| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| C Prip-Buus, D Perdereau, F Foufelle, J Maury, P Ferre, J Girar. Induction of fatty-acid-synthase gene expression by glucose in primary culture of rat hepatocytes. Dependency upon glucokinase activity. European journal of biochemistry. vol 230. issue 1. 1995-08-09. PMID:7601115. |
the regulation of fas expression by glucose and hormones (insulin, dexamethasone and triiodothyronine) was studied in cultured hepatocytes from suckling rats. |
1995-08-09 |
2023-08-12 |
rat |
| V Rolland, I Dugail, X Le Liepvre, M Lava. Evidence of increased glyceraldehyde-3-phosphate dehydrogenase and fatty acid synthetase promoter activities in transiently transfected adipocytes from genetically obese rats. The Journal of biological chemistry. vol 270. issue 3. 1995-02-24. PMID:7836367. |
using this system we found a direct effect of insulin on gapdh and fas gene expression in rat adipocytes. |
1995-02-24 |
2023-08-12 |
rat |
| R B Harri. Factors influencing energy intake of rats fed either a high-fat or a fat mimetic diet. International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity. vol 18. issue 9. 1995-02-07. PMID:7812418. |
in rats fed mimetic diet, energy intake = 77.3 initial weight + 4.5 hepatic fas -2.4 serum free fatty acids + 68.4 serum insulin (r2 = 0.67). |
1995-02-07 |
2023-08-12 |
rat |
| Y Zhu, A G Goodridge, S R Stapleto. Zinc, vanadate and selenate inhibit the tri-iodothyronine-induced expression of fatty acid synthase and malic enzyme in chick-embryo hepatocytes in culture. The Biochemical journal. vol 303 ( Pt 1). 1994-11-09. PMID:7945243. |
in chick-embryo hepatocytes in culture, insulin amplifies the tri-iodothyronine (t3)-induced enzyme activity, and the level and rate of transcription of mrna for both fatty acid synthase (fas) and malic enzyme (me). |
1994-11-09 |
2023-08-12 |
Not clear |
| Y Zhu, A G Goodridge, S R Stapleto. Zinc, vanadate and selenate inhibit the tri-iodothyronine-induced expression of fatty acid synthase and malic enzyme in chick-embryo hepatocytes in culture. The Biochemical journal. vol 303 ( Pt 1). 1994-11-09. PMID:7945243. |
like insulin, these agents had little or no effect on the basal activities for fas and me in chick-embryo hepatocytes in culture for 48 h. unlike insulin, however, zinc, vanadate and selenate inhibited the t3-induced activities and mrna levels of both fas and me. |
1994-11-09 |
2023-08-12 |
Not clear |
| S S Wolf, G Hofer, K F Beck, K Roder, M Schweize. Insulin-responsive regions of the rat fatty acid synthase gene promoter. Biochemical and biophysical research communications. vol 203. issue 2. 1994-10-18. PMID:8093078. |
here we show that insulin may play a role in the diet-induced regulation of the rat fatty acid synthase (fas; ec 2.3.1.85). |
1994-10-18 |
2023-08-12 |
human |
| S S Wolf, G Hofer, K F Beck, K Roder, M Schweize. Insulin-responsive regions of the rat fatty acid synthase gene promoter. Biochemical and biophysical research communications. vol 203. issue 2. 1994-10-18. PMID:8093078. |
transient transfection of human and rat hepatoma cell lines with successively deleted fas/cat promoter fusion plasmids was used to determine the effect of insulin on fas promoter activity. |
1994-10-18 |
2023-08-12 |
human |
| N Moustaïd, R S Beyer, H S Su. Identification of an insulin response element in the fatty acid synthase promoter. The Journal of biological chemistry. vol 269. issue 8. 1994-04-01. PMID:8119899. |
we have previously reported that insulin increases fatty acid synthase (fas) gene transcription, and that sequences responsible for positive regulation are located within the first 332 base pairs of the fas promoter. |
1994-04-01 |
2023-08-12 |
mouse |
| N Moustaïd, R S Beyer, H S Su. Identification of an insulin response element in the fatty acid synthase promoter. The Journal of biological chemistry. vol 269. issue 8. 1994-04-01. PMID:8119899. |
to define minimal sequences required for insulin regulation within this region, chimeric constructs containing serial 5' deletions starting at -318 and extending through position +67 of the rat fas gene ligated to the luciferase reporter gene were transfected into 3t3-l1 adipocytes. |
1994-04-01 |
2023-08-12 |
mouse |
| N Moustaïd, R S Beyer, H S Su. Identification of an insulin response element in the fatty acid synthase promoter. The Journal of biological chemistry. vol 269. issue 8. 1994-04-01. PMID:8119899. |
this stimulation of the fas promoter activity by insulin was dose-dependent. |
1994-04-01 |
2023-08-12 |
mouse |
| N Moustaïd, R S Beyer, H S Su. Identification of an insulin response element in the fatty acid synthase promoter. The Journal of biological chemistry. vol 269. issue 8. 1994-04-01. PMID:8119899. |
