| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jing Ma, Max Bellon, Judith M Wishart, Richard Young, L Ashley Blackshaw, Karen L Jones, Michael Horowitz, Christopher K Rayne. Effect of the artificial sweetener, sucralose, on gastric emptying and incretin hormone release in healthy subjects. American journal of physiology. Gastrointestinal and liver physiology. vol 296. issue 4. 2009-06-17. PMID:19221011. |
glp-1, gip, and insulin also increased after sucrose (p=0.0001) but not after either load of sucralose or saline. |
2009-06-17 |
2023-08-12 |
mouse |
| Jing Ma, Max Bellon, Judith M Wishart, Richard Young, L Ashley Blackshaw, Karen L Jones, Michael Horowitz, Christopher K Rayne. Effect of the artificial sweetener, sucralose, on gastric emptying and incretin hormone release in healthy subjects. American journal of physiology. Gastrointestinal and liver physiology. vol 296. issue 4. 2009-06-17. PMID:19221011. |
we conclude that sucralose, delivered by intragastric infusion, does not stimulate insulin, glp-1, or gip release or slow gastric emptying in healthy humans. |
2009-06-17 |
2023-08-12 |
mouse |
| Anita Mofidi Najjar, Patricia M Parsons, Alison M Duncan, Lindsay E Robinson, Rickey Y Yada, Terry E Graha. The acute impact of ingestion of breads of varying composition on blood glucose, insulin and incretins following first and second meals. The British journal of nutrition. vol 101. issue 3. 2009-06-11. PMID:18570696. |
blood was sampled for 3 h following bread ingestion and a further 2 h after the second meal for determination of glucose, insulin, paracetamol (indirect marker of gastric emptying), glucose-dependent insulinotropic polypeptide (gip) and glucagon-like peptide-1 (glp-1). |
2009-06-11 |
2023-08-12 |
human |
| Akira Shimotoyodome, Daisuke Fukuoka, Junko Suzuki, Yoshie Fujii, Tomohito Mizuno, Shinichi Meguro, Ichiro Tokimitsu, Tadashi Has. Coingestion of acylglycerols differentially affects glucose-induced insulin secretion via glucose-dependent insulinotropic polypeptide in C57BL/6J mice. Endocrinology. vol 150. issue 5. 2009-06-08. PMID:19179446. |
diacylglycerol (dag) promoted lower postprandial gip and triglyceride responses and, when ingested with glucose, a lower insulin response compared with triacylglycerol of a similar fatty acid composition. |
2009-06-08 |
2023-08-12 |
mouse |
| Akira Shimotoyodome, Daisuke Fukuoka, Junko Suzuki, Yoshie Fujii, Tomohito Mizuno, Shinichi Meguro, Ichiro Tokimitsu, Tadashi Has. Coingestion of acylglycerols differentially affects glucose-induced insulin secretion via glucose-dependent insulinotropic polypeptide in C57BL/6J mice. Endocrinology. vol 150. issue 5. 2009-06-08. PMID:19179446. |
dag promotes a lower gip and thereby reduced insulin responses compared with triacylglycerol, which may differentially influence postprandial energy homeostasis. |
2009-06-08 |
2023-08-12 |
mouse |
| P V Højberg, T Vilsbøll, R Rabøl, F K Knop, M Bache, T Krarup, J J Holst, S Madsba. Four weeks of near-normalisation of blood glucose improves the insulin response to glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide in patients with type 2 diabetes. Diabetologia. vol 52. issue 2. 2009-05-15. PMID:19037628. |
the aim of the present study was to investigate whether 4 weeks of near-normalisation of the blood glucose level could improve insulin responses to gip and glp-1 in patients with type 2 diabetes. |
2009-05-15 |
2023-08-12 |
Not clear |
