| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Florian Lippl, Florian Kircher, Johannes Erdmann, Hans-Dieter Allescher, Volker Schusdziarr. Effect of GIP, GLP-1, insulin and gastrin on ghrelin release in the isolated rat stomach. Regulatory peptides. vol 119. issue 1-2. 2004-11-19. PMID:15093702. |
to elucidate their potential role, glucagon-like peptide-1 (glp-1), gastric inhibitory polypeptide (gip), insulin, gastrin and somatostatin were examined on isolated rat stomach ghrelin secretion, which offers the advantage of avoiding systemic interactions. |
2004-11-19 |
2023-08-12 |
rat |
| Taner Damci, Serap Yalin, Huriye Balci, Zeynep Osar, Ustun Korugan, Mucahit Ozyazar, Hasan Ilkov. Orlistat augments postprandial increases in glucagon-like peptide 1 in obese type 2 diabetic patients. Diabetes care. vol 27. issue 5. 2004-11-16. PMID:15111524. |
glucagon-like peptide 1 (glp-1) and glucose-dependent insulinotropic peptide (gip) are gut hormones that are secreted in response to food intake, and they both stimulate insulin secretion. |
2004-11-16 |
2023-08-12 |
Not clear |
| M Diamant, M C M Bunck, R J Hein. [Analogs of glucagon-like peptide-1 (GLP-1): an old concept as a new treatment of patients with diabetes mellitus type 2]. Nederlands tijdschrift voor geneeskunde. vol 148. issue 39. 2004-11-16. PMID:15495988. |
glp-1 and gip stimulate beta-cell proliferation and differentiation, whereas glp-1 only inhibits gastric emptying and glucagon secretion, reduces food intake and improves insulin sensitivity. |
2004-11-16 |
2023-08-12 |
human |
| Raik Wolf, Torsten Hoffmann, Fred Rosche, Hans-Ulrich Demut. Simultaneous determination of incretin hormones and their truncated forms from human plasma by immunoprecipitation and liquid chromatography-mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. vol 803. issue 1. 2004-11-09. PMID:15026002. |
the incretins, glucose-dependent insulinotropic peptide (gip(1-42)) and glucagon-like peptide 1 (glp-1(7-36)), are involved in regulation of gastric emptying, glucose homeostasis, body fat regulation and the glucose-induced insulin secretion from the endocrine pancreas. |
2004-11-09 |
2023-08-12 |
human |
| Katsushi Tsukiyama, Yuichiro Yamada, Kazumasa Miyawaki, Akihiro Hamasaki, Kazuaki Nagashima, Masaya Hosokawa, Shimpei Fujimoto, Akira Takahashi, Kentaro Toyoda, Shinya Toyokuni, Yutaka Oiso, Yutaka Sein. Gastric inhibitory polypeptide is the major insulinotropic factor in K(ATP) null mice. European journal of endocrinology. vol 151. issue 3. 2004-11-08. PMID:15362972. |
gastric inhibitory polypeptide (gip) is a physiological incretin that stimulates insulin release upon ingestion of nutrients. |
2004-11-08 |
2023-08-12 |
mouse |
| Katsushi Tsukiyama, Yuichiro Yamada, Kazumasa Miyawaki, Akihiro Hamasaki, Kazuaki Nagashima, Masaya Hosokawa, Shimpei Fujimoto, Akira Takahashi, Kentaro Toyoda, Shinya Toyokuni, Yutaka Oiso, Yutaka Sein. Gastric inhibitory polypeptide is the major insulinotropic factor in K(ATP) null mice. European journal of endocrinology. vol 151. issue 3. 2004-11-08. PMID:15362972. |
to determine if gip is the insulinotropic factor in insulin secretion in k(atp) channel-deficient mice, we generated double-knockout kir6.2 and gip receptor null mice and compared them with kir6.2 knockout mice. |
2004-11-08 |
2023-08-12 |
mouse |
| Abelardo Aguilera, Antonio Cirugeda, Ruth Amair, Gabriela Sansone, Laura Alegre, Rosa Codoceo, M Auxiliadora Bajo, Gloria del Peso, Juan J Díez, José A Sánchez-Tomero, Rafael Selga. Ghrelin plasma levels and appetite in peritoneal dialysis patients. Advances in peritoneal dialysis. Conference on Peritoneal Dialysis. vol 20. 2004-11-06. PMID:15384825. |
