| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Reawika Chaikomin, Selena Doran, Karen L Jones, Christine Feinle-Bisset, Deirdre O'Donovan, Christopher K Rayner, Michael Horowit. Initially more rapid small intestinal glucose delivery increases plasma insulin, GIP, and GLP-1 but does not improve overall glycemia in healthy subjects. American journal of physiology. Endocrinology and metabolism. vol 289. issue 3. 2005-09-21. PMID:15886226. |
the latter is also dependent on stimulation of insulin secretion by glucose-dependent insulinotropic polypeptide (gip) and glucagon-like peptide-1 (glp-1). |
2005-09-21 |
2023-08-12 |
human |
| Reawika Chaikomin, Selena Doran, Karen L Jones, Christine Feinle-Bisset, Deirdre O'Donovan, Christopher K Rayner, Michael Horowit. Initially more rapid small intestinal glucose delivery increases plasma insulin, GIP, and GLP-1 but does not improve overall glycemia in healthy subjects. American journal of physiology. Endocrinology and metabolism. vol 289. issue 3. 2005-09-21. PMID:15886226. |
between t = 0 and 75 min, plasma insulin, gip, and glp-1 were higher with the variable infusion. |
2005-09-21 |
2023-08-12 |
human |
| J F Gautier, S Fetita, E Sobngwi, C Salaün-Marti. Biological actions of the incretins GIP and GLP-1 and therapeutic perspectives in patients with type 2 diabetes. Diabetes & metabolism. vol 31. issue 3 Pt 1. 2005-09-21. PMID:16142014. |
in humans, the incretin effect is mainly caused by two peptide hormones, glucose-dependent insulin releasing polypeptide gip, and glucagon-like peptide-1 glp-1. |
2005-09-21 |
2023-08-12 |
Not clear |
| Juris J Meier, Guido Kemmeries, Jens J Holst, Michael A Nauc. Erythromycin antagonizes the deceleration of gastric emptying by glucagon-like peptide 1 and unmasks its insulinotropic effect in healthy subjects. Diabetes. vol 54. issue 7. 2005-09-13. PMID:15983224. |
capillary and venous blood samples were drawn for the determination of glucose (glucose oxidase), insulin, c-peptide, glp-1, glucagon, gastric inhibitory polypeptide (gip), and pancreatic polypeptide (specific immunoassays). |
2005-09-13 |
2023-08-12 |
human |
| Olli Laukkanen, Jaana Lindström, Johan Eriksson, Timo T Valle, Helena Hämäläinen, Pirjo Ilanne-Parikka, Sirkka Keinänen-Kiukaanniemi, Jaakko Tuomilehto, Matti Uusitupa, Markku Laaks. Polymorphisms in the SLC2A2 (GLUT2) gene are associated with the conversion from impaired glucose tolerance to type 2 diabetes: the Finnish Diabetes Prevention Study. Diabetes. vol 54. issue 7. 2005-09-13. PMID:15983230. |
the aim of this study was to investigate whether single nucleotide polymorphisms (snps) in the genes regulating insulin secretion (slc2a2 [encoding glut2], gck, tcf1 [encoding hnf-1alpha], hnf4a, gip, and glp1r) are associated with the conversion from impaired glucose tolerance (igt) to type 2 diabetes in participants of the finnish diabetes prevention study. |
2005-09-13 |
2023-08-12 |
human |
| A Rucha, E J Verspoh. Heterologous desensitization of insulin secretion by GIP (glucose-dependent insulinotropic peptide) in INS-1 cells: the significance of Galphai2 and investigations on the mechanism involved. Cell biochemistry and function. vol 23. issue 3. 2005-08-04. PMID:15376236. |
heterologous desensitization of insulin secretion by gip (glucose-dependent insulinotropic peptide) in ins-1 cells: the significance of galphai2 and investigations on the mechanism involved. |
2005-08-04 |
2023-08-12 |
Not clear |
| A Rucha, E J Verspoh. Heterologous desensitization of insulin secretion by GIP (glucose-dependent insulinotropic peptide) in INS-1 cells: the significance of Galphai2 and investigations on the mechanism involved. Cell biochemistry and function. vol 23. issue 3. 2005-08-04. PMID:15376236. |
