| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rui Huo, Meili Zhang, Yakun Zhang, Xue Bai, Yuanyuan Zhang, Xinyue Gu. Effects of Oat Complex High-Fiber Formula Powder on the Composition of Intestinal Microbiota and Enzyme Activities in Mice Induced by a High-Fat Diet. Frontiers in nutrition. vol 9. 2022-06-10. PMID:35685874. |
after 8 weeks of treatment, the body weight of mice were observed and measured to determine the composition of tract flora, liver leptin content, insulin content, and activities of amp-activated protein kinase (ampk), lipoprotein lipase (lpl), fatty acid synthetase (fas), sterol-regulatory element-binding proteins (srebps), and acetyl coa carboxylase 1 (acc1). |
2022-06-10 |
2023-08-14 |
mouse |
| Jing-Yi Liu, Yi-Chen Zhang, Li-Ni Song, Lin Zhang, Fang-Yuan Yang, Xiao-Rong Zhu, Zhi-Qiang Cheng, Xi Cao, Jin-Kui Yan. Nifuroxazide ameliorates lipid and glucose metabolism in palmitate-induced HepG2 cells. RSC advances. vol 9. issue 67. 2022-05-11. PMID:35540668. |
the expression of hepatic lipogenic proteins (accα, srebp-1c, fas), gluconeogenesis enzymes (pepck, g6pase, and irs2), the il-6/stat3/socs3 inflammatory axis, and the insulin signaling pathway was determined. |
2022-05-11 |
2023-08-13 |
Not clear |
| Alisa B Nelson, Lisa S Chow, Curtis C Hughey, Peter A Crawford, Patrycja Puchalsk. Artifactual FA dimers mimic FAHFA signals in untargeted metabolomics pipelines. Journal of lipid research. vol 63. issue 5. 2022-04-29. PMID:35315332. |
fa esters of hydroxy fas (fahfas) are lipokines with extensive structural and regional isomeric diversity that impact multiple physiological functions, including insulin sensitivity and glucose homeostasis. |
2022-04-29 |
2023-08-16 |
human |
| Kazim Sahin, Cemal Orhan, Osman Kucuk, Mehmet Tuzcu, Nurhan Sahin, Ibrahim H Ozercan, Sarah Sylla, Sara P Ojalvo, James R Komorowsk. Effects of magnesium picolinate, zinc picolinate, and selenomethionine co-supplementation on reproductive hormones, and glucose and lipid metabolism-related protein expressions in male rats fed a high-fat diet. Food chemistry. Molecular sciences. vol 4. 2022-04-13. PMID:35415682. |
body weights, visceral fat, serum glucose, insulin, total cholesterol, triglycerides, leptin, malondialdehyde (mda) concentrations as well as liver sterol regulatory element-binding protein-1c (srebp-1c), liver x receptor alpha (lxrα), atp citrate lyase (acly), fatty acid synthase (fas), and nuclear factor kappa b (nf-κb) levels increased, while serum testosterone, follicle-stimulating hormone (fsh), luteinizing hormone (lh), sex hormone-binding globulin (shbg), and insulin-like growth factor (igf-1) concentrations along with liver nuclear factor erythroid 2-related factor 2 (nrf2) levels declined in hfd rats ( |
2022-04-13 |
2023-08-13 |
rat |
| Runzhou Sun, Ruixin Xiao, Pengfei Lv, Feifei Guo, Yanling Gong, Meixing Ya. Pink Lotus Essential Oil and Alleviates on Free Fatty Acid Induced Steatosis in HepG2 Cells via PI3K/Akt and NF-κB Pathways. Journal of oleo science. vol 71. issue 1. 2022-01-11. PMID:35013040. |
lipid metabolism enzymes including fatty acid synthase (fas), acetyl-coa carboxylase (acc), stearoyl-coa desaturase 1 (scd-1), and carnitine palmitoyltransferase-1 (cpt-1), insulin signaling pathways including phosphatidylinositol 3 kinase (pi3k) and protein kinase b akt, inflammatory signaling pathways such as nuclear factor kappa-b (nf-κb), were determined by western blotting. |
