| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Emma Ahlqvist, Peter Osmark, Tiina Kuulasmaa, Kasper Pilgaard, Bilal Omar, Charlotte Brøns, Olga Kotova, Anna V Zetterqvist, Alena Stancáková, Anna Jonsson, Ola Hansson, Johanna Kuusisto, Timothy J Kieffer, Tiinamaija Tuomi, Bo Isomaa, Sten Madsbad, Maria F Gomez, Pernille Poulsen, Markku Laakso, Eva Degerman, Jussi Pihlajamäki, Nils Wierup, Allan Vaag, Leif Groop, Valeriya Lyssenk. Link between GIP and osteopontin in adipose tissue and insulin resistance. Diabetes. vol 62. issue 6. 2013-08-02. PMID:23349498. |
together, these data suggest a role for gip not only as an incretin hormone but also as a trigger of inflammation and insulin resistance in adipose tissue. |
2013-08-02 |
2023-08-12 |
rat |
| Hiroyuki Koshiyam. Further possible mechanisms of dipeptidyl peptidase-4 inhibitors to decrease blood glucose in subjects with type 2 diabetes. Japanese clinical medicine. vol 2. 2013-07-25. PMID:23885193. |
i present here several possible mechanisms of dpp-4 inhibitors to reduce blood glucose in type 2 diabetes; first, to inhibit glucagon secretion, second, to stimulate glucose-dependent insulinotropic peptide (gip) secretion, which may regain its action to stimulate insulin secretion when hyperglycemia has been improved, third, to recover the response to sulfonylureas by restoring pancreatic atp levels, fourth, to stimulate glucagon-like peptide 1 (glp-1 ) secretion directly from the intestine, and finally to inhibit the action of dpp-4 as an adipokine. |
2013-07-25 |
2023-08-12 |
human |
| Vikas K Bhat, Barry D Kerr, Peter R Flatt, Victor A Gaul. A novel GIP-oxyntomodulin hybrid peptide acting through GIP, glucagon and GLP-1 receptors exhibits weight reducing and anti-diabetic properties. Biochemical pharmacology. vol 85. issue 11. 2013-07-16. PMID:23518155. |
gip is the principle physiological regulator of postprandial insulin secretion. |
2013-07-16 |
2023-08-12 |
mouse |
| Vikas K Bhat, Barry D Kerr, Peter R Flatt, Victor A Gaul. A novel GIP-oxyntomodulin hybrid peptide acting through GIP, glucagon and GLP-1 receptors exhibits weight reducing and anti-diabetic properties. Biochemical pharmacology. vol 85. issue 11. 2013-07-16. PMID:23518155. |
da(2)gip-oxm exerts positive beneficial actions on glucose homeostasis, beta-cell insulin secretion and body weight, mediated through gip, glucagon and glp-1 receptors. |
2013-07-16 |
2023-08-12 |
mouse |
| K Færch, K Pilgaard, F K Knop, T Hansen, O Pedersen, T Jørgensen, J J Hols. Incretin and pancreatic hormone secretion in Caucasian non-diabetic carriers of the TCF7L2 rs7903146 risk T allele. Diabetes, obesity & metabolism. vol 15. issue 1. 2013-07-02. PMID:22862926. |
we characterised 62 non-diabetic, middle-aged, caucasians with and without the t risk allele of rs7903146 in transcription factor 7-like 2 (tcf7l2) with regard to secretion of insulin, glucagon, glucose-dependent insulinotropic polypeptide (gip), glucagon-like peptide-1 (glp-1) as well as insulin sensitivity and endogenous glucose production. |
2013-07-02 |
2023-08-12 |
human |
| K Færch, K Pilgaard, F K Knop, T Hansen, O Pedersen, T Jørgensen, J J Hols. Incretin and pancreatic hormone secretion in Caucasian non-diabetic carriers of the TCF7L2 rs7903146 risk T allele. Diabetes, obesity & metabolism. vol 15. issue 1. 2013-07-02. PMID:22862926. |
after adjustment for age and sex, risk t allele carriers had higher haemoglobin a1c levels (p = 0.030), reduced first-phase insulin response (p = 0.048), higher peripheral insulin sensitivity (p = 0.050) and lower fasting gip concentrations (p = 0.003) than cc allele carriers. |
2013-07-02 |
2023-08-12 |
