| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Malgorzata E Kiec-Klimczak, Dorota M Pach, Magdalena E Pogwizd, Alicja B Hubalewska-Dydejczy. Incretins yesterday, pleiotropic gastrointestinal hormones today:glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). Recent patents on endocrine, metabolic & immune drug discovery. vol 5. issue 3. 2012-03-30. PMID:21913887. |
these hormones perform several functions: they stimulate insulin secretion in the pancreatic beta cells; they inhibit glucagon release from the alpha cells of the pancreas (gip not in humans); they slow down gastric emptying and may directly suppress appetite; and, moreover, they indirectly increase peripheral glucose tolerance/insulin sensitivity. |
2012-03-30 |
2023-08-12 |
Not clear |
| Sameer Mohammad, Lavoisier S Ramos, Jochen Buck, Lonny R Levin, Francesco Rubino, Timothy E McGra. Gastric inhibitory peptide controls adipose insulin sensitivity via activation of cAMP-response element-binding protein and p110β isoform of phosphatidylinositol 3-kinase. The Journal of biological chemistry. vol 286. issue 50. 2012-03-27. PMID:22027830. |
the best known function of gip is to enhance glucose-dependent insulin secretion from pancreatic β-cells. |
2012-03-27 |
2023-08-12 |
Not clear |
| Sameer Mohammad, Lavoisier S Ramos, Jochen Buck, Lonny R Levin, Francesco Rubino, Timothy E McGra. Gastric inhibitory peptide controls adipose insulin sensitivity via activation of cAMP-response element-binding protein and p110β isoform of phosphatidylinositol 3-kinase. The Journal of biological chemistry. vol 286. issue 50. 2012-03-27. PMID:22027830. |
here, we demonstrate that gip increases insulin-dependent translocation of the glut4 glucose transporter to the plasma membrane and exclusion of foxo1 transcription factor from the nucleus in adipocytes, establishing that gip has a general effect on insulin action in adipocytes. |
2012-03-27 |
2023-08-12 |
Not clear |
| Sameer Mohammad, Lavoisier S Ramos, Jochen Buck, Lonny R Levin, Francesco Rubino, Timothy E McGra. Gastric inhibitory peptide controls adipose insulin sensitivity via activation of cAMP-response element-binding protein and p110β isoform of phosphatidylinositol 3-kinase. The Journal of biological chemistry. vol 286. issue 50. 2012-03-27. PMID:22027830. |
using pharmacologic and molecular genetic approaches, we show that the effect of gip on adipocyte insulin sensitivity requires activation of both the camp/protein kinase a/creb signaling module and p110β phosphoinositol-3' kinase, establishing a novel signal transduction pathway modulating insulin action in adipocytes. |
2012-03-27 |
2023-08-12 |
Not clear |
| Sameer Mohammad, Lavoisier S Ramos, Jochen Buck, Lonny R Levin, Francesco Rubino, Timothy E McGra. Gastric inhibitory peptide controls adipose insulin sensitivity via activation of cAMP-response element-binding protein and p110β isoform of phosphatidylinositol 3-kinase. The Journal of biological chemistry. vol 286. issue 50. 2012-03-27. PMID:22027830. |
this insulin-sensitizing effect is specific for gip because isoproterenol, which elevates adipocyte camp and activates pka/creb signaling, does not affect adipocyte insulin sensitivity. |
2012-03-27 |
2023-08-12 |
Not clear |
| Mi Jin Moon, Hee Young Kim, Sumi Park, Dong-Kyu Kim, Eun Bee Cho, Cho Rong Park, Dong-Joo You, Jong-Ik Hwang, Kyungjin Kim, Han Choe, Jae Young Seon. Evolutionarily conserved residues at glucagon-like peptide-1 (GLP-1) receptor core confer ligand-induced receptor activation. The Journal of biological chemistry. vol 287. issue 6. 2012-03-25. PMID:22105074. |
