| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S M Younan, L A Rashe. Impairment of the insulinotropic effect of gastric inhibitory polypeptide (GIP) in obese and diabetic rats is related to the down-regulation of its pancreatic receptors. General physiology and biophysics. vol 26. issue 3. 2008-02-19. PMID:18063845. |
in type 2 diabetes, there is a possibility that an important part of the impaired insulin secretion is due to the gastric inhibitory polypeptide (gip) hormone. |
2008-02-19 |
2023-08-12 |
rat |
| S M Younan, L A Rashe. Impairment of the insulinotropic effect of gastric inhibitory polypeptide (GIP) in obese and diabetic rats is related to the down-regulation of its pancreatic receptors. General physiology and biophysics. vol 26. issue 3. 2008-02-19. PMID:18063845. |
this study investigated changes that occur in the pancreatic gip receptors' (gip-rs) expression and in gip secretion in obese and type 2 diabetic rats and its relation to plasma glucose and insulin levels during oral glucose tolerance test (ogtt) compared to control rats. |
2008-02-19 |
2023-08-12 |
rat |
| S M Younan, L A Rashe. Impairment of the insulinotropic effect of gastric inhibitory polypeptide (GIP) in obese and diabetic rats is related to the down-regulation of its pancreatic receptors. General physiology and biophysics. vol 26. issue 3. 2008-02-19. PMID:18063845. |
in conclusion, both obese and diabetic rats had an impaired early-phase insulinotropic effect of gip due to impaired gene expression of gip-rs which could be a potential target to prevent transition of obesity to diabetes and to improve insulin secretion in the latter. |
2008-02-19 |
2023-08-12 |
rat |
| Su-Jin Kim, Cuilan Nian, Christopher H S McIntos. Resistin is a key mediator of glucose-dependent insulinotropic polypeptide (GIP) stimulation of lipoprotein lipase (LPL) activity in adipocytes. The Journal of biological chemistry. vol 282. issue 47. 2008-01-23. PMID:17890220. |
in differentiated 3t3-l1 adipocytes, gip, in the presence of insulin, increased resistin secretion through a pathway involving p38 mitogen-activated protein kinase (p38 mapk) and the stress-activated protein kinase/jun amino-terminal kinase (sapk/jnk). |
2008-01-23 |
2023-08-12 |
rat |
| V A Gault, P L McClean, R S Cassidy, N Irwin, P R Flat. Chemical gastric inhibitory polypeptide receptor antagonism protects against obesity, insulin resistance, glucose intolerance and associated disturbances in mice fed high-fat and cafeteria diets. Diabetologia. vol 50. issue 8. 2008-01-07. PMID:17558485. |
gastric inhibitory polypeptide (gip) receptor antagonism with (pro(3))gip improves glucose tolerance and ameliorates insulin resistance and abnormalities of islet structure/function in ob/ob mice. |
2008-01-07 |
2023-08-12 |
mouse |
| V A Gault, P L McClean, R S Cassidy, N Irwin, P R Flat. Chemical gastric inhibitory polypeptide receptor antagonism protects against obesity, insulin resistance, glucose intolerance and associated disturbances in mice fed high-fat and cafeteria diets. Diabetologia. vol 50. issue 8. 2008-01-07. PMID:17558485. |
this study examined the ability of (pro(3))gip to counter the development of obesity, insulin resistance and diabetes in mice fed high-fat and cafeteria diets. |
2008-01-07 |
2023-08-12 |
mouse |
| Iñigo Alaña, J Paul G Malthouse, Finbarr P M O'Harte, Chandralal M Hewag. The bioactive conformation of glucose-dependent insulinotropic polypeptide by NMR and CD spectroscopy. Proteins. vol 68. issue 1. 2007-12-31. PMID:17393464. |
glucose-dependent insulinotropic polypeptide (gip) is a gastrointestinal incretin hormone, which modulates physiological insulin secretion. |
