| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nigel Irwin, Paula L McClean, Steven Patterson, Kerry Hunter, Peter R Flat. Active immunisation against gastric inhibitory polypeptide (GIP) improves blood glucose control in an animal model of obesity-diabetes. Biological chemistry. vol 390. issue 1. 2009-03-12. PMID:18937625. |
there was a tendency for decreased circulating insulin in gip immunised mice. |
2009-03-12 |
2023-08-12 |
mouse |
| Nigel Irwin, Paula L McClean, Steven Patterson, Kerry Hunter, Peter R Flat. Active immunisation against gastric inhibitory polypeptide (GIP) improves blood glucose control in an animal model of obesity-diabetes. Biological chemistry. vol 390. issue 1. 2009-03-12. PMID:18937625. |
furthermore, insulin sensitivity was similar in mice immunised against gip and respective controls. |
2009-03-12 |
2023-08-12 |
mouse |
| J Girar. The incretins: from the concept to their use in the treatment of type 2 diabetes. Part A: incretins: concept and physiological functions. Diabetes & metabolism. vol 34. issue 6 Pt 1. 2009-02-26. PMID:19036624. |
gip and glp-1 stimulate insulin biosynthesis and insulin secretion in a glucose-dependent manner. |
2009-02-26 |
2023-08-12 |
Not clear |
| Jens Juul Holst, Tina Vilsbøll, Carolyn F Deaco. The incretin system and its role in type 2 diabetes mellitus. Molecular and cellular endocrinology. vol 297. issue 1-2. 2009-02-25. PMID:18786605. |
in such patients, the secretion of gip is near normal, but its effect on insulin secretion, particularly the late phase, is severely impaired. |
2009-02-25 |
2023-08-12 |
human |
| Jens Juul Holst, Tina Vilsbøll, Carolyn F Deaco. The incretin system and its role in type 2 diabetes mellitus. Molecular and cellular endocrinology. vol 297. issue 1-2. 2009-02-25. PMID:18786605. |
the impaired action of glp-1 and gip in t2dm may be at least partly restored by improved glycaemic control, as shown in studies involving 4 weeks of intensive insulin therapy. |
2009-02-25 |
2023-08-12 |
human |
| Maria P Yavropoulou, Kalliopi Kotsa, Isaak Kesisoglou, Olympia Anastasiou, John G Yovo. Intracerebroventricular infusion of neuropeptide Y increases glucose dependent-insulinotropic peptide secretion in the fasting conscious dog. Peptides. vol 29. issue 12. 2009-02-19. PMID:18848851. |
plasma insulin, and gip concentrations were measured after i.c.v infusion of 5, 10 and 25 microg of npy dissolved in 0.5 ml of artificial cerebrospinal fluid (a csf). |
2009-02-19 |
2023-08-12 |
dog |
| Maria P Yavropoulou, Kalliopi Kotsa, Isaak Kesisoglou, Olympia Anastasiou, John G Yovo. Intracerebroventricular infusion of neuropeptide Y increases glucose dependent-insulinotropic peptide secretion in the fasting conscious dog. Peptides. vol 29. issue 12. 2009-02-19. PMID:18848851. |
the secretion of gip and insulin were increased after the injection of npy in a different pattern. |
2009-02-19 |
2023-08-12 |
dog |
| Janet B McGil. Impact of incretin therapy on islet dysfunction: an underlying defect in the pathophysiology of type 2 diabetes. Postgraduate medicine. vol 121. issue 1. 2009-02-19. PMID:19179813. |
insulin, glucagon, amylin, the incretin hormones glucose-dependent insulinotropic polypeptide (gip) and glucagon-like peptide-1 (glp-1), and other hormones and enzymes interact to maintain glucose homeostasis and normal cellular metabolism. |
2009-02-19 |
2023-08-12 |
Not clear |
| Wook Kim, Josephine M Ega. The role of incretins in glucose homeostasis and diabetes treatment. Pharmacological reviews. vol 60. issue 4. 2009-02-12. PMID:19074620. |
however, in type 2 diabetes (t2dm), gip no longer modulates glucose-dependent insulin secretion, even at supraphysiological (pharmacological) plasma levels, and therefore gip incompetence is detrimental to beta-cell function, especially after eating. |
2009-02-12 |
2023-08-12 |
Not clear |
| Beata Matuszek, Monika Lenart-Lipińska, Andrzej Nowakowsk. [Incretin hormones in the treatment of type 2 diabetes. Part II. Incretins - new possibilities for pharmacotherapy of type 2 diabetes]. Endokrynologia Polska. vol 59. issue 4. 2009-02-05. PMID:18777503. |
it is hypothesized that at the basis of this pathology lies an incretin defect of insulinotropic gut-derived hormones, relying on decreased secretion of glp-1 (glucagon-like peptide 1), with preserved insulinotropic effect, whereas gip (glucose-dependent insulinotropic polypeptide) secretion remains within physiological limits, but its action is mostly impaired due to total loss of possibility for stimulation of the second phase insulin secretion. |
2009-02-05 |
2023-08-12 |
human |
