| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Randi Uglehold. Glucose-dependent Insulinotropic Polypeptide (GIP): From prohormone to actions in endocrine pancreas and adipose tissue. Danish medical bulletin. vol 58. issue 12. 2013-04-01. PMID:22142579. |
an acute and established function of gip is to exert its incretin function thereby enhancing glucose stimulated insulin secretion necessary for prompt disposal of nutrients, yet gip also stimulates glucagon secretion to increase blood glucose. |
2013-04-01 |
2023-08-12 |
mouse |
| Randi Uglehold. Glucose-dependent Insulinotropic Polypeptide (GIP): From prohormone to actions in endocrine pancreas and adipose tissue. Danish medical bulletin. vol 58. issue 12. 2013-04-01. PMID:22142579. |
in the diabetic state the insulinotropic effect of gip is impaired and an early inexpedient glucagon stimulation in response to a meal further counteracts effects of insulin and worsens glycaemic control. |
2013-04-01 |
2023-08-12 |
mouse |
| Kazuyo Suzuki, Norio Harada, Shunsuke Yamane, Yasuhiko Nakamura, Kazuki Sasaki, Daniela Nasteska, Erina Joo, Kimitaka Shibue, Takanari Harada, Akihiro Hamasaki, Kentaro Toyoda, Kazuaki Nagashima, Nobuya Inagak. Transcriptional regulatory factor X6 (Rfx6) increases gastric inhibitory polypeptide (GIP) expression in enteroendocrine K-cells and is involved in GIP hypersecretion in high fat diet-induced obesity. The Journal of biological chemistry. vol 288. issue 3. 2013-03-26. PMID:23192339. |
gip potentiates glucose-stimulated insulin secretion and induces energy accumulation into adipose tissue, resulting in obesity. |
2013-03-26 |
2023-08-12 |
mouse |
| Radhika V Seimon, Ixchel M Brennan, Antonietta Russo, Tanya J Little, Karen L Jones, Scott Standfield, Judith M Wishart, Michael Horowitz, Christine Feinle-Bisse. Gastric emptying, mouth-to-cecum transit, and glycemic, insulin, incretin, and energy intake responses to a mixed-nutrient liquid in lean, overweight, and obese males. American journal of physiology. Endocrinology and metabolism. vol 304. issue 3. 2013-03-25. PMID:23211514. |
twenty lean, 20 overweight, and 20 obese males had measurements of ge, oro-cecal transit, and blood glucose, insulin, glp-1, and gip concentrations for 5 h after ingestion of a mixed-nutrient drink (500 ml, 532 kcal); ei at a subsequent buffet lunch was determined. |
2013-03-25 |
2023-08-12 |
human |
| Yuichiro Yamad. [Diabetes mellitus and osteoporosis. Incretin as a coordinator of glucose and bone metabolism]. Clinical calcium. vol 22. issue 9. 2013-03-20. PMID:22932289. |
glp-1 and gip play an important role as incretin to stimulate insulin secretion from pancreatic β-cells and to maintain the homeostasis of glucose metabolism. |
2013-03-20 |
2023-08-12 |
Not clear |
| Bethany P Cummings, Andrew A Bremer, Timothy J Kieffer, David D'Alessio, Peter J Have. Investigation of the mechanisms contributing to the compensatory increase in insulin secretion during dexamethasone-induced insulin resistance in rhesus macaques. The Journal of endocrinology. vol 216. issue 2. 2013-03-11. PMID:23151361. |
dexamethasone-treated animals exhibited a significant increase in both insulin and glucose-dependent insulinotropic polypeptide (gip) secretion during the feeding study (p<0.05). |
2013-03-11 |
2023-08-12 |
Not clear |
| Bethany P Cummings, Andrew A Bremer, Timothy J Kieffer, David D'Alessio, Peter J Have. Investigation of the mechanisms contributing to the compensatory increase in insulin secretion during dexamethasone-induced insulin resistance in rhesus macaques. The Journal of endocrinology. vol 216. issue 2. 2013-03-11. PMID:23151361. |
