| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| B Ahré. Incretin dysfunction in type 2 diabetes: clinical impact and future perspectives. Diabetes & metabolism. vol 39. issue 3. 2014-03-28. PMID:23643349. |
in contrast, the insulinotropic effects of both gip and glp-1 are impaired in type 2 diabetes with greater suppression of insulin secretion augmentation with gip than with glp-1. |
2014-03-28 |
2023-08-12 |
human |
| Tomasz Wikarek, Jerzy Chudek, Aleksander Owczarek, Magdalena Olszanecka-Glinianowic. Effect of dietary macronutrients on postprandial incretin hormone release and satiety in obese and normal-weight women. The British journal of nutrition. vol 111. issue 2. 2014-03-21. PMID:23920407. |
a total of eleven obese and nine normal-weight women were recruited for the assessment of plasma concentrations of glucagon-like peptide-1 (glp-1), glucose-dependent insulinotropic polypeptide (gip) and insulin and the sensation of satiety and hunger using a visual analogue scale before and during a 6 h period after administration of three different macronutrient test meals. |
2014-03-21 |
2023-08-12 |
Not clear |
| Tomasz Wikarek, Jerzy Chudek, Aleksander Owczarek, Magdalena Olszanecka-Glinianowic. Effect of dietary macronutrients on postprandial incretin hormone release and satiety in obese and normal-weight women. The British journal of nutrition. vol 111. issue 2. 2014-03-21. PMID:23920407. |
in conclusion, the findings of the present study suggest that: (1) satiety sensation after consumption of carbohydrate and protein meals in the obese group is related to the postprandial insulin response, while after consumption of a fatty meal, it is related to the postprandial glp-1 release; (2) the postprandial gip response does not influence the sensation of satiety and hunger; (3) the reduced glp-1 release after the intake of a fatty meal in obese individuals may explain impaired satiety sensation; (4) the impaired postprandial gip response is not related to the consumption of macronutrients and may be the early indicator of incretin axis dysfunction in obese women. |
2014-03-21 |
2023-08-12 |
Not clear |
| B Solun, D Marcoviciu, D Dicke. Dipeptidyl peptidase-4 inhibitors and their effects on the cardiovascular system. Current cardiology reports. vol 15. issue 8. 2014-03-05. PMID:23812835. |
they exert their actions through degradation inhibition of endogenous glucagon-like peptides (glp-1) and glucose-dependent insulinotropic peptides (gip), with a resulting increase in glucose mediated insulin secretion and a suppression of glucagon secretion. |
2014-03-05 |
2023-08-12 |
Not clear |
| Victor A Gault, Vikas K Bhat, Nigel Irwin, Peter R Flat. A novel glucagon-like peptide-1 (GLP-1)/glucagon hybrid peptide with triple-acting agonist activity at glucose-dependent insulinotropic polypeptide, GLP-1, and glucagon receptors and therapeutic potential in high fat-fed mice. The Journal of biological chemistry. vol 288. issue 49. 2014-02-13. PMID:24165127. |
glucagon-like peptide-1 (glp-1), glucose-dependent insulinotropic polypeptide (gip), and glucagon bind to related members of the same receptor superfamily and exert important effects on glucose homeostasis, insulin secretion, and energy regulation. |
2014-02-13 |
2023-08-12 |
mouse |
| Yong Zhu, Walter H Hsu, James H Holli. The impact of food viscosity on eating rate, subjective appetite, glycemic response and gastric emptying rate. PloS one. vol 8. issue 6. 2014-01-30. PMID:23818981. |
the plasma samples were assayed for insulin, glucose-dependent insulinotropic peptide (gip), glucose and acetaminophen. |
2014-01-30 |
2023-08-12 |
human |
| Pitchai Balakumar, Sokkalingam A Dhanara. Cardiovascular pleiotropic actions of DPP-4 inhibitors: a step at the cutting edge in understanding their additional therapeutic potentials. Cellular signalling. vol 25. issue 9. 2014-01-27. PMID:23707531. |
