| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R Lupi, S Del Guerra, V D'Aleo, U Boggi, F Filipponi, P Marchett. The direct effects of GLP-1 and GIP, alone or in combination, on human pancreatic islets. Regulatory peptides. vol 165. issue 2-3. 2011-04-14. PMID:20472004. |
following prolonged exposure to the incretins, improved insulin secretion was observed, and transcription of insulin, pdx-1 and bcl-2 was increased in both non-diabetic and diabetic islets, with the combination of glp-1 and gip showing more significant effects. |
2011-04-14 |
2023-08-12 |
human |
| Young Min Cho, Timothy J Kieffe. K-cells and glucose-dependent insulinotropic polypeptide in health and disease. Vitamins and hormones. vol 84. 2011-04-05. PMID:21094898. |
the meal-dependent nature of gip release makes k-cells a potential target for genetically engineered production of satiety factors or glucose-lowering agents, for example, insulin. |
2011-04-05 |
2023-08-12 |
mouse |
| Maria P Yavropoulou, John G Yovo. Central regulation of glucose-dependent insulinotropic polypeptide secretion. Vitamins and hormones. vol 84. 2011-04-05. PMID:21094900. |
glucose-dependent insulinotropic peptide (gip) and glucagon-like peptide-1 (glp-1) are potent stimulators of glucose-dependent insulin secretion, a phenomenon known as incretin effect. |
2011-04-05 |
2023-08-12 |
Not clear |
| Per M Hellströ. Glucagon-like peptide-1 gastrointestinal regulatory role in metabolism and motility. Vitamins and hormones. vol 84. 2011-04-05. PMID:21094906. |
the incretin hormones, glucagon-like peptide-1 (glp-1) and glucose-dependent insulinotropic peptide (gip), work together to reduce postprandial hyperglycemia by glucose-dependent insulin secretion and inhibition of glucagon release, as well as inhibition of gi motility and gastric emptying. |
2011-04-05 |
2023-08-12 |
human |
| Kristine J Hare, Filip K Kno. Incretin-based therapy and type 2 diabetes. Vitamins and hormones. vol 84. 2011-04-05. PMID:21094909. |
therefore, the actions of glp-1 and gip, which include potentiation of meal-induced insulin secretion and trophic effects on the beta-cell, have attracted a lot of interest. |
2011-04-05 |
2023-08-12 |
Not clear |
| Unmesh Shah, Timothy J Kowalsk. GPR119 agonists for the potential treatment of type 2 diabetes and related metabolic disorders. Vitamins and hormones. vol 84. 2011-04-05. PMID:21094910. |
the activation of gpr119 increases the intracellular accumulation of camp, leading to enhanced glucose-dependent insulin secretion from pancreatic β-cells and increased release of the gut peptides glp-1 (glucagon-like peptide 1), gip (glucose-dependent insulinotropic peptide) and pyy (polypeptide yy). |
2011-04-05 |
2023-08-12 |
Not clear |
| Michael A Nauc. Incretin-based therapies for type 2 diabetes mellitus: properties, functions, and clinical implications. The American journal of medicine. vol 124. issue 1 Suppl. 2011-03-22. PMID:21194578. |
the incretin hormones, glucose-dependent insulinotropic polypeptide (gip) and glucagonlike peptide-1 (glp-1), which are secreted by cells of the gastrointestinal tract in response to meal ingestion, exercise important glucoregulatory effects, including the glucose-dependent potentiation of insulin secretion by pancreatic β-cells. |
2011-03-22 |
2023-08-12 |
Not clear |
| Katrine B Hansen, Tina Vilsbøll, Jonatan I Bagger, Jens J Holst, Filip K Kno. Increased postprandial GIP and glucagon responses, but unaltered GLP-1 response after intervention with steroid hormone, relative physical inactivity, and high-calorie diet in healthy subjects. The Journal of clinical endocrinology and metabolism. vol 96. issue 2. 2011-03-21. PMID:21047927. |
we aimed to determine the impact of insulin resistance and reduced glucose tolerance on postprandial gip, glp-1, and glucagon responses in healthy subjects. |
2011-03-21 |
2023-08-12 |
human |
| Barry D Kerr, Anneliese J S Flatt, Peter R Flatt, Victor A Gaul. Characterization and biological actions of N-terminal truncated forms of glucose-dependent insulinotropic polypeptide. Biochemical and biophysical research communications. vol 404. issue 3. 2011-03-11. PMID:21184739. |
compared with native gip, in vitro insulinotropic activity of gip(3-42), gip(4-42), gip(5-42), gip(7-42) and gip(8-42) was reduced (p<0.05 to p<0.001), with gip(4-42), gip(5-42), gip(7-42) and gip(8-42) also potently inhibiting gip-stimulated insulin secretion (p<0.001). |
2011-03-11 |
2023-08-12 |
mouse |
