| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Flurin Item, Stephan Wueest, Vera Lemos, Sokrates Stein, Fabrizio C Lucchini, Rémy Denzler, Muriel C Fisser, Tenagne D Challa, Eija Pirinen, Youngsoo Kim, Silvio Hemmi, Erich Gulbins, Atan Gross, Lorraine A O'Reilly, Markus Stoffel, Johan Auwerx, Daniel Konra. Fas cell surface death receptor controls hepatic lipid metabolism by regulating mitochondrial function. Nature communications. vol 8. issue 1. 2018-02-02. PMID:28883393. |
show that fas, a member of the tnf receptor superfamily, contributes to mitochondrial dysfunction, steatosis development, and insulin resistance under high fat diet. |
2018-02-02 |
2023-08-13 |
mouse |
| Yogi Umbarawan, Mas Rizky A A Syamsunarno, Hideru Obinata, Aiko Yamaguchi, Hiroaki Sunaga, Hiroki Matsui, Takako Hishiki, Tomomi Matsuura, Norimichi Koitabashi, Masaru Obokata, Hirofumi Hanaoka, Anwarul Haque, Fumio Kunimoto, Yoshito Tsushima, Makoto Suematsu, Masahiko Kurabayashi, Tatsuya Is. Robust suppression of cardiac energy catabolism with marked accumulation of energy substrates during lipopolysaccharide-induced cardiac dysfunction in mice. Metabolism: clinical and experimental. vol 77. 2017-11-27. PMID:28941596. |
myocardial contractile dysfunction in sepsis has been attributed mainly to increased inflammatory cytokines, insulin resistance, and impaired oxidative phosphorylation of fatty acids (fas). |
2017-11-27 |
2023-08-13 |
mouse |
| Alba Bosquet, Sandra Guaita-Esteruelas, Paula Saavedra, Ricardo Rodríguez-Calvo, Mercedes Heras, Josefa Girona, Lluís Masan. Exogenous FABP4 induces endoplasmic reticulum stress in HepG2 liver cells. Atherosclerosis. vol 249. 2017-11-20. PMID:27155388. |
fas contribute to ir by promoting endoplasmic reticulum stress (er stress) and altering the insulin signaling pathway. |
2017-11-20 |
2023-08-13 |
Not clear |
| Wayne Smith, Gavin R Norton, Angela J Woodiwiss, Amanda Lochner, Eugene F du Toi. Dependence of Cardiac Systolic Function on Elevated Fatty Acid Availability in Obese, Insulin-Resistant Rats. Journal of cardiac failure. vol 22. issue 7. 2017-11-09. PMID:27107735. |
we hypothesized that in obesity with prediabetic insulin resistance, circulating fatty acids (fas) become a valuable fuel source in the maintenance of normal systolic function. |
2017-11-09 |
2023-08-13 |
rat |
| Frédéric Capel, Naoufel Cheraiti, Cécile Acquaviva, Carole Hénique, Justine Bertrand-Michel, Christine Vianey-Saban, Carina Prip-Buus, Béatrice Mori. Oleate dose-dependently regulates palmitate metabolism and insulin signaling in C2C12 myotubes. Biochimica et biophysica acta. vol 1861. issue 12 Pt A. 2017-10-19. PMID:27725263. |
because the protective effect of oleate against palmitate-induced insulin resistance may be lessened in skeletal muscle once cell metabolism is overloaded by fatty acids (fas), we examined the impact of varying amounts of oleate on palmitate metabolic channeling and insulin signaling in c2c12 myotubes. |
2017-10-19 |
2023-08-13 |
Not clear |
| Zhuanjian Li, Yongcai Wang, Xiaoxiao Tian, Pengfei Shang, Hong Chen, Xiangtao Kang, Yadong Tian, Ruili Ha. Characterization of the visfatin gene and its expression pattern and effect on 3T3-L1 adipocyte differentiation in chickens. Gene. vol 632. 2017-10-03. PMID:28851613. |
a visfatin fusion protein caused a significant increase in the expression of adipocyte differentiation markers (pparγ, ap2, c/ebpα, and fas) compared with the control group and a decrease compared with the insulin group. |
2017-10-03 |
2023-08-13 |
chicken |
| Yang Li, Yang Liu, Guoxun Che. Vitamin A status affects the plasma parameters and regulation of hepatic genes in streptozotocin-induced diabetic rats. Biochimie. vol 137. 2017-08-17. PMID:28238841. |
insulin treatment induced gck, srebp-1c and fas and suppressed pck1 expression levels in the liver of stz-vas and stz-vad rats. |
