| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Qing Zhong, Takashi Itokawa, Supriya Sridhar, Ke-Hong Ding, Ding Xie, Baolin Kang, Wendy B Bollag, Roni J Bollag, Mark Hamrick, Karl Insogna, Carlos M Isale. Effects of glucose-dependent insulinotropic peptide on osteoclast function. American journal of physiology. Endocrinology and metabolism. vol 292. issue 2. 2007-03-19. PMID:17003233. |
glucose-dependent insulinotropic peptide (gip), a known modulator of glucose-induced insulin secretion, is secreted from intestinal endocrine cells in response to nutrient ingestion. |
2007-03-19 |
2023-08-12 |
Not clear |
| Tanya Hansotia, Adriano Maida, Grace Flock, Yuichiro Yamada, Katsushi Tsukiyama, Yutaka Seino, Daniel J Drucke. Extrapancreatic incretin receptors modulate glucose homeostasis, body weight, and energy expenditure. The Journal of clinical investigation. vol 117. issue 1. 2007-03-07. PMID:17187081. |
the incretin hormones glucagon-like peptide-1 (glp-1) and glucose-dependent insulinotropic polypeptide (gip) control glucose homeostasis through well-defined actions on the islet beta cell via stimulation of insulin secretion and preservation and expansion of beta cell mass. |
2007-03-07 |
2023-08-12 |
mouse |
| Filip K Knop, Tina Vilsbøll, Steen Larsen, Patricia V Højberg, Aage Vølund, Sten Madsbad, Jens J Holst, Thure Kraru. Increased postprandial responses of GLP-1 and GIP in patients with chronic pancreatitis and steatorrhea following pancreatic enzyme substitution. American journal of physiology. Endocrinology and metabolism. vol 292. issue 1. 2007-02-16. PMID:16954337. |
we aimed to investigate how assimilation of nutrients affects the postprandial responses of glucagon-like peptide-1 (glp-1) and glucose-dependent insulinotropic polypeptide (gip) and to evaluate the effect of pancreatic enzyme substitution (pes) on insulin secretion in patients with chronic pancreatitis (cp) and pancreatic exocrine insufficiency (pei). |
2007-02-16 |
2023-08-12 |
human |
| Filip K Knop, Tina Vilsbøll, Steen Larsen, Patricia V Højberg, Aage Vølund, Sten Madsbad, Jens J Holst, Thure Kraru. Increased postprandial responses of GLP-1 and GIP in patients with chronic pancreatitis and steatorrhea following pancreatic enzyme substitution. American journal of physiology. Endocrinology and metabolism. vol 292. issue 1. 2007-02-16. PMID:16954337. |
these results suggest that the secretion of glp-1 and gip is under influence of the digestion and absorption of nutrients in the small intestine and that pes increases insulin secretion. |
2007-02-16 |
2023-08-12 |
human |
| Brian D Green, Peter R Flatt, Clifford J Baile. Dipeptidyl peptidase IV (DPP IV) inhibitors: A newly emerging drug class for the treatment of type 2 diabetes. Diabetes & vascular disease research. vol 3. issue 3. 2007-01-26. PMID:17160910. |
inhibition of dpp iv prolongs and enhances the activity of endogenous glp-1 and gip, which serve as important prandial stimulators of insulin secretion and regulators of blood glucose control. |
2007-01-26 |
2023-08-12 |
Not clear |
| Nigel Irwin, Brian D Green, Jeremy C Parker, Victor A Gault, Finbarr P M O'Harte, Peter R Flat. Biological activity and antidiabetic potential of synthetic fragment peptides of glucose-dependent insulinotropic polypeptide, GIP(1-16) and (Pro3)GIP(1-16). Regulatory peptides. vol 135. issue 1-2. 2007-01-22. PMID:16675042. |
glucose-dependent insulinotropic polypeptide (gip) is a key physiological insulin releasing peptide and potential antidiabetic agent. |
2007-01-22 |
2023-08-12 |
mouse |
| Nigel Irwin, Brian D Green, Jeremy C Parker, Victor A Gault, Finbarr P M O'Harte, Peter R Flat. Biological activity and antidiabetic potential of synthetic fragment peptides of glucose-dependent insulinotropic polypeptide, GIP(1-16) and (Pro3)GIP(1-16). Regulatory peptides. vol 135. issue 1-2. 2007-01-22. PMID:16675042. |
