| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Srividya Vasu, R Charlotte Moffett, Bernard Thorens, Peter R Flat. Role of endogenous GLP-1 and GIP in beta cell compensatory responses to insulin resistance and cellular stress. PloS one. vol 9. issue 6. 2015-10-07. PMID:24967820. |
role of endogenous glp-1 and gip in beta cell compensatory responses to insulin resistance and cellular stress. |
2015-10-07 |
2023-08-13 |
mouse |
| Srividya Vasu, R Charlotte Moffett, Bernard Thorens, Peter R Flat. Role of endogenous GLP-1 and GIP in beta cell compensatory responses to insulin resistance and cellular stress. PloS one. vol 9. issue 6. 2015-10-07. PMID:24967820. |
role of glp-1 and gip in beta cell compensatory responses to beta cell attack and insulin resistance were examined in c57bl/6 mice lacking functional receptors for glp-1 and gip. |
2015-10-07 |
2023-08-13 |
mouse |
| Srividya Vasu, R Charlotte Moffett, Bernard Thorens, Peter R Flat. Role of endogenous GLP-1 and GIP in beta cell compensatory responses to insulin resistance and cellular stress. PloS one. vol 9. issue 6. 2015-10-07. PMID:24967820. |
in contrast, hydrocortisone treatment and induction of insulin resistance increased islet numbers and area, with enhanced beta cell replication, elevated mass of beta and alpha cells, together with co-expression of glp-1 and gip with glucagon in islets. |
2015-10-07 |
2023-08-13 |
mouse |
| Srividya Vasu, R Charlotte Moffett, Bernard Thorens, Peter R Flat. Role of endogenous GLP-1 and GIP in beta cell compensatory responses to insulin resistance and cellular stress. PloS one. vol 9. issue 6. 2015-10-07. PMID:24967820. |
our observations cannot be explained by simple changes in circulating incretin concentrations, suggesting that intra-islet glp-1 and gip make a significant contribution to islet adaptation, particularly expansion of beta cell mass and compensatory islet compensation to hydrocortisone and insulin resistance. |
2015-10-07 |
2023-08-13 |
mouse |
| Christina Daousi, Jonathan H Pinkney, Jacqueline Cleator, John P Wilding, L R Ranganat. Acute peripheral administration of synthetic human GLP-1 (7-36 amide) decreases circulating IL-6 in obese patients with type 2 diabetes mellitus: a potential role for GLP-1 in modulation of the diabetic pro-inflammatory state? Regulatory peptides. vol 183. 2015-09-30. PMID:23499806. |
to explore the effects of acute administration of glp-1 and gip on circulating levels of key adipocyte-derived hormones and gut-brain peptides with established roles in energy and appetite regulation, modulation of insulin sensitivity and inflammation. |
2015-09-30 |
2023-08-12 |
human |
| Yusuke Seino, Hidetada Ogata, Ryuya Maekawa, Takako Izumoto, Atsushi Iida, Norio Harada, Takashi Miki, Susumu Seino, Nobuya Inagaki, Shin Tsunekawa, Yutaka Oiso, Yoji Hamad. Fructose induces glucose-dependent insulinotropic polypeptide, glucagon-like peptide-1 and insulin secretion: Role of adenosine triphosphate-sensitive K(+) channels. Journal of diabetes investigation. vol 6. issue 5. 2015-09-29. PMID:26417408. |
in the present study, we investigated the involvement of the katp channel in fructose-induced gip, glp-1 and insulin secretion in mice. |
2015-09-29 |
2023-08-13 |
mouse |
| Yusuke Seino, Hidetada Ogata, Ryuya Maekawa, Takako Izumoto, Atsushi Iida, Norio Harada, Takashi Miki, Susumu Seino, Nobuya Inagaki, Shin Tsunekawa, Yutaka Oiso, Yoji Hamad. Fructose induces glucose-dependent insulinotropic polypeptide, glucagon-like peptide-1 and insulin secretion: Role of adenosine triphosphate-sensitive K(+) channels. Journal of diabetes investigation. vol 6. issue 5. 2015-09-29. PMID:26417408. |