however, no effect of insulin was observed when fusion constructs containing fas promoter sequences spanning from -25 or from -19 to +67 were transfected into adipocytes. |
1994-04-01 |
2023-08-12 |
mouse |
| N Moustaïd, R S Beyer, H S Su. Identification of an insulin response element in the fatty acid synthase promoter. The Journal of biological chemistry. vol 269. issue 8. 1994-04-01. PMID:8119899. |
these results suggest that the insulin response sequences of the fas gene may be located in the region from -67 to -25. |
1994-04-01 |
2023-08-12 |
mouse |
| N Moustaïd, R S Beyer, H S Su. Identification of an insulin response element in the fatty acid synthase promoter. The Journal of biological chemistry. vol 269. issue 8. 1994-04-01. PMID:8119899. |
thus, we have identified novel cis-acting dna sequences responsible for insulin regulation of the fas gene, which interact with nuclear protein(s) from liver and adipocytes and which are found to share limited homology to insulin response sequences present in other genes. |
1994-04-01 |
2023-08-12 |
mouse |
| b' J Girard, D Perdereau, F Foufelle, C Prip-Buus, P Ferr\\xc3\\xa. Regulation of lipogenic enzyme gene expression by nutrients and hormones. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 8. issue 1. 1994-03-10. PMID:7905448.' |
an increased glucose metabolism is necessary for the expression of insulin effects on fatty acid synthase (fas) and acetyl-coa carboxylase (acc) mrna accumulation in white adipose tissue, as insulin is ineffective in vitro in the absence of glucose. |
1994-03-10 |
2023-08-12 |
rat |
| N Moustaïd, K Sakamoto, S Clarke, R S Beyer, H S Su. Regulation of fatty acid synthase gene transcription. Sequences that confer a positive insulin effect and differentiation-dependent expression in 3T3-L1 preadipocytes are present in the 332 bp promoter. The Biochemical journal. vol 292 ( Pt 3). 1993-07-27. PMID:8318007. |
we have previously reported induction of fatty acid synthase (fas) gene expression by insulin and adipocyte differentiation in 3t3-l1 cells. |
1993-07-27 |
2023-08-12 |
rat |
| N Moustaïd, K Sakamoto, S Clarke, R S Beyer, H S Su. Regulation of fatty acid synthase gene transcription. Sequences that confer a positive insulin effect and differentiation-dependent expression in 3T3-L1 preadipocytes are present in the 332 bp promoter. The Biochemical journal. vol 292 ( Pt 3). 1993-07-27. PMID:8318007. |
in order to identify sequences responsible for insulin regulation of the fas gene, chimaeric constructs containing serial deletions of the 5'-flanking region of the rat fas gene ligated to the chloramphenicol acetyltransferase (cat) reporter gene were prepared and transfected into 3t3-l1 cells. |
1993-07-27 |
2023-08-12 |
rat |
| N Moustaïd, K Sakamoto, S Clarke, R S Beyer, H S Su. Regulation of fatty acid synthase gene transcription. Sequences that confer a positive insulin effect and differentiation-dependent expression in 3T3-L1 preadipocytes are present in the 332 bp promoter. The Biochemical journal. vol 292 ( Pt 3). 1993-07-27. PMID:8318007. |
these results indicate that sequences responsible for insulin regulation of fas gene are also located within 332 bp of the transcription start site. |
1993-07-27 |
2023-08-12 |
rat |
| b' F Foufelle, B Gouhot, J P P\\xc3\\xa9gorier, D Perdereau, J Girard, P Ferr\\xc3\\xa. Glucose stimulation of lipogenic enzyme gene expression in cultured white adipose tissue. A role for glucose 6-phosphate. The Journal of biological chemistry. vol 267. issue 29. 1992-11-18. PMID:1356982.' |
insulin (100 nm) added in the presence of lactate and pyruvate did not stimulate the expression of fas and acc. |
1992-11-18 |
2023-08-11 |
rat |
| E J Hajduch, M C Guerre-Millo, I A Hainault, C M Guichard, M M Lava. Expression of glucose transporters (GLUT 1 and GLUT 4) in primary cultured rat adipocytes: differential evolution with time and chronic insulin effect. Journal of cellular biochemistry. vol 49. issue 3. 1992-09-10. PMID:1644862. |
chronic exposure to insulin added at day 2 had no effect on glut 4 expression but increased the expression of glut 1 and fas by 70% and 36%, respectively. |
1992-09-10 |
2023-08-11 |
rat |
| E J Hajduch, M C Guerre-Millo, I A Hainault, C M Guichard, M M Lava. Expression of glucose transporters (GLUT 1 and GLUT 4) in primary cultured rat adipocytes: differential evolution with time and chronic insulin effect. Journal of cellular biochemistry. vol 49. issue 3. 1992-09-10. PMID:1644862. |
glucose consumption increased only slightly with insulin (+160%), in good keeping with the low levels of expression of both glut 4 and fas in these cultured cells. |
1992-09-10 |
2023-08-11 |
rat |