the bioactivity of two modified c-terminally truncated fragment gip peptides, gip(1-16) and (pro3)gip(1-16), was examined in terms of insulin secretion and glucose homeostasis using brin-bd11 cells and type 2 diabetic mice. |
2007-01-22 |
2023-08-12 |
mouse |
| Nigel Irwin, Brian D Green, Jeremy C Parker, Victor A Gault, Finbarr P M O'Harte, Peter R Flat. Biological activity and antidiabetic potential of synthetic fragment peptides of glucose-dependent insulinotropic polypeptide, GIP(1-16) and (Pro3)GIP(1-16). Regulatory peptides. vol 135. issue 1-2. 2007-01-22. PMID:16675042. |
in vitro insulin release studies demonstrated that gip(1-16) and (pro3)gip(1-16) possessed weak gip-receptor agonist and antagonistic properties, respectively. |
2007-01-22 |
2023-08-12 |
mouse |
| Nigel Irwin, Brian D Green, Jeremy C Parker, Victor A Gault, Finbarr P M O'Harte, Peter R Flat. Biological activity and antidiabetic potential of synthetic fragment peptides of glucose-dependent insulinotropic polypeptide, GIP(1-16) and (Pro3)GIP(1-16). Regulatory peptides. vol 135. issue 1-2. 2007-01-22. PMID:16675042. |
intraperitoneal administration of gip(1-16) in combination with glucose to obese diabetic (ob/ob) mice did not effect the glycaemic excursion and had a marginal effect on insulin release. |
2007-01-22 |
2023-08-12 |
mouse |
| Nigel Irwin, Brian D Green, Jeremy C Parker, Victor A Gault, Finbarr P M O'Harte, Peter R Flat. Biological activity and antidiabetic potential of synthetic fragment peptides of glucose-dependent insulinotropic polypeptide, GIP(1-16) and (Pro3)GIP(1-16). Regulatory peptides. vol 135. issue 1-2. 2007-01-22. PMID:16675042. |
no significant effects were observed on food intake, body weight, hba1c, glucose tolerance, metabolic response to feeding and either insulin secretion or insulin sensitivity following prolonged (pro3)gip(1-16) treatment. |
2007-01-22 |
2023-08-12 |
mouse |
| J C Parker, K S Lavery, N Irwin, B D Green, B Greer, P Harriott, F P M O'Harte, V A Gault, P R Flat. Effects of sub-chronic exposure to naturally occurring N-terminally truncated metabolites of glucose-dependent insulinotrophic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1), GIP(3-42) and GLP-1(9-36)amide, on insulin secretion and glucose homeostasis in ob/ob mice. The Journal of endocrinology. vol 191. issue 1. 2006-12-29. PMID:17065392. |
effects of sub-chronic exposure to naturally occurring n-terminally truncated metabolites of glucose-dependent insulinotrophic polypeptide (gip) and glucagon-like peptide-1 (glp-1), gip(3-42) and glp-1(9-36)amide, on insulin secretion and glucose homeostasis in ob/ob mice. |
2006-12-29 |
2023-08-12 |
mouse |
| J C Parker, K S Lavery, N Irwin, B D Green, B Greer, P Harriott, F P M O'Harte, V A Gault, P R Flat. Effects of sub-chronic exposure to naturally occurring N-terminally truncated metabolites of glucose-dependent insulinotrophic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1), GIP(3-42) and GLP-1(9-36)amide, on insulin secretion and glucose homeostasis in ob/ob mice. The Journal of endocrinology. vol 191. issue 1. 2006-12-29. PMID:17065392. |
these data indicate that sub-chronic exposure to gip and glp-1 metabolites does not result in physiological impairment of insulin secretion or blood glucose control. |
2006-12-29 |
2023-08-12 |
mouse |
| J C Parker, K S Lavery, N Irwin, B D Green, B Greer, P Harriott, F P M O'Harte, V A Gault, P R Flat. Effects of sub-chronic exposure to naturally occurring N-terminally truncated metabolites of glucose-dependent insulinotrophic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1), GIP(3-42) and GLP-1(9-36)amide, on insulin secretion and glucose homeostasis in ob/ob mice. The Journal of endocrinology. vol 191. issue 1. 2006-12-29. PMID:17065392. |
gip(3-42) might exert an overall beneficial effect by improving insulin sensitivity through extrapancreatic action. |
2006-12-29 |
2023-08-12 |
mouse |
