| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Carolyn F Deacon, Astrid Plamboeck, Mette M Rosenkilde, Jocelyn de Heer, Jens J Hols. GIP-(3-42) does not antagonize insulinotropic effects of GIP at physiological concentrations. American journal of physiology. Endocrinology and metabolism. vol 291. issue 3. 2006-09-26. PMID:16608883. |
in the isolated perfused rat pancreas, gip-(3-42) alone had no effect on insulin output and only reduced the response to gip (1 nm) when coinfused in >50-fold molar excess (ic(50), 138 nm). |
2006-09-26 |
2023-08-12 |
mouse |
| Tanya J Little, Selena Doran, James H Meyer, Andre J P M Smout, Deirdre G O'Donovan, Keng-Liang Wu, Karen L Jones, Judith Wishart, Christopher K Rayner, Michael Horowitz, Christine Feinle-Bisse. The release of GLP-1 and ghrelin, but not GIP and CCK, by glucose is dependent upon the length of small intestine exposed. American journal of physiology. Endocrinology and metabolism. vol 291. issue 3. 2006-09-26. PMID:16684852. |
the aims of this study were to determine the effects of modifying the length of small intestine exposed to glucose on plasma concentrations of glp-1 and also glucose-dependent insulinotropic peptide (gip), insulin, cholecystokinin (cck) and ghrelin, and antropyloric pressures. |
2006-09-26 |
2023-08-12 |
Not clear |
| Nigel Irwin, Gillian C Clarke, Brian D Green, Brett Greer, Patrick Harriott, Victor A Gault, Finbarr P M O'Harte, Peter R Flat. Evaluation of the antidiabetic activity of DPP IV resistant N-terminally modified versus mid-chain acylated analogues of glucose-dependent insulinotropic polypeptide. Biochemical pharmacology. vol 72. issue 6. 2006-09-26. PMID:16859646. |
the metabolic and insulin secretory responses to native gip were also enhanced in 14-day analogue treated mice, revealing no evidence of gip-receptor desensitization. |
2006-09-26 |
2023-08-12 |
mouse |
| B Gallwit. Therapies for the treatment of type 2 diabetes mellitus based on incretin action. Minerva endocrinologica. vol 31. issue 2. 2006-08-30. PMID:16682937. |
type 2 diabetes is characterized by an incretin defect: while gip does not stimulate insulin secretion, glp-1 action is still preserved under supraphysiological concentrations. |
2006-08-30 |
2023-08-12 |
Not clear |
| Juris J Meier, Michael A Nauc. Incretins and the development of type 2 diabetes. Current diabetes reports. vol 6. issue 3. 2006-08-25. PMID:16898571. |
the incretin hormones gastric inhibitory polypeptide (gip) and glucagon-like peptide 1 (glp-1) are released in response to nutrient ingestion and potentiate glucose-stimulated insulin secretion from pancreatic beta cells. |
2006-08-25 |
2023-08-12 |
Not clear |
| Nigel Irwin, Brian D Green, Victor A Gault, Roslyn S Cassidy, Finbarr P M O'Harte, Patrick Harriott, Peter R Flat. Effects on glucose homeostasis and insulin secretion of long term activation of the glucose-dependent insulinotropic polypeptide (GIP) receptor by N-AcGIP(LysPAL37) in normal mice. Peptides. vol 27. issue 4. 2006-08-11. PMID:16181707. |
effects on glucose homeostasis and insulin secretion of long term activation of the glucose-dependent insulinotropic polypeptide (gip) receptor by n-acgip(lyspal37) in normal mice. |
2006-08-11 |
2023-08-12 |
mouse |
| Nigel Irwin, Brian D Green, Victor A Gault, Roslyn S Cassidy, Finbarr P M O'Harte, Patrick Harriott, Peter R Flat. Effects on glucose homeostasis and insulin secretion of long term activation of the glucose-dependent insulinotropic polypeptide (GIP) receptor by N-AcGIP(LysPAL37) in normal mice. Peptides. vol 27. issue 4. 2006-08-11. PMID:16181707. |