the incretin hormones such as glucagon-like peptide-1 (glp-1) and glucose-dependent insulinotropic polypeptide (gip) are released from the small intestine into the vasculature during a meal, and these incretins have a potential to release insulin from pancreatic beta cells of islets of langerhans, affording a glucose-lowering action. |
2014-01-27 |
2023-08-12 |
human |
| Bodo C Melnik, Swen Malte John, Gerd Schmit. Milk is not just food but most likely a genetic transfection system activating mTORC1 signaling for postnatal growth. Nutrition journal. vol 12. 2014-01-16. PMID:23883112. |
this review presents milk as a materno-neonatal relay system functioning by transfer of preferential amino acids, which increase plasma levels of glucose-dependent insulinotropic polypeptide (gip), glucagon-like peptide-1 (glp-1), insulin, growth hormone (gh) and insulin-like growth factor-1 (igf-1) for mtorc1 activation. |
2014-01-16 |
2023-08-12 |
human |
| Steven D Coon, John H Schwartz, Vazhaikkurichi M Rajendran, Lisa Jepeal, Satish K Sing. Glucose-dependent insulinotropic polypeptide regulates dipeptide absorption in mouse jejunum. American journal of physiology. Gastrointestinal and liver physiology. vol 305. issue 10. 2014-01-06. PMID:24072682. |
glucose-dependent insulinotropic polypeptide (gip) secreted from jejunal mucosal k cells augments insulin secretion and plays a critical role in the pathogenesis of obesity and type 2 diabetes mellitus. |
2014-01-06 |
2023-08-12 |
mouse |
| Daniel J Drucke. Incretin action in the pancreas: potential promise, possible perils, and pathological pitfalls. Diabetes. vol 62. issue 10. 2013-12-10. PMID:23818527. |
glucagon-like peptide-1 (glp-1) and glucose-dependent insulinotropic polypeptide (gip) are incretin hormones that control the secretion of insulin, glucagon, and somatostatin to facilitate glucose disposal. |
2013-12-10 |
2023-08-12 |
human |
| David J Hodson, Ryan K Mitchell, Elisa A Bellomo, Gao Sun, Laurent Vinet, Paolo Meda, Daliang Li, Wen-Hong Li, Marco Bugliani, Piero Marchetti, Domenico Bosco, Lorenzo Piemonti, Paul Johnson, Stephen J Hughes, Guy A Rutte. Lipotoxicity disrupts incretin-regulated human β cell connectivity. The Journal of clinical investigation. vol 123. issue 10. 2013-11-26. PMID:24018562. |
we found that glp-1 and gip recruit a highly coordinated subnetwork of β cells that are targeted by lipotoxicity to suppress insulin secretion. |
2013-11-26 |
2023-08-12 |
mouse |
| Noriyuki Higuchi, Tohru Hira, Nao Yamada, Hiroshi Har. Oral administration of corn zein hydrolysate stimulates GLP-1 and GIP secretion and improves glucose tolerance in male normal rats and Goto-Kakizaki rats. Endocrinology. vol 154. issue 9. 2013-11-12. PMID:23798598. |
blood samples were collected from the tail vein or by using the jugular catheter to measure glucose, insulin, glp-1, and gip levels. |
2013-11-12 |
2023-08-12 |
rat |
| Yoshiki Kusunoki, Tomoyuki Katsuno, Makiko Myojin, Kana Miyakoshi, Takashi Ikawa, Toshihiro Matsuo, Fumihiro Ochi, Masaru Tokuda, Kazuki Murai, Masayuki Miuchi, Tomoya Hamaguchi, Jun-ichiro Miyagawa, Mitsuyoshi Namb. Effect of additional administration of acarbose on blood glucose fluctuations and postprandial hyperglycemia in patients with type 2 diabetes mellitus under treatment with alogliptin. Endocrine journal. vol 60. issue 4. 2013-10-22. PMID:23220949. |
in addition, a meal tolerance test was conducted to monitor changes in insulin secretion and active glp-1 and total gip values. |
2013-10-22 |
2023-08-12 |
human |
| A M Duffy, C Hölsche. The incretin analogue D-Ala2GIP reduces plaque load, astrogliosis and oxidative stress in an APP/PS1 mouse model of Alzheimer's disease. Neuroscience. vol 228. 2013-09-23. PMID:23103794. |
glucose-dependent insulinotropic polypeptide (gip), an incretin hormone, normalises insulin signalling and also acts as a neuroprotective growth factor. |
