| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Alastair D Green, Srividya Vasu, Neville H McClenaghan, Peter R Flat. Pseudoislet formation enhances gene expression, insulin secretion and cytoprotective mechanisms of clonal human insulin-secreting 1.1B4 cells. Pflugers Archiv : European journal of physiology. vol 467. issue 10. 2016-06-27. PMID:25559846. |
incubation with the incretin gut hormones glp-1 and gip caused dose-dependent stimulation of insulin secretion from 1.1b4 cell monolayers and pseudoislets. |
2016-06-27 |
2023-08-13 |
human |
| Jianping Xu, Xinhua Xiao, Yuxiu Li, Jia Zheng, Wenhui Li, Qian Zhang, Zhixin Wan. The effect of gum chewing on blood GLP-1 concentration in fasted, healthy, non-obese men. Endocrine. vol 50. issue 1. 2016-06-20. PMID:25758865. |
no significant differences in the blood concentration of glucose, insulin and gip or hunger were observed between groups. |
2016-06-20 |
2023-08-13 |
human |
| Lauryn M Nyhoff, Timothy D Heden, Heather J Leidy, Nathan C Winn, Young-Min Park, John P Thyfault, Jill A Kanale. Prior exercise does not alter the incretin response to a subsequent meal in obese women. Peptides. vol 71. 2016-06-17. PMID:26188172. |
frequent blood samples were analyzed for glucose, lactate, insulin, glucagon, glucagon-like peptide-1 (glp-1), glucose-dependent insulinotropic polypeptide (gip), and c-peptide concentrations throughout 280min of testing. |
2016-06-17 |
2023-08-13 |
human |
| Mukul R Jain, Amit A Joharapurkar, Rajesh H Bahekar, Harilal Patel, Pradip Jadav, Samadhan G Kshirsagar, Vishal J Patel, Kartikkumar N Patel, Vikram K Ramanathan, Pankaj R Patel, Ranjit C Desa. Pharmacological characterization of ZYDPLA1, a novel long-acting dipeptidyl peptidase-4 inhibitor. Journal of diabetes. vol 7. issue 5. 2016-06-07. PMID:25327540. |
dipeptidyl peptidase-4 (dpp-4) is responsible for degradation of glucagon-like peptide 1 (glp-1) and gastric inhibitory polypeptide (gip), the endogenous incretins that stimulate glucose-dependent insulin secretion. |
2016-06-07 |
2023-08-13 |
Not clear |
| Sara T Hjuler, Kim V Andreassen, Sofie Gydesen, Morten A Karsdal, Kim Henrikse. KBP-042 improves bodyweight and glucose homeostasis with indices of increased insulin sensitivity irrespective of route of administration. European journal of pharmacology. vol 762. 2016-05-24. PMID:26027795. |
furthermore, kbp-042 was found to reduce incretins glp-1 and gip and considerably, improve gastric emptying, and to alleviate leptin resistance, as well as insulin resistance. |
2016-05-24 |
2023-08-13 |
rat |
| Jiaqiang Zhou, Zheng Hao, Nigel Irwin, Hans-Rudolf Berthoud, Jianping Y. Gastric inhibitory polypeptide (GIP) is selectively decreased in the roux-limb of dietary obese mice after RYGB surgery. PloS one. vol 10. issue 8. 2016-05-17. PMID:26266950. |
gastric inhibitory polypeptide (gip, glucose-dependent insulinotropic polypeptide) is expressed by intestinal k cells to regulate glucose-induced insulin secretion. |
2016-05-17 |
2023-08-13 |
mouse |
| Jiaqiang Zhou, Zheng Hao, Nigel Irwin, Hans-Rudolf Berthoud, Jianping Y. Gastric inhibitory polypeptide (GIP) is selectively decreased in the roux-limb of dietary obese mice after RYGB surgery. PloS one. vol 10. issue 8. 2016-05-17. PMID:26266950. |
the gip alteration was associated with chow diet preference, sustained weight loss and insulin sensitization in rygb mice. |
2016-05-17 |
2023-08-13 |
mouse |
