity effect of dag. |
2012-10-11 |
2023-08-12 |
mouse |
| Akira Shimotoyodome, Noriko Osaki, Koji Onizawa, Tomohito Mizuno, Chika Suzukamo, Fumiaki Okahara, Daisuke Fukuoka, Tadashi Has. Dietary 1-monoolein decreases postprandial GIP release by reducing jejunal transport of glucose and fatty acid in rodents. American journal of physiology. Gastrointestinal and liver physiology. vol 303. issue 3. 2012-10-11. PMID:22651926. |
this study was designed to clarify the effect of 1-monoacylglycerol [oleic acid-rich (1-mo)], the characteristic metabolite of dag, on postprandial insulin and gip secretion, and the underlying mechanism. |
2012-10-11 |
2023-08-12 |
mouse |
| Akira Shimotoyodome, Noriko Osaki, Koji Onizawa, Tomohito Mizuno, Chika Suzukamo, Fumiaki Okahara, Daisuke Fukuoka, Tadashi Has. Dietary 1-monoolein decreases postprandial GIP release by reducing jejunal transport of glucose and fatty acid in rodents. American journal of physiology. Gastrointestinal and liver physiology. vol 303. issue 3. 2012-10-11. PMID:22651926. |
although glucose-stimulated insulin and gip release was augmented by the addition of fat, coingestion of 1-mo reduced the postprandial hormone release in a dose-dependent manner. |
2012-10-11 |
2023-08-12 |
mouse |
| Akira Shimotoyodome, Noriko Osaki, Koji Onizawa, Tomohito Mizuno, Chika Suzukamo, Fumiaki Okahara, Daisuke Fukuoka, Tadashi Has. Dietary 1-monoolein decreases postprandial GIP release by reducing jejunal transport of glucose and fatty acid in rodents. American journal of physiology. Gastrointestinal and liver physiology. vol 303. issue 3. 2012-10-11. PMID:22651926. |
we conclude that dietary 1-mo attenuates postprandial gip and insulin secretion by reducing the intestinal transport of the gip secretagogues, which may be mediated via sglt-1 and fat/cd36. |
2012-10-11 |
2023-08-12 |
mouse |
| Ronald Christopher, Aziz Kari. Clinical pharmacology of alogliptin, a dipeptidyl peptidase-4 inhibitor, for the treatment of Type 2 diabetes. Expert review of clinical pharmacology. vol 2. issue 6. 2012-10-02. PMID:22112254. |
glp-1 and gip are released in response to food ingestion; they enhance nutrient-induced insulin secretion and inhibit postprandial glucagon secretion. |
2012-10-02 |
2023-08-12 |
human |
| Yu-Ting A Chiang, Wilfred Ip, Tianru Ji. The role of the Wnt signaling pathway in incretin hormone production and function. Frontiers in physiology. vol 3. 2012-10-02. PMID:22934027. |
in addition to insulin and glucagon produced by pancreatic islets, two incretin hormones, namely glucagon-like peptide-1 (glp-1) and gastric inhibitory polypeptide (gip, also known as glucose-dependent insulinotropic peptide), also play important roles in blood glucose homeostasis. |
2012-10-02 |
2023-08-12 |
Not clear |
| Roberto Burattini, Micaela Morettin. Identification of an integrated mathematical model of standard oral glucose tolerance test for characterization of insulin potentiation in health. Computer methods and programs in biomedicine. vol 107. issue 2. 2012-09-27. PMID:21803437. |
model behaviour was tested vs. mean plasma glucagon-like peptide 1 (glp-1), glucose-dependent insulinotropic polypeptide (gip), glucose and insulin measurements from two different laboratories, where glycemic profiles observed during a 75 g ogtt were matched in healthy subjects (hc1- and hc2-group, respectively) by means of an isoglycemic intravenous glucose (i-ivg) infusion. |
2012-09-27 |
2023-08-12 |
human |
| Roberto Burattini, Micaela Morettin. Identification of an integrated mathematical model of standard oral glucose tolerance test for characterization of insulin potentiation in health. Computer methods and programs in biomedicine. vol 107. issue 2. 2012-09-27. PMID:21803437. |