2007-12-31 |
2023-08-12 |
Not clear |
| Carolyn F Deacon, Richard D Carr, Jens J Hols. DPP-4 inhibitor therapy: new directions in the treatment of type 2 diabetes. Frontiers in bioscience : a journal and virtual library. vol 13. 2007-12-11. PMID:17981667. |
one emerging area of interest is centred upon the actions of the incretin hormones glucagon-like peptide-1 (glp-1) and glucose-dependent insulinotropic polypeptide (gip), which enhance meal-induced insulin secretion and have trophic effects on the beta-cell. |
2007-12-11 |
2023-08-12 |
Not clear |
| Chizumi Yamada, Yuichiro Yamada, Katsushi Tsukiyama, Kotaro Yamada, Shunsuke Yamane, Norio Harada, Kazumasa Miyawaki, Yutaka Seino, Nobuya Inagak. Genetic inactivation of GIP signaling reverses aging-associated insulin resistance through body composition changes. Biochemical and biophysical research communications. vol 364. issue 1. 2007-11-26. PMID:17937928. |
genetic inactivation of gip signaling reverses aging-associated insulin resistance through body composition changes. |
2007-11-26 |
2023-08-12 |
mouse |
| Chizumi Yamada, Yuichiro Yamada, Katsushi Tsukiyama, Kotaro Yamada, Shunsuke Yamane, Norio Harada, Kazumasa Miyawaki, Yutaka Seino, Nobuya Inagak. Genetic inactivation of GIP signaling reverses aging-associated insulin resistance through body composition changes. Biochemical and biophysical research communications. vol 364. issue 1. 2007-11-26. PMID:17937928. |
we therefore conclude that genetic inactivation of gip signaling can prevent the development of aging-associated insulin resistance through body composition changes. |
2007-11-26 |
2023-08-12 |
mouse |
| Inke Nitz, Eva Fisher, Cornelia Weikert, Barbara Burwinkel, Yun Li, Matthias Möhlig, Heiner Boeing, Stefan Schreiber, Jürgen Schrezenmeir, Frank Dörin. Association analyses of GIP and GIPR polymorphisms with traits of the metabolic syndrome. Molecular nutrition & food research. vol 51. issue 8. 2007-11-09. PMID:17624916. |
glucose-dependent insulinotropic polypeptide (gip) stimulates insulin release via interaction with its pancreatic receptor (gip receptor (gipr)). |
2007-11-09 |
2023-08-12 |
human |
| Charlotta Dornonville de la Cour, Per Norlén, Rolf Håkanso. Secretion of ghrelin from rat stomach ghrelin cells in response to local microinfusion of candidate messenger compounds: a microdialysis study. Regulatory peptides. vol 143. issue 1-3. 2007-11-06. PMID:17573135. |
all other candidate messengers were without measurable effects, including acetylcholine, serotonin, histamine, gaba, aspartic acid, glutamic acid, glycine, vip, pacap, cgrp, substance p, npy, pyy, pp, gastrin, cck, gip, insulin, glucagon, glp and glucose. |
2007-11-06 |
2023-08-12 |
rat |
| Olga D Carlson, Jehan D David, Jessica M Schrieder, Dennis C Muller, Hyeung-Jin Jang, Byung-Joon Kim, Josephine M Ega. Contribution of nonesterified fatty acids to insulin resistance in the elderly with normal fasting but diabetic 2-hour postchallenge plasma glucose levels: the Baltimore Longitudinal Study of Aging. Metabolism: clinical and experimental. vol 56. issue 10. 2007-10-29. PMID:17884459. |
we measured plasma levels of glucose, insulin, c-peptide, glucagon-like peptide-1 (glp-1), glucose-dependent insulinotropic peptide (gip), ghrelin, leptin, adiponectin, resistin, c-reactive protein, cytokines, and their soluble receptors, as well as nonesterified free fatty acids (nefas). |
2007-10-29 |
2023-08-12 |
human |
| Juris J Meier, Jens J Holst, Wolfgang E Schmidt, Michael A Nauc. Reduction of hepatic insulin clearance after oral glucose ingestion is not mediated by glucagon-like peptide 1 or gastric inhibitory polypeptide in humans. American journal of physiology. Endocrinology and metabolism. vol 293. issue 3. 2007-10-24. PMID:17609256. |
