| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nigel Irwin, Jacqueline M E Francis, Peter R Flat. Insulin modulates glucose-dependent insulinotropic polypeptide (GIP) secretion from enteroendocrine K cells in rats. Biological chemistry. vol 392. issue 10. 2011-12-20. PMID:21851286. |
plasma glucose and insulin concentrations were not affected by oral fat, but fat-induced gip secretion was particularly (p < 0.05) increased in insulinoma-bearing rats. |
2011-12-20 |
2023-08-12 |
rat |
| Nigel Irwin, Jacqueline M E Francis, Peter R Flat. Insulin modulates glucose-dependent insulinotropic polypeptide (GIP) secretion from enteroendocrine K cells in rats. Biological chemistry. vol 392. issue 10. 2011-12-20. PMID:21851286. |
exogenous gip enhanced (p < 0.05) glucose-lowering in all groups of rats accompanied by insulin releasing (p < 0.001) effects in insulinoma-bearing and control rats. |
2011-12-20 |
2023-08-12 |
rat |
| Nigel Irwin, Jacqueline M E Francis, Peter R Flat. Insulin modulates glucose-dependent insulinotropic polypeptide (GIP) secretion from enteroendocrine K cells in rats. Biological chemistry. vol 392. issue 10. 2011-12-20. PMID:21851286. |
these data suggest that circulating insulin has direct and indirect effects on the synthesis and secretion of gip. |
2011-12-20 |
2023-08-12 |
rat |
| L B Katz, J J Gambale, P L Rothenberg, S R Vanapalli, N Vaccaro, L Xi, D C Polidori, E Vets, T C Sarich, P P Stei. Pharmacokinetics, pharmacodynamics, safety, and tolerability of JNJ-38431055, a novel GPR119 receptor agonist and potential antidiabetes agent, in healthy male subjects. Clinical pharmacology and therapeutics. vol 90. issue 5. 2011-12-07. PMID:21975348. |
as compared with placebo, single-dose oral jnj-38431055 increased postmeal plasma glucagon-like peptide 1 (glp-1), glucose-dependent insulinotropic peptide (gip), and peptide yy (pyy) concentrations but did not significantly decrease glucose excursion or increase insulin secretion. |
2011-12-07 |
2023-08-12 |
human |
| Nadja Herbach, Martina Bergmayr, Burkhard Göke, Eckhard Wolf, Ruediger Wank. Postnatal development of numbers and mean sizes of pancreatic islets and beta-cells in healthy mice and GIPR(dn) transgenic diabetic mice. PloS one. vol 6. issue 7. 2011-12-06. PMID:21818396. |
insulin secretion in response to pharmacological doses of gip was preserved in gipr(dn) transgenic mice, and serum insulin to pancreatic insulin content in response to glp-1 and arginine was significantly higher in gipr(dn) transgenic mice vs. controls. |
2011-12-06 |
2023-08-12 |
mouse |
| Natalia N Rudovich, Victoria J Nikiforova, Baerbel Otto, Olga Pivovarova, Ozlem Gögebakan, Alexander Erban, Matthias Möhlig, Martin O Weickert, Joachim Spranger, Matthias H Tschöp, Lothar Willmitzer, Michael Nauck, Andreas F H Pfeiffe. Metabolomic linkage reveals functional interaction between glucose-dependent insulinotropic polypeptide and ghrelin in humans. American journal of physiology. Endocrinology and metabolism. vol 301. issue 4. 2011-11-18. PMID:21586700. |
on the basis of the growing evidence that glucose-dependent insulinotropic polypeptide (gip) is involved in the control of fuel metabolism, we hypothesized that gip and/or insulin, directly or via changes in plasma metabolites, might affect circulating ghrelin. |
2011-11-18 |
2023-08-12 |
human |
| Natalia N Rudovich, Victoria J Nikiforova, Baerbel Otto, Olga Pivovarova, Ozlem Gögebakan, Alexander Erban, Matthias Möhlig, Martin O Weickert, Joachim Spranger, Matthias H Tschöp, Lothar Willmitzer, Michael Nauck, Andreas F H Pfeiffe. Metabolomic linkage reveals functional interaction between glucose-dependent insulinotropic polypeptide and ghrelin in humans. American journal of physiology. Endocrinology and metabolism. vol 301. issue 4. 2011-11-18. PMID:21586700. |
the gip and insulin effects on circulating ghrelin were analyzed within the framework of those networks. |
2011-11-18 |
2023-08-12 |
human |