these results show that fructose-induced gip and glp-1 secretion is katp channel-independent and that fructose-induced insulin secretion is katp channel-dependent. |
2015-09-29 |
2023-08-13 |
mouse |
| Diana Röhrborn, Nina Wronkowitz, Juergen Ecke. DPP4 in Diabetes. Frontiers in immunology. vol 6. 2015-08-18. PMID:26284071. |
since the incretin hormones, glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide (gip), are major regulators of post-prandial insulin secretion, inhibition of dpp4 by the gliptin family of drugs has gained considerable interest for the therapy of type 2 diabetic patients. |
2015-08-18 |
2023-08-13 |
human |
| Robert L Dobbins, Frank L Greenway, Lihong Chen, Yaping Liu, Sharon L Breed, Susan M Andrews, Jeffrey A Wald, Ann Walker, Chari D Smit. Selective sodium-dependent glucose transporter 1 inhibitors block glucose absorption and impair glucose-dependent insulinotropic peptide release. American journal of physiology. Gastrointestinal and liver physiology. vol 308. issue 11. 2015-08-12. PMID:25767259. |
sglt1 inhibitor effects on plasma glucose, insulin, gastric inhibitory peptide (gip), and glucagon-like peptide-1 (glp-1) concentrations were also measured during a standard meal. |
2015-08-12 |
2023-08-13 |
human |
| Robert L Dobbins, Frank L Greenway, Lihong Chen, Yaping Liu, Sharon L Breed, Susan M Andrews, Jeffrey A Wald, Ann Walker, Chari D Smit. Selective sodium-dependent glucose transporter 1 inhibitors block glucose absorption and impair glucose-dependent insulinotropic peptide release. American journal of physiology. Gastrointestinal and liver physiology. vol 308. issue 11. 2015-08-12. PMID:25767259. |
incremental glucose, insulin, and gip concentrations were decreased, indicating downregulation of β-cell and k cell secretion. |
2015-08-12 |
2023-08-13 |
human |
| Robert L Dobbins, Frank L Greenway, Lihong Chen, Yaping Liu, Sharon L Breed, Susan M Andrews, Jeffrey A Wald, Ann Walker, Chari D Smit. Selective sodium-dependent glucose transporter 1 inhibitors block glucose absorption and impair glucose-dependent insulinotropic peptide release. American journal of physiology. Gastrointestinal and liver physiology. vol 308. issue 11. 2015-08-12. PMID:25767259. |
incremental concentrations of insulin, c-peptide, and gip were reduced for 2 h with premeal gsk-1614235. |
2015-08-12 |
2023-08-13 |
human |
| Haitham Abdulla, Bethan Phillips, Kenneth Smith, Daniel Wilkinson, Philip J Atherton, Iskandar Idri. Physiological mechanisms of action of incretin and insulin in regulating skeletal muscle metabolism. Current diabetes reviews. vol 10. issue 5. 2015-08-11. PMID:25323297. |
meanwhile glucagon-like peptide (glp-1) and glucose- dependent insulinotropic peptide (gip) are incretin hormones released from the gut into the bloodstream in response to macronutrients, and have an established role in enhancing insulin secretion. |
2015-08-11 |
2023-08-13 |
Not clear |
| Naresh Ramesh, Sima Mortazavi, Suraj Unniappa. Nesfatin-1 stimulates glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide secretion from STC-1 cells in vitro. Biochemical and biophysical research communications. vol 462. issue 2. 2015-08-04. PMID:25930999. |
meal responsive insulin secretion is regulated by incretins glucagon-like peptide-1 (glp-1) and glucose dependent insulinotropic polypeptide (gip). |