therefore, we determined insulin clearance in response to endogenously secreted and exogenously administered gip and glp-1. |
2007-10-24 |
2023-08-12 |
Not clear |
| Juris J Meier, Jens J Holst, Wolfgang E Schmidt, Michael A Nauc. Reduction of hepatic insulin clearance after oral glucose ingestion is not mediated by glucagon-like peptide 1 or gastric inhibitory polypeptide in humans. American journal of physiology. Endocrinology and metabolism. vol 293. issue 3. 2007-10-24. PMID:17609256. |
insulin clearance was estimated from the molar c-peptide-to-insulin ratio calculated at basal conditions and from the respective areas under the curve after glucose, gip, or glp-1 administration. |
2007-10-24 |
2023-08-12 |
Not clear |
| Juris J Meier, Jens J Holst, Wolfgang E Schmidt, Michael A Nauc. Reduction of hepatic insulin clearance after oral glucose ingestion is not mediated by glucagon-like peptide 1 or gastric inhibitory polypeptide in humans. American journal of physiology. Endocrinology and metabolism. vol 293. issue 3. 2007-10-24. PMID:17609256. |
the endogenous secretion of gip or glp-1 was unrelated to the changes in insulin clearance. |
2007-10-24 |
2023-08-12 |
Not clear |
| Juris J Meier, Jens J Holst, Wolfgang E Schmidt, Michael A Nauc. Reduction of hepatic insulin clearance after oral glucose ingestion is not mediated by glucagon-like peptide 1 or gastric inhibitory polypeptide in humans. American journal of physiology. Endocrinology and metabolism. vol 293. issue 3. 2007-10-24. PMID:17609256. |
neither gip nor glp-1 has significant effects on insulin extraction. |
2007-10-24 |
2023-08-12 |
Not clear |
| Amelia N Pilichiewicz, Reawika Chaikomin, Ixchel M Brennan, Judith M Wishart, Christopher K Rayner, Karen L Jones, Andre J P M Smout, Michael Horowitz, Christine Feinle-Bisse. Load-dependent effects of duodenal glucose on glycemia, gastrointestinal hormones, antropyloroduodenal motility, and energy intake in healthy men. American journal of physiology. Endocrinology and metabolism. vol 293. issue 3. 2007-10-24. PMID:17609258. |
the rises in insulin, glp-1, gip, and cck were related to the glucose load (r > 0.82, p < 0.05). |
2007-10-24 |
2023-08-12 |
human |
| Amelia N Pilichiewicz, Reawika Chaikomin, Ixchel M Brennan, Judith M Wishart, Christopher K Rayner, Karen L Jones, Andre J P M Smout, Michael Horowitz, Christine Feinle-Bisse. Load-dependent effects of duodenal glucose on glycemia, gastrointestinal hormones, antropyloroduodenal motility, and energy intake in healthy men. American journal of physiology. Endocrinology and metabolism. vol 293. issue 3. 2007-10-24. PMID:17609258. |
in conclusion, variations in duodenal glucose loads have differential effects on blood glucose, plasma insulin, glp-1, gip and cck, antropyloroduodenal motility, and energy intake in healthy subjects. |
2007-10-24 |
2023-08-12 |
human |
| Nicola A Duffy, Brian D Green, Nigel Irwin, Victor A Gault, Aine M McKillop, Finbarr P M O'Harte, Peter R Flat. Effects of antidiabetic drugs on dipeptidyl peptidase IV activity: nateglinide is an inhibitor of DPP IV and augments the antidiabetic activity of glucagon-like peptide-1. European journal of pharmacology. vol 568. issue 1-3. 2007-10-19. PMID:17573070. |
nateglinide similarly benefited the glucose and insulin responses to feeding in ob/ob mice and such actions were abolished by co-administration of exendin(9-39) and (pro(3))gip to block incretin hormone action. |
2007-10-19 |
2023-08-12 |
mouse |