human |
| Yuka Mitsuhashi, Daisuke Nagaoka, Karen E Bigley, Tomoshige Umeda, Kazuya Otsuji, John E Baue. Metabolic and Hormonal Alterations with Diacylglycerol and Low Glycemic Index Starch during Canine Weight Loss. ISRN veterinary science. vol 2012. 2013-06-14. PMID:23762590. |
at weeks 1 and 8, fasting plasma insulin, glucose, nonesterified fatty acid (nefa), glucose-dependent insulinotropic polypeptide (gip), and glucagon-like peptide-1 (glp-1) were determined. |
2013-06-14 |
2023-08-12 |
Not clear |
| Yuka Mitsuhashi, Daisuke Nagaoka, Karen E Bigley, Tomoshige Umeda, Kazuya Otsuji, John E Baue. Metabolic and Hormonal Alterations with Diacylglycerol and Low Glycemic Index Starch during Canine Weight Loss. ISRN veterinary science. vol 2012. 2013-06-14. PMID:23762590. |
weight loss did not affect fasting insulin, glucose, and nefa, but fasting gip increased and glp-1 decreased. |
2013-06-14 |
2023-08-12 |
Not clear |
| Shauna S Runchey, Liisa M Valsta, Yvonne Schwarz, Chiachi Wang, Xiaoling Song, Johanna W Lampe, Marian L Neuhouse. Effect of low- and high-glycemic load on circulating incretins in a randomized clinical trial. Metabolism: clinical and experimental. vol 62. issue 2. 2013-06-03. PMID:22959497. |
we aimed to assess effects of dietary glycemic load on fasting and post-prandial glucose, insulin and incretin (i.e., glucose-dependent insulinotropic polypeptide (gip) and glucagon-like peptide-1 (glp-1)) concentrations and to examine for effect modification by adiposity. |
2013-06-03 |
2023-08-12 |
Not clear |
| S Ono, Y Suzuki, N Fukui, T Sugai, J Watanabe, N Tsuneyama, T Somey. Association between the GIPR gene and the insulin level after glucose loading in schizophrenia patients treated with olanzapine. The pharmacogenomics journal. vol 12. issue 6. 2013-05-30. PMID:21747410. |
glucose-dependent insulinotropic polypeptide (gip) is known to affect insulin secretion by pancreatic β cells. |
2013-05-30 |
2023-08-12 |
Not clear |
| S Ono, Y Suzuki, N Fukui, T Sugai, J Watanabe, N Tsuneyama, T Somey. Association between the GIPR gene and the insulin level after glucose loading in schizophrenia patients treated with olanzapine. The pharmacogenomics journal. vol 12. issue 6. 2013-05-30. PMID:21747410. |
recently, a meta-analysis study reported an association between a gip receptor (gipr) gene polymorphism (rs10423928) and insulin secretion measured by an oral glucose tolerance test (ogtt). |
2013-05-30 |
2023-08-12 |
Not clear |
| Zhong Chen, Li Yan, Xiao-ying Fu, Hua-zhang Yang, Jian Kuan. [Effect of different dietary loads on glucose-dependent insulinotropic polypeptide in subjects with normal glucose tolerance]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University. vol 31. issue 12. 2013-05-02. PMID:22200706. |
to investigate the secretion patterns of glucose-dependent insulinotropic polypeptide (gip) after different dietary loads in subjects with normal glucose tolerance (ngt) and their relation to insulin secretion and plasma glucose levels. |
2013-05-02 |
2023-08-12 |
human |
| E Ekholm, N Shaat, J J Hols. Characterization of beta cell and incretin function in patients with MODY1 (HNF4A MODY) and MODY3 (HNF1A MODY) in a Swedish patient collection. Acta diabetologica. vol 49. issue 5. 2013-04-29. PMID:21761282. |
clinical characteristics and biochemical data (glucose, proinsulin, insulin, c-peptide, glp-1 and gip) during a test meal were compared between mody patients from eight different families. |
2013-04-29 |
2023-08-12 |
human |
| E Ekholm, N Shaat, J J Hols. Characterization of beta cell and incretin function in patients with MODY1 (HNF4A MODY) and MODY3 (HNF1A MODY) in a Swedish patient collection. Acta diabetologica. vol 49. issue 5. 2013-04-29. PMID:21761282. |