| Barry D Kerr, Nigel Irwin, Peter R Flatt, Victor A Gaul. Prolonged GIP receptor activation using stable mini-PEGylated GIP improves glucose homeostasis and beta-cell function in age-related glucose intolerance. Peptides. vol 30. issue 2. 2009-05-07. PMID:19026698. |
gip[mpeg] decreased glucose and increased insulin concentrations when administered prior to a glucose challenge. |
2009-05-07 |
2023-08-12 |
mouse |
| Pernille Fog Svendsen, Lisbeth Nilas, Sten Madsbad, Jens Juul Hols. Incretin hormone secretion in women with polycystic ovary syndrome: roles of obesity, insulin sensitivity, and treatment with metformin. Metabolism: clinical and experimental. vol 58. issue 5. 2009-05-04. PMID:19375579. |
in normal subjects, the incretin hormones glucagon-like peptide-1 (glp-1) and glucose-dependent insulinotropic polypeptide (gip) are responsible for 70% of the insulin response during a meal; but in diabetic subjects and other insulin-resistant conditions, the incretin effect is impaired. |
2009-05-04 |
2023-08-12 |
human |
| Pernille Fog Svendsen, Lisbeth Nilas, Sten Madsbad, Jens Juul Hols. Incretin hormone secretion in women with polycystic ovary syndrome: roles of obesity, insulin sensitivity, and treatment with metformin. Metabolism: clinical and experimental. vol 58. issue 5. 2009-05-04. PMID:19375579. |
plasma concentrations of gip and glp-1 were determined frequently during a 75-g glucose tolerance test, and insulin sensitivity was evaluated by the euglycemic hyperinsulinemic clamp. |
2009-05-04 |
2023-08-12 |
human |
| T Edholm, K Cejvan, S M Abdel-Halim, S Efendic, P T Schmidt, P M Hellströ. The incretin hormones GIP and GLP-1 in diabetic rats: effects on insulin secretion and small bowel motility. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. vol 21. issue 3. 2009-05-01. PMID:19126188. |
the incretin hormones gip and glp-1 in diabetic rats: effects on insulin secretion and small bowel motility. |
2009-05-01 |
2023-08-12 |
rat |
| T Edholm, K Cejvan, S M Abdel-Halim, S Efendic, P T Schmidt, P M Hellströ. The incretin hormones GIP and GLP-1 in diabetic rats: effects on insulin secretion and small bowel motility. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. vol 21. issue 3. 2009-05-01. PMID:19126188. |
the aim of this study was to investigate if altered responsiveness to glucose-dependent insulinotropic peptide (gip) and glucagon-like peptide-1 (glp-1) as regards insulin release and small bowel motility could bring further clarity to the pathophysiology of diabetes in the goto-kakizaki (gk) rat. |
2009-05-01 |
2023-08-12 |
rat |
| T Edholm, K Cejvan, S M Abdel-Halim, S Efendic, P T Schmidt, P M Hellströ. The incretin hormones GIP and GLP-1 in diabetic rats: effects on insulin secretion and small bowel motility. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. vol 21. issue 3. 2009-05-01. PMID:19126188. |
under euglycemia, gip and glp-1 stimulated the initial insulin response by 10-fold in gk rats (p < 0.05). |
2009-05-01 |
2023-08-12 |
rat |
| T Edholm, K Cejvan, S M Abdel-Halim, S Efendic, P T Schmidt, P M Hellströ. The incretin hormones GIP and GLP-1 in diabetic rats: effects on insulin secretion and small bowel motility. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. vol 21. issue 3. 2009-05-01. PMID:19126188. |
at later hyperglycemia, the insulin response to gip and glp-1 was blunted to about one-third compared with controls (p < 0.05). |
2009-05-01 |
2023-08-12 |
rat |
| T Edholm, K Cejvan, S M Abdel-Halim, S Efendic, P T Schmidt, P M Hellströ. The incretin hormones GIP and GLP-1 in diabetic rats: effects on insulin secretion and small bowel motility. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. vol 21. issue 3. 2009-05-01. PMID:19126188. |
