| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Y S Moon, M J Latasa, K H Kim, D Wang, H S Su. Two 5'-regions are required for nutritional and insulin regulation of the fatty-acid synthase promoter in transgenic mice. The Journal of biological chemistry. vol 275. issue 14. 2000-05-08. PMID:10744693. |
this study demonstrates that the sequence requirement for fas gene regulation employing an in vitro culture system does not reflect the in vivo situation and that two 5'-flanking regions are required for proper nutritional and insulin regulation of the fas gene. |
2000-05-08 |
2023-08-12 |
mouse |
| S Jacqueminet, I Briaud, C Rouault, G Reach, V Poitou. Inhibition of insulin gene expression by long-term exposure of pancreatic beta cells to palmitate is dependent on the presence of a stimulatory glucose concentration. Metabolism: clinical and experimental. vol 49. issue 4. 2000-05-04. PMID:10778881. |
long-term exposure of pancreatic beta cells to elevated levels of fatty acids (fas) impairs glucose-induced insulin secretion. |
2000-05-04 |
2023-08-12 |
rat |
| S Jacqueminet, I Briaud, C Rouault, G Reach, V Poitou. Inhibition of insulin gene expression by long-term exposure of pancreatic beta cells to palmitate is dependent on the presence of a stimulatory glucose concentration. Metabolism: clinical and experimental. vol 49. issue 4. 2000-05-04. PMID:10778881. |
however, the effects of fas on insulin gene expression are controversial. |
2000-05-04 |
2023-08-12 |
rat |
| S Jacqueminet, I Briaud, C Rouault, G Reach, V Poitou. Inhibition of insulin gene expression by long-term exposure of pancreatic beta cells to palmitate is dependent on the presence of a stimulatory glucose concentration. Metabolism: clinical and experimental. vol 49. issue 4. 2000-05-04. PMID:10778881. |
we hypothesized that fas adversely affect insulin gene expression only in the presence of elevated glucose concentrations. |
2000-05-04 |
2023-08-12 |
rat |
| M Standridge, R Alemzadeh, M Zemel, J Koontz, N Moustaid-Mouss. Diazoxide down-regulates leptin and lipid metabolizing enzymes in adipose tissue of Zucker rats. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 14. issue 3. 2000-04-10. PMID:10698960. |
although diazoxide (5 microm) alone did not change fas activity in cultured 3t3-l1 adipocytes, it significantly attenuated insulin's effect on fas activity (p<0.001). |
2000-04-10 |
2023-08-12 |
rat |
| M K Newell, M E Harper, K Fortner, J Desbarats, A Russo, S A Hube. Does the oxidative/glycolytic ratio determine proliferation or death in immune recognition? Annals of the New York Academy of Sciences. vol 887. 2000-02-25. PMID:10668465. |
we demonstrate the reciprocal relationship that inducing a shift in metabolism toward glycolysis by supplying glucose and insulin results in the upregulation of immunologically recognizable molecules such as cell surface fas. |
2000-02-25 |
2023-08-12 |
Not clear |
| U Zumsteg, S Frigerio, G A Hollände. Nitric oxide production and Fas surface expression mediate two independent pathways of cytokine-induced murine beta-cell damage. Diabetes. vol 49. issue 1. 2000-01-18. PMID:10615948. |
here we report that a combination of these cytokines inhibits insulin release, stimulates inducible nitric oxide synthase (inos), and upregulates the surface expression of fas in nit-1 beta-cells and intact mouse islets. |
2000-01-18 |
2023-08-12 |
mouse |
| R Fiebig, M T Gore, L L J. Exercise attenuates nuclear protein binding to gene regulatory sequences of hepatic fatty acid synthase. Journal of applied physiology (Bethesda, Md. : 1985). vol 87. issue 3. 1999-10-14. PMID:10484571. |
gel mobility shift assay indicated that r rats had twofold higher liver nuclear protein binding to oligonucleotides corresponding to the insulin responsive sequence (-71/-50) and carbohydrate response element (+283/+303) on the fas promoter, compared with f rats. |
1999-10-14 |
2023-08-12 |
rat |
| R Fiebig, M T Gore, L L J. Exercise attenuates nuclear protein binding to gene regulatory sequences of hepatic fatty acid synthase. Journal of applied physiology (Bethesda, Md. : 1985). vol 87. issue 3. 1999-10-14. PMID:10484571. |
the results reveal that dietary induction of hepatic fas is stimulated by increased nuclear protein binding to insulin responsive sequence and carbohydrate response element, whereas exhaustive exercise attenuates the binding, which may precede downregulation of fas mrna and enzyme synthesis reported in our previous work (m. a. griffiths, r. fiebig, m. t. gore, d. h. baker, k. esser, l. oscai, and l. l. ji. |
1999-10-14 |
2023-08-12 |
rat |
| N Giannoukakis, W A Rudert, S C Ghivizzani, A Gambotto, C Ricordi, M Trucco, P D Robbin. Adenoviral gene transfer of the interleukin-1 receptor antagonist protein to human islets prevents IL-1beta-induced beta-cell impairment and activation of islet cell apoptosis in vitro. Diabetes. vol 48. issue 9. 1999-09-30. PMID:10480601. |
in particular, il-1beta can impair glucose-stimulated insulin production in beta-cells in vitro and can sensitize them to fas (cd95)/fasl-triggered apoptosis. |
1999-09-30 |
2023-08-12 |
human |
| A D Mooradian, S G Alber. The age-related changes in lipogenic enzymes: the role of dietary factors and thyroid hormone responsiveness. Mechanisms of ageing and development. vol 108. issue 2. 1999-09-09. PMID:10400307. |