the auc insulin during the test meal was strongly correlated with the gip secretion (correlation coefficient 1.0, p < 0.001). |
2013-04-29 |
2023-08-12 |
human |
| E Ekholm, N Shaat, J J Hols. Characterization of beta cell and incretin function in patients with MODY1 (HNF4A MODY) and MODY3 (HNF1A MODY) in a Swedish patient collection. Acta diabetologica. vol 49. issue 5. 2013-04-29. PMID:21761282. |
auc insulin during the test meal was strongly correlated with gip secretion, whereas no such correlation was seen for insulin and glp-1. |
2013-04-29 |
2023-08-12 |
human |
| E Ekholm, N Shaat, J J Hols. Characterization of beta cell and incretin function in patients with MODY1 (HNF4A MODY) and MODY3 (HNF1A MODY) in a Swedish patient collection. Acta diabetologica. vol 49. issue 5. 2013-04-29. PMID:21761282. |
thus, gip may be a more important factor for insulin secretion than glp-1 in mody patients. |
2013-04-29 |
2023-08-12 |
human |
| David P Sonne, Kristine J Hare, Pernille Martens, Jens F Rehfeld, Jens J Holst, Tina Vilsbøll, Filip K Kno. Postprandial gut hormone responses and glucose metabolism in cholecystectomized patients. American journal of physiology. Gastrointestinal and liver physiology. vol 304. issue 4. 2013-04-19. PMID:23275610. |
basal and postprandial plasma concentrations of glucose, insulin, c-peptide, glucagon, glp-1, glucose-dependent insulinotropic polypeptide (gip), glucagon-like peptide-2 (glp-2), cholecystokinin (cck), and gastrin were measured. |
2013-04-19 |
2023-08-12 |
human |
| Ayako Fukami, Yusuke Seino, Nobuaki Ozaki, Michiyo Yamamoto, Chisato Sugiyama, Eriko Sakamoto-Miura, Tatsuhito Himeno, Yoshiko Takagishi, Shin Tsunekawa, Safina Ali, Daniel J Drucker, Yoshiharu Murata, Yutaka Seino, Yutaka Oiso, Yoshitaka Hayash. Ectopic expression of GIP in pancreatic β-cells maintains enhanced insulin secretion in mice with complete absence of proglucagon-derived peptides. Diabetes. vol 62. issue 2. 2013-04-11. PMID:23099862. |
ectopic expression of gip in pancreatic β-cells maintains enhanced insulin secretion in mice with complete absence of proglucagon-derived peptides. |
2013-04-11 |
2023-08-12 |
mouse |
| Ayako Fukami, Yusuke Seino, Nobuaki Ozaki, Michiyo Yamamoto, Chisato Sugiyama, Eriko Sakamoto-Miura, Tatsuhito Himeno, Yoshiko Takagishi, Shin Tsunekawa, Safina Ali, Daniel J Drucker, Yoshiharu Murata, Yutaka Seino, Yutaka Oiso, Yoshitaka Hayash. Ectopic expression of GIP in pancreatic β-cells maintains enhanced insulin secretion in mice with complete absence of proglucagon-derived peptides. Diabetes. vol 62. issue 2. 2013-04-11. PMID:23099862. |
blockade of gip action in vitro and in vivo by camp antagonism and genetic deletion of the gip receptor, respectively, almost completely abrogated enhanced insulin secretion in gcg(gfp/gfp) mice. |
2013-04-11 |
2023-08-12 |
mouse |
| Ayako Fukami, Yusuke Seino, Nobuaki Ozaki, Michiyo Yamamoto, Chisato Sugiyama, Eriko Sakamoto-Miura, Tatsuhito Himeno, Yoshiko Takagishi, Shin Tsunekawa, Safina Ali, Daniel J Drucker, Yoshiharu Murata, Yutaka Seino, Yutaka Oiso, Yoshitaka Hayash. Ectopic expression of GIP in pancreatic β-cells maintains enhanced insulin secretion in mice with complete absence of proglucagon-derived peptides. Diabetes. vol 62. issue 2. 2013-04-11. PMID:23099862. |
these results indicate that ectopic gip expression in β-cells maintains insulin secretion in the absence of proglucagon-derived peptides (pgdps), revealing a novel compensatory mechanism for sustaining incretin hormone action in islets. |
2013-04-11 |
2023-08-12 |
mouse |