| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ayman Hyder, Basma Sheta, Manar Eissa, Jürgen Schrezenmei. Silencing the FABP3 gene in insulin-secreting cells reduces fatty acid uptake and protects against lipotoxicity. Acta diabetologica. 2024-07-03. PMID:38960943. |
long-term exposure of pancreatic islets to fatty acids (fas), common in obesity, metabolic syndrome, and type 2 diabetes, leads to a compensatory hyperactivity followed by inflammation, apoptosis, dysfunctional beta cells, and results in insulin dependence of the patient. |
2024-07-03 |
2024-07-10 |
Not clear |
| Cuiyu Li, Bin Fang, Yuanyuan Wei, Rou Mo, Xing Lin, Quanfang Huan. The Regulatory Mechanism of Smilax China L. Saponins against Nonalcoholic Fatty Liver Is Revealed by Metabolomics and Transcriptomics. Journal of oleo science. vol 73. issue 5. 2024-05-01. PMID:38692892. |
the effect of scs on liver injury was observed by h&e staining and the regulative mechanism of scs on lipid formation was exposed by detecting oil red o, insulin resistance (ir), and fatty acids synthesis (fas). |
2024-05-01 |
2024-05-04 |
rat |
| Cuiyu Li, Bin Fang, Yuanyuan Wei, Rou Mo, Xing Lin, Quanfang Huan. The Regulatory Mechanism of Smilax China L. Saponins against Nonalcoholic Fatty Liver Is Revealed by Metabolomics and Transcriptomics. Journal of oleo science. vol 73. issue 5. 2024-05-01. PMID:38692892. |
this study demonstrates that scs significantly ameliorates lipid metabolic disturbance in rats with nafld by relieving insulin resistance, inhibiting the fas enzymes, and regulating the sphingolipid and glycerophospholipid metabolism pathways. |
2024-05-01 |
2024-05-04 |
rat |
| Yae Rim Choi, Young-Suk Kim, Min Jung Ki. Cinnamyl Alcohol Attenuates Adipogenesis in 3T3-L1 Cells by Arresting the Cell Cycle. International journal of molecular sciences. vol 25. issue 2. 2024-01-23. PMID:38255766. |
as evidenced by oil red o staining, western blotting, and real-time pcr (rt-pcr) analyses, ca treatment (6.25-25 μm) for 8 d significantly inhibited lipid accumulation in a concentration-dependent manner and downregulated adipogenesis-related markers (peroxisome proliferator-activated receptor γ (pparγ), ccaat/enhancer-binding protein α (c/ebpα), fatty acid binding protein 4 (fabp4), adiponectin, fatty acid synthase (fas)) in 3-isobutyl-1-methylxanthine, dexamethasone, and insulin(mdi)-treated 3t3-l1 adipocytes. |
2024-01-23 |
2024-01-25 |
Not clear |
| Aidan P Holman, Kimberly Quinn, Rakesh Kumar, Sebastian Kmiecik, Abid Ali, Dmitry Kurousk. Fatty Acids Reverse the Supramolecular Chirality of Insulin Fibrils. The journal of physical chemistry letters. 2023-07-27. PMID:37498215. |
using vibrational circular dichroism, we found that all analyzed fas reversed the supramolecular chirality of insulin fibrils. |
2023-07-27 |
2023-08-14 |
Not clear |
| Aidan P Holman, Kimberly Quinn, Rakesh Kumar, Sebastian Kmiecik, Abid Ali, Dmitry Kurousk. Fatty Acids Reverse the Supramolecular Chirality of Insulin Fibrils. The journal of physical chemistry letters. 2023-07-27. PMID:37498215. |
molecular dynamics simulations showed that strong hydrophobic interactions were formed between the long aliphatic tails of fas and hydrophobic amino acid residues of insulin. |
2023-07-27 |
2023-08-14 |
Not clear |
| M Zanjirband, R Hodayi, Z Safaeinejad, M H Nasr-Esfahani, R Ghaedi-Heydar. Evaluation of the p53 pathway in polycystic ovarian syndrome pathogenesis and apoptosis enhancement in human granulosa cells through transcriptome data analysis. Scientific reports. vol 13. issue 1. 2023-07-19. PMID:37468508. |
