| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wendy A M Blom, Anne Lluch, Sophie Vinoy, Annette Stafleu, Robin van den Berg, Jens J Holst, Frans J Kok, Henk F J Hendrik. Effects of gastric emptying on the postprandial ghrelin response. American journal of physiology. Endocrinology and metabolism. vol 290. issue 2. 2006-02-22. PMID:16188911. |
ghrelin concentrations were only weakly correlated with insulin concentrations (saline r = -0.36; 95% ci = -0.69, 0.09; glp- 1 r = -0.42; 95% ci = -0.73, 0.03), but strongly inversely correlated with gip concentrations (saline r = -0.74; 95% ci= -0.89, -0.45; glp-1 r = -0.63; 95% ci = -0.84, -0.27). |
2006-02-22 |
2023-08-12 |
human |
| R Jorde, P G Burhol, H L Waldu. The effect of atropine on plasma gastric inhibitory polypeptide (GIP), serum insulin, and blood glucose after intraduodenal infusion of fat. Scandinavian journal of gastroenterology. vol 16. issue 3. 2006-02-14. PMID:16435472. |
the effect of atropine on plasma gastric inhibitory polypeptide (gip), serum insulin, and blood glucose after intraduodenal infusion of fat. |
2006-02-14 |
2023-08-12 |
Not clear |
| R Jorde, P G Burhol, H L Waldu. The effect of atropine on plasma gastric inhibitory polypeptide (GIP), serum insulin, and blood glucose after intraduodenal infusion of fat. Scandinavian journal of gastroenterology. vol 16. issue 3. 2006-02-14. PMID:16435472. |
on the day without atropine, plasma gip and serum insulin increased significantly. |
2006-02-14 |
2023-08-12 |
Not clear |
| R Jorde, P G Burhol, H L Waldu. The effect of atropine on plasma gastric inhibitory polypeptide (GIP), serum insulin, and blood glucose after intraduodenal infusion of fat. Scandinavian journal of gastroenterology. vol 16. issue 3. 2006-02-14. PMID:16435472. |
the increases in plasma gip and serum insulin were significantly attenuated by atropine. |
2006-02-14 |
2023-08-12 |
Not clear |
| B T Cooper, C H Walsh, G K Holmes, A D Wright, W T Cooke, S R Bloo. GIP and insulin responses to oral glucose in coeliac patients before and after treatment. Scandinavian journal of gastroenterology. vol 16. issue 3. 2006-02-14. PMID:16435484. |
gip and insulin responses to oral glucose in coeliac patients before and after treatment. |
2006-02-14 |
2023-08-12 |
Not clear |
| B T Cooper, C H Walsh, G K Holmes, A D Wright, W T Cooke, S R Bloo. GIP and insulin responses to oral glucose in coeliac patients before and after treatment. Scandinavian journal of gastroenterology. vol 16. issue 3. 2006-02-14. PMID:16435484. |
the responses of plasma gastric inhibitory polypeptide (gip) and insulin to oral glucose were studied in five patients with untreated coeliac disease. |
2006-02-14 |
2023-08-12 |
Not clear |
| B T Cooper, C H Walsh, G K Holmes, A D Wright, W T Cooke, S R Bloo. GIP and insulin responses to oral glucose in coeliac patients before and after treatment. Scandinavian journal of gastroenterology. vol 16. issue 3. 2006-02-14. PMID:16435484. |
in the untreated patients, the blood glucose, serum insulin, and gip levels were significantly lower than in the controls. |
2006-02-14 |
2023-08-12 |
Not clear |
| B T Cooper, C H Walsh, G K Holmes, A D Wright, W T Cooke, S R Bloo. GIP and insulin responses to oral glucose in coeliac patients before and after treatment. Scandinavian journal of gastroenterology. vol 16. issue 3. 2006-02-14. PMID:16435484. |
after gluten withdrawal there was an improvement towards normality in the responses of blood glucose, serum insulin, and gip. |
2006-02-14 |
2023-08-12 |
Not clear |
| M O Weickert, M Mohlig, C Koebnick, J J Holst, P Namsolleck, M Ristow, M Osterhoff, H Rochlitz, N Rudovich, J Spranger, A F H Pfeiffe. Impact of cereal fibre on glucose-regulating factors. Diabetologia. vol 48. issue 11. 2006-01-26. PMID:16172868. |
