| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Takashi Miki, Kohtaro Minami, Hidehiro Shinozaki, Kimio Matsumura, Atsunori Saraya, Hiroki Ikeda, Yuichiro Yamada, Jens Juul Holst, Susumu Sein. Distinct effects of glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 on insulin secretion and gut motility. Diabetes. vol 54. issue 4. 2005-06-03. PMID:15793244. |
although both gip and glp-1 increase the intracellular camp concentration and potentiate insulin secretion, these results demonstrate that the glp-1 and gip signaling pathways involve the k(atp) channel differently. |
2005-06-03 |
2023-08-12 |
mouse |
| Sue Stock, Pierre Leichner, Alfred C K Wong, Mohamed A Ghatei, Timothy J Kieffer, Stephen R Bloom, Jean-Pierre Chanoin. Ghrelin, peptide YY, glucose-dependent insulinotropic polypeptide, and hunger responses to a mixed meal in anorexic, obese, and control female adolescents. The Journal of clinical endocrinology and metabolism. vol 90. issue 4. 2005-05-31. PMID:15657373. |
pyy, ghrelin, gip, insulin, and glucose concentrations and four markers of satiety were measured for 240 min after a mixed meal. |
2005-05-31 |
2023-08-12 |
human |
| Sue Stock, Pierre Leichner, Alfred C K Wong, Mohamed A Ghatei, Timothy J Kieffer, Stephen R Bloom, Jean-Pierre Chanoin. Ghrelin, peptide YY, glucose-dependent insulinotropic polypeptide, and hunger responses to a mixed meal in anorexic, obese, and control female adolescents. The Journal of clinical endocrinology and metabolism. vol 90. issue 4. 2005-05-31. PMID:15657373. |
there was a negative correlation between fasting ghrelin (but not pyy or gip) and bmi and insulin (r2= 0.33) and a positive correlation between the decrease in hunger 15 min after the meal and pyy concentrations at 15 min (r2= 0.20). |
2005-05-31 |
2023-08-12 |
human |
| Sue Stock, Pierre Leichner, Alfred C K Wong, Mohamed A Ghatei, Timothy J Kieffer, Stephen R Bloom, Jean-Pierre Chanoin. Ghrelin, peptide YY, glucose-dependent insulinotropic polypeptide, and hunger responses to a mixed meal in anorexic, obese, and control female adolescents. The Journal of clinical endocrinology and metabolism. vol 90. issue 4. 2005-05-31. PMID:15657373. |
the lower gip observed in an subjects despite a similar caloric intake may appropriately prevent an excessive insulin response in these patients. |
2005-05-31 |
2023-08-12 |
human |
| Michael A Nauck, Andrea El-Ouaghlidi, Bartholomäus Gabrys, Katrin Hücking, Jens J Holst, Carolyn F Deacon, Baptist Gallwitz, Wolfgang E Schmidt, Juris J Meie. Secretion of incretin hormones (GIP and GLP-1) and incretin effect after oral glucose in first-degree relatives of patients with type 2 diabetes. Regulatory peptides. vol 122. issue 3. 2005-05-19. PMID:15491793. |
since insulin secretion in response to exogenous gastric inhibitory polypeptide (gip) is diminished not only in patients with type 2 diabetes, but also in their normal glucose-tolerant first-degree relatives, it was the aim to investigate the integrity of the entero-insular axis in such subjects. |
2005-05-19 |
2023-08-12 |
human |
| Y Yamada, Y Sein. Physiology of GIP--a lesson from GIP receptor knockout mice. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 36. issue 11-12. 2005-05-12. PMID:15655707. |
however, the physiological role of gip has been generally thought to stimulate insulin secretion from pancreatic beta-cells, and the other actions of gip have received little attention. |
2005-05-12 |
2023-08-12 |
mouse |
| Y Yamada, Y Sein. Physiology of GIP--a lesson from GIP receptor knockout mice. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 36. issue 11-12. 2005-05-12. PMID:15655707. |
from these studies, we now know that gip not only mediates early insulin secretion by acting on pancreatic beta-cells, but also links overnutrition to obesity by acting on adipocytes. |
2005-05-12 |
2023-08-12 |
mouse |
| B Thoren. Physiology of GLP-1--lessons from glucoincretin receptor knockout mice. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 36. issue 11-12. 2005-05-12. PMID:15655706. |
however, a critical role for this hormone and its receptor was demonstrated in the function of the hepatoportal vein glucose sensor, in contrast to that of the pancreatic beta-cells, although absence of both glp-1 and gip receptors leads to a more severe phenotype characterized by a beta-cell-autonomous defect in glucose-stimulated insulin secretion. |
2005-05-12 |
2023-08-12 |
mouse |
| R D Wideman, T J Kieffe. Glucose-dependent insulinotropic polypeptide as a regulator of beta cell function and fate. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 36. issue 11-12. 2005-05-12. PMID:15655709. |
perhaps the most important effect of gip is its potentiation of insulin secretion. |
2005-05-12 |
2023-08-12 |
Not clear |
| A Vella, R A Rizz. Extrapancreatic effects of GIP and GLP-1. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 36. issue 11-12. 2005-05-12. PMID:15655715. |
glucagon-like peptide-1 (glp1) and, to a lesser extent, glucose-dependent insulinotropic polypeptide (gip) are potent stimulators of insulin secretion, and consequently have significant effects on the regulation of the glucose metabolism. |
