| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Norio Harad. [Structure and function of incretin receptor]. Nihon rinsho. Japanese journal of clinical medicine. vol 69. issue 5. 2011-07-08. PMID:21595264. |
gip and glp-1 have not only pancreatic effect, such as potentiation of insulin secretion but also many extrapancreatic effects. |
2011-07-08 |
2023-08-12 |
human |
| Masafumi Ono, Keisuke Oe, Toshiji Saibar. [Attenuation of fatty accumulation in hepatocyte by incretin--expectation of novel medicine for treatment of NASH]. Nihon rinsho. Japanese journal of clinical medicine. vol 69. issue 5. 2011-07-08. PMID:21595271. |
glucagon-like peptide 1 (glp-1) and glucose-dependent insulinotropic polypeptide(gip) function as incretin and stimulate glucose-mediated insulin production by pancreatic beta cells. |
2011-07-08 |
2023-08-12 |
Not clear |
| Mayumi Enya, Yukio Horikawa, Jun Taked. [Association between polymorphisms of TCF7L2 and type 2 diabetes with special reference to incretin action]. Nihon rinsho. Japanese journal of clinical medicine. vol 69. issue 5. 2011-07-08. PMID:21595284. |
although the mechanisms by which tcf7l2 affects susceptibility to type 2 diabetes remain to be elucidated, several studies have shown that decreased tcf7l2 protein inhibits the insulin secretory response to oral glucose through impaired incretin action(glp-1, gip). |
2011-07-08 |
2023-08-12 |
Not clear |
| Takuma Narit. [Effects of GIP receptor antagonist for treatment of obesity]. Nihon rinsho. Japanese journal of clinical medicine. vol 69. issue 5. 2011-07-08. PMID:21595285. |
glucose-dependent insulinotropic polypeptide(gip) has been known as a peptide hormone with the effects not only of the augmentation of glucose induced insulin secretion but of the fat accumulation in adipocytes, of the bone formation and of the modulation of brain function. |
2011-07-08 |
2023-08-12 |
Not clear |
| N Irwin, J M E Francis, P R Flat. Alterations of glucose-dependent insulinotropic polypeptide (GIP) during cold acclimation. Regulatory peptides. vol 167. issue 1. 2011-06-29. PMID:21146561. |
the glycaemic response to oral glucose was improved (p<0.01) in all cold exposed rats, with significantly (p<0.05) elevated gip responses in ad libitum fed rats and significantly (p<0.05) reduced insulin responses in pair fed rats. |
2011-06-29 |
2023-08-12 |
rat |
| Madeleine Speck, Young Min Cho, Ali Asadi, Francesco Rubino, Timothy J Kieffe. Duodenal-jejunal bypass protects GK rats from {beta}-cell loss and aggravation of hyperglycemia and increases enteroendocrine cells coexpressing GIP and GLP-1. American journal of physiology. Endocrinology and metabolism. vol 300. issue 5. 2011-06-28. PMID:21304061. |
blood glucose levels and glucose tolerance were monitored, and the plasma insulin, glucagon-like peptide-1 (glp-1), and glucose-dependent insulinotropic polypeptide (gip) levels were measured. |
2011-06-28 |
2023-08-12 |
rat |
| Madeleine Speck, Young Min Cho, Ali Asadi, Francesco Rubino, Timothy J Kieffe. Duodenal-jejunal bypass protects GK rats from {beta}-cell loss and aggravation of hyperglycemia and increases enteroendocrine cells coexpressing GIP and GLP-1. American journal of physiology. Endocrinology and metabolism. vol 300. issue 5. 2011-06-28. PMID:21304061. |
compared with the sham-gk rats, the djb-gk rats had an increased β-cell area and a decreased islet fibrosis, increased insulin secretion with increased glp-1 secretion in response to a mixed meal, and an increased population of cells coexpressing gip and glp-1 in the jejunum anastomosed to the stomach. |
2011-06-28 |
2023-08-12 |
rat |
| Erik N Hansen, Robyn A Tamboli, James M Isbell, Jabbar Saliba, Julia P Dunn, Pamela A Marks-Shulman, Naji N Abumra. Role of the foregut in the early improvement in glucose tolerance and insulin sensitivity following Roux-en-Y gastric bypass surgery. American journal of physiology. Gastrointestinal and liver physiology. vol 300. issue 5. 2011-06-28. PMID:21372167. |
the ratio of insulin auc to glp-1 and gip auc decreased after surgery (p =.001 and 0.061, respectively) without an effect of delivery route over time (both p ≥ 0.646). |
2011-06-28 |
2023-08-12 |
human |
| Su-Jin Kim, Cuilan Nian, Christopher H S McIntos. Adipocyte expression of the glucose-dependent insulinotropic polypeptide receptor involves gene regulation by PPARγ and histone acetylation. Journal of lipid research. vol 52. issue 4. 2011-06-23. PMID:21245029. |
gip acted synergistically with insulin to increase neutral lipid accumulation during progression of 3t3-l1 preadipocytes to the adipocyte phenotype. |
2011-06-23 |
2023-08-12 |
Not clear |
| Su-Jin Kim, Cuilan Nian, Christopher H S McIntos. Adipocyte expression of the glucose-dependent insulinotropic polypeptide receptor involves gene regulation by PPARγ and histone acetylation. Journal of lipid research. vol 52. issue 4. 2011-06-23. PMID:21245029. |
taken together, these studies show that gip and insulin act in a synergistic manner on 3t3-l1 cell development and that adipocyte gipr expression is upregulated through a mechanism involving interactions between pparγ and a gipr promoter region containing an acetylated histone region. |