2015-08-04 |
2023-08-13 |
mouse |
| K Aaboe, S Akram, C F Deacon, J J Holst, S Madsbad, T Kraru. Restoration of the insulinotropic effect of glucose-dependent insulinotropic polypeptide contributes to the antidiabetic effect of dipeptidyl peptidase-4 inhibitors. Diabetes, obesity & metabolism. vol 17. issue 1. 2015-07-14. PMID:25243647. |
to examine whether 12 weeks of treatment with a dipeptidyl peptidase-4 (dpp-4) inhibitor, sitagliptin, influences the insulin secretion induced by glucose, glucose-dependent insulinotropic polypeptide (gip) and glucagon-like peptide-1 (glp-1) during a hyperglycaemic clamp in patients with type 2 diabetes (t2dm). |
2015-07-14 |
2023-08-13 |
Not clear |
| Cesar A Sommer, Gustavo Mostoslavsk. RNA-Seq analysis of enteroendocrine cells reveals a role for FABP5 in the control of GIP secretion. Molecular endocrinology (Baltimore, Md.). vol 28. issue 11. 2015-07-07. PMID:25268051. |
gip acts on adipocytes to increase lipid uptake and enhance adipokine secretion, promoting weight gain and insulin resistance. |
2015-07-07 |
2023-08-13 |
mouse |
| S Al-Sabah, M Al-Fulaij, H A Ahme. Selectivity of peptide ligands for the human incretin receptors expressed in HEK-293 cells. European journal of pharmacology. vol 741. 2015-06-22. PMID:25179575. |
the increase in insulin response to oral glucose compared with glucose given by intravenous injection is termed the incretin effect and is mediated by two peptide hormones secreted from the gut in response to nutrient intake: glucagon-like peptide-1 (glp-1) and glucose-dependent insulinotropic polypeptide (gip). |
2015-06-22 |
2023-08-13 |
human |
| M Michael Wolfe, Michael O Boyla. Obesity and the gastrointestinal tract: you are what you eat. Journal of clinical gastroenterology. vol 48. issue 10. 2015-06-10. PMID:24828362. |
gip appears to offer an additional survival benefit by not only stimulating intestinal glucose transport and maximally releasing insulin to facilitate nutrient storage but also by its insulin-mimetic properties, including enhanced uptake of glucose by adipocytes. |
2015-06-10 |
2023-08-13 |
Not clear |
| M Michael Wolfe, Michael O Boyla. Obesity and the gastrointestinal tract: you are what you eat. Journal of clinical gastroenterology. vol 48. issue 10. 2015-06-10. PMID:24828362. |
this physiological redundancy offered by insulin and gip ensured the survival of organisms during times when food was scarce. |
2015-06-10 |
2023-08-13 |
Not clear |
| Chia Lin Chang, James J Cai, Shang Yu Huang, Po Jen Cheng, Ho Yen Chueh, Sheau Yu Teddy Hs. Adaptive human CDKAL1 variants underlie hormonal response variations at the enteroinsular axis. PloS one. vol 9. issue 9. 2015-05-28. PMID:25222615. |
we screened single nucleotide polymorphisms in genes that had been associated with energy-balance regulation for unusual genetic patterns in human populations, followed by studying associations among selected variants and serum levels of gip, insulin, and c-peptide in pregnant women after an oral glucose tolerance test. |
2015-05-28 |
2023-08-13 |
human |
| Chia Lin Chang, James J Cai, Shang Yu Huang, Po Jen Cheng, Ho Yen Chueh, Sheau Yu Teddy Hs. Adaptive human CDKAL1 variants underlie hormonal response variations at the enteroinsular axis. PloS one. vol 9. issue 9. 2015-05-28. PMID:25222615. |
importantly, studies of serum hormone levels showed that variants in cdkal1 are associated with glucose-induced gip and insulin responses (p<0.05). |
2015-05-28 |
2023-08-13 |
human |