results have shown differentially expressed p53 target genes involved in apoptosis (bax, fas, pmaip1, and casp8), cell cycle (cyclins, cyclin dependent kinases), glucose metabolism and insulin resistance (thbs1), and p53 regulation (mdm2). |
2023-07-19 |
2023-08-14 |
human |
| Addison Frese, Cody Goode, Kiryl Zhaliazka, Aidan Holman, Tianyi Dou, Dmitry Kurousk. Length and Saturation of Fatty Acids in Phosphatidylserine Determine the Rate of Lysozyme Aggregation Simultaneously Altering the Structure and Toxicity of Amyloid Oligomers and Fibrils. Protein science : a publication of the Protein Society. 2023-07-04. PMID:37402649. |
we found that both length and saturation of fas in ps contribute to the aggregation rate of insulin. |
2023-07-04 |
2023-08-14 |
Not clear |
| Addison Frese, Cody Goode, Kiryl Zhaliazka, Aidan Holman, Tianyi Dou, Dmitry Kurousk. Length and Saturation of Fatty Acids in Phosphatidylserine Determine the Rate of Lysozyme Aggregation Simultaneously Altering the Structure and Toxicity of Amyloid Oligomers and Fibrils. Protein science : a publication of the Protein Society. 2023-07-04. PMID:37402649. |
our results demonstrate that the presence of double bonds in fas accelerated the rate of insulin aggregation relative to ps with fully saturated fas. |
2023-07-04 |
2023-08-14 |
Not clear |
| Xiaoqiong Zhu, Liu Chen, Jiansheng Lin, Mingqin Ba, Junqiu Liao, Ping Zhang, Cunxi Zha. Association between fatty acids and the risk of impaired glucose tolerance and type 2 diabetes mellitus in American adults: NHANES 2005-2016. Nutrition & diabetes. vol 13. issue 1. 2023-05-01. PMID:37127641. |
fatty acids (fas) play a major role in regulating insulin sensitivity. |
2023-05-01 |
2023-08-14 |
Not clear |
| Naghmeh Jannat Ali Pour, Hossein Zabihi-Mahmoudabadi, Reyhane Ebrahimi, Mir Saeed Yekaninejad, Seyyed Mohammad Reza Hashemnia, Reza Meshkani, Solaleh Emamgholipou. Principal component analysis of adipose tissue gene expression of lipogenic and adipogenic factors in obesity. BMC endocrine disorders. vol 23. issue 1. 2023-04-27. PMID:37106328. |
we aimed to study the relationship of the transcript levels of peroxisome proliferator activator receptor γ (pparγ), ccaat/enhancer-binding protein alpha (c/ebp-α), liver x receptor (lxr), sterol regulatory element-binding protein-1c (srebp-1c), fatty acid synthase (fas), and acetyl-coa carboxylase (acc) in subcutaneous adipose tissue (sat) and visceral adipose tissue (vat) from obese and normal-weight women with a variety of anthropometric indices, metabolic and biochemical parameters, and insulin resistance. |
2023-04-27 |
2023-08-14 |
Not clear |
| Ayman Hyde. Naturally-occurring carboxylic acids from traditional antidiabetic plants as potential pancreatic islet FABP3 inhibitors. A molecular docking-aided study. Chemico-biological interactions. 2023-01-29. PMID:36709838. |
in diabetes, which is a lipid disease, long-term exposure of pancreatic islet beta cells to fatty acids (fas) increases basal insulin release, reduces glucose-stimulated insulin secretion, causes islet beta cell inflammation, failure and apoptosis. |
2023-01-29 |
2023-08-14 |
Not clear |
| Arnulfo Ramos-Jiménez, Ruth A Zavala-Lira, Verónica Moreno-Brito, Everardo González-Rodrígue. FAT/CD36 Participation in Human Skeletal Muscle Lipid Metabolism: A Systematic Review. Journal of clinical medicine. vol 12. issue 1. 2023-01-08. PMID:36615118. |
fatty acid translocase/cluster of differentiation 36 (fat/cd36) is a multifunctional membrane protein activated by a high-fat diet, physical exercise, fatty acids (fas), leptin, and insulin. |