to characterize the cellular mechanisms that might be responsible for heterologous desensitization in an insulin secretory cell system (ins-1), we investigated the link between g-protein alphai2 level and insulin secretion as the biological effect after prolonged incubation with glucose-dependent insulinotropic polypeptide (gip). |
2005-08-04 |
2023-08-12 |
Not clear |
| A Rucha, E J Verspoh. Heterologous desensitization of insulin secretion by GIP (glucose-dependent insulinotropic peptide) in INS-1 cells: the significance of Galphai2 and investigations on the mechanism involved. Cell biochemistry and function. vol 23. issue 3. 2005-08-04. PMID:15376236. |
persistent activation (8 h) of the gip signalling pathway decreased the glp (glucagon-like peptide)-1 dependent insulin secretion (specific radioimmunoassay) accompanied by an upregulation of g-protein alphai2 protein level to about 126% whereas g-protein alphai3 and alphas protein levels remained unchanged (assessed by western blots using specific antibodies). |
2005-08-04 |
2023-08-12 |
Not clear |
| A Rucha, E J Verspoh. Heterologous desensitization of insulin secretion by GIP (glucose-dependent insulinotropic peptide) in INS-1 cells: the significance of Galphai2 and investigations on the mechanism involved. Cell biochemistry and function. vol 23. issue 3. 2005-08-04. PMID:15376236. |
heterologous desensitization of glp-1-dependent insulin secretion by pretreatment with gip, however, was not inhibited by calcium/calmodulin-dependent enzymes (using kn-62 and fk 506), but only by suppressing the camp/pka signalling pathway using rp-8-br-camps. |
2005-08-04 |
2023-08-12 |
Not clear |
| Carolyn F Deaco. What do we know about the secretion and degradation of incretin hormones? Regulatory peptides. vol 128. issue 2. 2005-08-04. PMID:15780431. |
the incretin hormones, glucose-dependent insulinotropic peptide (gip) and glucagon-like peptide-1 (glp-1) are secreted from endocrine cells located in the intestinal mucosa, and act to enhance meal-induced insulin secretion. |
2005-08-04 |
2023-08-12 |
human |
| John Dupr. Glycaemic effects of incretins in Type 1 diabetes mellitus: a concise review, with emphasis on studies in humans. Regulatory peptides. vol 128. issue 2. 2005-08-04. PMID:15780434. |
preservation of the insulin response to parenteral glucagon-like peptide-1 (glp-1), contrasting with lack of stimulation of insulin secretion by the other known incretin gastric inhibitory polypeptide (gip), prompted studies with exogenous glp-1 in recent-onset type 1 diabetes. |
2005-08-04 |
2023-08-12 |
human |
| Su-Jin Kim, Kyle Winter, Cuilan Nian, Makoto Tsuneoka, Yoshiro Koda, Christopher H S McIntos. Glucose-dependent insulinotropic polypeptide (GIP) stimulation of pancreatic beta-cell survival is dependent upon phosphatidylinositol 3-kinase (PI3K)/protein kinase B (PKB) signaling, inactivation of the forkhead transcription factor Foxo1, and down-regulation of bax expression. The Journal of biological chemistry. vol 280. issue 23. 2005-08-02. PMID:15817464. |
the hormone glucose-dependent insulinotropic polypeptide (gip) potently stimulates insulin secretion and promotes beta-cell proliferation and cell survival. |
2005-08-02 |
2023-08-12 |
mouse |
| Full-Young Chang, Tseng-Shing Chen, Shou-Dong Lee, Ming-Luen Doong, Guey-Hwa Yeh, Paulus S Wan. Pentagastrin-induced gastric acid secretion in the diabetic rats: role of insulin. The Chinese journal of physiology. vol 47. issue 4. 2005-07-19. PMID:15803750. |
measured basal and stimulated plasma gip levels of those diabetic rats during acid stimulation remained higher, regardless of insulin treatment (p < 0.05). |
2005-07-19 |
2023-08-12 |
rat |
| Full-Young Chang, Tseng-Shing Chen, Shou-Dong Lee, Ming-Luen Doong, Guey-Hwa Yeh, Paulus S Wan. Pentagastrin-induced gastric acid secretion in the diabetic rats: role of insulin. The Chinese journal of physiology. vol 47. issue 4. 2005-07-19. PMID:15803750. |
