| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Renate E van Genugten, Daniël H van Raalte, Michaela Diaman. Does glucagon-like peptide-1 receptor agonist therapy add value in the treatment of type 2 diabetes? Focus on exenatide. Diabetes research and clinical practice. vol 86 Suppl 1. 2010-04-23. PMID:20115929. |
the incretin hormones glucagon-like peptide (glp)-1 and glucose-dependent insulinotropic polypeptide (gip) are secreted in the gut upon meal ingestion and lower blood glucose by glucose-dependent stimulation of insulin secretion and production. |
2010-04-23 |
2023-08-12 |
Not clear |
| Maria P Yavropoulou, Kalliopi Kotsa, Isaak Kesisoglou, Anna Gotzamani-Psarakou, John G Yovo. Effect of intracerebroventricular infusion of neurotensin in glucose-dependent insulinotropic peptide secretion in dogs. Peptides. vol 31. issue 1. 2010-04-22. PMID:19799951. |
we have previously studied the effect of intracerebroventricular (icv) infusion of insulin, npy and bombesin in the regulation of gip secretion. |
2010-04-22 |
2023-08-12 |
Not clear |
| Maria P Yavropoulou, Kalliopi Kotsa, Isaak Kesisoglou, Anna Gotzamani-Psarakou, John G Yovo. Effect of intracerebroventricular infusion of neurotensin in glucose-dependent insulinotropic peptide secretion in dogs. Peptides. vol 31. issue 1. 2010-04-22. PMID:19799951. |
plasma levels of glucose, insulin and gip were assayed. |
2010-04-22 |
2023-08-12 |
Not clear |
| A-J Scheen, J De Flines, A De Roover, N Paquo. Bariatric surgery in patients with type 2 diabetes: benefits, risks, indications and perspectives. Diabetes & metabolism. vol 35. issue 6 Pt 2. 2010-04-12. PMID:20152741. |
indeed, increased levels of glucagon-like peptide-1 (glp-1) and glucose-dependent insulinotropic polypeptide (gip) may lead to improved beta-cell function and insulin secretion as well as reduced insulin resistance associated with weight loss. |
2010-04-12 |
2023-08-12 |
Not clear |
| Josina M Rijkelijkhuizen, Kelly McQuarrie, Cynthia J Girman, Peter P Stein, Andrea Mari, Jens J Holst, Giel Nijpels, Jacqueline M Dekke. Effects of meal size and composition on incretin, alpha-cell, and beta-cell responses. Metabolism: clinical and experimental. vol 59. issue 4. 2010-04-07. PMID:19846181. |
the incretins glucagon-like peptide-1 (glp-1) and glucose-dependent insulinotropic polypeptide (gip) regulate postprandial insulin release from the beta-cells. |
2010-04-07 |
2023-08-12 |
human |
| Josina M Rijkelijkhuizen, Kelly McQuarrie, Cynthia J Girman, Peter P Stein, Andrea Mari, Jens J Holst, Giel Nijpels, Jacqueline M Dekke. Effects of meal size and composition on incretin, alpha-cell, and beta-cell responses. Metabolism: clinical and experimental. vol 59. issue 4. 2010-04-07. PMID:19846181. |
non-model-based and model-based estimates of beta-cell function and incremental areas under the curve of glucose, insulin, c-peptide, glucagon, glp-1, and gip were calculated. |
2010-04-07 |
2023-08-12 |
human |
| Meena Asmar, Winnie Tangaa, Sten Madsbad, Kristine Hare, Arne Astrup, Anne Flint, Jens Bülow, Jens Juul Hols. On the role of glucose-dependent insulintropic polypeptide in postprandial metabolism in humans. American journal of physiology. Endocrinology and metabolism. vol 298. issue 3. 2010-03-30. PMID:19996386. |
insulin increased on all gip days compared with saline days (p < 0.05). |
2010-03-30 |
2023-08-12 |
Not clear |
| Meena Asmar, Winnie Tangaa, Sten Madsbad, Kristine Hare, Arne Astrup, Anne Flint, Jens Bülow, Jens Juul Hols. On the role of glucose-dependent insulintropic polypeptide in postprandial metabolism in humans. American journal of physiology. Endocrinology and metabolism. vol 298. issue 3. 2010-03-30. PMID:19996386. |
however, both insulin and gip lower post-intralipid ffa concentration, gip probably via stimulation of insulin secretion, increasing ffa reesterification. |
2010-03-30 |
2023-08-12 |
Not clear |
| Jeffrey S Freema. Role of the incretin pathway in the pathogenesis of type 2 diabetes mellitus. Cleveland Clinic journal of medicine. vol 76 Suppl 5. 2010-03-16. PMID:19952298. |
nutrient intake stimulates the secretion of the gastrointestinal incretin hormones, glucagon-like peptide-1 (glp-1) and glucose-dependent insulinotropic polypeptide (gip), which exert glucose-dependent insulinotropic effects and assist pancreatic insulin and glucagon in maintaining glucose homeostasis. |
2010-03-16 |
2023-08-12 |
Not clear |
| Unmesh Sha. GPR119 agonists: a promising new approach for the treatment of type 2 diabetes and related metabolic disorders. Current opinion in drug discovery & development. vol 12. issue 4. 2010-01-28. PMID:19562648. |
the activation of gpr119 increases the intracellular accumulation of camp, leading to enhanced glucose-dependent insulin secretion and increased levels of the incretin hormones glp-1 (glucagon-like peptide 1) and gip (glucose-dependent insulinotropic peptide). |
2010-01-28 |
2023-08-12 |
human |
| N Irwin, P R Flat. Evidence for beneficial effects of compromised gastric inhibitory polypeptide action in obesity-related diabetes and possible therapeutic implications. Diabetologia. vol 52. issue 9. 2010-01-08. PMID:19533083. |
