| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ayodele Olufemi Morakinyo, Titilola Aderonke Samuel, Funmileyi Olubajo Awobajo, Gabriel Olorunleke Oludare, Adekunle Mofoloruns. High-Dose Perinatal Folic-Acid Supplementation Alters Insulin Sensitivity in Sprague-Dawley Rats and Diminishes the Expression of Adiponectin. Journal of dietary supplements. vol 16. issue 1. 2019-05-17. PMID:29451831. |
high-dose fas may promote insulin resistance and dyslipidemia and disrupt glucose metabolism possibly by depressing adiponectin expression. |
2019-05-17 |
2023-08-13 |
rat |
| Min Xu, Xi-Ming Zheng, Fang Jiang, Wei-Qiang Qi. MicroRNA-190b regulates lipid metabolism and insulin sensitivity by targeting IGF-1 and ADAMTS9 in non-alcoholic fatty liver disease. Journal of cellular biochemistry. vol 119. issue 7. 2019-05-08. PMID:29575055. |
it also reduced expression of the lipogenic genes fatty acid synthase (fas) and 3-hydroxy-3-methylglutarylcoa reductase (hmgcr), alleviated hepatic steatosis, improved glucose tolerance, elevated insulin sensitivity, and activated insulin receptor substrate (irs)2/akt signaling in vivo and/or in vitro. |
2019-05-08 |
2023-08-13 |
mouse |
| Zhi-Xing Li, Hai-Hua Zhang, Dan-Chun Lan, Hong-Tao Zhang, Xiao-Zhuan Chen, Jian Su. [Effect of Eletroacupuncture Intervention on Insulin Resistance, Lipid Metabolic Disorder and Expression of Hepatic SREBP-1 c and Fatty Acid Synthase Proteins in Rats with Hyperlipidemia]. Zhen ci yan jiu = Acupuncture research. vol 43. issue 1. 2019-04-03. PMID:29383887. |
to observe the effect of electroacupuncture(ea) of "fenglong" (st 40) and "sanyinjiao" (sp 6) on lipid metabolic disorder, insulin resistance (ir) and expression of sterol regulatory element blinding protein-1 (srebp-1) c and fatty acid synthase (fas) proteins in the liver tissue in hyperlipidemia rats with ir, so as to reveal its mechanisms underlying improvement of ir. |
2019-04-03 |
2023-08-13 |
rat |
| Paula Saavedra-García, Katie Nichols, Zimam Mahmud, Lavender Yuen-Nam Fan, Eric W-F La. Unravelling the role of fatty acid metabolism in cancer through the FOXO3-FOXM1 axis. Molecular and cellular endocrinology. vol 462. issue Pt B. 2019-02-12. PMID:28087388. |
meanwhile, insulin and some adipokines, that are up-regulated by fas, are also involved in cancer development and poor prognosis. |
2019-02-12 |
2023-08-13 |
Not clear |
| Shishuo Sun, Pengcheng Tan, Xiaoheng Huang, Wei Zhang, Chen Kong, Fangfang Ren, Xiong S. Ubiquitinated CD36 sustains insulin-stimulated Akt activation by stabilizing insulin receptor substrate 1 in myotubes. The Journal of biological chemistry. vol 293. issue 7. 2019-02-05. PMID:29269414. |
moreover, high concentrations of fatty acids (fas) and glucose involved in the etiology of obesity-associated insulin resistance also contribute to the regulation of irs1 degradation. |
2019-02-05 |
2023-08-13 |
Not clear |
| Martina Schweiger, Matthias Romauch, Renate Schreiber, Gernot F Grabner, Sabrina Hütter, Petra Kotzbeck, Pia Benedikt, Thomas O Eichmann, Sohsuke Yamada, Oskar Knittelfelder, Clemens Diwoky, Carina Doler, Nicole Mayer, Werner De Cecco, Rolf Breinbauer, Robert Zimmermann, Rudolf Zechne. Pharmacological inhibition of adipose triglyceride lipase corrects high-fat diet-induced insulin resistance and hepatosteatosis in mice. Nature communications. vol 8. 2018-11-09. PMID:28327588. |
elevated circulating fatty acids (fas) contribute to the development of obesity-associated metabolic complications such as insulin resistance (ir) and non-alcoholic fatty liver disease (nafld). |
2018-11-09 |
2023-08-13 |
mouse |
| Adriana Carino, Sabrina Cipriani, Silvia Marchianò, Michele Biagioli, Chiara Santorelli, Annibale Donini, Angela Zampella, Maria Chiara Monti, Stefano Fiorucc. BAR502, a dual FXR and GPBAR1 agonist, promotes browning of white adipose tissue and reverses liver steatosis and fibrosis. Scientific reports. vol 7. 2018-11-06. PMID:28202906. |
