| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sheng Zhang, Songyan Wang, Matthew D Puhl, Xuntian Jiang, Krzysztof L Hyrc, Erin Laciny, Michael J Wallendorf, Kirk L Pappan, Joseph T Coyle, Burton M Wic. Global biochemical profiling identifies β-hydroxypyruvate as a potential mediator of type 2 diabetes in mice and humans. Diabetes. vol 64. issue 4. 2015-05-22. PMID:25368100. |
glucose-dependent insulinotropic polypeptide (gip) and glp-1 are incretins secreted by respective k and l enteroendocrine cells after eating and amplify glucose-stimulated insulin secretion (gsis). |
2015-05-22 |
2023-08-13 |
mouse |
| T Wu, S S Thazhath, C S Marathe, M J Bound, K L Jones, M Horowitz, C K Rayne. Comparative effect of intraduodenal and intrajejunal glucose infusion on the gut-incretin axis response in healthy males. Nutrition & diabetes. vol 5. 2015-05-19. PMID:25985092. |
we compared responses of plasma glucagon-like peptide-1 (glp-1), glucose-dependent insulinotropic polypeptide (gip), insulin and glucagon, and blood glucose to a standardised glucose infusion into the proximal jejunum and duodenum in healthy humans. |
2015-05-19 |
2023-08-13 |
Not clear |
| T Wu, S S Thazhath, C S Marathe, M J Bound, K L Jones, M Horowitz, C K Rayne. Comparative effect of intraduodenal and intrajejunal glucose infusion on the gut-incretin axis response in healthy males. Nutrition & diabetes. vol 5. 2015-05-19. PMID:25985092. |
plasma glp-1, gip and insulin responses, as well as the insulin:glucose ratio and the insulinogenic index 1 (igi1) were greater (p<0.05 for each) after intrajejunal (i.j.) |
2015-05-19 |
2023-08-13 |
Not clear |
| Na-Hyung Kim, Taeyang Yu, Dae Ho Le. The nonglycemic actions of dipeptidyl peptidase-4 inhibitors. BioMed research international. vol 2014. 2015-05-11. PMID:25140306. |
two important incretin hormones, glucagon-like peptide-1 (glp-1) and glucose-dependent insulinotropic peptide (gip), enhance meal-stimulated insulin secretion from pancreatic β-cells, but are inactivated by dpp-4. |
2015-05-11 |
2023-08-13 |
Not clear |
| Kazue Itoh, Ririko Moriguchi, Yuichiro Yamada, Misuzu Fujita, Takako Yamato, Masayo Oumi, Jens Juul Holst, Yutaka Sein. High saturated fatty acid intake induces insulin secretion by elevating gastric inhibitory polypeptide levels in healthy individuals. Nutrition research (New York, N.Y.). vol 34. issue 8. 2015-05-11. PMID:25172378. |
we hypothesized that high saturated fatty acid intake increases insulin and gastric inhibitory polypeptide (gip) secretion. |
2015-05-11 |
2023-08-13 |
human |
| Kazue Itoh, Ririko Moriguchi, Yuichiro Yamada, Misuzu Fujita, Takako Yamato, Masayo Oumi, Jens Juul Holst, Yutaka Sein. High saturated fatty acid intake induces insulin secretion by elevating gastric inhibitory polypeptide levels in healthy individuals. Nutrition research (New York, N.Y.). vol 34. issue 8. 2015-05-11. PMID:25172378. |
to clarify the effect of ingested fatty acid composition on glucose levels, we conducted an intervention study to investigate the insulin and plasma gip responses in 11 healthy women, including a dietary control. |
2015-05-11 |
2023-08-13 |
human |
| Kazue Itoh, Ririko Moriguchi, Yuichiro Yamada, Misuzu Fujita, Takako Yamato, Masayo Oumi, Jens Juul Holst, Yutaka Sein. High saturated fatty acid intake induces insulin secretion by elevating gastric inhibitory polypeptide levels in healthy individuals. Nutrition research (New York, N.Y.). vol 34. issue 8. 2015-05-11. PMID:25172378. |
in addition, the difference in the incremental gip between fb-30 and f-30 correlated significantly and positively with that of the insulin. |
2015-05-11 |
2023-08-13 |
human |
