| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Barry D Kerr, Nigel Irwin, Finbarr P M O'Harte, Clifford J Bailey, Peter R Flatt, Victor A Gaul. Fatty acid derivatised analogues of glucose-dependent insulinotropic polypeptide with improved antihyperglycaemic and insulinotropic properties. Biochemical pharmacology. vol 78. issue 8. 2009-10-19. PMID:19523458. |
all gip analogues exhibited resistance to dipeptidylpeptidase-iv (dpp-iv) and significantly improved in vitro camp production and insulin secretion. |
2009-10-19 |
2023-08-12 |
mouse |
| Barry D Kerr, Nigel Irwin, Finbarr P M O'Harte, Clifford J Bailey, Peter R Flatt, Victor A Gaul. Fatty acid derivatised analogues of glucose-dependent insulinotropic polypeptide with improved antihyperglycaemic and insulinotropic properties. Biochemical pharmacology. vol 78. issue 8. 2009-10-19. PMID:19523458. |
administration of gip analogues to ob/ob mice significantly lowered plasma glucose-gip(lys(37)myr), n-acgip(lys(37)myr) and gip(lys(37)pal) increased plasma insulin concentrations. |
2009-10-19 |
2023-08-12 |
mouse |
| Barry D Kerr, Nigel Irwin, Finbarr P M O'Harte, Clifford J Bailey, Peter R Flatt, Victor A Gaul. Fatty acid derivatised analogues of glucose-dependent insulinotropic polypeptide with improved antihyperglycaemic and insulinotropic properties. Biochemical pharmacology. vol 78. issue 8. 2009-10-19. PMID:19523458. |
daily administration of gip(lys(37)myr) and n-acgip(lys(37)myr) to ob/ob mice for 24 days decreased glucose and significantly improved plasma insulin, glucose tolerance and beta-cell glucose responsiveness. |
2009-10-19 |
2023-08-12 |
mouse |
| C Daousi, J P H Wilding, S Aditya, B H Durham, J Cleator, J H Pinkney, L R Ranganat. Effects of peripheral administration of synthetic human glucose-dependent insulinotropic peptide (GIP) on energy expenditure and subjective appetite sensations in healthy normal weight subjects and obese patients with type 2 diabetes. Clinical endocrinology. vol 71. issue 2. 2009-09-28. PMID:19178509. |
apart from their role in insulin secretion and glucose homeostasis, the incretin hormones glucagon-like peptide-1 (glp-1) and glucose-dependent insulinotropic peptide (gip) exert a number of extra-pancreatic effects which in the case of gip remain largely unknown. |
2009-09-28 |
2023-08-12 |
human |
| Charlotte Brøns, Christine B Jensen, Heidi Storgaard, Natalie J Hiscock, Andrew White, Julie S Appel, Stine Jacobsen, Emma Nilsson, Claus M Larsen, Arne Astrup, Bjørn Quistorff, Allan Vaa. Impact of short-term high-fat feeding on glucose and insulin metabolism in young healthy men. The Journal of physiology. vol 587. issue Pt 10. 2009-09-03. PMID:19332493. |
the increased insulin secretion may compensate for hepatic insulin resistance possibly mediated by elevated gip secretion. |
2009-09-03 |
2023-08-12 |
Not clear |
| Charlotte Brøns, Christine B Jensen, Heidi Storgaard, Natalie J Hiscock, Andrew White, Julie S Appel, Stine Jacobsen, Emma Nilsson, Claus M Larsen, Arne Astrup, Bjørn Quistorff, Allan Vaa. Impact of short-term high-fat feeding on glucose and insulin metabolism in young healthy men. The Journal of physiology. vol 587. issue Pt 10. 2009-09-03. PMID:19332493. |
increased insulin secretion precedes the development of peripheral insulin resistance, mitochondrial dysfunction and obesity in response to overfeeding, suggesting a role for insulin per se as well gip, in the development of peripheral insulin resistance and obesity. |
2009-09-03 |
2023-08-12 |
Not clear |
| Maria P Yavropoulou, Kalliopi Kotsa, Olympia Anastasiou, Thomas M O'Dorisio, Theodore N Pappas, John G Yovo. Effect of intracerebroventricular infusion of insulin on glucose-dependent insulinotropic peptide in dogs. Neuroscience letters. vol 460. issue 2. 2009-09-02. PMID:19477229. |