| Natalia N Rudovich, Victoria J Nikiforova, Baerbel Otto, Olga Pivovarova, Ozlem Gögebakan, Alexander Erban, Matthias Möhlig, Martin O Weickert, Joachim Spranger, Matthias H Tschöp, Lothar Willmitzer, Michael Nauck, Andreas F H Pfeiffe. Metabolomic linkage reveals functional interaction between glucose-dependent insulinotropic polypeptide and ghrelin in humans. American journal of physiology. Endocrinology and metabolism. vol 301. issue 4. 2011-11-18. PMID:21586700. |
ghrelin levels were significantly lower during hc with gip than with placebo, despite insulin levels not differing significantly. |
2011-11-18 |
2023-08-12 |
human |
| Natalia N Rudovich, Victoria J Nikiforova, Baerbel Otto, Olga Pivovarova, Ozlem Gögebakan, Alexander Erban, Matthias Möhlig, Martin O Weickert, Joachim Spranger, Matthias H Tschöp, Lothar Willmitzer, Michael Nauck, Andreas F H Pfeiffe. Metabolomic linkage reveals functional interaction between glucose-dependent insulinotropic polypeptide and ghrelin in humans. American journal of physiology. Endocrinology and metabolism. vol 301. issue 4. 2011-11-18. PMID:21586700. |
these observations were independent of insulin and offer potential mechanistic underpinnings for the involvement of gip in systemic control of energy metabolism. |
2011-11-18 |
2023-08-12 |
human |
| Christian Hölsche. Diabetes as a risk factor for Alzheimer's disease: insulin signalling impairment in the brain as an alternative model of Alzheimer's disease. Biochemical Society transactions. vol 39. issue 4. 2011-11-15. PMID:21787319. |
in particular, the incretins glp-1 (glucagon-like peptide-1) and gip (glucose-dependent insolinotropic polypeptide) are hormones that re-sensitize insulin signalling. |
2011-11-15 |
2023-08-12 |
mouse |
| Yu Sasaki, Hiroaki Takeda, Takeshi Sato, Tomohiko Orii, Shoichiro Fujishima, Ko Nagino, Shoichi Nishise, Hideki Saito, Yasuhisa Tanaka, Sumio Kawat. Increased levels of serum glucose-dependent insulinotropic polypeptide as a novel risk factor for human colorectal adenoma. Metabolism: clinical and experimental. vol 60. issue 9. 2011-11-09. PMID:21353263. |
glucose-dependent insulinotropic polypeptide (gip) stimulates insulin secretion from the pancreas and promotes fat accumulation in adipocytes. |
2011-11-09 |
2023-08-12 |
human |
| Yu Sasaki, Hiroaki Takeda, Takeshi Sato, Tomohiko Orii, Shoichiro Fujishima, Ko Nagino, Shoichi Nishise, Hideki Saito, Yasuhisa Tanaka, Sumio Kawat. Increased levels of serum glucose-dependent insulinotropic polypeptide as a novel risk factor for human colorectal adenoma. Metabolism: clinical and experimental. vol 60. issue 9. 2011-11-09. PMID:21353263. |
the mean levels of fasting gip (34.9 ± 49.5 vs 25.0 ± 20.1 pg/ml, p = .04), triglyceride, glucose, and insulin and the values of the homeostasis model assessment of insulin resistance in the colorectal adenoma group were significantly higher than those in the control group. |
2011-11-09 |
2023-08-12 |
human |
| Yu Sasaki, Hiroaki Takeda, Takeshi Sato, Tomohiko Orii, Shoichiro Fujishima, Ko Nagino, Shoichi Nishise, Hideki Saito, Yasuhisa Tanaka, Sumio Kawat. Increased levels of serum glucose-dependent insulinotropic polypeptide as a novel risk factor for human colorectal adenoma. Metabolism: clinical and experimental. vol 60. issue 9. 2011-11-09. PMID:21353263. |
quartile analysis demonstrated that increased levels of gip were related to increased levels of fasting insulin and values of homeostasis model assessment β-cell. |
2011-11-09 |
2023-08-12 |
human |
| Victor A Gault, Barry D Kerr, Patrick Harriott, Peter R Flat. Administration of an acylated GLP-1 and GIP preparation provides added beneficial glucose-lowering and insulinotropic actions over single incretins in mice with Type 2 diabetes and obesity. Clinical science (London, England : 1979). vol 121. issue 3. 2011-11-08. PMID:21332446. |
glp-1, gip, liraglutide, n-acgip(lys(37)myr) (n-acetylgip with myristic acid conjugated at lys(37)), a simple combination of both peptides and a lira-acgip preparation [overnight preparation of liraglutide and n-acgip(lys(37)myr)] were incubated with dpp-iv (dipeptidyl peptidase-iv) to assess peptide stability, and brin-bd11 cells were used to evaluate camp production and insulin secretion. |
