| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jill A Kanaley, Timothy D Heden, Ying Liu, Timothy J Fairchil. Alteration of postprandial glucose and insulin concentrations with meal frequency and composition. The British journal of nutrition. vol 112. issue 9. 2015-02-23. PMID:25231499. |
blood samples were collected every 10 min and analysed for glucose, insulin, c-peptide and gip. |
2015-02-23 |
2023-08-13 |
human |
| Jill A Kanaley, Timothy D Heden, Ying Liu, Timothy J Fairchil. Alteration of postprandial glucose and insulin concentrations with meal frequency and composition. The British journal of nutrition. vol 112. issue 9. 2015-02-23. PMID:25231499. |
insulin secretion, gip concentrations and the glucose:insulin ratio were not altered by meal frequency or composition. |
2015-02-23 |
2023-08-13 |
human |
| Antonella Napolitano, Sam Miller, Andrew W Nicholls, David Baker, Stephanie Van Horn, Elizabeth Thomas, Deepak Rajpal, Aaron Spivak, James R Brown, Derek J Nune. Novel gut-based pharmacology of metformin in patients with type 2 diabetes mellitus. PloS one. vol 9. issue 7. 2015-02-21. PMID:24988476. |
at these timepoints we profiled glucose, insulin, gut hormones (glucagon-like peptide-1 (glp-1), peptide tyrosine-tyrosine (pyy) and glucose-dependent insulinotropic peptide (gip) and bile acids in blood, as well as duodenal and faecal bile acids and gut microbiota. |
2015-02-21 |
2023-08-13 |
human |
| Yong Zhu, Walter H Hsu, James H Holli. Increased number of chews during a fixed-amount meal suppresses postprandial appetite and modulates glycemic response in older males. Physiology & behavior. vol 133. 2015-02-19. PMID:24857719. |
blood samples were collected at the same time for measurement of glucose, insulin, and glucose-dependent insulinotropic peptide (gip). |
2015-02-19 |
2023-08-13 |
human |
| Yong Zhu, Walter H Hsu, James H Holli. Increased number of chews during a fixed-amount meal suppresses postprandial appetite and modulates glycemic response in older males. Physiology & behavior. vol 133. 2015-02-19. PMID:24857719. |
plasma concentrations of glucose, insulin, and gip were significantly higher at meal completion when 40 chews were made (all p<0.01), and became significantly lower during the late postprandial period (all p<0.05). |
2015-02-19 |
2023-08-13 |
human |
| Maria Hauge, Marie A Vestmar, Anna S Husted, Jeppe P Ekberg, Michael J Wright, Jerry Di Salvo, Adam B Weinglass, Maja S Engelstoft, Andreas N Madsen, Michael Lückmann, Michael W Miller, Maria E Trujillo, Thomas M Frimurer, Birgitte Holst, Andrew D Howard, Thue W Schwart. GPR40 (FFAR1) - Combined Gs and Gq signaling in vitro is associated with robust incretin secretagogue action ex vivo and in vivo. Molecular metabolism. vol 4. issue 1. 2015-02-16. PMID:25685685. |
gpr40 (ffar1), a clinically proven anti-diabetes target, is a gq-coupled receptor for long chain fatty acids (lcfa) stimulating insulin secretion directly and mediating a major part of the dietary triglyceride-induced secretion of the incretins glp-1 and gip. |
2015-02-16 |
2023-08-13 |
Not clear |
| Derek J Nunez, Mark A Bush, David A Collins, Susan L McMullen, Dawn Gillmor, Glen Apseloff, George Atiee, Leonor Corsino, Linda Morrow, Paul L Feldma. Gut hormone pharmacology of a novel GPR119 agonist (GSK1292263), metformin, and sitagliptin in type 2 diabetes mellitus: results from two randomized studies. PloS one. vol 9. issue 4. 2015-01-27. PMID:24699248. |
oral glucose and meal challenges were used to assess the effects on plasma glucose, insulin, c-peptide, glucagon, peptide tyrosine-tyrosine (pyy), glucagon-like peptide-1 (glp-1) and glucose-dependent insulinotropic peptide (gip). |
2015-01-27 |
2023-08-13 |
human |
