| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Eiichi Ogawa, Masaya Hosokawa, Norio Harada, Shunsuke Yamane, Akihiro Hamasaki, Kentaro Toyoda, Shimpei Fujimoto, Yoshihito Fujita, Kazuhito Fukuda, Katsushi Tsukiyama, Yuichiro Yamada, Yutaka Seino, Nobuya Inagak. The effect of gastric inhibitory polypeptide on intestinal glucose absorption and intestinal motility in mice. Biochemical and biophysical research communications. vol 404. issue 1. 2011-02-14. PMID:21095180. |
gastric inhibitory polypeptide (gip) is released from the small intestine upon meal ingestion and increases insulin secretion from pancreatic β cells. |
2011-02-14 |
2023-08-12 |
mouse |
| T Edholm, M Degerblad, P Grybäck, L Hilsted, J J Holst, H Jacobsson, S Efendic, P T Schmidt, P M Hellströ. Differential incretin effects of GIP and GLP-1 on gastric emptying, appetite, and insulin-glucose homeostasis. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. vol 22. issue 11. 2011-02-08. PMID:20584260. |
the aim of this study was to investigate effects of gip and glp-1 on gastric emptying and appetite after a mixed meal, and effects on insulin secretion and glucose disposal in humans. |
2011-02-08 |
2023-08-12 |
Not clear |
| Davida F Kruger, Bruce Bode, Geralyn R Spollet. Understanding GLP-1 analogs and enhancing patients success. The Diabetes educator. vol 36 Suppl 3. 2011-02-02. PMID:20736387. |
the incretin hormones, glucagon-like peptide-1 (glp-1) and glucose-dependent insulinotropic polypeptide (gip), are now known to play major roles in endogenous glucose control, including regulation of insulin, glucagon, and hepatic glucose metabolism. |
2011-02-02 |
2023-08-12 |
Not clear |
| Nigel Irwin, Victor Gault, Peter R Flat. Therapeutic potential of the original incretin hormone glucose-dependent insulinotropic polypeptide: diabetes, obesity, osteoporosis and Alzheimer's disease? Expert opinion on investigational drugs. vol 19. issue 9. 2011-01-31. PMID:20698813. |
glucose-dependent insulinotropic polypeptide (gip) is an incretin hormone that potentiates nutrient-induced insulin release. |
2011-01-31 |
2023-08-12 |
Not clear |
| Daniel Prabakaran, Baogui Wang, Joseph D Feuerstein, Jennifer A Sinclair, Priti Bijpuria, Lisa I Jepeal, M Michael Wolf. Glucose-dependent insulinotropic polypeptide stimulates the proliferation of colorectal cancer cells. Regulatory peptides. vol 163. issue 1-3. 2011-01-26. PMID:20433877. |
glucose-dependent insulinotropic polypeptide (gip) is a gastrointestinal regulatory peptide whose primary physiologic role is to stimulate postprandial pancreatic insulin secretion. |
2011-01-26 |
2023-08-12 |
mouse |
| Daniel Prabakaran, Baogui Wang, Joseph D Feuerstein, Jennifer A Sinclair, Priti Bijpuria, Lisa I Jepeal, M Michael Wolf. Glucose-dependent insulinotropic polypeptide stimulates the proliferation of colorectal cancer cells. Regulatory peptides. vol 163. issue 1-3. 2011-01-26. PMID:20433877. |
like insulin, gip has been linked to enhanced nutrient efficiency, which occurred during the course of evolution. |
2011-01-26 |
2023-08-12 |
mouse |
| Mikkel Christensen, Filip K Knop, Tina Vilsbøll, Kasper Aaboe, Jens J Holst, Sten Madsbad, Thure Kraru. Glucagon-like peptide-2, but not glucose-dependent insulinotropic polypeptide, stimulates glucagon release in patients with type 1 diabetes. Regulatory peptides. vol 163. issue 1-3. 2011-01-26. PMID:20580750. |
this study investigated the glucagon-releasing properties of the hormones glucagon-like peptide-2 (glp-2) and glucose-dependent insulinotropic polypeptide (gip) in 8 patients with type 1 diabetes mellitus (t1dm) without paracrine intraislet influence of insulin (c-peptide negative following a 5 g intravenous arginine stimulation; on study days only treated with basal insulin substitution). |