2022-01-11 |
2023-08-13 |
Not clear |
| Javad Daneshmoghadam, Abolfazl Omidifar, Nader Akbari Dilmaghani, Zahereh Karimi, Solaleh Emamgholipour, Mehrnoosh Shanak. The gene expression of long non-coding RNAs (lncRNAs): MEG3 and H19 in adipose tissues from obese women and its association with insulin resistance and obesity indices. Journal of clinical laboratory analysis. vol 35. issue 5. 2021-11-23. PMID:33616223. |
moreover, we sought to identify the association of expression of meg3 and h19 in sat and vat with obesity parameters, insulin resistance, and the mrna expression of possible target genes involved in adipogenesis and lipogenesis including peroxisome proliferator-activated receptor gamma (pparγ), fatty acid synthase (fas), and acetyl-coa carboxylase (acc). |
2021-11-23 |
2023-08-13 |
Not clear |
| Y J Park, S Lee, T J Kieffer, G L Warnock, N Safikhan, M Speck, Z Hao, M Woo, L Marzba. Deletion of Fas protects islet beta cells from cytotoxic effects of human islet amyloid polypeptide. Diabetologia. 2021-10-21. PMID:22301943. |
cultured hiapp-expressing mouse islets with fas deletion had similar amyloid levels, but lower caspase-3 activation and beta cell apoptosis, and a higher islet beta:alpha cell ratio and insulin response to glucose, compared with islets expressing fas and hiapp. |
2021-10-21 |
2023-08-12 |
mouse |
| Xiuli Li, Rong Wang, Na Zhou, Xiaohui Wang, Qingyan Liu, Yuqin Bai, Yin Bai, Zhijie Liu, Huiming Yang, Jihong Zou, Hongxia Wang, Tiewei Sh. Quercetin improves insulin resistance and hepatic lipid accumulation Biomedical reports. vol 1. issue 1. 2021-10-21. PMID:24648896. |
these results demonstrated that quercetin was able to improve insulin resistance and hepatic lipid accumulation by suppressing two lipogenesis gene expression levels of srebp-1c and fas. |
2021-10-21 |
2023-08-12 |
Not clear |
| Seo Woo Nam, Min Seuk Kim, Younho Han, Kwang Youl Le. WJCPR11 reverses the TNF-α-induced inhibition of adipocyte differentiation and glucose uptake. Biochemical and biophysical research communications. vol 578. 2021-10-11. PMID:34562655. |
it increased the mrna expression levels and protein abundance of adipogenic markers, including peroxisome proliferator-activated receptor γ (pparγ), glucose transporter type 4 (glut4), and fatty acid synthase (fas), and markedly enhanced the level of adiponectin, a distinct marker of insulin sensitivity. |
2021-10-11 |
2023-08-13 |
Not clear |
| Mohammad Nosrati-Oskouie, Nazanin Sadat Aghili-Moghaddam, Thozhukat Sathyapalan, Amirhossein Sahebka. Impact of curcumin on fatty acid metabolism. Phytotherapy research : PTR. vol 35. issue 9. 2021-09-29. PMID:33825246. |
free fatty acids (ffas) and fatty acid synthesis (fas) activity have significantly contributed to disease states such as insulin resistance, obesity, type 2 diabetes, myocardial infarction, blood pressure, and several types of cancer. |
2021-09-29 |
2023-08-13 |
Not clear |
| Mohammad Nosrati-Oskouie, Nazanin Sadat Aghili-Moghaddam, Thozhukat Sathyapalan, Amirhossein Sahebka. Impact of curcumin on fatty acid metabolism. Phytotherapy research : PTR. vol 35. issue 9. 2021-09-29. PMID:33825246. |