2023-01-08 |
2023-08-14 |
human |
| Karina Sánchez-Alegría, Clorinda Aria. Functional consequences of brain exposure to saturated fatty acids: From energy metabolism and insulin resistance to neuronal damage. Endocrinology, diabetes & metabolism. 2022-11-02. PMID:36321333. |
saturated fatty acids (fas) are the main component of high-fat diets (hfds), and high consumption has been associated with the development of insulin resistance, endoplasmic reticulum stress and mitochondrial dysfunction in neuronal cells. |
2022-11-02 |
2023-08-14 |
Not clear |
| Shilpa R Nagarajan, Eloise Cross, Elspeth Johnson, Fabio Sanna, Lorna J Daniels, David W Ray, Leanne Hodso. Determining the temporal, dose, and composition effects of nutritional substrates in an in vitro model of intrahepatocellular triglyceride accumulation. Physiological reports. vol 10. issue 20. 2022-10-27. PMID:36301719. |
therefore, the aims of this study were to investigate the effect of modifying media composition, concentration, and treatment frequency of sugars, fas and insulin on intrahepatocellular triglyceride content and intracellular glucose, fa and circadian function. |
2022-10-27 |
2023-08-14 |
human |
| Adilson Guilherme, Leslie A Rowland, Hui Wang, Michael P Czec. The adipocyte supersystem of insulin and cAMP signaling. Trends in cell biology. 2022-08-21. PMID:35989245. |
adipocytes sequester triglyceride (tg) in fed conditions stimulated by insulin, while in fasting catecholamines trigger tg hydrolysis, releasing glycerol and fatty acids (fas). |
2022-08-21 |
2023-08-14 |
Not clear |
| Mikhail Matveyenka, Stanislav Rizevsky, Dmitry Kurousk. Length and Unsaturation of Fatty Acids of Phosphatidic Acid Determines the Aggregation Rate of Insulin and Modifies the Structure and Toxicity of Insulin Aggregates. ACS chemical neuroscience. 2022-08-05. PMID:35930674. |
in this study, we investigated the effect of pa with different lengths and unsaturation of fas on insulin aggregation. |
2022-08-05 |
2023-08-14 |
Not clear |
| Mikhail Matveyenka, Stanislav Rizevsky, Dmitry Kurousk. Length and Unsaturation of Fatty Acids of Phosphatidic Acid Determines the Aggregation Rate of Insulin and Modifies the Structure and Toxicity of Insulin Aggregates. ACS chemical neuroscience. 2022-08-05. PMID:35930674. |
we found that pa with c16:0 fas strongly inhibited insulin aggregation, whereas pa with c18:0 fas accelerated it. |
2022-08-05 |
2023-08-14 |
Not clear |
| Mikhail Matveyenka, Stanislav Rizevsky, Dmitry Kurousk. Length and Unsaturation of Fatty Acids of Phosphatidic Acid Determines the Aggregation Rate of Insulin and Modifies the Structure and Toxicity of Insulin Aggregates. ACS chemical neuroscience. 2022-08-05. PMID:35930674. |
furthermore, pa with unsaturated (c18:1) fas made the insulin form extremely long and thick fibrils that were not observed for pas with saturated fas. |
2022-08-05 |
2023-08-14 |
Not clear |
| Somaya Z Mansour, Enas M Moustafa, Fatma S M Moawe. Modulation of endoplasmic reticulum stress via sulforaphane-mediated AMPK upregulation against nonalcoholic fatty liver disease in rats. Cell stress & chaperones. 2022-07-02. PMID:35779187. |
as a result, the lipid profile, liver enzymes, glucose, insulin, il-1β, adipokines (leptin and resistin), and pi3k/akt protein levels, as well as the mrna gene expression of er stress markers (ire-1, sxbp-1, perk, atf4, and chop), fatty acid synthase (fas), peroxisome proliferator-activated receptor-α (ppar-α). |
2022-07-02 |
2023-08-14 |
rat |