| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| L Pénicaud, P Ferré, F Assimacopoulos-Jeannet, D Perdereau, A Leturque, B Jeanrenaud, L Picon, J Girar. Increased gene expression of lipogenic enzymes and glucose transporter in white adipose tissue of suckling and weaned obese Zucker rats. The Biochemical journal. vol 279 ( Pt 1). 1991-11-12. PMID:1681802. |
these results indicate the existence of an enhanced expression of glut 4, fas and acc in white adipose tissue of young obese fa/fa rats which could be related to the increased plasma insulin levels. |
1991-11-12 |
2023-08-11 |
rat |
| W L Blake, S D Clark. Induction of adipose fatty acid binding protein (a-FABP) by insulin-like growth factor-1 (IGF-1) in 3T3-L1 preadipocytes. Biochemical and biophysical research communications. vol 173. issue 1. 1991-01-24. PMID:1701639. |
using the abundance of a-fabp and fatty acid synthase (fas) as criteria of differentiation, igf-1 was found to be 10-fold more potent than insulin as an inducer of preadipocyte differentiation. |
1991-01-24 |
2023-08-11 |
cattle |
| W L Blake, S D Clark. Induction of adipose fatty acid binding protein (a-FABP) by insulin-like growth factor-1 (IGF-1) in 3T3-L1 preadipocytes. Biochemical and biophysical research communications. vol 173. issue 1. 1991-01-24. PMID:1701639. |
as little as 0.5 nm igf-1 induced expression of fas and a-fabp mrnas whereas a minimum of 5 nm insulin was required. |
1991-01-24 |
2023-08-11 |
cattle |
| J J Rumessen, S Bodé, O Hamberg, E Gudmand-Høye. Fructans of Jerusalem artichokes: intestinal transport, absorption, fermentation, and influence on blood glucose, insulin, and C-peptide responses in healthy subjects. The American journal of clinical nutrition. vol 52. issue 4. 1990-10-19. PMID:2206038. |
fructans (fas) isolated from jerusalem artichokes (helianthus tuberosus) were studied with respect to intestinal handling and influence on blood glucose (bg), insulin, and c-peptide responses in eight healthy subjects. |
1990-10-19 |
2023-08-11 |
human |
| S E Mills, C Y Liu, Y Gu, A P Schincke. Effects of ractopamine on adipose tissue metabolism and insulin binding in finishing hogs. Interaction with genotype and slaughter weight. Domestic animal endocrinology. vol 7. issue 2. 1990-08-21. PMID:2196159. |
backfat was removed at slaughter and rates of lipolysis and fatty acid synthesis (fs), activities of malic enzyme (me) and fatty acid synthetase (fas), and insulin binding to adipocytes were assessed. |
1990-08-21 |
2023-08-11 |
Not clear |
| A G Goodridge, W R Carpenter, J E Fisch, M J Goldman, K Kameda, S R Stapleto. Structure and regulation of the avian gene for fatty acid synthase. Reproduction, nutrition, development. vol 29. issue 3. 1990-01-25. PMID:2590394. |
starvation, glucagon and cyclic amp inhibit, and refeeding starved animals and insulin or igf-i plus triiodothyronine stimulate accumulation of fas and its mrna in liver; transcription is the primary regulated step. |
1990-01-25 |
2023-08-11 |
Not clear |
| J D Paulauskis, H S Su. Hormonal regulation of mouse fatty acid synthase gene transcription in liver. The Journal of biological chemistry. vol 264. issue 1. 1989-02-07. PMID:2535847. |
blot analysis of poly(a+) rna showed a rapid and dramatic insulin induction of fatty acid synthase (fas) mrna in diabetic mouse liver. |
1989-02-07 |
2023-08-11 |
mouse |
| J D Paulauskis, H S Su. Hormonal regulation of mouse fatty acid synthase gene transcription in liver. The Journal of biological chemistry. vol 264. issue 1. 1989-02-07. PMID:2535847. |
insulin administration to diabetic mice increased the mrna level 4-fold within 1 h, and a maximum of 19-fold was reached in 6 h. the nutritional induction of fas mrna by fasting/refeeding was abolished by streptozotocin-induced diabetes and also by dibutyryl camp administered during refeeding in normal animals, demonstrating the roles of insulin and camp during nutritional manipulation. |
1989-02-07 |
2023-08-11 |
mouse |
| J D Paulauskis, H S Su. Hormonal regulation of mouse fatty acid synthase gene transcription in liver. The Journal of biological chemistry. vol 264. issue 1. 1989-02-07. PMID:2535847. |