we investigated whether a short-term dietary intervention with purified insoluble fibres influences acute and delayed responses of glucose, insulin, glucose-dependent insulinotropic polypeptide (gip) and glucagon-like peptide 1. |
2006-01-26 |
2023-08-12 |
Not clear |
| Nigel Irwin, Victor A Gault, Brian D Green, Brett Greer, Patrick Harriott, Clifford J Bailey, Peter R Flatt, Finbarr P M O'Hart. Antidiabetic potential of two novel fatty acid derivatised, N-terminally modified analogues of glucose-dependent insulinotropic polypeptide (GIP): N-AcGIP(LysPAL16) and N-AcGIP(LysPAL37). Biological chemistry. vol 386. issue 7. 2005-12-23. PMID:16207089. |
in contrast to gip, which was rapidly degraded by in vitro incubation with dipeptidylpeptidase iv (dpp iv) (52% intact after 2 h), the analogues remained fully intact for up to 24 h. both fatty acid-derivatised analogues stimulated camp production in gip receptor chinese hamster lung (chl) fibroblasts (ec50 12.1-13.0 nm) and significantly improved in vitro insulin secretion from brin-bd11 cells (1.1- to 2.4-fold; p < 0.05 to p < 0.001) compared to control (5.6 mm glucose). |
2005-12-23 |
2023-08-12 |
mouse |
| Heying Zhou, Yuichiro Yamada, Katsushi Tsukiyama, Kazumasa Miyawaki, Masaya Hosokawa, Kazuaki Nagashima, Kentaro Toyoda, Rei Naitoh, Wataru Mizunoya, Tohru Fushiki, Takashi Kadowaki, Yutaka Sein. Gastric inhibitory polypeptide modulates adiposity and fat oxidation under diminished insulin action. Biochemical and biophysical research communications. vol 335. issue 3. 2005-11-07. PMID:16105663. |
gut hormone gastric inhibitory polypeptide (gip) stimulates insulin secretion from pancreatic beta-cells upon ingestion of nutrients. |
2005-11-07 |
2023-08-12 |
mouse |
| Heying Zhou, Yuichiro Yamada, Katsushi Tsukiyama, Kazumasa Miyawaki, Masaya Hosokawa, Kazuaki Nagashima, Kentaro Toyoda, Rei Naitoh, Wataru Mizunoya, Tohru Fushiki, Takashi Kadowaki, Yutaka Sein. Gastric inhibitory polypeptide modulates adiposity and fat oxidation under diminished insulin action. Biochemical and biophysical research communications. vol 335. issue 3. 2005-11-07. PMID:16105663. |
inhibition of gip signaling prevents the onset of obesity and consequent insulin resistance induced by high-fat diet. |
2005-11-07 |
2023-08-12 |
mouse |
| Heying Zhou, Yuichiro Yamada, Katsushi Tsukiyama, Kazumasa Miyawaki, Masaya Hosokawa, Kazuaki Nagashima, Kentaro Toyoda, Rei Naitoh, Wataru Mizunoya, Tohru Fushiki, Takashi Kadowaki, Yutaka Sein. Gastric inhibitory polypeptide modulates adiposity and fat oxidation under diminished insulin action. Biochemical and biophysical research communications. vol 335. issue 3. 2005-11-07. PMID:16105663. |
in this study, we investigated the role of gip in accumulation of triglycerides into adipocytes and in fat oxidation peripherally using insulin receptor substrate (irs)-1-deficient mice and revealed that irs-1(-/-)gipr(-/-) mice exhibited both reduced adiposity and ameliorated insulin resistance. |
2005-11-07 |
2023-08-12 |
mouse |
| Heying Zhou, Yuichiro Yamada, Katsushi Tsukiyama, Kazumasa Miyawaki, Masaya Hosokawa, Kazuaki Nagashima, Kentaro Toyoda, Rei Naitoh, Wataru Mizunoya, Tohru Fushiki, Takashi Kadowaki, Yutaka Sein. Gastric inhibitory polypeptide modulates adiposity and fat oxidation under diminished insulin action. Biochemical and biophysical research communications. vol 335. issue 3. 2005-11-07. PMID:16105663. |
these results suggest that gip plays a crucial role in switching from fat oxidation to fat accumulation under the diminished insulin action as a potential target for secondary prevention of insulin resistance. |
2005-11-07 |
2023-08-12 |
mouse |
