| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Linda Ahlkvist, Bilal Omar, Giovanni Pacini, Bo Ahré. Evidence for neural contribution to islet effects of DPP-4 inhibition in mice. European journal of pharmacology. vol 780. 2017-03-06. PMID:26997369. |
based on these findings, we suggest that muscarinic mechanisms contribute to the stimulation of insulin secretion by dpp-4 inhibition through neural effects induced by glp-1 and gip whereas neural effects do not affect the levels of glp-1 or gip or the islet effects of the two incretin hormones. |
2017-03-06 |
2023-08-13 |
mouse |
| Fei Wang, Liang Zhou, Xiudao Song, Guoqiang Liang, Heng Xu, Lurong Zhang, Guorong Jian. Acute Reduction of Incretin Effect and Glucose Intolerance in Rats by Single Intragastric Administration of 3-deoxyglucosone. Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association. vol 125. issue 1. 2017-03-03. PMID:27658000. |
in this study, to examine the acute effects of single intragastric administration of 3dg at dose of potentially single-meal intake on plasma glucose, insulin, glucagon, total glp-1 and total gip levels in response to a glucose load, ogtt was performed immediately in normal kunming mice or sprague-dawleys rats after 3dg administration. |
2017-03-03 |
2023-08-13 |
mouse |
| Raymond A Pederson, Christopher Hs McIntos. Discovery of gastric inhibitory polypeptide and its subsequent fate: Personal reflections. Journal of diabetes investigation. vol 7 Suppl 1. 2017-02-08. PMID:27186348. |
further studies showed that gip strongly stimulated the secretion of insulin, in the presence of elevated glucose, and this 'incretin' action is now considered to be its most important; an alternative for the gip acronym, glucose-dependent insulinotropic polypeptide, was therefore introduced. |
2017-02-08 |
2023-08-13 |
human |
| Shunsuke Yamane, Norio Harada, Nobuya Inagak. Mechanisms of fat-induced gastric inhibitory polypeptide/glucose-dependent insulinotropic polypeptide secretion from K cells. Journal of diabetes investigation. vol 7 Suppl 1. 2017-02-08. PMID:27186351. |
gastric inhibitory polypeptide/glucose-dependent insulinotropic polypeptide (gip) is one of the incretins, which are gastrointestinal hormones released in response to nutrient ingestion and potentiate glucose-stimulated insulin secretion. |
2017-02-08 |
2023-08-13 |
mouse |
| Yusuke Seino, Ryuya Maekawa, Hidetada Ogata, Yoshitaka Hayash. Carbohydrate-induced secretion of glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1. Journal of diabetes investigation. vol 7 Suppl 1. 2017-02-08. PMID:27186352. |
recently, it was reported that gip and glp-1-producing cells are present also in pancreatic islets, and islet-derived gip and glp-1 contribute to glucose-induced insulin secretion from pancreatic β-cells. |
2017-02-08 |
2023-08-13 |
Not clear |
| Yukihiro Fujita, Tsuyoshi Yanagimachi, Yasutaka Takeda, Jun Honjo, Yumi Takiyama, Atsuko Abiko, Yuichi Makino, Masakazu Haned. Alternative form of glucose-dependent insulinotropic polypepide and its physiology. Journal of diabetes investigation. vol 7 Suppl 1. 2017-02-08. PMID:27186353. |
though early studies have shown the possible gip isoforms by gel filtration profiles from porcine or human intestinal extracts analyzed by radioimmunoassay (ria), gip is currently believed to consist of 42 amino acids (gip1-42), which are released from gut k-cells and promote postprandial insulin release. |
2017-02-08 |
2023-08-13 |
human |
| Akihiro Mori, Kaori Ueda, Peter Lee, Hitomi Oda, Katsumi Ishioka, Toshiro Arai, Toshinori Sak. Effect of Acarbose, Sitagliptin and combination therapy on blood glucose, insulin, and incretin hormone concentrations in experimentally induced postprandial hyperglycemia of healthy cats. Research in veterinary science. vol 106. 2017-02-03. PMID:27234550. |