our results suggest that insulin has the ability to attenuate pentagastrin-stimulated acid output in rats, whereas gip is not involved in this attenuation. |
2005-07-19 |
2023-08-12 |
rat |
| O Andersen, S B Haugaard, J J Holst, C F Deacon, J Iversen, U B Andersen, J O Nielsen, S Madsba. Enhanced glucagon-like peptide-1 (GLP-1) response to oral glucose in glucose-intolerant HIV-infected patients on antiretroviral therapy. HIV medicine. vol 6. issue 2. 2005-07-18. PMID:15807714. |
we investigated whether the incretin hormones glucagon-like peptide-1 (glp-1) and glucose-dependent insulinotropic polypeptide (gip), which are major regulators of glucose tolerance through the stimulation of insulin secretion, contribute to impaired glucose tolerance (igt) among hiv-infected patients on highly active antiretroviral therapy (haart). |
2005-07-18 |
2023-08-12 |
Not clear |
| J R Lindsay, N A Duffy, A M McKillop, J Ardill, F P M O'Harte, P R Flatt, P M Bel. Inhibition of dipeptidyl peptidase IV activity by oral metformin in Type 2 diabetes. Diabetic medicine : a journal of the British Diabetic Association. vol 22. issue 5. 2005-07-18. PMID:15842525. |
glucagon-like peptide-1 (glp-1) and gastric inhibitory polypeptide (gip) are important insulinotropic hormones that enhance the insulin secretory response to feeding. |
2005-07-18 |
2023-08-12 |
Not clear |
| Diana Gentilcore, Renuka Visvanathan, Antonietta Russo, Reawika Chaikomin, Julie E Stevens, Judith M Wishart, Anne Tonkin, Michael Horowitz, Karen L Jone. Role of nitric oxide mechanisms in gastric emptying of, and the blood pressure and glycemic responses to, oral glucose in healthy older subjects. American journal of physiology. Gastrointestinal and liver physiology. vol 288. issue 6. 2005-06-21. PMID:15691867. |
ge, bp (systolic and diastolic), heart rate (hr), blood glucose, plasma insulin, and incretin hormones, glucose-dependant insulinotropic-polypeptide (gip), and glucagon-like peptide-1 (glp-1), were measured. |
2005-06-21 |
2023-08-12 |
human |
| Takashi Miki, Kohtaro Minami, Hidehiro Shinozaki, Kimio Matsumura, Atsunori Saraya, Hiroki Ikeda, Yuichiro Yamada, Jens Juul Holst, Susumu Sein. Distinct effects of glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 on insulin secretion and gut motility. Diabetes. vol 54. issue 4. 2005-06-03. PMID:15793244. |
glucose-induced insulin secretion from pancreatic beta-cells depends critically on atp-sensitive k(+) channel (k(atp) channel) activity, but it is not known whether k(atp) channels are involved in the potentiation of insulin secretion by glucose-dependent insulinotropic polypeptide (gip). |
2005-06-03 |
2023-08-12 |
mouse |
| Takashi Miki, Kohtaro Minami, Hidehiro Shinozaki, Kimio Matsumura, Atsunori Saraya, Hiroki Ikeda, Yuichiro Yamada, Jens Juul Holst, Susumu Sein. Distinct effects of glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 on insulin secretion and gut motility. Diabetes. vol 54. issue 4. 2005-06-03. PMID:15793244. |
in kir6.2(-/-) mice, potentiation of insulin secretion by gip in vivo was markedly attenuated, indicating that k(atp) channels are essential in the insulinotropic effect of gip. |
2005-06-03 |
2023-08-12 |
mouse |
| Takashi Miki, Kohtaro Minami, Hidehiro Shinozaki, Kimio Matsumura, Atsunori Saraya, Hiroki Ikeda, Yuichiro Yamada, Jens Juul Holst, Susumu Sein. Distinct effects of glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 on insulin secretion and gut motility. Diabetes. vol 54. issue 4. 2005-06-03. PMID:15793244. |
perfusion experiments of kir6.2(-/-) mice revealed severely impaired potentiation of insulin secretion by 1 nmol/l gip and substantial potentiation by 1 nmol/l glp-1. |
2005-06-03 |
2023-08-12 |
mouse |