2017-08-17 |
2023-08-13 |
rat |
| Yusuke Taguchi, Yuka Toyoshima, Reiko Tokita, Hisanori Kato, Shin-Ichiro Takahashi, Shiro Minam. Triglyceride synthesis in hepatocytes isolated from rats fed a low-protein diet is enhanced independently of upregulation of insulin signaling. Biochemical and biophysical research communications. vol 490. issue 3. 2017-08-14. PMID:28647371. |
the amounts of tg synthesized from both glucose and palmitate, as well as acc1 and fas protein levels, were increased at the basal state in 5c hepatocytes, but were not further increased by insulin. |
2017-08-14 |
2023-08-13 |
rat |
| Guizhen Qiu, Wei Tian, Mei Huan, Jinlong Chen, Haitao F. Formononetin exhibits anti-hyperglycemic activity in alloxan-induced type 1 diabetic mice. Experimental biology and medicine (Maywood, N.J.). vol 242. issue 2. 2017-06-29. PMID:27412955. |
the results indicated that formononetin (5, 10, and 20 mg/kg; oral administration) reversed the alloxan-induced increase of some indices (fasting blood glucose level and fas and caspase-3 mrna and proteins levels in pancreas tissue) and reduction of some indices (body weight gain, oral glucose tolerance, insulin activity, hepatic glycogen level, pancreatic and duodenal homeobox-1, insulin receptor substrate 2, glucokinase and glucose transporter 2, mrna and proteins levels in pancreas tissue, and glucokinase mrna and protein levels in liver tissue). |
2017-06-29 |
2023-08-13 |
mouse |
| Junyan Jin, Xiaoming Zhu, Dong Han, Yunxia Yang, Haokun Liu, Shouqi Xi. Different regulation of insulin on glucose and lipid metabolism in 2 strains of gibel carp. General and comparative endocrinology. vol 246. 2017-05-12. PMID:28069424. |
conversely, very strong lipogenic capacity, as indicated by higher mrna levels of transcription factor of fatty acid anabolism (srebp1) and lipogenic enzymes (acc, acly, and fas) and decrease lipolytic capacity as indicated by lower mrna levels of fatty acid oxidation enzymes in the liver (aco3) and muscle (cpt1a and aco3) detected in the a strain after insulin injection. |
2017-05-12 |
2023-08-13 |
cattle |
| Amandine Thomas, Elise Belaidi, Judith Aron-Wisnewsky, Gerard C van der Zon, Patrick Levy, Karine Clement, Jean-Louis Pepin, Diane Godin-Ribuot, Bruno Guiga. Hypoxia-inducible factor prolyl hydroxylase 1 (PHD1) deficiency promotes hepatic steatosis and liver-specific insulin resistance in mice. Scientific reports. vol 6. 2017-03-09. PMID:27094951. |
phd1 deficiency led to increase in glycolytic gene expression, lipogenic proteins acc and fas, hepatic steatosis and liver-specific insulin resistance. |
2017-03-09 |
2023-08-13 |
mouse |
| Fabiane Ferreira Martins, Thereza Cristina Lonzetti Bargut, Marcia Barbosa Aguila, Carlos Alberto Mandarim-de-Lacerd. Thermogenesis, fatty acid synthesis with oxidation, and inflammation in the brown adipose tissue of ob/ob (-/-) mice. Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft. vol 210. 2017-03-09. PMID:27986616. |
the ob/ob group also showed impaired gene expression for lipid utilization (perilipin was increased, while other markers were diminished: carnitine palmitoyltransferase-1b, cpt-1b; cluster of differentiation 36, cd36; fatty acid binding protein 4, fabp4; fatty acid synthase, fas, and sterol regulatory element-binding protein 1c, srebp1c), and altered protein expression of insulin signaling (diminished pakt, tc10, and glut-4). |
2017-03-09 |
2023-08-13 |
mouse |
| Lara Bellini, Mélanie Campana, Rana Mahfouz, Aurélie Carlier, Julien Véret, Christophe Magnan, Eric Hajduch, Hervé Le Stunf. Targeting sphingolipid metabolism in the treatment of obesity/type 2 diabetes. Expert opinion on therapeutic targets. vol 19. issue 8. 2017-01-10. PMID:25814122. |
excess circulating fatty acids (fas), which characterize obesity, induce insulin resistance, steatosis, β cells dysfunction and apoptosis. |
2017-01-10 |