2011-01-26 |
2023-08-12 |
Not clear |
| Su-Jin Kim, Cuilan Nian, Christopher H S McIntos. GIP increases human adipocyte LPL expression through CREB and TORC2-mediated trans-activation of the LPL gene. Journal of lipid research. vol 51. issue 11. 2011-01-19. PMID:20693566. |
gip in the presence of insulin increased lpl gene expression in human adipocytes and lpl promoter activity in gip receptor-expressing hek-293 cells, and both effects were greatly reduced by the transcription inhibitor actinomycin d. subsequent studies established that gip increased phosphorylation of serine 133 in camp-response element binding protein (creb) and the nuclear localization of camp-responsive creb coactivator 2 (torc2) through a pathway involving phosphatidylinositol 3-kinase (pi3-k), pkb, and amp-activated protein kinase (ampk). |
2011-01-19 |
2023-08-12 |
human |
| Su-Jin Kim, Cuilan Nian, Christopher H S McIntos. GIP increases human adipocyte LPL expression through CREB and TORC2-mediated trans-activation of the LPL gene. Journal of lipid research. vol 51. issue 11. 2011-01-19. PMID:20693566. |
however, in the presence of insulin, gip failed to activate the camp/pka pathway. |
2011-01-19 |
2023-08-12 |
human |
| Su-Jin Kim, Cuilan Nian, Christopher H S McIntos. GIP increases human adipocyte LPL expression through CREB and TORC2-mediated trans-activation of the LPL gene. Journal of lipid research. vol 51. issue 11. 2011-01-19. PMID:20693566. |
the lipogenic effects of gip in the presence of insulin are therefore at least partially mediated by upregulation of adipocyte lpl gene transcription through a pathway involving pi3-k/pkb/ampk-dependent creb/torc2 activation. |
2011-01-19 |
2023-08-12 |
human |
| Paul Kuo, Max Bellon, Judith Wishart, André J Smout, Richard H Holloway, Robert J L Fraser, Michael Horowitz, Karen L Jones, Christopher K Rayne. Effects of metoclopramide on duodenal motility and flow events, glucose absorption, and incretin hormone release in response to intraduodenal glucose infusion. American journal of physiology. Gastrointestinal and liver physiology. vol 299. issue 6. 2011-01-18. PMID:20829521. |
metoclopramide was associated with increased plasma concentrations of glp-1 (p < 0.05) and gip (p = 0.07) but lower plasma insulin concentrations (p < 0.05). |
2011-01-18 |
2023-08-12 |
human |
| Paul Kuo, Max Bellon, Judith Wishart, André J Smout, Richard H Holloway, Robert J L Fraser, Michael Horowitz, Karen L Jones, Christopher K Rayne. Effects of metoclopramide on duodenal motility and flow events, glucose absorption, and incretin hormone release in response to intraduodenal glucose infusion. American journal of physiology. Gastrointestinal and liver physiology. vol 299. issue 6. 2011-01-18. PMID:20829521. |
furthermore, glp-1 and gip release increased with metoclopramide, but insulin release paradoxically decreased. |
2011-01-18 |
2023-08-12 |
human |
| Michelle C Musson, Lisa I Jepeal, Torfay Sharifnia, M Michael Wolf. Evolutionary conservation of glucose-dependent insulinotropic polypeptide (GIP) gene regulation and the enteroinsular axis. Regulatory peptides. vol 164. issue 2-3. 2011-01-12. PMID:20621665. |
glucose-dependent insulinotropic polypeptide (gip), an important component of the enteroinsular axis, is a potent stimulator of insulin secretion, functioning to maintain nutrient efficiency. |
2011-01-12 |
2023-08-12 |
zebrafish |