under the hypothesis of an additive effect of glp-1 and gip on insulin potentiation, our results demonstrated a substantial equivalence of the two models in matching the data. |
2012-09-27 |
2023-08-12 |
human |
| Daisuke Yabe, Yutaka Sein. Two incretin hormones GLP-1 and GIP: comparison of their actions in insulin secretion and β cell preservation. Progress in biophysics and molecular biology. vol 107. issue 2. 2012-09-20. PMID:21820006. |
two incretin hormones glp-1 and gip: comparison of their actions in insulin secretion and β cell preservation. |
2012-09-20 |
2023-08-12 |
Not clear |
| Daisuke Yabe, Yutaka Sein. Two incretin hormones GLP-1 and GIP: comparison of their actions in insulin secretion and β cell preservation. Progress in biophysics and molecular biology. vol 107. issue 2. 2012-09-20. PMID:21820006. |
gastric inhibitory polypeptide (gip) and glucagon-like peptide-1 (glp-1) are the two primary incretin hormones secreted from the intestine upon ingestion of glucose or nutrients to stimulate insulin secretion from pancreatic β cells. |
2012-09-20 |
2023-08-12 |
Not clear |
| Wendell J Lu, Qing Yang, Li Yang, Dana Lee, David D'Alessio, Patrick Ts. Chylomicron formation and secretion is required for lipid-stimulated release of incretins GLP-1 and GIP. Lipids. vol 47. issue 6. 2012-09-20. PMID:22297815. |
glucagon-like peptide-1 (glp-1) and glucose-dependent insulinotropic polypeptide (gip) are incretins produced in the intestine that play a central role in glucose metabolism and insulin secretion. |
2012-09-20 |
2023-08-12 |
Not clear |
| Kyuzi Kamoi, You Shinozaki, Kazuo Furukawa, Hideo Sasak. Potential correlation between plasma total GIP levels and body mass index in Japanese patients with types 1 or 2 diabetes mellitus. Endocrine journal. vol 59. issue 4. 2012-09-19. PMID:22301939. |
plasma glucose (pg), serum insulin (s-iri), serum c-peptide (s-cpr), and plasma total gip (p-total gip) levels were measured at 0, 30, and 60 minutes after tm (560 kcal) in patients with t1dm (n = 15, group 1) and t2dm (n = 29, group 2) treated with various medications. |
2012-09-19 |
2023-08-12 |
Not clear |
| Elisa Guarino, Laura Nigi, Aurora Patti, Cecilia Fondelli, Francesco Dott. Combination therapy with metformin plus vildagliptin in type 2 diabetes mellitus. Expert opinion on pharmacotherapy. vol 13. issue 9. 2012-09-14. PMID:22397507. |
dipeptidyl peptidase-4 (dpp-4) inhibitors are among the most recent additions to the therapeutic options for t2dm and are able to increase circulating levels of glucagon-like peptide-1 (glp-1) and glucose-dependent insulinotropic polypeptide (gip), thus stimulating glucose-dependent insulin secretion. |
2012-09-14 |
2023-08-12 |
Not clear |
| Burton M Wice, Dominic N Reeds, Hung D Tran, Dan L Crimmins, Bruce W Patterson, Judit Dunai, Michael J Wallendorf, Jack H Ladenson, Dennis T Villareal, Kenneth S Polonsk. Xenin-25 amplifies GIP-mediated insulin secretion in humans with normal and impaired glucose tolerance but not type 2 diabetes. Diabetes. vol 61. issue 7. 2012-09-10. PMID:22522617. |
glucose-dependent insulinotropic polypeptide (gip) potentiates glucose-stimulated insulin secretion (gsis). |
2012-09-10 |
2023-08-12 |
mouse |
| Burton M Wice, Dominic N Reeds, Hung D Tran, Dan L Crimmins, Bruce W Patterson, Judit Dunai, Michael J Wallendorf, Jack H Ladenson, Dennis T Villareal, Kenneth S Polonsk. Xenin-25 amplifies GIP-mediated insulin secretion in humans with normal and impaired glucose tolerance but not type 2 diabetes. Diabetes. vol 61. issue 7. 2012-09-10. PMID:22522617. |
although magnitudes of insulin secretory responses to gip were similar in all groups, isrs were not restored to normal in subjects with igt and t2dm. |
2012-09-10 |
2023-08-12 |
mouse |