at the same time, negative relationships were observed between blood ghrelin and gip (r = -0.42, p < 0.05), insulin (r = -0.4, p < 0.05), leptin (r = -0.45, p < 0.05), and creatinine clearance [r = -0.33, p = 0.08 (nonsignificant)]. |
2004-11-06 |
2023-08-12 |
human |
| Natalia N Rudovich, Helmut J Rochlitz, Andreas F H Pfeiffe. Reduced hepatic insulin extraction in response to gastric inhibitory polypeptide compensates for reduced insulin secretion in normal-weight and normal glucose tolerant first-degree relatives of type 2 diabetic patients. Diabetes. vol 53. issue 9. 2004-10-26. PMID:15331546. |
our objective was to study whether young first-degree relatives of patients with type 2 diabetes (fdrs) have altered insulin secretion and insulin clearance in response to gastric inhibitory polypeptide (gip) in combination with glucose and arginine. |
2004-10-26 |
2023-08-12 |
human |
| Natalia N Rudovich, Helmut J Rochlitz, Andreas F H Pfeiffe. Reduced hepatic insulin extraction in response to gastric inhibitory polypeptide compensates for reduced insulin secretion in normal-weight and normal glucose tolerant first-degree relatives of type 2 diabetic patients. Diabetes. vol 53. issue 9. 2004-10-26. PMID:15331546. |
insulin clearance was significantly reduced in the group of fdrs under basal conditions and in response to gip, but there was no general defect in insulin clearance in response to glucose and arginine. |
2004-10-26 |
2023-08-12 |
human |
| Natalia N Rudovich, Helmut J Rochlitz, Andreas F H Pfeiffe. Reduced hepatic insulin extraction in response to gastric inhibitory polypeptide compensates for reduced insulin secretion in normal-weight and normal glucose tolerant first-degree relatives of type 2 diabetic patients. Diabetes. vol 53. issue 9. 2004-10-26. PMID:15331546. |
the homa(ir) correlated negatively (p < 0.01) with insulin clearance under basal conditions (r = -0.96) and under gip infusion (r = -0.56). |
2004-10-26 |
2023-08-12 |
human |
| B Thoren. [GIP and GLP-1: multiplicity of regulator mechanisms for insulin secretion]. Journees annuelles de diabetologie de l'Hotel-Dieu. 2004-09-23. PMID:15259310. |
[gip and glp-1: multiplicity of regulator mechanisms for insulin secretion]. |
2004-09-23 |
2023-08-12 |
Not clear |
| Simon A Hinke, Susanne Manhart, Madeleine Speck, Raymond A Pederson, Hans-Ulrich Demuth, Christopher H S McIntos. In depth analysis of the N-terminal bioactive domain of gastric inhibitory polypeptide. Life sciences. vol 75. issue 15. 2004-09-16. PMID:15302229. |
gastric inhibitory polypeptide/glucose-dependent insulinotropic polypeptide (gip) is an important gastrointestinal regulator of insulin release and glucose homeostasis following a meal. |
2004-09-16 |
2023-08-12 |
Not clear |
| Jens Juul Holst, Jesper Gromad. Role of incretin hormones in the regulation of insulin secretion in diabetic and nondiabetic humans. American journal of physiology. Endocrinology and metabolism. vol 287. issue 2. 2004-08-30. PMID:15271645. |
on the other hand, the insulintropic effect of glp-1 is preserved, whereas the effect of gip is greatly reduced, mainly because of a complete loss of the normal gip-induced potentiation of second-phase insulin secretion. |
2004-08-30 |
2023-08-12 |
Not clear |
| Mitsuhiko Umahara, Shuichi Okada, Kihachi Ohshima, Masatomo Mor. Glucose-dependent insulinotropic polypeptide induced growth hormone secretion in acromegaly. Endocrine journal. vol 50. issue 5. 2004-08-25. PMID:14614222. |