furthermore, increases in postprandial gip secretion with dexamethasone treatment appear to contribute to the effect of dexamethasone treatment to increase insulin secretion. |
2013-03-11 |
2023-08-12 |
Not clear |
| Grace B Flock, Xiemin Cao, Marlena Maziarz, Daniel J Drucke. Activation of enteroendocrine membrane progesterone receptors promotes incretin secretion and improves glucose tolerance in mice. Diabetes. vol 62. issue 1. 2013-03-08. PMID:22933106. |
enteral progesterone administration increased plasma levels of glp-1, glucose-dependent insulinotropic polypeptide (gip), and insulin, and improved oral glucose tolerance in an ru486-insensitve manner in mice: however, systemic progesterone exposure did not improve glucose homeostasis. |
2013-03-08 |
2023-08-12 |
mouse |
| Katharina Timper, Jean Grisouard, Nadine S Sauter, Tanja Herzog-Radimerski, Kaethi Dembinski, Ralph Peterli, Daniel M Frey, Henryk Zulewski, Ulrich Keller, Beat Müller, Mirjam Christ-Crai. Glucose-dependent insulinotropic polypeptide induces cytokine expression, lipolysis, and insulin resistance in human adipocytes. American journal of physiology. Endocrinology and metabolism. vol 304. issue 1. 2013-02-27. PMID:23092914. |
we investigated whether gip affects inflammation, lipolysis, and insulin resistance in human adipocytes. |
2013-02-27 |
2023-08-12 |
human |
| Katharina Timper, Jean Grisouard, Nadine S Sauter, Tanja Herzog-Radimerski, Kaethi Dembinski, Ralph Peterli, Daniel M Frey, Henryk Zulewski, Ulrich Keller, Beat Müller, Mirjam Christ-Crai. Glucose-dependent insulinotropic polypeptide induces cytokine expression, lipolysis, and insulin resistance in human adipocytes. American journal of physiology. Endocrinology and metabolism. vol 304. issue 1. 2013-02-27. PMID:23092914. |
in conclusion, gip induces an inflammatory and prolipolytic response via the pka -nf-κb-il-1 pathway and impairs insulin sensitivity of glucose uptake in human adipocytes. |
2013-02-27 |
2023-08-12 |
human |
| Gonzalo Encina, Fernando Ezquer, Paulette Conget, Yedy Israe. Insulin is secreted upon glucose stimulation by both gastrointestinal enteroendocrine K-cells and L-cells engineered with the preproinsulin gene. Biological research. vol 44. issue 3. 2013-02-20. PMID:22688918. |
transgenic mice carrying the human insulin gene driven by the k-cell glucose-dependent insulinotropic peptide (gip) promoter secrete insulin and display normal glucose tolerance tests after their pancreatic p-cells have been destroyed. |
2013-02-20 |
2023-08-12 |
mouse |
| Gonzalo Encina, Fernando Ezquer, Paulette Conget, Yedy Israe. Insulin is secreted upon glucose stimulation by both gastrointestinal enteroendocrine K-cells and L-cells engineered with the preproinsulin gene. Biological research. vol 44. issue 3. 2013-02-20. PMID:22688918. |
when the mouse enteroendocrine stc-1 cell line was transfected with the human preproinsulin gene, driven either by the k-cell specific gip promoter or by the constitutive cytomegalovirus (cmv) promoter, human insulin co-localizes in vesicles that contain gip (gip or cmv promoter) or glp-1 (cmv promoter). |
2013-02-20 |
2023-08-12 |
mouse |
| Gonzalo Encina, Fernando Ezquer, Paulette Conget, Yedy Israe. Insulin is secreted upon glucose stimulation by both gastrointestinal enteroendocrine K-cells and L-cells engineered with the preproinsulin gene. Biological research. vol 44. issue 3. 2013-02-20. PMID:22688918. |