the aim of this study was to evaluate a possible effect of intracerebroventricular administration of insulin in a centrally mediated regulation of gip. |
2009-09-02 |
2023-08-12 |
Not clear |
| Luan Shu, Aleksey V Matveyenko, Julie Kerr-Conte, Jae-Hyoung Cho, Christopher H S McIntosh, Kathrin Maedle. Decreased TCF7L2 protein levels in type 2 diabetes mellitus correlate with downregulation of GIP- and GLP-1 receptors and impaired beta-cell function. Human molecular genetics. vol 18. issue 13. 2009-08-13. PMID:19386626. |
also, insulin secretion stimulated by glucose, glp-1 and gip, but not kcl or cyclic adenosine monophosphate (camp) was impaired in sitcf7l2-treated isolated human islets. |
2009-08-13 |
2023-08-12 |
mouse |
| Bettina A Buhren, Marcia Gasis, Bernard Thorens, Hans Werner Müller, Frank Boss. Glucose-dependent insulinotropic polypeptide (GIP) and its receptor (GIPR): cellular localization, lesion-affected expression, and impaired regenerative axonal growth. Journal of neuroscience research. vol 87. issue 8. 2009-07-30. PMID:19170165. |
glucose-dependent insulinotropic polypeptide (gip) was initially described to be rapidly regulated by endocrine cells in response to nutrient ingestion, with stimulatory effects on insulin synthesis and release. |
2009-07-30 |
2023-08-12 |
mouse |
| Karen R Kelly, Latina M Brooks, Thomas P J Solomon, Sangeeta R Kashyap, Valerie B O'Leary, John P Kirwa. The glucose-dependent insulinotropic polypeptide and glucose-stimulated insulin response to exercise training and diet in obesity. American journal of physiology. Endocrinology and metabolism. vol 296. issue 6. 2009-07-16. PMID:19351807. |
aging and obesity are characterized by decreased beta-cell sensitivity and defects in the potentiation of nutrient-stimulated insulin secretion by gip. |
2009-07-16 |
2023-08-12 |
Not clear |
| Karen R Kelly, Latina M Brooks, Thomas P J Solomon, Sangeeta R Kashyap, Valerie B O'Leary, John P Kirwa. The glucose-dependent insulinotropic polypeptide and glucose-stimulated insulin response to exercise training and diet in obesity. American journal of physiology. Endocrinology and metabolism. vol 296. issue 6. 2009-07-16. PMID:19351807. |
exercise and diet are known to improve glucose metabolism and the pancreatic insulin response to glucose, and this effect may be mediated through the incretin effect of gip. |
2009-07-16 |
2023-08-12 |
Not clear |
| Karen R Kelly, Latina M Brooks, Thomas P J Solomon, Sangeeta R Kashyap, Valerie B O'Leary, John P Kirwa. The glucose-dependent insulinotropic polypeptide and glucose-stimulated insulin response to exercise training and diet in obesity. American journal of physiology. Endocrinology and metabolism. vol 296. issue 6. 2009-07-16. PMID:19351807. |
in addition to gip, plasma pyy(3-36), insulin, and glucose responses were measured during a 3-h, 75-g oral glucose tolerance test. |
2009-07-16 |
2023-08-12 |
Not clear |
| Karen R Kelly, Latina M Brooks, Thomas P J Solomon, Sangeeta R Kashyap, Valerie B O'Leary, John P Kirwa. The glucose-dependent insulinotropic polypeptide and glucose-stimulated insulin response to exercise training and diet in obesity. American journal of physiology. Endocrinology and metabolism. vol 296. issue 6. 2009-07-16. PMID:19351807. |
the glucose-stimulated insulin response was reduced after ex-hypo (p = 0.02), as was the glucose-stimulated gip response (p < 0.05). |
2009-07-16 |
2023-08-12 |
Not clear |
| Karen R Kelly, Latina M Brooks, Thomas P J Solomon, Sangeeta R Kashyap, Valerie B O'Leary, John P Kirwa. The glucose-dependent insulinotropic polypeptide and glucose-stimulated insulin response to exercise training and diet in obesity. American journal of physiology. Endocrinology and metabolism. vol 296. issue 6. 2009-07-16. PMID:19351807. |