glucose-dependent insulinotropic polypeptide (gip), a peptide released from the intestines after meals, is thought to stimulate insulin secretion. |
2004-08-25 |
2023-08-12 |
Not clear |
| B D Green, V A Gault, P R Flatt, P Harriott, B Greer, F P M O'Hart. Comparative effects of GLP-1 and GIP on cAMP production, insulin secretion, and in vivo antidiabetic actions following substitution of Ala8/Ala2 with 2-aminobutyric acid. Archives of biochemistry and biophysics. vol 428. issue 2. 2004-08-16. PMID:15246869. |
comparative effects of glp-1 and gip on camp production, insulin secretion, and in vivo antidiabetic actions following substitution of ala8/ala2 with 2-aminobutyric acid. |
2004-08-16 |
2023-08-12 |
mouse |
| Dominique Delmeire, Daisy Flamez, Karen Moens, Simon A Hinke, Chris Van Schravendijk, Daniel Pipeleers, Frans Schui. Prior in vitro exposure to GLP-1 with or without GIP can influence the subsequent beta cell responsiveness. Biochemical pharmacology. vol 68. issue 1. 2004-07-19. PMID:15183115. |
glucagon-like peptide-1 (7-36) amide (glp-1) and glucose-dependent insulinotropic peptide (gip) potentiate glucose-induced insulin release when present at the time of nutrient stimulation. |
2004-07-19 |
2023-08-12 |
rat |
| Dominique Delmeire, Daisy Flamez, Karen Moens, Simon A Hinke, Chris Van Schravendijk, Daniel Pipeleers, Frans Schui. Prior in vitro exposure to GLP-1 with or without GIP can influence the subsequent beta cell responsiveness. Biochemical pharmacology. vol 68. issue 1. 2004-07-19. PMID:15183115. |
however, when both glp-1 and gip, each at 0.5 nm, were added to the one hour pulses, they not only amplified insulin release during the pulses, as was the case with their single addition, but also increased the secretory response to a subsequent stimulation by glucose and glp-1. |
2004-07-19 |
2023-08-12 |
rat |
| E Rask, T Olsson, S Söderberg, J j Holst Jj, A Tura, G Pacini, B Ahré. Insulin secretion and incretin hormones after oral glucose in non-obese subjects with impaired glucose tolerance. Metabolism: clinical and experimental. vol 53. issue 5. 2004-07-08. PMID:15131768. |
in this study, we sought to establish the interrelation between insulin secretion and insulin sensitivity after oral glucose in non-obese subjects with igt and we also examined this interrelation in relation to the 2 main incretins, glucagon-like peptide (glp-1) and gastric inhibitory polypeptide (gip). |
2004-07-08 |
2023-08-12 |
human |
| E Rask, T Olsson, S Söderberg, J j Holst Jj, A Tura, G Pacini, B Ahré. Insulin secretion and incretin hormones after oral glucose in non-obese subjects with impaired glucose tolerance. Metabolism: clinical and experimental. vol 53. issue 5. 2004-07-08. PMID:15131768. |
to that end, 13 women with igt and 17 women with normal glucose tolerance (ngt) underwent an oral glucose tolerance test (ogtt) with measurements of glucose, insulin, c-peptide, glp-1, and gip. |
2004-07-08 |
2023-08-12 |
human |
| Juris J Meier, Michael A Nauck, Daniel Kranz, Jens J Holst, Carolyn F Deacon, Dirk Gaeckler, Wolfgang E Schmidt, Baptist Gallwit. Secretion, degradation, and elimination of glucagon-like peptide 1 and gastric inhibitory polypeptide in patients with chronic renal insufficiency and healthy control subjects. Diabetes. vol 53. issue 3. 2004-06-08. PMID:14988249. |
venous blood samples were drawn for the determination of glucose (glucose oxidase), insulin, c-peptide, glp-1 (total and intact), and gip (total and intact; specific immunoassays). |
2004-06-08 |
2023-08-12 |
human |