| Simon Veedfald, Astrid Plamboeck, Carolyn F Deacon, Bolette Hartmann, Filip K Knop, Tina Vilsbøll, Jens J Hols. Cephalic phase secretion of insulin and other enteropancreatic hormones in humans. American journal of physiology. Gastrointestinal and liver physiology. vol 310. issue 1. 2016-05-02. PMID:26492921. |
neither insulin, c-peptide, glucose-dependent insulinotropic polypeptide (gip), nor glucagon-like peptide-1 (glp-1) levels changed in response to msf or atropine. |
2016-05-02 |
2023-08-13 |
human |
| Simon Veedfald, Astrid Plamboeck, Carolyn F Deacon, Bolette Hartmann, Filip K Knop, Tina Vilsbøll, Jens J Hols. Cephalic phase secretion of insulin and other enteropancreatic hormones in humans. American journal of physiology. Gastrointestinal and liver physiology. vol 310. issue 1. 2016-05-02. PMID:26492921. |
despite adequate pp responses, a cephalic phase response was absent for insulin, glucagon, glp-1, gip, and ghrelin. |
2016-05-02 |
2023-08-13 |
human |
| Stacey MacNeil, Rachel M Rebry, Ian J Tetlow, Michael J Emes, Bruce McKeown, Terry E Graha. Resistant starch intake at breakfast affects postprandial responses in type 2 diabetics and enhances the glucose-dependent insulinotropic polypeptide--insulin relationship following a second meal. Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme. vol 38. issue 12. 2016-04-22. PMID:24195618. |
following the first meal, b elicited a lower glucose incremental area under the curve (iauc) than c (p < 0.05), d (p < 0.05), and a (trend; p = 0.07), lower insulin iauc than a (p < 0.05) and c (p < 0.05), and lower glucose-dependent insulinotropic polypeptide (gip) iauc than a (p < 0.05). |
2016-04-22 |
2023-08-12 |
Not clear |
| Stacey MacNeil, Rachel M Rebry, Ian J Tetlow, Michael J Emes, Bruce McKeown, Terry E Graha. Resistant starch intake at breakfast affects postprandial responses in type 2 diabetics and enhances the glucose-dependent insulinotropic polypeptide--insulin relationship following a second meal. Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme. vol 38. issue 12. 2016-04-22. PMID:24195618. |
there was a positive correlation (p < 0.05) between gip and insulin iaucs after the 2nd meal, and c had a 3 times greater slope than the other treatments (r = 0.91, p < 0.001), yet lacked a significant concomitant improvement in glucose disposal. |
2016-04-22 |
2023-08-12 |
Not clear |
| Man-man Li, Bai-xia Zhang, Shuai-bing He, Rao Zheng, Yan-ling Zhang, Yun Wan. [Elucidating hypoglycemic mechanism of Dendrobium nobile through auxiliary elucidation system for traditional Chinese medicine mechanism]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 40. issue 19. 2016-04-21. PMID:26975089. |
the molecular mechanism of d. nobile to t2dm includes: (1) regulating lipid metabolism by lowering triglyceride; (2) reducing insulin resistance; (3) protecting islet cells; (4) promoting the glucose-dependent insulin tropic peptide (gip) secretion; (5) inhibiting calcium channel. |
2016-04-21 |
2023-08-13 |
Not clear |
| Michael O Boylan, Patricia A Glazebrook, Milos Tatalovic, M Michael Wolf. Gastric inhibitory polypeptide immunoneutralization attenuates development of obesity in mice. American journal of physiology. Endocrinology and metabolism. vol 309. issue 12. 2016-04-11. PMID:26487006. |
specific mab directed against the carboxy terminus of mouse gip was identified, and its effects on the insulin response to oral and to intraperitoneal (ip) glucose and on weight gain were evaluated. |
2016-04-11 |
2023-08-13 |
mouse |