the initially high, but later low insulin responsiveness to stimulation with gip and glp-1 along with inhibition of small bowel motility in the gk rat indicates a preserved incretin response on motility in diabetes type 2. |
2009-05-01 |
2023-08-12 |
rat |
| Feruze Yilmaz Enç, Tunç Ones, H Levent Akin, Fuat Dede, H Turgut Turoğlu, Gözde Ulfer, Nural Bekiroğlu, Goncagül Haklar, Jens F Rehfeld, Jens J Holst, Nefise B Ulusoy, Neşe Imeryü. Orlistat accelerates gastric emptying and attenuates GIP release in healthy subjects. American journal of physiology. Gastrointestinal and liver physiology. vol 296. issue 3. 2009-04-28. PMID:19109408. |
orlistat significantly attenuated the secretion of glucose-dependent insulinotropic polypeptide (gip) but did not alter the plasma responses of cholecystokinin (cck), glucagon-like peptide-1 (glp-1), pancreatic polypeptide (pp), and insulin. |
2009-04-28 |
2023-08-12 |
human |
| Martha M Funnel. The therapeutic role of incretin mimetics and DPP-4 inhibitors. The Diabetes educator. vol 35 Suppl 1. 2009-04-27. PMID:19218562. |
gastric inhibitory peptide (gip) and glucagon-like peptide-1 (glp-1) stimulate the secretion of insulin when blood glucose levels are elevated and inhibit the postprandial release of glucagon. |
2009-04-27 |
2023-08-12 |
Not clear |
| Yukihiro Fujita, Rhonda D Wideman, Madeleine Speck, Ali Asadi, David S King, Travis D Webber, Masakazu Haneda, Timothy J Kieffe. Incretin release from gut is acutely enhanced by sugar but not by sweeteners in vivo. American journal of physiology. Endocrinology and metabolism. vol 296. issue 3. 2009-04-20. PMID:19106249. |
glucose-dependent insulinotropic polypeptide (gip) and glucagon-like peptide-1 (glp-1) are released during meals from endocrine cells located in the gut mucosa and stimulate insulin secretion from pancreatic beta-cells in a glucose-dependent manner. |
2009-04-20 |
2023-08-12 |
rat |
| Filip K Knop, Tina Vilsbøll, Jens J Hols. Incretin-based therapy of type 2 diabetes mellitus. Current protein & peptide science. vol 10. issue 1. 2009-04-07. PMID:19275672. |
therefore, the actions of glp-1 and gip, which include potentation of meal-induced insulin secretion and trophic effects on the beta-cell, have attracted a lot of interest. |
2009-04-07 |
2023-08-12 |
Not clear |
| F M Gribbl. RD Lawrence Lecture 2008: Targeting GLP-1 release as a potential strategy for the therapy of Type 2 diabetes. Diabetic medicine : a journal of the British Diabetic Association. vol 25. issue 8. 2009-04-02. PMID:18959599. |
glucagon-like peptide-1 (glp-1) and glucose-dependent insulinotropic polypeptide (gip) are gastrointestinal hormones that play an important role in stimulating postprandial insulin release from pancreatic beta-cells. |
2009-04-02 |
2023-08-12 |
Not clear |
| Rajesh Gupta, Sameer S Walunj, Ranjeet K Tokala, Kishore V L Parsa, Santosh Kumar Singh, Manojit Pa. Emerging drug candidates of dipeptidyl peptidase IV (DPP IV) inhibitor class for the treatment of Type 2 Diabetes. Current drug targets. vol 10. issue 1. 2009-03-27. PMID:19149538. |
inhibition of plasma dpp iv enzyme leads to enhanced endogenous glp-1 and gip activity, which ultimately results in the potentiation of insulin secretion by pancreatic beta-cells and subsequent lowering of blood glucose levels, hba[1(c)], glucagon secretion and liver glucose production. |
2009-03-27 |
2023-08-12 |
Not clear |