| Kazue Itoh, Ririko Moriguchi, Yuichiro Yamada, Misuzu Fujita, Takako Yamato, Masayo Oumi, Jens Juul Holst, Yutaka Sein. High saturated fatty acid intake induces insulin secretion by elevating gastric inhibitory polypeptide levels in healthy individuals. Nutrition research (New York, N.Y.). vol 34. issue 8. 2015-05-11. PMID:25172378. |
these results suggest that a high saturated fatty acid content stimulates postprandial insulin release via increased gip secretion. |
2015-05-11 |
2023-08-13 |
human |
| Shu Chen, Fumiaki Okahara, Noriko Osaki, Akira Shimotoyodom. Increased GIP signaling induces adipose inflammation via a HIF-1α-dependent pathway and impairs insulin sensitivity in mice. American journal of physiology. Endocrinology and metabolism. vol 308. issue 5. 2015-05-01. PMID:25537494. |
increased gip signaling induces adipose inflammation via a hif-1α-dependent pathway and impairs insulin sensitivity in mice. |
2015-05-01 |
2023-08-13 |
mouse |
| Shu Chen, Fumiaki Okahara, Noriko Osaki, Akira Shimotoyodom. Increased GIP signaling induces adipose inflammation via a HIF-1α-dependent pathway and impairs insulin sensitivity in mice. American journal of physiology. Endocrinology and metabolism. vol 308. issue 5. 2015-05-01. PMID:25537494. |
gip stimulates proinflammatory gene expression and impairs insulin sensitivity in cultured adipocytes. |
2015-05-01 |
2023-08-13 |
mouse |
| Shu Chen, Fumiaki Okahara, Noriko Osaki, Akira Shimotoyodom. Increased GIP signaling induces adipose inflammation via a HIF-1α-dependent pathway and impairs insulin sensitivity in mice. American journal of physiology. Endocrinology and metabolism. vol 308. issue 5. 2015-05-01. PMID:25537494. |
we administered gip intraperitoneally to misty (lean) and db/db (obese) mice and examined adipose tissue inflammation and insulin sensitivity. |
2015-05-01 |
2023-08-13 |
mouse |
| Shu Chen, Fumiaki Okahara, Noriko Osaki, Akira Shimotoyodom. Increased GIP signaling induces adipose inflammation via a HIF-1α-dependent pathway and impairs insulin sensitivity in mice. American journal of physiology. Endocrinology and metabolism. vol 308. issue 5. 2015-05-01. PMID:25537494. |
thus, increased gip signaling plays a significant role in adipose tissue inflammation and thereby insulin resistance in obese mice, and hif-1α may contribute to this process. |
2015-05-01 |
2023-08-13 |
mouse |
| Kristian Karstoft, Stefan P Mortensen, Sine H Knudsen, Thomas P J Solomo. Direct effect of incretin hormones on glucose and glycerol metabolism and hemodynamics. American journal of physiology. Endocrinology and metabolism. vol 308. issue 5. 2015-05-01. PMID:25564476. |
on the contrary, during hyperglycemia, gip increases femoral artery blood flow with no effect on glucose metabolism, whereas glp-1 increases glucose disposal, potentially due to increased insulin levels. |
2015-05-01 |
2023-08-13 |
Not clear |
| Paresh Dandona, Husam Ghanim, Sanaa Abuaysheh, Kelly Green, Manav Batra, Sandeep Dhindsa, Antoine Makdissi, Reema Patel, Ajay Chaudhur. Decreased insulin secretion and incretin concentrations and increased glucagon concentrations after a high-fat meal when compared with a high-fruit and -fiber meal. American journal of physiology. Endocrinology and metabolism. vol 308. issue 3. 2015-04-14. PMID:25406260. |
this study was conducted to investigate whether a high-fat/high-carbohydrate (hfhc) meal induces an increase in plasma concentrations of glucagon, dipeptidyl peptidase-iv (dpp-iv), and cd26 expression in mononuclear cells (mnc) while reducing insulin, c-peptide, proinsulin, gip, and glp-1 concentrations. |
2015-04-14 |
2023-08-13 |
human |
| Paresh Dandona, Husam Ghanim, Sanaa Abuaysheh, Kelly Green, Manav Batra, Sandeep Dhindsa, Antoine Makdissi, Reema Patel, Ajay Chaudhur. Decreased insulin secretion and incretin concentrations and increased glucagon concentrations after a high-fat meal when compared with a high-fruit and -fiber meal. American journal of physiology. Endocrinology and metabolism. vol 308. issue 3. 2015-04-14. PMID:25406260. |