| Michael O Boylan, Patricia A Glazebrook, Milos Tatalovic, M Michael Wolf. Gastric inhibitory polypeptide immunoneutralization attenuates development of obesity in mice. American journal of physiology. Endocrinology and metabolism. vol 309. issue 12. 2016-04-11. PMID:26487006. |
administration of mab (30 mg/kg body wt, bw) to mice attenuated the insulin response to oral glucose by 70% and completely eliminated the response to ip glucose coadministered with human gip. |
2016-04-11 |
2023-08-13 |
mouse |
| Bettina Karin Wölnerhanssen, Anne Christin Meyer-Gerspach, André Schmidt, Nina Zimak, Ralph Peterli, Christoph Beglinger, Stefan Borgward. Dissociable Behavioral, Physiological and Neural Effects of Acute Glucose and Fructose Ingestion: A Pilot Study. PloS one. vol 10. issue 6. 2016-04-05. PMID:26107810. |
glucose ingestion induced significantly greater elevations in plasma glucose, insulin, glp-1 and gip, while feelings of fullness increased and prospective food consumption decreased relative to fructose. |
2016-04-05 |
2023-08-13 |
human |
| Alessandra Puddu, Roberta Sanguineti, Fabrizio Montecucco, Giorgio Luciano Vivian. Effects of High Glucose Levels and Glycated Serum on GIP Responsiveness in the Pancreatic Beta Cell Line HIT-T15. Journal of diabetes research. vol 2015. 2016-03-29. PMID:26221611. |
glucose-dependent insulinotropic peptide (gip) is an incretin hormone produced in the gastrointestinal tract that stimulates glucose dependent insulin secretion. |
2016-03-29 |
2023-08-13 |
Not clear |
| Alessandra Puddu, Roberta Sanguineti, Fabrizio Montecucco, Giorgio Luciano Vivian. Effects of High Glucose Levels and Glycated Serum on GIP Responsiveness in the Pancreatic Beta Cell Line HIT-T15. Journal of diabetes research. vol 2015. 2016-03-29. PMID:26221611. |
impaired incretin response has been documented in diabetic patients and was mainly related to the inability of the pancreatic beta cells to secrete insulin in response to gip. |
2016-03-29 |
2023-08-13 |
Not clear |
| Alessandra Puddu, Roberta Sanguineti, Fabrizio Montecucco, Giorgio Luciano Vivian. Effects of High Glucose Levels and Glycated Serum on GIP Responsiveness in the Pancreatic Beta Cell Line HIT-T15. Journal of diabetes research. vol 2015. 2016-03-29. PMID:26221611. |
cells were cultured for 5 days in low (ctr) or high glucose (hg) concentration in the presence of ages (gs) to evaluate the expression of gip receptor (gipr), the intracellular signaling activated by gip, and secretion of insulin in response to gip. |
2016-03-29 |
2023-08-13 |
Not clear |
| Alessandra Puddu, Roberta Sanguineti, Fabrizio Montecucco, Giorgio Luciano Vivian. Effects of High Glucose Levels and Glycated Serum on GIP Responsiveness in the Pancreatic Beta Cell Line HIT-T15. Journal of diabetes research. vol 2015. 2016-03-29. PMID:26221611. |
the results showed that incubation with gs alone altered intracellular gip signaling and decreased insulin secretion as compared to ctr. |
2016-03-29 |
2023-08-13 |
Not clear |
| Gianluca Rosso, Annamaria Cattaneo, Roberta Zanardini, Massimo Gennarelli, Giuseppe Maina, Luisella Bocchio-Chiavett. Glucose metabolism alterations in patients with bipolar disorder. Journal of affective disorders. vol 184. 2016-03-14. PMID:26120808. |
the present study was aimed to investigate putative alterations in markers linked to metabolic dysfunctions as c-peptide, ghrelin, gip, glp-1, glucagon, insulin, leptin, pai-1 (total), resistin and visfatin in a sample of bd patients compared to controls. |
2016-03-14 |
2023-08-13 |
Not clear |