exposure to glucose of engineered stc-1 cells led to a marked insulin secretion, which was 7-fold greater when the insulin gene was driven by the cmv promoter (expressed both in k-cells and l-cells) than when it was driven by the gip promoter (expressed only in k-cells). |
2013-02-20 |
2023-08-12 |
mouse |
| Sheng Zhang, Krzysztof Hyrc, Songyan Wang, Burton M Wic. Xenin-25 increases cytosolic free calcium levels and acetylcholine release from a subset of myenteric neurons. American journal of physiology. Gastrointestinal and liver physiology. vol 303. issue 12. 2013-02-06. PMID:23086920. |
we previously showed exogenously administered xen, with gip but not alone, increases insulin secretion in humans and mice. |
2013-02-06 |
2023-08-12 |
mouse |
| Anthony Beucher, Elisabet Gjernes, Caitlin Collin, Monica Courtney, Aline Meunier, Patrick Collombat, Gérard Gradwoh. The homeodomain-containing transcription factors Arx and Pax4 control enteroendocrine subtype specification in mice. PloS one. vol 7. issue 5. 2013-01-24. PMID:22570716. |
these cells produce over ten different hormones including glp-1 and gip peptides known to promote insulin secretion. |
2013-01-24 |
2023-08-12 |
mouse |
| Bilal Omar, Elin Banke, Emilia Guirguis, Lina Åkesson, Vincent Manganiello, Valeriya Lyssenko, Leif Groop, Maria F Gomez, Eva Degerma. Regulation of the pro-inflammatory cytokine osteopontin by GIP in adipocytes--a role for the transcription factor NFAT and phosphodiesterase 3B. Biochemical and biophysical research communications. vol 425. issue 4. 2013-01-18. PMID:22892131. |
given the established link between osteopontin and insulin resistance, our data suggest that gip by stimulating osteopontin expression, also could promote insulin resistance in adipocytes. |
2013-01-18 |
2023-08-12 |
mouse |
| Young Min Cho, Catherine E Merchant, Timothy J Kieffe. Targeting the glucagon receptor family for diabetes and obesity therapy. Pharmacology & therapeutics. vol 135. issue 3. 2013-01-14. PMID:22659620. |
gip is rapidly released from intestinal k-cells following food intake and stimulates glucose-dependent insulin secretion from β-cells and the storage of fat in adipocytes. |
2013-01-14 |
2023-08-12 |
Not clear |
| Young Min Cho, Catherine E Merchant, Timothy J Kieffe. Targeting the glucagon receptor family for diabetes and obesity therapy. Pharmacology & therapeutics. vol 135. issue 3. 2013-01-14. PMID:22659620. |
similar to gip, glp-1 is released from intestinal l-cells following food intake and potentiates glucose-dependent insulin secretion from β-cells. |
2013-01-14 |
2023-08-12 |
Not clear |
| Pengzhou Li, Shaihong Zhu, Dawei Zhang, Yan Liu, Guohui Wang, Liyong Zhu, Fei Y. [Glucose-dependent insulinotropic peptide in Type 2 diabetes after gastric bypass surgery]. Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences. vol 36. issue 10. 2013-01-10. PMID:22086011. |
continual high-fat diet powerfully stimulated gip secretion, leading to obesity and harmful lipid deposition in islet cells and peripheral tissues, and giving rise to insulin resistance and major disturbances in the secretion of insulin. |
2013-01-10 |
2023-08-12 |
Not clear |
| D X Brown, M Choudhury, M Evan. Linagliptin as add-on therapy for type 2 diabetes - an overview. Drugs of today (Barcelona, Spain : 1998). vol 48. issue 10. 2012-12-28. PMID:23110260. |
the pathogenesis of type 2 diabetes (t2d) can result in decreased levels of glucagon-like peptide 1 (glp-1) and glucose-dependent insulinotropic polypeptide (gip), which under normal circumstances increase insulin secretion and suppress glucagon release. |
2012-12-28 |
2023-08-12 |
Not clear |