2023-08-13 |
Not clear |
| Anton J M Wagenmakers, Juliette A Strauss, Sam O Shepherd, Michelle A Keske, Matthew Cock. Increased muscle blood supply and transendothelial nutrient and insulin transport induced by food intake and exercise: effect of obesity and ageing. The Journal of physiology. vol 594. issue 8. 2016-12-26. PMID:25627798. |
both mechanisms increase the endothelial surface area and therefore transendothelial transport of glucose, fatty acids (fas) and insulin by specific transporters, present in high concentrations in the capillary endothelium. |
2016-12-26 |
2023-08-13 |
Not clear |
| Xiulan Chen, Shimeng Xu, Shasha Wei, Yaqin Deng, Yiran Li, Fuquan Yang, Pingsheng Li. Comparative Proteomic Study of Fatty Acid-treated Myoblasts Reveals Role of Cox-2 in Palmitate-induced Insulin Resistance. Scientific reports. vol 6. 2016-12-23. PMID:26899878. |
accumulated studies demonstrate that saturated fatty acids (fas) such as palmitic acid (pa) inhibit insulin signaling in skeletal muscle cells and monounsaturated fatty acids such as oleic acid (oa) reverse the effect of pa on insulin signaling. |
2016-12-23 |
2023-08-13 |
Not clear |
| Thereza Cristina Lonzetti Bargut, Vanessa Souza-Mello, Carlos Alberto Mandarim-de-Lacerda, Marcia Barbosa Aguil. Fish oil diet modulates epididymal and inguinal adipocyte metabolism in mice. Food & function. vol 7. issue 3. 2016-12-14. PMID:26876019. |
the hf-l group had a greater body mass (bm) gain, insulin resistance, increased gene expression related to lipogenesis (cd36, ap2, srebp1c, and fas), decreased gene expression of perilipin in both ewat and swat, and reduced expression of genes related to beta-oxidation (cpt-1a) and to mitochondrial biogenesis (pgc1alpha, nrf1, and tfam) in ewat and swat. |
2016-12-14 |
2023-08-13 |
mouse |
| Mei-Qin Zhuo, Zhi Luo, Ya-Xiong Pan, Kun Wu, Yao-Fang Fan, Li-Han Zhang, Yu-Feng Son. Effects of insulin and its related signaling pathways on lipid metabolism in the yellow catfish Pelteobagrus fulvidraco. The Journal of experimental biology. vol 218. issue Pt 19. 2016-11-04. PMID:26254320. |
insulin tended to increase hepatic lipid accumulation, the activity of lipogenic enzymes (6pgd, g6pd, me, icdh and fas) and mrna levels of fas, g6pd, 6pgd, cpt ia and pparγ, but down-regulated pparα mrna level. |
2016-11-04 |
2023-08-13 |
Not clear |
| Chong Yew Tan, Samuel Virtue, Steven Murfitt, Lee D Roberts, Lee D Robert, Yi Hui Phua, Martin Dale, Julian L Griffin, Francisco Tinahones, Philipp E Scherer, Antonio Vidal-Pui. Adipose tissue fatty acid chain length and mono-unsaturation increases with obesity and insulin resistance. Scientific reports. vol 5. 2016-11-01. PMID:26679101. |
in mouse models with increasing obesity and insulin resistance, there was an increase in scwat Δ9 desaturated fas (scd ratio) and fas with 18-carbons (elovl6 ratio) in mice. |
2016-11-01 |
2023-08-13 |
mouse |
| Sander Kooijman, José K van den Heuvel, Patrick C N Rense. Neuronal Control of Brown Fat Activity. Trends in endocrinology and metabolism: TEM. vol 26. issue 11. 2016-09-06. PMID:26482876. |
given that activated bat has a high capacity to take up and burn fatty acids (fas) and glucose, pharmacological stimulation of brown fat in humans by either targeting the hypothalamus or mimicking outflow of the sympathetic nervous system might help improve glucose metabolism and insulin sensitivity, and also lower body fat. |
2016-09-06 |
2023-08-13 |
Not clear |
| C Austin Pickens, Karen H Matsuo, Jenifer I Fento. Relationship between Body Mass Index, C-Peptide, and Delta-5-Desaturase Enzyme Activity Estimates in Adult Males. PloS one. vol 11. issue 3. 2016-09-06. PMID:27023786. |
obesity, in particular abdominal obesity, alters the composition of plasma and tissue fatty acids (fas), which contributes to inflammation and insulin resistance. |
2016-09-06 |
2023-08-13 |
Not clear |