| Barry D Kerr, Anneliese J S Flatt, Peter R Flatt, Victor A Gaul. Characterization and biological actions of N-terminal truncated forms of glucose-dependent insulinotropic polypeptide. Biochemical and biophysical research communications. vol 404. issue 3. 2011-03-11. PMID:21184739. |
when gip(8-42) was co-administered with native gip it countered the ability of the native peptide to lower plasma glucose and increase circulating insulin concentrations. |
2011-03-11 |
2023-08-12 |
mouse |
| Krishna Prasadan, Masayuki Koizumi, Sidhartha Tulachan, Chiyo Shiota, Nikesh Lath, Jose Paredes, Ping Guo, Yousef El-Gohary, Marcus Malek, Sohail Shah, George K Gitte. The expression and function of glucose-dependent insulinotropic polypeptide in the embryonic mouse pancreas. Diabetes. vol 60. issue 2. 2011-03-10. PMID:21270265. |
gip is an incretin, known to modulate glucose-induced insulin secretion. |
2011-03-10 |
2023-08-12 |
mouse |
| Grace Flock, Dianne Holland, Yutaka Seino, Daniel J Drucke. GPR119 regulates murine glucose homeostasis through incretin receptor-dependent and independent mechanisms. Endocrinology. vol 152. issue 2. 2011-02-25. PMID:21068156. |
experimental endpoints included plasma glucose, insulin, glucagon, glucagon-like peptide-1 (glp-1), glucose-dependent insulinotropic peptide (gip), and peptide yy. |
2011-02-25 |
2023-08-12 |
mouse |
| Grace Flock, Dianne Holland, Yutaka Seino, Daniel J Drucke. GPR119 regulates murine glucose homeostasis through incretin receptor-dependent and independent mechanisms. Endocrinology. vol 152. issue 2. 2011-02-25. PMID:21068156. |
ar231453 stimulated insulin secretion from wt and dirko islets in a glucose-dependent manner, improved glucose homeostasis, and augmented plasma levels of glp-1, gip, and insulin in wt and gipr-/- mice. |
2011-02-25 |
2023-08-12 |
mouse |
| Grace Flock, Dianne Holland, Yutaka Seino, Daniel J Drucke. GPR119 regulates murine glucose homeostasis through incretin receptor-dependent and independent mechanisms. Endocrinology. vol 152. issue 2. 2011-02-25. PMID:21068156. |
in contrast, although ar231453 increased levels of glp-1, gip, and insulin, it failed to lower glucose in glp1r-/- and dirko mice. |
2011-02-25 |
2023-08-12 |
mouse |
| Andreas F H Pfeiffer, Natalia Rudovich, Martin O Weickert, Frank Iske. Role of the gut Peptide glucose-induced insulinomimetic Peptide in energy balance. Results and problems in cell differentiation. vol 52. 2011-02-15. PMID:20865381. |
gip releases insulin from the β cells of the pancreatic islets of langerhans and therefore is an incretin hormone. |
2011-02-15 |
2023-08-12 |
mouse |
| Andreas F H Pfeiffer, Natalia Rudovich, Martin O Weickert, Frank Iske. Role of the gut Peptide glucose-induced insulinomimetic Peptide in energy balance. Results and problems in cell differentiation. vol 52. 2011-02-15. PMID:20865381. |
thus, gip elicits central effects in response to nutrients that protect against obesity and insulin resistance. |
2011-02-15 |
2023-08-12 |
mouse |
| Andreas F H Pfeiffer, Natalia Rudovich, Martin O Weickert, Frank Iske. Role of the gut Peptide glucose-induced insulinomimetic Peptide in energy balance. Results and problems in cell differentiation. vol 52. 2011-02-15. PMID:20865381. |
at basal glucose, gip does not elicit insulin release. |
2011-02-15 |
2023-08-12 |
mouse |
| J Skrha, J Hilgertová, M Jarolímková, M Kunešová, M Hil. Meal test for glucose-dependent insulinotropic peptide (GIP) in obese and type 2 diabetic patients. Physiological research. vol 59. issue 5. 2011-02-14. PMID:20406045. |
glucose-dependent insulinotropic peptide (gip) contributes to incretin effect of insulin secretion which is impaired in type 2 diabetes mellitus. |
2011-02-14 |
2023-08-12 |
Not clear |
| J Skrha, J Hilgertová, M Jarolímková, M Kunešová, M Hil. Meal test for glucose-dependent insulinotropic peptide (GIP) in obese and type 2 diabetic patients. Physiological research. vol 59. issue 5. 2011-02-14. PMID:20406045. |
serum concentrations of insulin, c-peptide and gip were estimated during the test. |
2011-02-14 |
2023-08-12 |
Not clear |
| J Skrha, J Hilgertová, M Jarolímková, M Kunešová, M Hil. Meal test for glucose-dependent insulinotropic peptide (GIP) in obese and type 2 diabetic patients. Physiological research. vol 59. issue 5. 2011-02-14. PMID:20406045. |
insulin concentration at 30 min was lower in diabetic than in non-diabetic persons and the gip action was delayed. |
2011-02-14 |
2023-08-12 |
Not clear |