2005-05-12 |
2023-08-12 |
Not clear |
| J J Meier, M A Nauc. GIP as a potential therapeutic agent? Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 36. issue 11-12. 2005-05-12. PMID:15655720. |
glucose-dependent insulinotropic polypeptide (gip) is released from k-cells in the gut after meal ingestion, and acts in concert with glucagon-like peptide 1 (glp-1) to augment glucose-stimulated insulin secretion. |
2005-05-12 |
2023-08-12 |
mouse |
| J J Meier, M A Nauc. GIP as a potential therapeutic agent? Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 36. issue 11-12. 2005-05-12. PMID:15655720. |
however, eliminating the effect of endogenous gip may at the same time impair postprandial insulin secretion, thereby severely disturbing glucose homeostasis. |
2005-05-12 |
2023-08-12 |
mouse |
| Andrea Mari, Amalia Gastaldelli, Andrea Natali, Torben Ostergard, Ole Schmitz, Ele Ferrannin. Characterization of beta-cell function impairment in first-degree relatives of type 2 diabetic subjects: modeling analysis of 24-h triple-meal tests. American journal of physiology. Endocrinology and metabolism. vol 288. issue 3. 2005-04-26. PMID:15522997. |
in conclusion, although in absolute terms isr is increased in insulin-resistant fdr, beta-cell function shows a cluster of interrelated abnormalities involving compensation for insulin resistance, potentiation, and sensitivity to gip, suggesting a beta-cell defect in the amplifying pathway of insulin secretion. |
2005-04-26 |
2023-08-12 |
human |
| Michael A Nauck, Birgit Baller, Juris J Meie. Gastric inhibitory polypeptide and glucagon-like peptide-1 in the pathogenesis of type 2 diabetes. Diabetes. vol 53 Suppl 3. 2005-04-14. PMID:15561910. |
the two hormones responsible for the incretin effect, glucose-dependent insulinotropic hormone (gip) and glucagon-like peptide-1 (glp-1), are secreted after oral glucose loads and augment insulin secretion in response to hyperglycemia. |
2005-04-14 |
2023-08-12 |
Not clear |
| Jens Juul Holst, Cathrine Orsko. The incretin approach for diabetes treatment: modulation of islet hormone release by GLP-1 agonism. Diabetes. vol 53 Suppl 3. 2005-04-14. PMID:15561911. |
together with the related hormone glucose-dependent insulinotropic polypeptide (gip), it is responsible for the incretin effect, the augmentation of insulin secretion after oral as opposed to intravenous administration of glucose. |
2005-04-14 |
2023-08-12 |
Not clear |
| Juris J Meier, Baptist Gallwitz, Bartholomaeus Kask, Carolyn F Deacon, Jens J Holst, Wolfgang E Schmidt, Michael A Nauc. Stimulation of insulin secretion by intravenous bolus injection and continuous infusion of gastric inhibitory polypeptide in patients with type 2 diabetes and healthy control subjects. Diabetes. vol 53 Suppl 3. 2005-04-14. PMID:15561915. |
it was the aim of this study to determine the response of insulin secretion to different gip doses administered by intravenous bolus injection and via continuous infusion in both healthy subjects and patients with type 2 diabetes. |
2005-04-14 |
2023-08-12 |
human |
| Juris J Meier, Baptist Gallwitz, Bartholomaeus Kask, Carolyn F Deacon, Jens J Holst, Wolfgang E Schmidt, Michael A Nauc. Stimulation of insulin secretion by intravenous bolus injection and continuous infusion of gastric inhibitory polypeptide in patients with type 2 diabetes and healthy control subjects. Diabetes. vol 53 Suppl 3. 2005-04-14. PMID:15561915. |
capillary and venous blood was drawn for glucose, insulin, c-peptide, and gip. |
2005-04-14 |
2023-08-12 |
human |
| Juris J Meier, Baptist Gallwitz, Bartholomaeus Kask, Carolyn F Deacon, Jens J Holst, Wolfgang E Schmidt, Michael A Nauc. Stimulation of insulin secretion by intravenous bolus injection and continuous infusion of gastric inhibitory polypeptide in patients with type 2 diabetes and healthy control subjects. Diabetes. vol 53 Suppl 3. 2005-04-14. PMID:15561915. |
gip bolus administration evoked a significant increase in plasma insulin levels in both patients with type 2 diabetes and healthy subjects. |
2005-04-14 |
2023-08-12 |
human |
| Juris J Meier, Baptist Gallwitz, Bartholomaeus Kask, Carolyn F Deacon, Jens J Holst, Wolfgang E Schmidt, Michael A Nauc. Stimulation of insulin secretion by intravenous bolus injection and continuous infusion of gastric inhibitory polypeptide in patients with type 2 diabetes and healthy control subjects. Diabetes. vol 53 Suppl 3. 2005-04-14. PMID:15561915. |
in contrast, the continuous gip infusion led to a weak increase in insulin secretion in both healthy subjects and type 2 diabetic patients. |
2005-04-14 |
2023-08-12 |
human |
| Juris J Meier, Baptist Gallwitz, Bartholomaeus Kask, Carolyn F Deacon, Jens J Holst, Wolfgang E Schmidt, Michael A Nauc. Stimulation of insulin secretion by intravenous bolus injection and continuous infusion of gastric inhibitory polypeptide in patients with type 2 diabetes and healthy control subjects. Diabetes. vol 53 Suppl 3. 2005-04-14. PMID:15561915. |
the dose-response relationship for the increase in insulin secretion after gip bolus administration was similar in both groups, although at different degrees of beta-cell function. |
2005-04-14 |
2023-08-12 |
human |