2011-06-23 |
2023-08-12 |
Not clear |
| Meena Asma. New physiological effects of the incretin hormones GLP-1 and GIP. Danish medical bulletin. vol 58. issue 2. 2011-06-02. PMID:21299928. |
in the second study, we investigated the effects of gip on the removal rate of plasma tag and ffa concentrations, which were increased after either a mixed meal or infusion of intralipid and insulin. |
2011-06-02 |
2023-08-12 |
Not clear |
| Meena Asma. New physiological effects of the incretin hormones GLP-1 and GIP. Danish medical bulletin. vol 58. issue 2. 2011-06-02. PMID:21299928. |
however, we found evidence for enhanced ffa re-esterification under conditions with combined high gip and insulin concentrations. |
2011-06-02 |
2023-08-12 |
Not clear |
| Isabelle Bourdel-Marchasson, Anja Schweizer, Sylvie Dejage. Incretin therapies in the management of elderly patients with type 2 diabetes mellitus. Hospital practice (1995). vol 39. issue 1. 2011-06-02. PMID:21441754. |
incretins (glucose-dependent insulinotropic polypeptide [gip] and glucagon-like peptide-1 [glp-1]) are hormones released post-meal from intestinal endocrine cells that stimulate insulin secretion and suppress postprandial glucagon secretion in a glucose-dependent manner. |
2011-06-02 |
2023-08-12 |
Not clear |
| A P Gjesing, L L Kjems, M A Vestmar, N Grarup, A Linneberg, C F Deacon, J J Holst, O Pedersen, T Hanse. Carriers of the TCF7L2 rs7903146 TT genotype have elevated levels of plasma glucose, serum proinsulin and plasma gastric inhibitory polypeptide (GIP) during a meal test. Diabetologia. vol 54. issue 1. 2011-05-11. PMID:20957343. |
we aimed to study circulating levels of glucose, proinsulin, insulin, c-peptide, glucagon, glucagon-like peptide-1 (glp-1), glucagon-like peptide-2 (glp-2) and gastric inhibitory polypeptide (gip) among individuals carrying the high-risk rs7903146 tt genotype and low-risk cc genotype following a meal test. |
2011-05-11 |
2023-08-12 |
Not clear |
| David W Porter, Nigel Irwin, Peter R Flatt, Christian Hölscher, Victor A Gaul. Prolonged GIP receptor activation improves cognitive function, hippocampal synaptic plasticity and glucose homeostasis in high-fat fed mice. European journal of pharmacology. vol 650. issue 2-3. 2011-05-02. PMID:21050845. |
(d-ala(2))gip did not affect food intake or plasma insulin levels irrespective of diet. |
2011-05-02 |
2023-08-12 |
mouse |
| Y M Cho, T J Kieffe. New aspects of an old drug: metformin as a glucagon-like peptide 1 (GLP-1) enhancer and sensitiser. Diabetologia. vol 54. issue 2. 2011-05-02. PMID:21116606. |
moreover, they show that metformin enhances the expression of the genes encoding the receptors for both glp-1 and glucose-dependent insulinotropic polypeptide (gip) in mouse islets and also increases the effects of gip and glp-1 on insulin secretion from beta cells. |
2011-05-02 |
2023-08-12 |
mouse |
| Victor A Gault, David W Porter, Nigel Irwin, Peter R Flat. Comparison of sub-chronic metabolic effects of stable forms of naturally occurring GIP(1-30) and GIP(1-42) in high-fat fed mice. The Journal of endocrinology. vol 208. issue 3. 2011-04-20. PMID:21212092. |
glucose-dependent insulinotropic polypeptide (gip) is a 42 amino acid hormone secreted from intestinal k-cells, which exhibits a number of actions including stimulation of insulin release. |
2011-04-20 |
2023-08-12 |
mouse |
| Prajwal R Regmi, Theo A T G van Kempen, J Jacques Matte, Ruurd T Zijlstr. Starch with high amylose and low in vitro digestibility increases short-chain fatty acid absorption, reduces peak insulin secretion, and modulates incretin secretion in pigs. The Journal of nutrition. vol 141. issue 3. 2011-04-20. PMID:21248198. |
the npa of glucose, insulin, c-peptide, and glucose-dependent insulinotropic polypeptide (gip) during 0-4 h postprandial were lower (p < 0.05) and those of butyrate and total scfa were higher (p < 0.05) when pigs consumed the diet containing slowly digestible compared with rapidly digestible starch. |
2011-04-20 |
2023-08-12 |
Not clear |
| Prajwal R Regmi, Theo A T G van Kempen, J Jacques Matte, Ruurd T Zijlstr. Starch with high amylose and low in vitro digestibility increases short-chain fatty acid absorption, reduces peak insulin secretion, and modulates incretin secretion in pigs. The Journal of nutrition. vol 141. issue 3. 2011-04-20. PMID:21248198. |
in conclusion, starch with high amylose and low in vitro digestibility decreases the kinetics of glucose absorption and insulin and gip secretion and increases scfa absorption and glucagon-like peptide-1 secretion. |
2011-04-20 |
2023-08-12 |
Not clear |
| R Lupi, S Del Guerra, V D'Aleo, U Boggi, F Filipponi, P Marchett. The direct effects of GLP-1 and GIP, alone or in combination, on human pancreatic islets. Regulatory peptides. vol 165. issue 2-3. 2011-04-14. PMID:20472004. |
acutely, both glp-1 and, more markedly so, gip, significantly potentiated glucose-stimulated insulin release, with no apparent synergic action. |
2011-04-14 |
2023-08-12 |
human |