2011-11-08 |
2023-08-12 |
mouse |
| Valeriya Lyssenko, Lena Eliasson, Olga Kotova, Kasper Pilgaard, Nils Wierup, Albert Salehi, Anna Wendt, Anna Jonsson, Yang Z De Marinis, Lisa M Berglund, Jalal Taneera, Alexander Balhuizen, Ola Hansson, Peter Osmark, Pontus Dunér, Charlotte Brøns, Alena Stancáková, Johanna Kuusisto, Marco Bugliani, Richa Saxena, Emma Ahlqvist, Timothy J Kieffer, Tiinamaija Tuomi, Bo Isomaa, Olle Melander, Emily Sonestedt, Marju Orho-Melander, Peter Nilsson, Sara Bonetti, Riccardo Bonadonna, Roberto Miccoli, Stefano Delprato, Piero Marchetti, Sten Madsbad, Pernille Poulsen, Allan Vaag, Markku Laakso, Maria F Gomez, Leif Groo. Pleiotropic effects of GIP on islet function involve osteopontin. Diabetes. vol 60. issue 9. 2011-10-31. PMID:21810601. |
the incretin hormone gip (glucose-dependent insulinotropic polypeptide) promotes pancreatic β-cell function by potentiating insulin secretion and β-cell proliferation. |
2011-10-31 |
2023-08-12 |
Not clear |
| Valeriya Lyssenko, Lena Eliasson, Olga Kotova, Kasper Pilgaard, Nils Wierup, Albert Salehi, Anna Wendt, Anna Jonsson, Yang Z De Marinis, Lisa M Berglund, Jalal Taneera, Alexander Balhuizen, Ola Hansson, Peter Osmark, Pontus Dunér, Charlotte Brøns, Alena Stancáková, Johanna Kuusisto, Marco Bugliani, Richa Saxena, Emma Ahlqvist, Timothy J Kieffer, Tiinamaija Tuomi, Bo Isomaa, Olle Melander, Emily Sonestedt, Marju Orho-Melander, Peter Nilsson, Sara Bonetti, Riccardo Bonadonna, Roberto Miccoli, Stefano Delprato, Piero Marchetti, Sten Madsbad, Pernille Poulsen, Allan Vaag, Markku Laakso, Maria F Gomez, Leif Groo. Pleiotropic effects of GIP on islet function involve osteopontin. Diabetes. vol 60. issue 9. 2011-10-31. PMID:21810601. |
recently, a combined analysis of several genome-wide association studies (meta-analysis of glucose and insulin-related traits consortium [magic]) showed association to postprandial insulin at the gip receptor (gipr) locus. |
2011-10-31 |
2023-08-12 |
Not clear |
| Javier Jimenez-Feltstrom, Albert Salehi, Sandra Meidute Abaraviciene, Ragnar Henningsson, Ingmar Lundquis. Abnormally decreased NO and augmented CO production in islets of the leptin-deficient ob/ob mouse might contribute to explain hyperinsulinemia and islet survival in leptin-resistant type 2 obese diabetes. Regulatory peptides. vol 170. issue 1-3. 2011-10-21. PMID:21620903. |
in ob/ob islets the insulinotropic peptides glucagon, glp-1 and gip suppressed nos activities and amplified glucose-stimulated insulin release. |
2011-10-21 |
2023-08-12 |
mouse |
| Emilie Faivre, Victor A Gault, Bernard Thorens, Christian Hölsche. Glucose-dependent insulinotropic polypeptide receptor knockout mice are impaired in learning, synaptic plasticity, and neurogenesis. Journal of neurophysiology. vol 105. issue 4. 2011-09-29. PMID:21273318. |
glucose-dependent insulinotropic polypeptide (gip) is a key incretin hormone, released from intestine after a meal, producing a glucose-dependent insulin secretion. |
2011-09-29 |
2023-08-12 |
mouse |
| Ewa Szalowska, Kees Meijer, Niels Kloosterhuis, Farhad Razaee, Marion Priebe, Roel J Von. Sub-chronic administration of stable GIP analog in mice decreases serum LPL activity and body weight. Peptides. vol 32. issue 5. 2011-09-23. PMID:21334410. |
afterwards, serum lpl activity and several biochemical parameters (tg, ffa, cholesterol, glucose, insulin, resistin, il-6, il-1β, tnfα, gip) were measured. |
2011-09-23 |
2023-08-12 |
mouse |
| Aurélie Waget, Cendrine Cabou, Myriam Masseboeuf, Pierre Cattan, Mattieu Armanet, Mélis Karaca, Julien Castel, Celine Garret, Gaëlle Payros, Adriano Maida, Thierry Sulpice, Jens J Holst, Daniel J Drucker, Christophe Magnan, Rémy Burceli. Physiological and pharmacological mechanisms through which the DPP-4 inhibitor sitagliptin regulates glycemia in mice. Endocrinology. vol 152. issue 8. 2011-09-21. PMID:21673098. |
furthermore, the dipeptides liberated from glp-1 (his-ala) and gip (tyr-ala) deteriorated glucose tolerance, reduced insulin, and increased portal glucagon levels. |
2011-09-21 |
2023-08-12 |
mouse |