therefore, the objective of this study was to determine the potential use of ac or stgp alone and in combination for diabetic cats, by observing their effect on short-term post-prandial serum glucose, insulin, and incretin hormone (active glucagon-like peptide-1 (glp-1) and total glucose dependent insulinotropic polypeptide (gip)) concentrations in five healthy cats, following ingestion of a meal with maltose. |
2017-02-03 |
2023-08-13 |
human |
| H A Hassing, M S Engelstoft, R M Sichlau, A N Madsen, J F Rehfeld, J Pedersen, R M Jones, J J Holst, T W Schwartz, M M Rosenkilde, H S Hanse. Oral 2-oleyl glyceryl ether improves glucose tolerance in mice through the GPR119 receptor. BioFactors (Oxford, England). vol 42. issue 6. 2017-01-31. PMID:27297962. |
finally, deletion of gpr119 in mice resulted in lower glucagon levels, whereas the levels of insulin and gip were unchanged. |
2017-01-31 |
2023-08-13 |
mouse |
| Eun Ju Ba. DPP-4 inhibitors in diabetic complications: role of DPP-4 beyond glucose control. Archives of pharmacal research. vol 39. issue 8. 2017-01-27. PMID:27502601. |
its mechanism of action for lowering blood glucose is essentially via inhibition of the rapid degradation of incretin hormones, such as glucagon-like peptide (glp)-1 and gastric inhibitory polypeptide (gip), thus the plasma concentration of glp-1 increases, which promotes insulin secretion from the pancreatic β cells and suppresses glucagon secretion from the α cells. |
2017-01-27 |
2023-08-13 |
Not clear |
| Mikkel Bring Christense. Glucose-dependent insulinotropic polypeptide: effects on insulin and glucagon secretion in humans. Danish medical journal. vol 63. issue 4. 2017-01-09. PMID:27034187. |
the overall aim of this phd thesis was to investigate how the blood glucose level affects the glucagon and insulin responses to gip in healthy subjects (study 1) and patients with type 2 diabetes (study 2), and more specifically to investigate the effects of gip and glp-1 at low blood glucose in patients with type 1 diabetes without endogenous insulin secretion (study 3). |
2017-01-09 |
2023-08-13 |
human |
| Mikkel Bring Christense. Glucose-dependent insulinotropic polypeptide: effects on insulin and glucagon secretion in humans. Danish medical journal. vol 63. issue 4. 2017-01-09. PMID:27034187. |
the results from the three studies indicate that gip has effects on insulin and glucagon responses highly dependent upon the blood glucose levels. |
2017-01-09 |
2023-08-13 |
human |
| Mikkel Bring Christense. Glucose-dependent insulinotropic polypeptide: effects on insulin and glucagon secretion in humans. Danish medical journal. vol 63. issue 4. 2017-01-09. PMID:27034187. |
at fasting glycaemia and lower levels of glycaemia, gip acts to increase glucagon with little effect on insulin release. |
2017-01-09 |
2023-08-13 |
human |
| Mikkel Bring Christense. Glucose-dependent insulinotropic polypeptide: effects on insulin and glucagon secretion in humans. Danish medical journal. vol 63. issue 4. 2017-01-09. PMID:27034187. |
at hyperglycaemia the insulin releasing effect of gip prevail, which lead to an increase in glucose disposal by approximately 75% in healthy subjects (study 1) and 25% in patients with type 2 diabetes (study 2) relative to placebo. |
2017-01-09 |
2023-08-13 |
human |
| Mikkel Bring Christense. Glucose-dependent insulinotropic polypeptide: effects on insulin and glucagon secretion in humans. Danish medical journal. vol 63. issue 4. 2017-01-09. PMID:27034187. |