run-on transcription analysis with isolated nuclei showed that the transcription rate of the fas gene increased 3.5-fold after 30 min, reached a maximum of 7-fold after 2 h of insulin administration in diabetic animals, and was maintained at the maximum level to 6 h. the camp, administered to previously fasted normal mice during refeeding of a high carbohydrate diet, abolished the increased transcription of the fas gene caused by nutritional manipulation. |
1989-02-07 |
2023-08-11 |
mouse |
| J D Paulauskis, H S Su. Hormonal regulation of mouse fatty acid synthase gene transcription in liver. The Journal of biological chemistry. vol 264. issue 1. 1989-02-07. PMID:2535847. |
these results indicate positive control by insulin and negative control by dibutyryl camp of fas gene transcription. |
1989-02-07 |
2023-08-11 |
mouse |
| J D Paulauskis, H S Su. Hormonal regulation of mouse fatty acid synthase gene transcription in liver. The Journal of biological chemistry. vol 264. issue 1. 1989-02-07. PMID:2535847. |
furthermore, the effect of insulin on the fas mrna level was abolished by cycloheximide administration. |
1989-02-07 |
2023-08-11 |
mouse |
| J D Paulauskis, H S Su. Hormonal regulation of mouse fatty acid synthase gene transcription in liver. The Journal of biological chemistry. vol 264. issue 1. 1989-02-07. PMID:2535847. |
this indicates that ongoing protein synthesis is necessary for the transcriptional activation of the fas gene by insulin. |
1989-02-07 |
2023-08-11 |
mouse |
| H S Baht, E D Saggerso. Comparison of triacylglycerol synthesis in rat brown and white adipocytes. Effects of hypothyroidism and streptozotocin-diabetes on enzyme activities and metabolic fluxes. The Biochemical journal. vol 250. issue 2. 1988-05-12. PMID:3355527. |
measurements were made of the maximum rate of triacylglycerol synthesis by monitoring the incorporation of [u-14c]glucose into acylglycerol glycerol in the presence of palmitate (1 mm) and insulin (4 nm) and of the activities of the following triacylglycerol-synthesizing enzymes: fatty acyl-coa synthetase (fas), mitochondrial and microsomal forms of glycerolphosphate acyltransferase (gpat), dihydroxyacetonephosphate acyltransferase (dhapat), monoacylglycerol phosphate acyltransferase (mgpat), mg2+-dependent phosphatidate phosphohydrolase (pph) and diacylglycerol acyltransferase (dgat). |
1988-05-12 |
2023-08-11 |
rat |
| E D Saggerson, C A Carpente. Effects of streptozotocin-diabetes and insulin administration in vivo or in vitro on the activities of five enzymes in the adipose-tissue triacylglycerol-synthesis pathway. The Biochemical journal. vol 243. issue 1. 1987-08-14. PMID:3300639. |
insulin administration to diabetic rats over 2 days restored activities of fas, both forms of gpat, mgpat and mg2+-dependent pph. |
1987-08-14 |
2023-08-11 |
rat |
| A A Itani, M J Arslania. The short-term regulation of fatty acid synthesis in the rat epididymal adipocytes. Comparative biochemistry and physiology. B, Comparative biochemistry. vol 81. issue 1. 1985-09-04. PMID:3893875. |
lipogenesis and fatty acid synthetase (fas) activity of isolated rat adipocytes that were treated with insulin or epinephrine were studied. |
1985-09-04 |
2023-08-11 |
human |
| A A Itani, M J Arslania. The short-term regulation of fatty acid synthesis in the rat epididymal adipocytes. Comparative biochemistry and physiology. B, Comparative biochemistry. vol 81. issue 1. 1985-09-04. PMID:3893875. |
rat adipocyte fas, unlike hepatic fas, was not subject to short-term regulation by insulin, although fatty acid synthesis showed such a response. |
1985-09-04 |
2023-08-11 |
human |
| K T Borer, E R Allen, R E Smalley, L Lundell, J Stockto. Recovery from energy deficit in golden hamsters. The American journal of physiology. vol 248. issue 4 Pt 2. 1985-05-14. PMID:3885758. |
increase in imis blocked the postprandial insulin release, reduced plasma insulin concentration and fas activity, and increased malic enzyme activity. |
1985-05-14 |
2023-08-11 |
Not clear |
| S Castells, E Mark, F Abaci, E Schwart. Growth retardation in fetal alcohol syndrome. Unresponsiveness to growth-promoting hormones. Developmental pharmacology and therapeutics. vol 3. issue 4. 1982-09-10. PMID:7201377. |
administration of hgh to 3 patients with fas had little effect upon nitrogen retention and did not increase plasma insulin concentrations, although serum somatomedin activity sharply increased in 1 patient evaluated for somatomedin response. |
1982-09-10 |
2023-08-12 |
Not clear |