most of the evidence is in-vivo and in-vitro studies that demonstrate that curcumin possesses regulatory properties on ffas levels through its effects on fas and β-oxidation activity as well as desaturation system, which could improve insulin resistance, obesity, and other ffas-related disorders. |
2021-09-29 |
2023-08-13 |
Not clear |
| Md Rafiqul Islam, Shihab Uddin, Md Raihan Chowdhury, Rie Wakabayashi, Muhammad Moniruzzaman, Masahiro Got. Insulin Transdermal Delivery System for Diabetes Treatment Using a Biocompatible Ionic Liquid-Based Microemulsion. ACS applied materials & interfaces. vol 13. issue 36. 2021-09-16. PMID:34460218. |
here, we developed ionic liquid (il)-in-oil microemulsion formulations (mefs) for transdermal insulin delivery using choline-fatty acids ([chl][fas])-comprising three different fas (c18:0, c18:1, and c18:2)-as biocompatible surface-active ils (sails). |
2021-09-16 |
2023-08-13 |
mouse |
| Yulia K Denisenko, Oxana Yu Kytikova, Tatyana P Novgorodtseva, Marina V Antonyuk, Tatyana A Gvozdenko, Tatyana A Kantu. Lipid-Induced Mechanisms of Metabolic Syndrome. Journal of obesity. vol 2020. 2021-09-13. PMID:32963827. |
in light of recent evidence, it has been shown that lipids, especially fatty acids (fas), are important signaling molecules that regulate the signaling pathways of insulin and inflammatory mediators. |
2021-09-13 |
2023-08-13 |
Not clear |
| Syed Aun Muhammad, Syeda Tahira Qousain Naqvi, Thanh Nguyen, Xiaogang Wu, Fahad Munir, Muhammad Babar Jamshed, QiYu Zhan. Cisplatin's potential for type 2 diabetes repositioning by inhibiting CDKN1A, FAS, and SESN1. Computers in biology and medicine. vol 135. 2021-09-13. PMID:34261004. |
from a list of differential expressed genes, cisplatin downregulated the cyclin-dependent kinase inhibitor 1 (cdkn1a), tumor necrosis factor (fas), and sestrin-1 (sesn1) genes responsible for modifying signaling pathways, including the p53, jak-stat, foxo, mapk, mtor, p13-akt, toll-like receptor (tlr), adipocytokine, and insulin signaling pathways. |
2021-09-13 |
2023-08-13 |
Not clear |
| Elham Alipoor, Mohammad Javad Hosseinzadeh-Attar, Shiva Salehi, Mostafa Dahmardehei, Mehdi Yaseri, Mohammad Reza Emami, Mehdi Hajian, Seyed Mahdi Rezayat, Shima Jazayer. Effect of Collagen Hydrolysate and Fish Oil on High-Sensitivity C-Reactive Protein and Glucose Homeostasis in Patients with severe Burn; a Randomized Clinical Trial. Archives of academic emergency medicine. vol 9. issue 1. 2021-08-19. PMID:34405148. |
the aim of this study was to investigate the effect of collagen hydrolysate and omega-3 fas on inflammation and insulin resistance in patients with major burns. |
2021-08-19 |
2023-08-13 |
Not clear |
| Ban-Hock Khor, Sharmela Sahathevan, Ayesha Sualeheen, Mohammad Syafiq Md Ali, Sreelakshmi Sankara Narayanan, Karuthan Chinna, Abdul Halim Abdul Gafor, Bak-Leong Goh, Ghazali Ahmad, Zaki Morad, Zulfitri Azuan Mat Daud, Pramod Khosla, Kalyana Sundram, Tilakavati Karupaia. Circulating fatty acid profiles are associated with protein energy wasting in maintenance hemodialysis patients: a cross-sectional study. Scientific reports. vol 11. issue 1. 2021-08-11. PMID:33446880. |
we investigated the associations between plasma triglyceride (tg) fas and markers of inflammation, insulin resistance, nutritional status and body composition. |