| D Gniuli, A Calcagno, L Dalla Libera, R Calvani, L Leccesi, M E Caristo, R Vettor, M Castagneto, G Ghirlanda, G Mingron. High-fat feeding stimulates endocrine, glucose-dependent insulinotropic polypeptide (GIP)-expressing cell hyperplasia in the duodenum of Wistar rats. Diabetologia. vol 53. issue 10. 2011-01-03. PMID:20585935. |
the present study aimed to elucidate the mechanisms through which a high-fat diet (hfd) induces insulin resistance and insulin hypersecretion by focusing on the effects on enteroendocrine cells, especially those secreting glucose-dependent insulinotropic polypeptide (gip). |
2011-01-03 |
2023-08-12 |
rat |
| Jeremy A Lavine, Alan D Atti. Gastrointestinal hormones and the regulation of β-cell mass. Annals of the New York Academy of Sciences. vol 1212. 2010-12-14. PMID:21039588. |
glucagon-like peptide 1 (glp-1), glucose-dependent insulinotropic polypeptide (gip), cholecystokinin (cck), and gastrin are gastrointestinal hormones that are secreted in response to nutrient intake, regulating digestion, insulin secretion, satiety, and β-cell mass. |
2010-12-14 |
2023-08-12 |
Not clear |
| Mi Jin Moon, Hee Young Kim, Sin Gon Kim, Juri Park, Dong Seop Choi, Jong-Ik Hwang, Jae Young Seon. Tyr1 and Ile7 of glucose-dependent insulinotropic polypeptide (GIP) confer differential ligand selectivity toward GIP and glucagon-like peptide-1 receptors. Molecules and cells. vol 30. issue 2. 2010-12-13. PMID:20799012. |
glucagon like peptide-1 (glp-1) and glucose-dependent insulinotropic polypeptide (gip) are incretin hormones released in response to food intake and potentiate insulin secretion from pancreatic beta cells through their distinct yet related g protein-coupled receptors, glp1r and gipr. |
2010-12-13 |
2023-08-12 |
Not clear |
| A J Schee. [Saxagliptin (Onglyza): new inhibitor of the dipeptidylpeptidase-4 for the oral treatment of type 2 diabetes]. Revue medicale de Liege. vol 65. issue 9. 2010-12-10. PMID:21086586. |
it increases the circulating levels of incretin hormones (glp-1, gip), which contributes to amplify the insulin secretory response to meals and to reduce postprandial hyperglycaemia and, subsequently, fasting glycaemia. |
2010-12-10 |
2023-08-12 |
Not clear |
| Li Yang, Xiaoming Li, Yong Ji, Alison B Kohan, David Q-H Wang, Philip N Howles, David Y Hui, Jianghua Lai, Patrick Ts. Effect of ezetimibe on incretin secretion in response to the intestinal absorption of a mixed meal. American journal of physiology. Gastrointestinal and liver physiology. vol 299. issue 5. 2010-11-12. PMID:20651007. |
since gip and glp-1 promote the actions of insulin, we hypothesized that ezetimibe may affect the secretion of gip and glp-1 by enteroendocrine cells into lymph in response to the intestinal absorption of a mixed meal (ensure). |
2010-11-12 |
2023-08-12 |
mouse |
| Sonali H Tikhele, Raghuvir R S Pissurlenkar, Sudha Srivastava, Anil Saran, Evans C Coutinh. Mapping interactions of gastric inhibitory polypeptide with GIPR N-terminus using NMR and molecular dynamics simulations. Journal of peptide science : an official publication of the European Peptide Society. vol 16. issue 8. 2010-11-03. PMID:20607844. |
glucose-dependent insulinotropic polypeptide (gastric inhibitory polypeptide, or gip), a 42-amino acid incretin hormone, modulates insulin secretion in a glucose-concentration-dependent manner. |
2010-11-03 |
2023-08-12 |
human |
| Ashley I Taylor, Nigel Irwin, Aine M McKillop, Steven Patterson, Peter R Flatt, Victor A Gaul. Evaluation of the degradation and metabolic effects of the gut peptide xenin on insulin secretion, glycaemic control and satiety. The Journal of endocrinology. vol 207. issue 1. 2010-10-12. PMID:20631047. |
xenin also exerted an additive effect on gip, glp1 and neurotensin-mediated insulin secretion. |
2010-10-12 |
2023-08-12 |
mouse |