glucagon-like peptide-1 (glp-1) and glucose-dependent insulinotropic polypeptide (gip) play important roles in insulin secretion through their receptors, glp1r and gipr. |
2012-03-25 |
2023-08-12 |
Not clear |
| Qibin Qi, George A Bray, Frank B Hu, Frank M Sacks, Lu Q. Weight-loss diets modify glucose-dependent insulinotropic polypeptide receptor rs2287019 genotype effects on changes in body weight, fasting glucose, and insulin resistance: the Preventing Overweight Using Novel Dietary Strategies trial. The American journal of clinical nutrition. vol 95. issue 2. 2012-03-06. PMID:22237064. |
glucose-dependent insulinotropic polypeptide [also known as gastric inhibitory polypeptide (gip)] and its receptor (gipr) may link overnutrition to obesity, insulin resistance, and type 2 diabetes. |
2012-03-06 |
2023-08-12 |
Not clear |
| Laura Mendieta, Teresa Tarrago, Ernest Giral. Recent patents of dipeptidyl peptidase IV inhibitors. Expert opinion on therapeutic patents. vol 21. issue 11. 2012-02-15. PMID:22017411. |
the incretin molecules glucagon-like peptide 1 (glp-1) and glucose-dependent insulinotropic peptide (gip) are hydrolyzed by dpp iv into inactive forms, which are unable to promote insulin secretion. |
2012-02-15 |
2023-08-12 |
Not clear |
| Charlotte Brøns, Stine Jacobsen, Natalie Hiscock, Andrew White, Emma Nilsson, David Dunger, Arne Astrup, Bjørn Quistorff, Allan Vaa. Effects of high-fat overfeeding on mitochondrial function, glucose and fat metabolism, and adipokine levels in low-birth-weight subjects. American journal of physiology. Endocrinology and metabolism. vol 302. issue 1. 2012-02-14. PMID:21917634. |
reduced increments in response to hfo of fasting plasma leptin, pp, and gip levels may contribute to insulin resistance, lower satiety, and impaired insulin secretion in lbw subjects. |
2012-02-14 |
2023-08-12 |
human |
| Holly E Bates, Jonathan E Campbell, John R Ussher, Laurie L Baggio, Adriano Maida, Yutaka Seino, Daniel J Drucke. Gipr is essential for adrenocortical steroidogenesis; however, corticosterone deficiency does not mediate the favorable metabolic phenotype of Gipr(-/-) mice. Diabetes. vol 61. issue 1. 2012-02-13. PMID:22043004. |
glucose-dependent insulinotropic polypeptide (gip) promotes glucose-dependent insulin secretion. |
2012-02-13 |
2023-08-12 |
mouse |
| Mikkel Christensen, Louise Vedtofte, Jens J Holst, Tina Vilsbøll, Filip K Kno. Glucose-dependent insulinotropic polypeptide: a bifunctional glucose-dependent regulator of glucagon and insulin secretion in humans. Diabetes. vol 60. issue 12. 2012-02-01. PMID:21984584. |
to evaluate the glucose dependency of glucose-dependent insulinotropic polypeptide (gip) effects on insulin and glucagon release in 10 healthy male subjects ([means ± sem] aged 23 ± 1 years, bmi 23 ± 1 kg/m(2), and hba(1c) 5.5 ± 0.1%). |
2012-02-01 |
2023-08-12 |
human |
| Akira Shimotoyodome, Junko Suzuki, Yoshiaki Kumamoto, Tadashi Hase, Akira Isoga. Regulation of postprandial blood metabolic variables by TEMPO-oxidized cellulose nanofibers. Biomacromolecules. vol 12. issue 10. 2012-01-27. PMID:21902221. |
the tempo-oxidized cellulose nanofibers (tocns) were orally administered with glucose and glyceryl trioleate to mice and postprandial responses of blood glucose, insulin, glucose-dependent insulinotropic polypeptide (gip), and triglycerides were studied. |
2012-01-27 |
2023-08-12 |
mouse |
| Akira Shimotoyodome, Junko Suzuki, Yoshiaki Kumamoto, Tadashi Hase, Akira Isoga. Regulation of postprandial blood metabolic variables by TEMPO-oxidized cellulose nanofibers. Biomacromolecules. vol 12. issue 10. 2012-01-27. PMID:21902221. |