| Jerry R Greenfield, I Sadaf Farooqi, Julia M Keogh, Elana Henning, Abdella M Habib, Anthea Blackwood, Frank Reimann, Jens J Holst, Fiona M Gribbl. Oral glutamine increases circulating glucagon-like peptide 1, glucagon, and insulin concentrations in lean, obese, and type 2 diabetic subjects. The American journal of clinical nutrition. vol 89. issue 1. 2009-02-05. PMID:19056578. |
incretin hormones, such as glucagon-like peptide 1 (glp-1) and glucose-dependent insulinotropic polypeptide (gip), play an important role in meal-related insulin secretion. |
2009-02-05 |
2023-08-12 |
human |
| V Koko, R Glisic, V Todorovic, N Drndarevic, O Mitrovi. Glucose-dependent insulinotropic polypeptide-producing K cells in dexamethasone-treated rats. Journal of microscopy. vol 232. issue 3. 2009-01-16. PMID:19094027. |
immunohistochemistry was carried out using antisera against the gip and insulin. |
2009-01-16 |
2023-08-12 |
rat |
| Richard D Carr, Marianne O Larsen, Maria Sörhede Winzell, Katarina Jelic, Ola Lindgren, Carolyn F Deacon, Bo Ahré. Incretin and islet hormonal responses to fat and protein ingestion in healthy men. American journal of physiology. Endocrinology and metabolism. vol 295. issue 4. 2008-11-17. PMID:18612044. |
following water ingestion, glucose, insulin, glucagon, glp-1, and gip levels and dpp-4 activity were stable during the 5-h study period. |
2008-11-17 |
2023-08-12 |
Not clear |
| Richard D Carr, Marianne O Larsen, Maria Sörhede Winzell, Katarina Jelic, Ola Lindgren, Carolyn F Deacon, Bo Ahré. Incretin and islet hormonal responses to fat and protein ingestion in healthy men. American journal of physiology. Endocrinology and metabolism. vol 295. issue 4. 2008-11-17. PMID:18612044. |
both fat and protein ingestion increased insulin, glucagon, gip, and glp-1 levels without affecting glucose levels or dpp-4 activity. |
2008-11-17 |
2023-08-12 |
Not clear |
| Richard D Carr, Marianne O Larsen, Maria Sörhede Winzell, Katarina Jelic, Ola Lindgren, Carolyn F Deacon, Bo Ahré. Incretin and islet hormonal responses to fat and protein ingestion in healthy men. American journal of physiology. Endocrinology and metabolism. vol 295. issue 4. 2008-11-17. PMID:18612044. |
after protein, the early gip, but not glp-1, responses correlated to insulin (r(2)=0.86; p=0.0001) but not glucagon responses. |
2008-11-17 |
2023-08-12 |
Not clear |
| Kevin B Moore, Christopher D Saude. Therapeutic potential of dipeptidyl peptidase-IV inhibitors in patients with diabetes mellitus. American journal of therapeutics. vol 15. issue 5. 2008-11-04. PMID:18806525. |
through the action of glp-1 and gip, dpp-iv inhibitors improve preprandial and postprandial glucose by enhancing insulin secretion and reducing postprandial concentrations of glucagon. |
2008-11-04 |
2023-08-12 |
Not clear |
| A E Relling, C K Reynold. Plasma concentrations of gut peptides in dairy cattle increase after calving. Journal of dairy science. vol 90. issue 1. 2008-09-12. PMID:17183100. |
the objective of the present study was to measure plasma concentrations of glp-1, gip, cck, insulin, glucose, and nonesterified fatty acids in blood plasma obtained from the coccygeal vein of 32 holstein cows at an average of 11 d before, and 5, 12, and 19 d after calving. |
2008-09-12 |
2023-08-12 |
cattle |
| A E Relling, C K Reynold. Feeding rumen-inert fats differing in their degree of saturation decreases intake and increases plasma concentrations of gut peptides in lactating dairy cows. Journal of dairy science. vol 90. issue 3. 2008-09-12. PMID:17297124. |
our objective was to determine the effect of feeding rumen-inert fats differing in their degree of saturation on dry matter intake (dmi), milk production, and plasma concentrations of insulin, glucagon-like peptide 1 (7-36) amide (glp-1), glucose-dependent insulinotropic polypeptide (gip), and cholecystokinin (cck) in lactating dairy cows. |
2008-09-12 |
2023-08-12 |
cattle |
| P R Flat. Dorothy Hodgkin Lecture 2008. Gastric inhibitory polypeptide (GIP) revisited: a new therapeutic target for obesity-diabetes? Diabetic medicine : a journal of the British Diabetic Association. vol 25. issue 7. 2008-08-20. PMID:18513308. |
such effects open up the possibility of exploiting gip receptor antagonism for the treatment of obesity and insulin resistance. |
2008-08-20 |
2023-08-12 |
mouse |
| J-F Gautier, S-P Choukem, J Girar. Physiology of incretins (GIP and GLP-1) and abnormalities in type 2 diabetes. Diabetes & metabolism. vol 34 Suppl 2. 2008-08-19. PMID:18640588. |
in humans, the incretin effect is mainly caused by two peptide hormones, glucose-dependent insulin releasing polypeptide (gip), and glucagon-like peptide-1 (glp-1). |
2008-08-19 |
2023-08-12 |
Not clear |