2013-09-23 |
2023-08-12 |
mouse |
| Peter Ravn, Chaithanya Madhurantakam, Susan Kunze, Evelyn Matthews, Claire Priest, Siobhan O'Brien, Andie Collinson, Monika Papworth, Maria Fritsch-Fredin, Lutz Jermutus, Lambertus Benthem, Markus Gruetter, Ronald H Jackso. Structural and pharmacological characterization of novel potent and selective monoclonal antibody antagonists of glucose-dependent insulinotropic polypeptide receptor. The Journal of biological chemistry. vol 288. issue 27. 2013-09-13. PMID:23689510. |
glucose-dependent insulinotropic polypeptide (gip) is an endogenous hormonal factor (incretin) that, upon binding to its receptor (gipr; a class b g-protein-coupled receptor), stimulates insulin secretion by beta cells in the pancreas. |
2013-09-13 |
2023-08-12 |
mouse |
| Peter Ravn, Chaithanya Madhurantakam, Susan Kunze, Evelyn Matthews, Claire Priest, Siobhan O'Brien, Andie Collinson, Monika Papworth, Maria Fritsch-Fredin, Lutz Jermutus, Lambertus Benthem, Markus Gruetter, Ronald H Jackso. Structural and pharmacological characterization of novel potent and selective monoclonal antibody antagonists of glucose-dependent insulinotropic polypeptide receptor. The Journal of biological chemistry. vol 288. issue 27. 2013-09-13. PMID:23689510. |
gipg013 antagonizes the gip receptor and inhibits gip-induced insulin secretion in vitro and in vivo. |
2013-09-13 |
2023-08-12 |
mouse |
| Yong Zhu, Walter H Hsu, James H Holli. Increasing the number of masticatory cycles is associated with reduced appetite and altered postprandial plasma concentrations of gut hormones, insulin and glucose. The British journal of nutrition. vol 110. issue 2. 2013-08-26. PMID:23181989. |
subjective appetite was measured by appetite questionnaires at regular intervals for 3 h after the meal and plasma samples were collected for the measurement of selected satiety-related hormones, glucose, insulin and glucose-dependent insulinotropic peptide (gip) concentrations. |
2013-08-26 |
2023-08-12 |
human |
| Yong Zhu, Walter H Hsu, James H Holli. Increasing the number of masticatory cycles is associated with reduced appetite and altered postprandial plasma concentrations of gut hormones, insulin and glucose. The British journal of nutrition. vol 110. issue 2. 2013-08-26. PMID:23181989. |
meanwhile, plasma concentrations of glucose (p= 0·024), insulin (p< 0·001) and gip (p< 0·001) were higher following the forty-chews meal. |
2013-08-26 |
2023-08-12 |
human |
| Emma Ahlqvist, Peter Osmark, Tiina Kuulasmaa, Kasper Pilgaard, Bilal Omar, Charlotte Brøns, Olga Kotova, Anna V Zetterqvist, Alena Stancáková, Anna Jonsson, Ola Hansson, Johanna Kuusisto, Timothy J Kieffer, Tiinamaija Tuomi, Bo Isomaa, Sten Madsbad, Maria F Gomez, Pernille Poulsen, Markku Laakso, Eva Degerman, Jussi Pihlajamäki, Nils Wierup, Allan Vaag, Leif Groop, Valeriya Lyssenk. Link between GIP and osteopontin in adipose tissue and insulin resistance. Diabetes. vol 62. issue 6. 2013-08-02. PMID:23349498. |
link between gip and osteopontin in adipose tissue and insulin resistance. |
2013-08-02 |
2023-08-12 |
rat |
| Emma Ahlqvist, Peter Osmark, Tiina Kuulasmaa, Kasper Pilgaard, Bilal Omar, Charlotte Brøns, Olga Kotova, Anna V Zetterqvist, Alena Stancáková, Anna Jonsson, Ola Hansson, Johanna Kuusisto, Timothy J Kieffer, Tiinamaija Tuomi, Bo Isomaa, Sten Madsbad, Maria F Gomez, Pernille Poulsen, Markku Laakso, Eva Degerman, Jussi Pihlajamäki, Nils Wierup, Allan Vaag, Leif Groop, Valeriya Lyssenk. Link between GIP and osteopontin in adipose tissue and insulin resistance. Diabetes. vol 62. issue 6. 2013-08-02. PMID:23349498. |
since glucose-dependent insulinotropic polypeptide (gip) is a strong stimulator of adipogenesis and may play a role in the development of obesity, we explored whether gip directly would stimulate opn expression in adipose tissue and thereby induce insulin resistance. |
2013-08-02 |
2023-08-12 |
rat |