furthermore, after the intervention, changes in insulin (deltai(0-30)/deltag(0-30)) and gip (delta(0-30)) secretion were correlated (r = 0.69, p = 0.05). |
2009-07-16 |
2023-08-12 |
Not clear |
| Karen R Kelly, Latina M Brooks, Thomas P J Solomon, Sangeeta R Kashyap, Valerie B O'Leary, John P Kirwa. The glucose-dependent insulinotropic polypeptide and glucose-stimulated insulin response to exercise training and diet in obesity. American journal of physiology. Endocrinology and metabolism. vol 296. issue 6. 2009-07-16. PMID:19351807. |
we conclude that 1) a combination of caloric restriction and exercise reduces the gip response to ingested glucose, 2) gip may mediate the attenuated glucose-stimulated insulin response after exercise/diet interventions, and 3) the increased pyy(3-36) response represents an improved capacity to regulate satiety and potentially body weight in older, obese, insulin-resistant adults. |
2009-07-16 |
2023-08-12 |
Not clear |
| Christopher H S McIntosh, Scott Widenmaier, Su-Jin Ki. Glucose-dependent insulinotropic polypeptide (Gastric Inhibitory Polypeptide; GIP). Vitamins and hormones. vol 80. 2009-06-23. PMID:19251046. |
both gip and glucagon-like peptide-1 (glp-1) stimulate insulin secretion in a glucose-dependent manner and are thus classified as incretins. |
2009-06-23 |
2023-08-12 |
Not clear |
| Christopher H S McIntosh, Scott Widenmaier, Su-Jin Ki. Glucose-dependent insulinotropic polypeptide (Gastric Inhibitory Polypeptide; GIP). Vitamins and hormones. vol 80. 2009-06-23. PMID:19251046. |
in adipose tissue, gip interacts with insulin to increase lipoprotein lipase activity and lipogenesis. |
2009-06-23 |
2023-08-12 |
Not clear |
| Xibao Liu, Norio Harada, Shunsuke Yamane, Lisa Kitajima, Saeko Uchida, Akihiro Hamasaki, Eri Mukai, Kentaro Toyoda, Chizumi Yamada, Yuichiro Yamada, Yutaka Seino, Nobuya Inagak. Effects of long-term dipeptidyl peptidase-IV inhibition on body composition and glucose tolerance in high fat diet-fed mice. Life sciences. vol 84. issue 25-26. 2009-06-23. PMID:19358859. |
however, the magnitude of the effects of enhanced glp-1 and gip signaling by long-term dpp-iv inhibition on body weight and insulin secretion has not been determined. |
2009-06-23 |
2023-08-12 |
mouse |
| Jing Ma, Max Bellon, Judith M Wishart, Richard Young, L Ashley Blackshaw, Karen L Jones, Michael Horowitz, Christopher K Rayne. Effect of the artificial sweetener, sucralose, on gastric emptying and incretin hormone release in healthy subjects. American journal of physiology. Gastrointestinal and liver physiology. vol 296. issue 4. 2009-06-17. PMID:19221011. |
we studied blood glucose, plasma levels of insulin, glp-1, and gip, and gastric emptying (by a breath test) in 7 healthy humans after intragastric infusions of 1) 50 g sucrose in water to a total volume of 500 ml (approximately 290 mosmol/l), 2) 80 mg sucralose in 500 ml normal saline (approximately 300 mosmol/l, 0.4 mm sucralose), 3) 800 mg sucralose in 500 ml normal saline (approximately 300 mosmol/l, 4 mm sucralose), and 4) 500 ml normal saline (approximately 300 mosmol/l), all labeled with 150 mg 13c-acetate. |
2009-06-17 |
2023-08-12 |
mouse |
| Jing Ma, Max Bellon, Judith M Wishart, Richard Young, L Ashley Blackshaw, Karen L Jones, Michael Horowitz, Christopher K Rayne. Effect of the artificial sweetener, sucralose, on gastric emptying and incretin hormone release in healthy subjects. American journal of physiology. Gastrointestinal and liver physiology. vol 296. issue 4. 2009-06-17. PMID:19221011. |
glp-1, gip, and insulin also increased after sucrose (p=0.0001) but not after either load of sucralose or saline. |
2009-06-17 |
2023-08-12 |
mouse |