these data indicate that long term activation of the gip receptor by daily treatment with n-acgip(lyspal37) improved glucose tolerance due to enhancement of pancreatic beta cell glucose responsiveness and insulin secretion. |
2006-08-11 |
2023-08-12 |
mouse |
| Iñigo Alaña, Jeremy C Parker, Victor A Gault, Peter R Flatt, Finbarr P M O'Harte, J Paul G Malthouse, Chandralal M Hewag. NMR and alanine scan studies of glucose-dependent insulinotropic polypeptide in water. The Journal of biological chemistry. vol 281. issue 24. 2006-08-01. PMID:16621806. |
glucose-dependent insulinotropic polypeptide (gip) is an incretin hormone that stimulates the secretion of insulin after ingestion of food. |
2006-08-01 |
2023-08-12 |
Not clear |
| Aine M O'Connor, Suresh Pola, Blathnaid M Ward, Davina Fillmore, Keith D Buchanan, John P Kirwa. The gastroenteroinsular response to glucose ingestion during postexercise recovery. American journal of physiology. Endocrinology and metabolism. vol 290. issue 6. 2006-07-13. PMID:16403776. |
during the first 60 min of recovery from exercise alone (expl), plasma vasoactive intestinal peptide (vip), gastrin, and glucagon-like peptide-1 (glp-1) all increased significantly, whereas glucose, insulin, and gastric inhibitory polypeptide (gip) were unchanged from the immediate postexercise value. |
2006-07-13 |
2023-08-12 |
Not clear |
| Aine M O'Connor, Suresh Pola, Blathnaid M Ward, Davina Fillmore, Keith D Buchanan, John P Kirwa. The gastroenteroinsular response to glucose ingestion during postexercise recovery. American journal of physiology. Endocrinology and metabolism. vol 290. issue 6. 2006-07-13. PMID:16403776. |
when glucose was ingested after exercise (exglu), glucose, insulin, vip, gastrin, glp-1, and gip were all increased (p < 0.01). |
2006-07-13 |
2023-08-12 |
Not clear |
| Aine M O'Connor, Suresh Pola, Blathnaid M Ward, Davina Fillmore, Keith D Buchanan, John P Kirwa. The gastroenteroinsular response to glucose ingestion during postexercise recovery. American journal of physiology. Endocrinology and metabolism. vol 290. issue 6. 2006-07-13. PMID:16403776. |
however, when glucose was ingested after resting for 2 h (conglu), vip levels were unaffected, although glucose, insulin, gastrin, glp-1, and gip levels increased (p < 0.05). |
2006-07-13 |
2023-08-12 |
Not clear |
| Renate E Wachters-Hagedoorn, Marion G Priebe, Janneke A J Heimweg, A Marius Heiner, Klaus N Englyst, Jens J Holst, Frans Stellaard, Roel J Von. The rate of intestinal glucose absorption is correlated with plasma glucose-dependent insulinotropic polypeptide concentrations in healthy men. The Journal of nutrition. vol 136. issue 6. 2006-06-22. PMID:16702313. |
in a crossover study, glucose, insulin, glp-1, and gip concentrations were monitored for 6 h after consumption of glucose, uncooked cornstarch (uccs) or corn pasta in 7 healthy men. |
2006-06-22 |
2023-08-12 |
Not clear |
| Joanna Kluz, Rajmund Adamie. [New therapeutic approach in patients with type 2 diabetes based on glucagon-like peptide 1 (GLP-1) and gastric inhibitory peptide (GIP)]. Postepy higieny i medycyny doswiadczalnej (Online). vol 60. 2006-05-16. PMID:16407790. |