both blood insulin and gip concentrations were decreased by tocn with a carboxyl content and aspect ratio of 1.2 mmol g(-1) and 120, respectively, in dose-dependent manners (0-0.3 mg g(-1) body weight). |
2012-01-27 |
2023-08-12 |
mouse |
| Akira Shimotoyodome, Junko Suzuki, Yoshiaki Kumamoto, Tadashi Hase, Akira Isoga. Regulation of postprandial blood metabolic variables by TEMPO-oxidized cellulose nanofibers. Biomacromolecules. vol 12. issue 10. 2012-01-27. PMID:21902221. |
of the tocns examined, that with a carboxyl content and aspect ratio of 1.2 mmol g(-1) and 120, respectively, was the most effective in reducing postprandial blood glucose, plasma insulin, gip, and triglyceride concentrations. |
2012-01-27 |
2023-08-12 |
mouse |
| E Paschetta, M Hvalryg, G Muss. Glucose-dependent insulinotropic polypeptide: from pathophysiology to therapeutic opportunities in obesity-associated disorders. Obesity reviews : an official journal of the International Association for the Study of Obesity. vol 12. issue 10. 2012-01-23. PMID:21815989. |
as gip levels are normal or elevated in obesity and diabetes, mounting evidence from chemical or genetic gip deletion in animal models of obesity-related diabetes suggests that gip may have a pro-obesogenic action and that a strategy antagonizing gip action may be beneficial in these conditions, clearing triglyceride deposits from adipose tissue, liver and muscle, and restoring normal insulin sensitivity. |
2012-01-23 |
2023-08-12 |
Not clear |
| Michelle C Musson, Lisa I Jepeal, John R Finnerty, M Michael Wolf. Evolutionary expression of glucose-dependent-insulinotropic polypeptide (GIP). Regulatory peptides. vol 171. issue 1-3. 2011-12-27. PMID:21723886. |
we examined the functional evolution of gip and its relationship with insulin to delineate their respective roles in promoting nutrient efficiency. |
2011-12-27 |
2023-08-12 |
mouse |
| Michelle C Musson, Lisa I Jepeal, John R Finnerty, M Michael Wolf. Evolutionary expression of glucose-dependent-insulinotropic polypeptide (GIP). Regulatory peptides. vol 171. issue 1-3. 2011-12-27. PMID:21723886. |
in contrast, gip and insulin expression were limited to the intestine and pancreas, respectively, in chicken and mouse. |
2011-12-27 |
2023-08-12 |
mouse |
| Michelle C Musson, Lisa I Jepeal, John R Finnerty, M Michael Wolf. Evolutionary expression of glucose-dependent-insulinotropic polypeptide (GIP). Regulatory peptides. vol 171. issue 1-3. 2011-12-27. PMID:21723886. |
these observations are consistent with the hypothesis that gip and insulin influence survival advantage by enhancing the efficiency of nutrient absorption and energy storage. |
2011-12-27 |
2023-08-12 |
mouse |
| Nigel Irwin, Jacqueline M E Francis, Peter R Flat. Insulin modulates glucose-dependent insulinotropic polypeptide (GIP) secretion from enteroendocrine K cells in rats. Biological chemistry. vol 392. issue 10. 2011-12-20. PMID:21851286. |
insulin modulates glucose-dependent insulinotropic polypeptide (gip) secretion from enteroendocrine k cells in rats. |
2011-12-20 |
2023-08-12 |
rat |
| Nigel Irwin, Jacqueline M E Francis, Peter R Flat. Insulin modulates glucose-dependent insulinotropic polypeptide (GIP) secretion from enteroendocrine K cells in rats. Biological chemistry. vol 392. issue 10. 2011-12-20. PMID:21851286. |
effects of insulin excess and deficiency on glucose-dependent insulinotropic polypeptide (gip) was examined in rats following insulinoma transplantation or streptozotocin (stz) administration. |
2011-12-20 |
2023-08-12 |
rat |