the presence of functional gip receptors on adipocytes and the key role played by gip in lipid metabolism and fat deposition suggest a possible beneficial effect of compromised gip action in obesity and insulin resistance. |
2010-01-08 |
2023-08-12 |
Not clear |
| N Irwin, P R Flat. Evidence for beneficial effects of compromised gastric inhibitory polypeptide action in obesity-related diabetes and possible therapeutic implications. Diabetologia. vol 52. issue 9. 2010-01-08. PMID:19533083. |
in addition, by causing preferential oxidation of fat, blockade of gip signalling clears triacylglycerol deposits from liver and muscle, thereby restoring mechanisms for suppression of hepatic glucose output and improving insulin sensitivity. |
2010-01-08 |
2023-08-12 |
Not clear |
| J M García-Martínez, A Chocarro-Calvo, C M Moya, C García-Jiméne. WNT/beta-catenin increases the production of incretins by entero-endocrine cells. Diabetologia. vol 52. issue 9. 2010-01-08. PMID:19582394. |
rates of diet-induced obesity, insulin resistance and type 2 diabetes are decreased when gip signalling is disturbed in mice, suggesting that gip plays a role in the onset of type 2 diabetes. |
2010-01-08 |
2023-08-12 |
mouse |
| Ryuichi Moriya, Takashi Shirakura, Junko Ito, Satoshi Mashiko, Toru Se. Activation of sodium-glucose cotransporter 1 ameliorates hyperglycemia by mediating incretin secretion in mice. American journal of physiology. Endocrinology and metabolism. vol 297. issue 6. 2009-12-23. PMID:19808907. |
interestingly, oral administration of mdg significantly increased plasma gip, glp-1, and insulin levels and reduced blood glucose levels during an intraperitoneal glucose tolerance test. |
2009-12-23 |
2023-08-12 |
mouse |
| Scott B Widenmaier, Ziliang Ao, Su-Jin Kim, Garth Warnock, Christopher H S McIntos. Suppression of p38 MAPK and JNK via Akt-mediated inhibition of apoptosis signal-regulating kinase 1 constitutes a core component of the beta-cell pro-survival effects of glucose-dependent insulinotropic polypeptide. The Journal of biological chemistry. vol 284. issue 44. 2009-12-14. PMID:19748889. |
glucose-dependent insulinotropic polypeptide (gip) potentiates glucose-stimulated insulin secretion, insulin biosynthesis, and beta-cell proliferation and survival. |
2009-12-14 |
2023-08-12 |
human |
| Michelle C Musson, Lisa I Jepeal, Patrick D Mabray, Irina V Zhdanova, Wellington V Cardoso, M Michael Wolf. Expression of glucose-dependent insulinotropic polypeptide in the zebrafish. American journal of physiology. Regulatory, integrative and comparative physiology. vol 297. issue 6. 2009-12-11. PMID:19793957. |
in mammals, glucose-dependent insulinotropic polypeptide (gip) is synthesized predominately in the small intestine and functions in conjunction with insulin to promote nutrient deposition. |
2009-12-11 |
2023-08-12 |
rat |
| Michelle C Musson, Lisa I Jepeal, Patrick D Mabray, Irina V Zhdanova, Wellington V Cardoso, M Michael Wolf. Expression of glucose-dependent insulinotropic polypeptide in the zebrafish. American journal of physiology. Regulatory, integrative and comparative physiology. vol 297. issue 6. 2009-12-11. PMID:19793957. |
analysis of gip and insulin (insa) expression in zebrafish larvae by rt-pcr demonstrated that although insa was detected as early as 24 h postfertilization (hpf), gip expression was not demonstrated until 72 hpf, shortly after the completion of endocrine pancreatic development but prior to the commencement of independent feeding. |
2009-12-11 |
2023-08-12 |
rat |
| Mark Kirby, Denise M T Yu, Steven O'Connor, Mark D Gorrel. Inhibitor selectivity in the clinical application of dipeptidyl peptidase-4 inhibition. Clinical science (London, England : 1979). vol 118. issue 1. 2009-12-02. PMID:19780719. |
dpp-4 (dipeptidyl peptidase-4) degrades the incretin hormones glp-1 (glucagon-like peptide-1) and gip (gastric inhibitory polypeptide), decreasing their stimulatory effects on beta-cell insulin secretion. |
2009-12-02 |
2023-08-12 |
Not clear |
| Sarah Melissa P Jacobo, Marcy L Guerra, Gregory H Hockerma. Cav1.2 and Cav1.3 are differentially coupled to glucagon-like peptide-1 potentiation of glucose-stimulated insulin secretion in the pancreatic beta-cell line INS-1. The Journal of pharmacology and experimental therapeutics. vol 331. issue 2. 2009-11-30. PMID:19710366. |
the incretin peptides, glucose-dependent insulinotropic polypeptide (gip) and glucagon-like peptide-1 (glp-1), potentiate glucose-stimulated insulin secretion (gsis) and beta-cell proliferation and differentiation. |
2009-11-30 |
2023-08-12 |
Not clear |
| Rolf Mentlei. Mechanisms underlying the rapid degradation and elimination of the incretin hormones GLP-1 and GIP. Best practice & research. Clinical endocrinology & metabolism. vol 23. issue 4. 2009-11-23. PMID:19748062. |
the incretin hormones glucagon-like peptide-1 (glp-1) and glucose-dependent insulinotropic peptide (gip, gastric inhibitory peptide) are secreted from intestinal l and k cells and stimulate insulin secretion from pancreatic beta cells. |
2009-11-23 |
2023-08-12 |
Not clear |