in conclusion, the studies position gip as a bifunctional blood glucose stabilising hormone that glucose-dependently regulates insulin and glucagon responses in humans. |
2017-01-09 |
2023-08-13 |
human |
| Yasuo Takeda, Ryuji Ikeda, Tomoko Kond. [Incretin as a Novel Treatment Strategy for NAFLD/NASH]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. vol 136. issue 4. 2017-01-09. PMID:27040341. |
two incretin hormones, glucagon-like peptide-1 (glp-1) and glucose-dependent insulinotropic polypeptide (gip), stimulate glucose-mediated insulin production in pancreatic β cells. |
2017-01-09 |
2023-08-13 |
Not clear |
| Bodil Ohlsson, Peter Höglund, Bodil Roth, Gassan Darwich. Modification of a traditional breakfast leads to increased satiety along with attenuated plasma increments of glucose, C-peptide, insulin, and glucose-dependent insulinotropic polypeptide in humans. Nutrition research (New York, N.Y.). vol 36. issue 4. 2016-12-21. PMID:27001281. |
plasma glucose was measured, and levels of c-peptide, ghrelin, glucagon, glucagon-like peptide-1, glucose-dependent insulinotropic polypeptide (gip), insulin, plasminogen activator inhibitor-1, and adipokines were analyzed by luminex. |
2016-12-21 |
2023-08-13 |
human |
| Bodil Ohlsson, Peter Höglund, Bodil Roth, Gassan Darwich. Modification of a traditional breakfast leads to increased satiety along with attenuated plasma increments of glucose, C-peptide, insulin, and glucose-dependent insulinotropic polypeptide in humans. Nutrition research (New York, N.Y.). vol 36. issue 4. 2016-12-21. PMID:27001281. |
postprandial increments of c-peptide, insulin, and gip were suppressed after test meal compared with reference meal (total delta area under the curve [p = .03, .006, and .004], delta area under the curve [p = .006, .003, and .02], max [p = .01, .007, and .002], and dmax [p = .004, .008, and .007], respectively). |
2016-12-21 |
2023-08-13 |
human |
| Bodil Ohlsson, Peter Höglund, Bodil Roth, Gassan Darwich. Modification of a traditional breakfast leads to increased satiety along with attenuated plasma increments of glucose, C-peptide, insulin, and glucose-dependent insulinotropic polypeptide in humans. Nutrition research (New York, N.Y.). vol 36. issue 4. 2016-12-21. PMID:27001281. |
a lower carbohydrate and higher fat and protein content provides greater satiety and attenuation of c-peptide, glucose, insulin, and gip responses compared with the reference breakfast but does not affect adipokines, ghrelin, glucagon, glucagon-like peptide-1, and plasminogen activator inhibitor-1. |
2016-12-21 |
2023-08-13 |
human |
| Chinmay S Marathe, Michelle Bound, Kylie Lange, Karen L Jones, Christopher K Rayner, Michael Horowit. Ethnic disparities in insulin and glucose-dependent insulinotropic peptide (GIP) responses to intraduodenal glucose in health. Acta diabetologica. vol 52. issue 4. 2016-12-13. PMID:25399343. |
ethnic disparities in insulin and glucose-dependent insulinotropic peptide (gip) responses to intraduodenal glucose in health. |
2016-12-13 |
2023-08-13 |
Not clear |
| Claire L Meek, Hannah B Lewis, Frank Reimann, Fiona M Gribble, Adrian J Par. The effect of bariatric surgery on gastrointestinal and pancreatic peptide hormones. Peptides. vol 77. 2016-12-13. PMID:26344355. |
the aim of this review is to summarise the effects of different bariatric surgery procedures upon gastrointestinal and pancreatic peptides, including ghrelin, gastrin, cholecystokinin (cck), glucose-dependent insulinotropic hormone (gip), glucagon-like peptide 1 (glp-1), peptide yy (pyy), oxyntomodulin, insulin, glucagon and somatostatin. |
2016-12-13 |
2023-08-13 |
Not clear |