treatment with bar502 caused a ≈10% reduction of b.w., increased insulin sensitivity and circulating levels of hdl, while reduced steatosis, inflammatory and fibrosis scores and liver expression of srepb1c, fas, pparγ, cd36 and cyp7a1 mrna. |
2018-11-06 |
2023-08-13 |
mouse |
| Sebastian Hauke, Kaya Keutler, Prasad Phapale, Dmytro A Yushchenko, Carsten Schult. Endogenous Fatty Acids Are Essential Signaling Factors of Pancreatic β-Cells and Insulin Secretion. Diabetes. vol 67. issue 10. 2018-10-09. PMID:29748290. |
fatty acids (fas) have been discussed as exogenous secretagogues of insulin for decades, especially after the fa receptor gpr40 (g-protein-coupled receptor 40) was discovered. |
2018-10-09 |
2023-08-13 |
Not clear |
| b' Petr Je\\xc5\\xbeek, Martin Jab\\xc5\\xafrek, Blanka Holendov\\xc3\\xa1, Lydie Plecit\\xc3\\xa1-Hlavat\\xc3\\xa. Fatty Acid-Stimulated Insulin Secretion vs. Lipotoxicity. Molecules (Basel, Switzerland). vol 23. issue 6. 2018-10-09. PMID:29921789.' |
considering fas not as mere amplifiers of glucose-stimulated insulin secretion (gsis), but as parallel insulin granule exocytosis inductors, partly independent of the k |
2018-10-09 |
2023-08-13 |
Not clear |
| Cécile L Bandet, Rana Mahfouz, Julien Véret, Athanassia Sotiropoulos, Maxime Poirier, Paola Giussani, Mélanie Campana, Erwann Philippe, Agnieszka Blachnio-Zabielska, Raphaëlle Ballaire, Xavier Le Liepvre, Olivier Bourron, Dušan Berkeš, Jan Górski, Pascal Ferré, Hervé Le Stunff, Fabienne Foufelle, Eric Hajduc. Ceramide Transporter CERT Is Involved in Muscle Insulin Signaling Defects Under Lipotoxic Conditions. Diabetes. vol 67. issue 7. 2018-08-16. PMID:29759974. |
one main mechanism of insulin resistance (ir), a key feature of type 2 diabetes, is the accumulation of saturated fatty acids (fas) in the muscles of obese patients with type 2 diabetes. |
2018-08-16 |
2023-08-13 |
Not clear |
| Ilvy M E Geraets, Dipanjan Chanda, Florence H J van Tienen, Arthur van den Wijngaard, Rick Kamps, Dietbert Neumann, Yilin Liu, Jan F C Glatz, Joost J F P Luiken, Miranda Nabbe. Human embryonic stem cell-derived cardiomyocytes as an in vitro model to study cardiac insulin resistance. Biochimica et biophysica acta. Molecular basis of disease. vol 1864. issue 5 Pt B. 2018-07-30. PMID:29277329. |
evidence indicates that this increased risk is linked to an altered cardiac substrate preference of the insulin resistant heart, which shifts from a balanced utilization of glucose and long-chain fatty acids (fas) towards an almost complete reliance on fas as main fuel source. |
2018-07-30 |
2023-08-13 |
human |
| Waleed F A Marei, Maria Arias Alvarez, Veerle Van Hoeck, Alfonso Gutierrez-Adan, Peter E J Bols, Jo L M R Lero. Effect of nutritionally induced hyperlipidaemia on in vitro bovine embryo quality depends on the type of major fatty acid in the diet. Reproduction, fertility, and development. vol 29. issue 9. 2018-07-23. PMID:27832581. |
introducing sat and unsat diets induced hyperlipidaemia (specifically hypercholesterolaemia and elevated free fas) and reduced insulin sensitivity. |
2018-07-23 |
2023-08-13 |
cattle |
| Marie-Eve Piché, Siôn A Parry, Fredrik Karpe, Leanne Hodso. Chylomicron-Derived Fatty Acid Spillover in Adipose Tissue: A Signature of Metabolic Health? The Journal of clinical endocrinology and metabolism. vol 103. issue 1. 2018-06-26. PMID:29099975. |
spillover of fatty acids (fas) into the plasma nonesterified fatty acid (nefa) pool, because of an inability of adipose tissue (at) to accommodate sufficient fat uptake, has been suggested to contribute to obesity-related insulin resistance. |
2018-06-26 |
2023-08-13 |
Not clear |
| Peng P. [Protection mechanisms of hesperidin on mouse with insulin resistance]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 41. issue 17. 2018-05-23. PMID:28920385. |