| Patricia López-Romero, Edgar Pichardo-Ontiveros, Azalia Avila-Nava, Natalia Vázquez-Manjarrez, Armando R Tovar, José Pedraza-Chaverri, Nimbe Torre. The effect of nopal (Opuntia ficus indica) on postprandial blood glucose, incretins, and antioxidant activity in Mexican patients with type 2 diabetes after consumption of two different composition breakfasts. Journal of the Academy of Nutrition and Dietetics. vol 114. issue 11. 2015-01-26. PMID:25132122. |
the purpose for conducting this study was to evaluate the glycemic index, insulinemic index, glucose-dependent insulinotropic peptide (gip) index, and the glucagon-like peptide 1 (glp-1) index, and the effect of nopal on patients with type 2 diabetes after consumption of a high-carbohydrate breakfast (hcb) or high-soy-protein breakfast (hspb) on the postprandial response of glucose, insulin, gip, glp-1, and antioxidant activity. |
2015-01-26 |
2023-08-13 |
human |
| Patricia López-Romero, Edgar Pichardo-Ontiveros, Azalia Avila-Nava, Natalia Vázquez-Manjarrez, Armando R Tovar, José Pedraza-Chaverri, Nimbe Torre. The effect of nopal (Opuntia ficus indica) on postprandial blood glucose, incretins, and antioxidant activity in Mexican patients with type 2 diabetes after consumption of two different composition breakfasts. Journal of the Academy of Nutrition and Dietetics. vol 114. issue 11. 2015-01-26. PMID:25132122. |
these findings suggest that nopal could reduce postprandial blood glucose, serum insulin, and plasma gip peaks, as well as increase antioxidant activity in healthy people and patients with type 2 diabetes. |
2015-01-26 |
2023-08-13 |
human |
| A A Koris. The antidiabetic action of camel milk in experimental type 2 diabetes mellitus: an overview on the changes in incretin hormones, insulin resistance, and inflammatory cytokines. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 46. issue 6. 2015-01-21. PMID:24627103. |
the changes in glucagon like peptide-1 (glp-1), glucose dependent insulinotropic peptide (gip), glucose tolerance, fasting and glucose-stimulated insulin secretion, insulin resistance (ir), tnf-α, tgf-β1, lipid profile, atherogenic index (ai), and body weight were investigated. |
2015-01-21 |
2023-08-12 |
rat |
| Jelena Kolic, Aliya F Spigelman, Alannah M Smith, Jocelyn E Manning Fox, Patrick E MacDonal. Insulin secretion induced by glucose-dependent insulinotropic polypeptide requires phosphatidylinositol 3-kinase γ in rodent and human β-cells. The Journal of biological chemistry. vol 289. issue 46. 2015-01-20. PMID:25288806. |
we therefore investigated the role of the pi3kγ catalytic subunit (p110γ) in insulin secretion and β-cell exocytosis stimulated by gip. |
2015-01-20 |
2023-08-13 |
mouse |
| Jelena Kolic, Aliya F Spigelman, Alannah M Smith, Jocelyn E Manning Fox, Patrick E MacDonal. Insulin secretion induced by glucose-dependent insulinotropic polypeptide requires phosphatidylinositol 3-kinase γ in rodent and human β-cells. The Journal of biological chemistry. vol 289. issue 46. 2015-01-20. PMID:25288806. |
finally, forced actin depolymerization with latrunculin b restored the exocytotic and secretory responses to gip during pi3kγ inhibition, demonstrating that the loss of gip-induced actin depolymerization was indeed limiting insulin exocytosis. |
2015-01-20 |
2023-08-13 |
mouse |
| Natalie A Terry, Erik R Walp, Randall A Lee, Klaus H Kaestner, Catherine Lee Ma. Impaired enteroendocrine development in intestinal-specific Islet1 mouse mutants causes impaired glucose homeostasis. American journal of physiology. Gastrointestinal and liver physiology. vol 307. issue 10. 2015-01-15. PMID:25214396. |
furthermore, enteroendocrine cells regulate glucose metabolism, with the incretin hormones glucagon-like peptide-1 (glp-1) and glucose-dependent insulinotropic polypeptide (gip) playing critical roles in stimulating insulin release by pancreatic β-cells. |
2015-01-15 |
2023-08-13 |
mouse |