2021-08-11 |
2023-08-13 |
Not clear |
| Tarek Khamis, Abdelalim F Abdelalim, Ahmed A Saeed, Nagah M Edress, Alaa Nafea, Huda F Ebian, Reem Algendy, Doaa M Hendawy, Ahmed Hamed Arisha, Somia Hassan Abdalla. Breast milk MSCs upregulated β-cells PDX1, Ngn3, and PCNA expression via remodeling ER stress /inflammatory /apoptotic signaling pathways in type 1 diabetic rats. European journal of pharmacology. vol 905. 2021-08-11. PMID:34004210. |
and, for the first time, our results revealed that intraperitoneally transplanted br-mscs homed to the diabetic islet and improved fasting blood glucose, serum insulin level, pancreatic oxidative stress, upregulated pancreatic mrna expression for: regenerative markers (pdx1, ngn3, pcna), ins, beta-cell receptors (irs1, irβ, pparγ), pancreatic growth factors (igf-1, vegfβ1, fgfβ), anti-inflammatory cytokine (il10) and anti-apoptotic marker (bcl2) too, br-mscs downregulated pancreatic mrna expression for: inflammatory markers (nfkβ, tnfα, il1β, il6, il8, mcp1), apoptotic markers for both intrinsic and extrinsic pathways (fas, fas-l, p53, p38, bax, caspase3), er stress markers (atf6, atf3, atf4, bip, chop, jnk, xbp1) and autophagy inhibitor (mtor). |
2021-08-11 |
2023-08-13 |
rat |
| V V Sathibabu Uddandrao, P Rameshreddy, P Brahmanaidu, Ponmurugan Ponnusamy, Santhanaraj Balakrishnan, Ravindar Naik Ramavat, K Swapna, Suresh Pothani, Harishankar Nemani, Balaji Meriga, S Vadivukkarasi, Nivedha P R, Saravanan Ganapath. Antiobesity efficacy of asiatic acid: down-regulation of adipogenic and inflammatory processes in high fat diet induced obese rats. Archives of physiology and biochemistry. vol 126. issue 5. 2021-05-31. PMID:30739501. |
changes in body composition, glucose, insulin resistance (ir) and lipid profiles of tissues, plasma and the pattern of gene expression of peroxisome proliferator-activated receptor-γ (ppar-γ) and its target genes fatty-acid synthase (fas), adipocyte protein-2 (ap2) and uncoupling protein-2 (ucp-2) and pro-inflammatory factor tumor necrosis factor (tnf)-α were observed in experimental rats. |
2021-05-31 |
2023-08-13 |
rat |
| Mohammad Nosrati-Oskouie, Emad Yuzbashian, Maryam Zarkesh, N S Aghili-Moghadam, Mehdi Hedayati, Mohammad Safarian, Golaleh Asghari, Alireza Khalaj, Parvin Mirmira. Association of plasma fatty acids pattern with omentin gene expression in human adipose tissues: A cross-sectional study. Nutrition, metabolism, and cardiovascular diseases : NMCD. vol 31. issue 3. 2021-03-17. PMID:33549440. |
omentin, as an adipokine, has been reported to improve insulin resistance and inflammation may be related to fatty acids (fas). |
2021-03-17 |
2023-08-13 |
human |
| Anne-Marie Lundsgaard, Andreas M Fritzen, Trine S Nicolaisen, Christian S Carl, Kim A Sjøberg, Steffen H Raun, Anders B Klein, Eva Sanchez-Quant, Jakob Langer, Cathrine Ørskov, Christoffer Clemmensen, Matthias H Tschöp, Erik A Richter, Bente Kiens, Maximilian Kleiner. Glucometabolic consequences of acute and prolonged inhibition of fatty acid oxidation. Journal of lipid research. vol 61. issue 1. 2021-02-08. PMID:31719103. |
excessive circulating fas have been proposed to promote insulin resistance (ir) of glucose metabolism by increasing the oxidation of fas over glucose. |
2021-02-08 |
2023-08-13 |
mouse |