| Valérie Baldacchino, Sylvie Oble, Patrick-Olivier Décarie, Isabelle Bourdeau, Pavel Hamet, Johanne Tremblay, André Lacroi. The Sp transcription factors are involved in the cellular expression of the human glucose-dependent insulinotropic polypeptide receptor gene and overexpressed in adrenals of patients with Cushing's syndrome. Journal of molecular endocrinology. vol 35. issue 1. 2005-10-27. PMID:16087722. |
the best characterized effect of glucose-dependent insulinotropic polypeptide (gip) is its stimulatory effect on insulin secretion by pancreatic beta-cells. |
2005-10-27 |
2023-08-12 |
human |
| Victor A Gault, Nigel Irwin, Brian D Green, Jane T McCluskey, Brett Greer, Clifford J Bailey, Patrick Harriott, Finbarr P M O'harte, Peter R Flat. Chemical ablation of gastric inhibitory polypeptide receptor action by daily (Pro3)GIP administration improves glucose tolerance and ameliorates insulin resistance and abnormalities of islet structure in obesity-related diabetes. Diabetes. vol 54. issue 8. 2005-10-20. PMID:16046312. |
chemical ablation of gastric inhibitory polypeptide receptor action by daily (pro3)gip administration improves glucose tolerance and ameliorates insulin resistance and abnormalities of islet structure in obesity-related diabetes. |
2005-10-20 |
2023-08-12 |
mouse |
| Victor A Gault, Nigel Irwin, Brian D Green, Jane T McCluskey, Brett Greer, Clifford J Bailey, Patrick Harriott, Finbarr P M O'harte, Peter R Flat. Chemical ablation of gastric inhibitory polypeptide receptor action by daily (Pro3)GIP administration improves glucose tolerance and ameliorates insulin resistance and abnormalities of islet structure in obesity-related diabetes. Diabetes. vol 54. issue 8. 2005-10-20. PMID:16046312. |
daily injection of (pro3)gip reduced pancreatic insulin content (1.3-fold; p < 0.05) and partially corrected the obesity-related islet hypertrophy and beta-cell hyperplasia of ob/ob mice. |
2005-10-20 |
2023-08-12 |
mouse |
| Victor A Gault, Nigel Irwin, Brian D Green, Jane T McCluskey, Brett Greer, Clifford J Bailey, Patrick Harriott, Finbarr P M O'harte, Peter R Flat. Chemical ablation of gastric inhibitory polypeptide receptor action by daily (Pro3)GIP administration improves glucose tolerance and ameliorates insulin resistance and abnormalities of islet structure in obesity-related diabetes. Diabetes. vol 54. issue 8. 2005-10-20. PMID:16046312. |
these studies highlight a role for gip in obesity-related glucose intolerance and emphasize the potential of specific gip-r antagonists as a new class of drugs for the alleviation of insulin resistance and treatment of type 2 diabetes. |
2005-10-20 |
2023-08-12 |
mouse |
| Su-Jin Kim, Woo Sung Choi, John Song Mou Han, Garth Warnock, David Fedida, Christopher H S McIntos. A novel mechanism for the suppression of a voltage-gated potassium channel by glucose-dependent insulinotropic polypeptide: protein kinase A-dependent endocytosis. The Journal of biological chemistry. vol 280. issue 31. 2005-10-12. PMID:15955806. |
the incretin hormone, glucose-dependent insulinotropic polypeptide (gip) stimulates insulin secretion by potentiating events underlying membrane depolarization and exerting direct effects on exocytosis. |
2005-10-12 |
2023-08-12 |
human |
| Reawika Chaikomin, Selena Doran, Karen L Jones, Christine Feinle-Bisset, Deirdre O'Donovan, Christopher K Rayner, Michael Horowit. Initially more rapid small intestinal glucose delivery increases plasma insulin, GIP, and GLP-1 but does not improve overall glycemia in healthy subjects. American journal of physiology. Endocrinology and metabolism. vol 289. issue 3. 2005-09-21. PMID:15886226. |
initially more rapid small intestinal glucose delivery increases plasma insulin, gip, and glp-1 but does not improve overall glycemia in healthy subjects. |
2005-09-21 |
2023-08-12 |
human |