| Jose Manuel García-Martínez, Ana Chocarro-Calvo, Antonio De la Vieja, Custodia García-Jiméne. Insulin drives glucose-dependent insulinotropic peptide expression via glucose-dependent regulation of FoxO1 and LEF1/β-catenin. Biochimica et biophysica acta. vol 1839. issue 11. 2015-01-13. PMID:25091498. |
here we show that insulin stimulates the expression of the major human incretin, glucose-dependent insulinotropic peptide (gip) in enteroendocrine cells but requires glucose to do it. |
2015-01-13 |
2023-08-13 |
human |
| Jose Manuel García-Martínez, Ana Chocarro-Calvo, Antonio De la Vieja, Custodia García-Jiméne. Insulin drives glucose-dependent insulinotropic peptide expression via glucose-dependent regulation of FoxO1 and LEF1/β-catenin. Biochimica et biophysica acta. vol 1839. issue 11. 2015-01-13. PMID:25091498. |
our results reveal a glucose-regulated feedback loop at the entero-insular axis, where glucose levels determine basal and insulin-induced gip expression; gip stimulation of insulin release, physiologically ensures a fine control of glucose homeostasis. |
2015-01-13 |
2023-08-13 |
human |
| M P Yavropoulou, K Kotsa, M Pikilidou, I Keisisoglou, J G Yovo. Effects of intracerebroventricular infusion of somatostatin-14 on peripheral glucoregulation in dogs. Journal of neuroendocrinology. vol 26. issue 1. 2015-01-10. PMID:24325321. |
serum levels of glucose, insulin and glucose-dependent insulinotrophic peptide (gip), plasma sst and serum gh levels were assayed. |
2015-01-10 |
2023-08-12 |
Not clear |
| Chen Varol, Isabel Zvibel, Lior Spektor, Fernanda Dana Mantelmacher, Milena Vugman, Tamar Thurm, Marian Khatib, Elinor Elmaliah, Zamir Halpern, Sigal Fishma. Long-acting glucose-dependent insulinotropic polypeptide ameliorates obesity-induced adipose tissue inflammation. Journal of immunology (Baltimore, Md. : 1950). vol 193. issue 8. 2015-01-07. PMID:25217161. |
the glucose-dependent insulinotropic polypeptide (gip) is an incretin hormone that mediates postprandial insulin secretion and has anabolic effects on the adipose tissue. |
2015-01-07 |
2023-08-13 |
mouse |
| J De Toro-Martín, E Fernández-Millán, E Lizárraga-Mollinedo, E López-Oliva, P Serradas, F Escrivá, C Alvare. Predominant role of GIP in the development of a metabolic syndrome-like phenotype in female Wistar rats submitted to forced catch-up growth. Endocrinology. vol 155. issue 10. 2015-01-05. PMID:25032669. |
in conclusion, the exacerbated production and secretion of gip after the catch-up growth seems to represent the stimulus for insulin hypersecretion and insulin resistance, ultimately resulting in derangement of glucose homeostasis. |
2015-01-05 |
2023-08-13 |
rat |
| Edward P Weiss, Nathaniel K Royer, Jonathan S Fisher, John O Holloszy, Luigi Fontan. Postprandial plasma incretin hormones in exercise-trained versus untrained subjects. Medicine and science in sports and exercise. vol 46. issue 6. 2014-12-08. PMID:24576859. |
after food ingestion, the incretin hormones, glucagon-like peptide-1 (glp-1) and glucose-dependent insulinotropic polypeptide (gip), are secreted by the intestines into circulation where they act on the pancreas to promote insulin secretion. |
2014-12-08 |
2023-08-12 |
human |
| Laurence G Trahair, Michael Horowitz, Chinmay S Marathe, Kylie Lange, Scott Standfield, Christopher K Rayner, Karen L Jone. Impact of gastric emptying to the glycemic and insulinemic responses to a 75-g oral glucose load in older subjects with normal and impaired glucose tolerance. Physiological reports. vol 2. issue 11. 2014-11-21. PMID:25413324. |
blood glucose, serum insulin and plasma glucagon-like peptide-1 (glp-1) and glucose-dependent insulinotropic peptide (gip) were measured, and the insulin sensitivity index (isi), and the disposition index (di), were calculated. |
2014-11-21 |
2023-08-13 |
human |