to determine whether resistance to insulin or to thyroid hormones rather than an inherent defect in enzyme activity expression account for the age-related changes in lipogenic enzymes, the activities of malic enzymes (me), fatty acid synthase (fas), glucose-6-phosphate dehydrogenase (g-6pd) and 6-phosphogluconate dehydrogenase (6-pgd) were assayed in hepatic, retroperitoneal fat and epididymal fat cytosol of male fischer 344 rats at 3.5, 12 and 25 months of age. |
1999-09-09 |
2023-08-12 |
rat |
| C Rufo, D Gasperikova, S D Clarke, M Teran-Garcia, M T Nakamur. Identification of a novel enhancer sequence in the distal promoter of the rat fatty acid synthase gene. Biochemical and biophysical research communications. vol 261. issue 2. 1999-09-08. PMID:10425197. |
the proximal promoter and first intron of the fatty acid synthase (fas) gene contains response sequences for insulin and glucose, but the 2- to 3-fold increase in fas promoter activity attributable to these sequences falls short of the 20- to 30-fold induction in hepatic fas gene transcription observed in fasted-refed rats. |
1999-09-08 |
2023-08-12 |
rat |
| C Rufo, D Gasperikova, S D Clarke, M Teran-Garcia, M T Nakamur. Identification of a novel enhancer sequence in the distal promoter of the rat fatty acid synthase gene. Biochemical and biophysical research communications. vol 261. issue 2. 1999-09-08. PMID:10425197. |
when rat hepatocytes were transfected with a cat construct that linked the region of -9700 and -4606 with the insulin response region located between -265 to +65, fas promoter activity was induced 15-fold. |
1999-09-08 |
2023-08-12 |
rat |
| S O Ebbesson, J Kennish, L Ebbesson, O Go, J Ye. Diabetes is related to fatty acid imbalance in Eskimos. International journal of circumpolar health. vol 58. issue 2. 1999-08-24. PMID:10429340. |
these data provide evidence that glucose intolerance and insulin resistance are associated with a deviation from a traditional diet of fish and marine mammals (high in omega-3 fas and low in saturated fats) to commercial foods (low in omega-3 fas and high in saturated fats). |
1999-08-24 |
2023-08-12 |
human |
| K Roder, S S Wolf, S Sickinger, M Schweize. FIRE3 in the promoter of the rat fatty acid synthase (FAS) gene binds the ubiquitous transcription factors CBF and USF but does not mediate an insulin response in a rat hepatoma cell line. European journal of biochemistry. vol 260. issue 3. 1999-05-06. PMID:10103003. |
fire3 in the promoter of the rat fatty acid synthase (fas) gene binds the ubiquitous transcription factors cbf and usf but does not mediate an insulin response in a rat hepatoma cell line. |
1999-05-06 |
2023-08-12 |
human |
| K Roder, S S Wolf, S Sickinger, M Schweize. FIRE3 in the promoter of the rat fatty acid synthase (FAS) gene binds the ubiquitous transcription factors CBF and USF but does not mediate an insulin response in a rat hepatoma cell line. European journal of biochemistry. vol 260. issue 3. 1999-05-06. PMID:10103003. |
transient transfection experiments using fas promoter constructs deleted for fire2 and fire3 demonstrate that neither of these elements mediates the insulin response of the fas promoter in the rat hepatoma cell line h4iie, however, ice at -103/-87 is responsible for mediating the effect of the insulin antagonist camp. |
1999-05-06 |
2023-08-12 |
human |
| K Roder, S S Wolf, S Sickinger, M Schweize. FIRE3 in the promoter of the rat fatty acid synthase (FAS) gene binds the ubiquitous transcription factors CBF and USF but does not mediate an insulin response in a rat hepatoma cell line. European journal of biochemistry. vol 260. issue 3. 1999-05-06. PMID:10103003. |
the hfire element located at -57/-34, in spite of its role in the glucose/insulin response in primary rat hepatocytes, is apparently not involved in the insulin regulation of the rat fas promoter in h4iie cells. |
1999-05-06 |
2023-08-12 |
human |
| H Fukuda, N Iritani, T Sugimoto, H Iked. Transcriptional regulation of fatty acid synthase gene by insulin/glucose, polyunsaturated fatty acid and leptin in hepatocytes and adipocytes in normal and genetically obese rats. European journal of biochemistry. vol 260. issue 2. 1999-04-26. PMID:10095788. |
leptin and polyunsaturated fatty acids appeared to suppress the insulin stimulation of fas transcription by reducing the insulin-binding capacities of receptors. |
1999-04-26 |
2023-08-12 |
rat |
| M Casado, V S Vallet, A Kahn, S Vaulon. Essential role in vivo of upstream stimulatory factors for a normal dietary response of the fatty acid synthase gene in the liver. The Journal of biological chemistry. vol 274. issue 4. 1999-02-16. PMID:9890958. |
in both types of mouse lines, defective in either usf1 or usf2, induction of the fas gene by refeeding a carbohydrate-rich diet was severely delayed, whereas expression of srebp1 was almost normal and insulin response unchanged. |
1999-02-16 |
2023-08-12 |
mouse |
| Y Q Liu, K Tornheim, J L Leah. Shared biochemical properties of glucotoxicity and lipotoxicity in islets decrease citrate synthase activity and increase phosphofructokinase activity. Diabetes. vol 47. issue 12. 1998-12-21. PMID:9836520. |
culturing islets with long-chain fatty acids (fas) replicates the basal insulin hypersecretion. |
1998-12-21 |
2023-08-12 |
rat |