apart from their glucose-dependent manner of stimulating insulin secretion, glp-1, its analogues, and gip have been demonstrated to stimulate beta-cell growth, differentiation, proliferation, and survival. |
2006-05-16 |
2023-08-12 |
Not clear |
| Laurie L Baggio, Daniel J Drucke. Therapeutic approaches to preserve islet mass in type 2 diabetes. Annual review of medicine. vol 57. 2006-05-04. PMID:16409149. |
similarly, glucose-dependent insulinotropic polypeptide (gip) receptor activation stimulates insulin secretion, enhances beta-cell proliferation, and reduces apoptosis. |
2006-05-04 |
2023-08-12 |
Not clear |
| Daniel J Drucke. The biology of incretin hormones. Cell metabolism. vol 3. issue 3. 2006-05-01. PMID:16517403. |
gut peptides, exemplified by glucagon-like peptide-1 (glp-1) and glucose-dependent insulinotropic polypeptide (gip) are secreted in a nutrient-dependent manner and stimulate glucose-dependent insulin secretion. |
2006-05-01 |
2023-08-12 |
human |
| Daniel J Drucke. The biology of incretin hormones. Cell metabolism. vol 3. issue 3. 2006-05-01. PMID:16517403. |
furthermore, glp-1, unlike gip, potently stimulates insulin secretion and reduces blood glucose in human subjects with type 2 diabetes. |
2006-05-01 |
2023-08-12 |
human |
| S Sondhi, J M Castellano, V Z Chong, R M Rogoza, K J Skoblenick, B A Dyck, J Gabriele, N Thomas, K Ki, Z B Pristupa, A N Singh, D MacCrimmon, P Voruganti, J Foster, R K Mishr. cDNA array reveals increased expression of glucose-dependent insulinotropic polypeptide following chronic clozapine treatment: role in atypical antipsychotic drug-induced adverse metabolic effects. The pharmacogenomics journal. vol 6. issue 2. 2006-04-28. PMID:16402076. |
gip is an insulinotropic agent with stimulatory effects on insulin synthesis and release from the pancreas. |
2006-04-28 |
2023-08-12 |
human |
| Nigel Irwin, Finbarr P M O'Harte, Victor A Gault, Brian D Green, Brett Greer, Patrick Harriott, Clifford J Bailey, Peter R Flat. GIP(Lys16PAL) and GIP(Lys37PAL): novel long-acting acylated analogues of glucose-dependent insulinotropic polypeptide with improved antidiabetic potential. Journal of medicinal chemistry. vol 49. issue 3. 2006-03-29. PMID:16451070. |
glucose-dependent insulinotropic polypeptide (gip) is a physiological insulin releasing peptide. |
2006-03-29 |
2023-08-12 |
mouse |
| Nigel Irwin, Finbarr P M O'Harte, Victor A Gault, Brian D Green, Brett Greer, Patrick Harriott, Clifford J Bailey, Peter R Flat. GIP(Lys16PAL) and GIP(Lys37PAL): novel long-acting acylated analogues of glucose-dependent insulinotropic polypeptide with improved antidiabetic potential. Journal of medicinal chemistry. vol 49. issue 3. 2006-03-29. PMID:16451070. |
in vitro studies demonstrated that gip analogues retained their ability to activate the gip receptor through production of camp and to stimulate insulin secretion. |
2006-03-29 |
2023-08-12 |
mouse |
| Nigel Irwin, Finbarr P M O'Harte, Victor A Gault, Brian D Green, Brett Greer, Patrick Harriott, Clifford J Bailey, Peter R Flat. GIP(Lys16PAL) and GIP(Lys37PAL): novel long-acting acylated analogues of glucose-dependent insulinotropic polypeptide with improved antidiabetic potential. Journal of medicinal chemistry. vol 49. issue 3. 2006-03-29. PMID:16451070. |
intraperitoneal administration of gip analogues to obese diabetic (ob/ob) mice significantly decreased the glycemic excursion and elicited increased and prolonged insulin responses compared to native gip. |
2006-03-29 |
2023-08-12 |
mouse |