we conclude that the proinflammatory hfhc meals result in lower insulin, c-peptide, proinsulin, and gip secretion in association with higher plasma glucagon and dpp-iv concentrations and cd26 expression in mnc compared with the aha meal. |
2015-04-14 |
2023-08-13 |
human |
| H Frances J Bligh, Ian F Godsland, Gary Frost, Karl J Hunter, Peter Murray, Katrina MacAulay, Della Hyliands, Duncan C S Talbot, John Casey, Theo P J Mulder, Mark J Berr. Plant-rich mixed meals based on Palaeolithic diet principles have a dramatic impact on incretin, peptide YY and satiety response, but show little effect on glucose and insulin homeostasis: an acute-effects randomised study. The British journal of nutrition. vol 113. issue 4. 2015-04-06. PMID:25661189. |
plasma glucose, insulin, glucagon-like peptide-1 (glp-1), glucose-dependent insulinotropic peptide (gip) and peptide yy (pyy) concentrations were measured over a period of 180 min. |
2015-04-06 |
2023-08-13 |
human |
| Gabriella A Heruc, Michael Horowitz, Carolyn F Deacon, Christine Feinle-Bisset, Christopher K Rayner, Natalie Luscombe-Marsh, Tanya J Littl. Effects of dipeptidyl peptidase IV inhibition on glycemic, gut hormone, triglyceride, energy expenditure, and energy intake responses to fat in healthy males. American journal of physiology. Endocrinology and metabolism. vol 307. issue 9. 2015-02-26. PMID:25231186. |
blood glucose, plasma insulin, glucagon, active glp-1, and gip and peptide yy (pyy)-(3-36) concentrations; resting energy expenditure; and energy intake at a subsequent buffet meal (time = 120-150 min) were quantified. |
2015-02-26 |
2023-08-13 |
Not clear |
| Gabriella A Heruc, Michael Horowitz, Carolyn F Deacon, Christine Feinle-Bisset, Christopher K Rayner, Natalie Luscombe-Marsh, Tanya J Littl. Effects of dipeptidyl peptidase IV inhibition on glycemic, gut hormone, triglyceride, energy expenditure, and energy intake responses to fat in healthy males. American journal of physiology. Endocrinology and metabolism. vol 307. issue 9. 2015-02-26. PMID:25231186. |
this was associated with increased insulin (p: 15,964 ± 1,193 vs. v: 18,243 ± 1,257 pmol·l⁻¹·min⁻¹, p < 0.05), reduced glucagon (p: 1,008 ± 52 vs. v: 902 ± 46 pmol·l⁻¹·min⁻¹, p < 0.05), enhanced active glp-1 (p: 294 ± 40 vs. v: 694 ± 78 pmol·l⁻¹·min⁻¹) and gip (p: 2,748 ± 77 vs. v: 4,256 ± 157 pmol·l⁻¹·min⁻¹), and reduced pyy-(3-36) (p: 9,527 ± 754 vs. v: 4,469 ± 431 pm/min) concentrations compared with placebo (p < 0.05, for all). |
2015-02-26 |
2023-08-13 |
Not clear |
| Gabriella A Heruc, Michael Horowitz, Carolyn F Deacon, Christine Feinle-Bisset, Christopher K Rayner, Natalie Luscombe-Marsh, Tanya J Littl. Effects of dipeptidyl peptidase IV inhibition on glycemic, gut hormone, triglyceride, energy expenditure, and energy intake responses to fat in healthy males. American journal of physiology. Endocrinology and metabolism. vol 307. issue 9. 2015-02-26. PMID:25231186. |
vildagliptin 1) modulates the effects of intraduodenal fat to enhance active glp-1 and gip, stimulate insulin, and suppress glucagon, thereby reducing glycemia and 2) increases energy expenditure. |
2015-02-26 |
2023-08-13 |
Not clear |
| Jill A Kanaley, Timothy D Heden, Ying Liu, Timothy J Fairchil. Alteration of postprandial glucose and insulin concentrations with meal frequency and composition. The British journal of nutrition. vol 112. issue 9. 2015-02-23. PMID:25231499. |
the present study examined glucose, insulin, c-peptide and glucose-dependent insulinotropic peptide (gip) responses in obese individuals when meals were ingested in a high-frequency pattern (every 2 h, 6m) or in a low-frequency pattern (every 4 h, 3m) over 12 h. |
2015-02-23 |
2023-08-13 |
human |