| Yoshikazu Miura, Hisao Matsu. Triphenyltin impairs a protein kinase A (PKA)-dependent increase of cytosolic Na+ and Ca2+ and PKA-independent increase of cytosolic Ca2+ associated with insulin secretion in hamster pancreatic beta-cells. Toxicology and applied pharmacology. vol 216. issue 3. 2006-12-06. PMID:16837018. |
oral administration of triphenyltin chloride (tpt) (60 mg/kg body weight) inhibits the insulin secretion by decreasing the cytoplasmic ca2+ concentration ([ca2+]i) induced by glucose-dependent insulinotropic polypeptide (gip) in pancreatic beta-cells of the hamster. |
2006-12-06 |
2023-08-12 |
Not clear |
| Yoshikazu Miura, Hisao Matsu. Triphenyltin impairs a protein kinase A (PKA)-dependent increase of cytosolic Na+ and Ca2+ and PKA-independent increase of cytosolic Ca2+ associated with insulin secretion in hamster pancreatic beta-cells. Toxicology and applied pharmacology. vol 216. issue 3. 2006-12-06. PMID:16837018. |
moreover, tpt administration significantly reduced the insulin secretion by 2 mm db-camp, glp-1, gip, and 8-pcpt-2'-o-me-camp with and without h-89, and that by 6-bnz-camp and forskolin. |
2006-12-06 |
2023-08-12 |
Not clear |
| J Skrh. [Pancreatic hormones and hormonal regulation of insulin secretion]. Casopis lekaru ceskych. vol 145. issue 8. 2006-11-09. PMID:16995414. |
incretin effect of glucose-dependent insulinotropic peptide (gip) and glucagon-like peptide 1 (glp-1) is significantly involved in the insulin secretion which is modulated by many other hormones. |
2006-11-09 |
2023-08-12 |
Not clear |
| Nigel Irwin, Brian D Green, Victor A Gault, Patrick Harriot, Finbarr P M O'Harte, Peter R Flat. Stable agonist of glucose-dependent insulinotropic polypeptide (GIP) restores pancreatic beta cell glucose responsiveness but not glucose intolerance in aging mice. Experimental gerontology. vol 41. issue 2. 2006-10-04. PMID:16378704. |
glucose-dependent insulinotropic polypeptide (gip) potentiates glucose-induced insulin secretion. |
2006-10-04 |
2023-08-12 |
mouse |
| Lamin Marenah, Jane T McCluskey, Yasser H A Abdel-Wahab, Finbarr P M O'Harte, Neville H McClenaghan, Peter R Flat. A stable analogue of glucose-dependent insulinotropic polypeptide, GIP(LysPAL16), enhances functional differentiation of mouse embryonic stem cells into cells expressing islet-specific genes and hormones. Biological chemistry. vol 387. issue 7. 2006-10-03. PMID:16913844. |
semi-quantitative pcr indicated mrna expression of islet development markers (nestin, pdx1, nkx6.1, oct4), mature pancreatic beta-cell markers (insulin, glucagon, glut2, sur1, kir6.1) and the gip receptor gene gip-r in undifferentiated (stage 1) cells, with increasing levels in differentiated stages 4 and 5. |
2006-10-03 |
2023-08-12 |
mouse |
| Lamin Marenah, Jane T McCluskey, Yasser H A Abdel-Wahab, Finbarr P M O'Harte, Neville H McClenaghan, Peter R Flat. A stable analogue of glucose-dependent insulinotropic polypeptide, GIP(LysPAL16), enhances functional differentiation of mouse embryonic stem cells into cells expressing islet-specific genes and hormones. Biological chemistry. vol 387. issue 7. 2006-10-03. PMID:16913844. |
after supplementation with gip(lyspal16), es cells at stage 4 released insulin in response to secretagogues and glucose in a concentration-dependent manner, with 35-100% increases in insulin release. |
2006-10-03 |
2023-08-12 |
mouse |
| Lamin Marenah, Jane T McCluskey, Yasser H A Abdel-Wahab, Finbarr P M O'Harte, Neville H McClenaghan, Peter R Flat. A stable analogue of glucose-dependent insulinotropic polypeptide, GIP(LysPAL16), enhances functional differentiation of mouse embryonic stem cells into cells expressing islet-specific genes and hormones. Biological chemistry. vol 387. issue 7. 2006-10-03. PMID:16913844. |
we conclude that the stable gip analogue enhanced differentiation of mouse es cells towards a phenotype expressing specific beta-cell genes and releasing insulin. |
2006-10-03 |
2023-08-12 |
mouse |