the mrna expression of insulin signaling pathway genes(ir, irs1, glut2, glut4), lipid metabolism pathway genes(srebp-1c, fas, acc, pparα) and ampk were analyzed by real-time pcr. |
2018-05-23 |
2023-08-13 |
mouse |
| Peng P. [Protection mechanisms of hesperidin on mouse with insulin resistance]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 41. issue 17. 2018-05-23. PMID:28920385. |
hesperidin, especially in high dose, upregulated the mrna expressions of ampk (p<0.05), which had impact on the gene expressions of insulin signaling pathway (ir, irs-1, glut2/4) (p<0.05) and lipid metabolism related genes (srebp-1c and fas and acc) (p<0.05). |
2018-05-23 |
2023-08-13 |
mouse |
| Mohammad Ishraq Zafar, Juan Zheng, Wen Kong, Xiaofeng Ye, Luoning Gou, Anita Regmi, Lu-Lu Che. The role of vascular endothelial growth factor-B in metabolic homoeostasis: current evidence. Bioscience reports. vol 37. issue 4. 2018-04-30. PMID:28798193. |
in conditions of hyperglycaemia and hypertriglyceridemia, this insufficient vascularization leads to the liberation of reactive oxygen species (ros), and disruption of nitric oxide (no) synthesis and endothelial signalling responsible for the uptake of circulating fatty acids (fas), whose accumulation in skeletal muscles and adipose tissue is widely associated with the impairment of insulin signalling. |
2018-04-30 |
2023-08-13 |
Not clear |
| Mohammad Ishraq Zafar, Juan Zheng, Wen Kong, Xiaofeng Ye, Luoning Gou, Anita Regmi, Lu-Lu Che. The role of vascular endothelial growth factor-B in metabolic homoeostasis: current evidence. Bioscience reports. vol 37. issue 4. 2018-04-30. PMID:28798193. |
potentially beneficial effects of vegf-b, achieved through enhanced blood flow (increased availability of insulin and glucose uptake in target organs) and decreased fas uptake (prevention of lipotoxicity and improved insulin signalling), and its safety for clinical use, remain to be clarified through future translational research. |
2018-04-30 |
2023-08-13 |
Not clear |
| Flurin Item, Stephan Wueest, Vera Lemos, Sokrates Stein, Fabrizio C Lucchini, Rémy Denzler, Muriel C Fisser, Tenagne D Challa, Eija Pirinen, Youngsoo Kim, Silvio Hemmi, Erich Gulbins, Atan Gross, Lorraine A O'Reilly, Markus Stoffel, Johan Auwerx, Daniel Konra. Fas cell surface death receptor controls hepatic lipid metabolism by regulating mitochondrial function. Nature communications. vol 8. issue 1. 2018-02-02. PMID:28883393. |
hepatic fas overexpression in chow-fed mice compromises fatty acid oxidation, mitochondrial respiration, and the abundance of mitochondrial respiratory complexes promoting hepatic lipid accumulation and insulin resistance. |
2018-02-02 |
2023-08-13 |
mouse |
| Flurin Item, Stephan Wueest, Vera Lemos, Sokrates Stein, Fabrizio C Lucchini, Rémy Denzler, Muriel C Fisser, Tenagne D Challa, Eija Pirinen, Youngsoo Kim, Silvio Hemmi, Erich Gulbins, Atan Gross, Lorraine A O'Reilly, Markus Stoffel, Johan Auwerx, Daniel Konra. Fas cell surface death receptor controls hepatic lipid metabolism by regulating mitochondrial function. Nature communications. vol 8. issue 1. 2018-02-02. PMID:28883393. |
in line, hepatocyte-specific ablation of fas improves mitochondrial function and ameliorates high-fat-diet-induced hepatic steatosis, glucose tolerance, and insulin resistance. |
2018-02-02 |
2023-08-13 |
mouse |
| Flurin Item, Stephan Wueest, Vera Lemos, Sokrates Stein, Fabrizio C Lucchini, Rémy Denzler, Muriel C Fisser, Tenagne D Challa, Eija Pirinen, Youngsoo Kim, Silvio Hemmi, Erich Gulbins, Atan Gross, Lorraine A O'Reilly, Markus Stoffel, Johan Auwerx, Daniel Konra. Fas cell surface death receptor controls hepatic lipid metabolism by regulating mitochondrial function. Nature communications. vol 8. issue 1. 2018-02-02. PMID:28883393. |
we suggest fas as a potential novel therapeutic target to treat obesity-associated fatty liver and insulin resistance.hepatic steatosis is a common disease closely associated with metabolic syndrome and insulin resistance. |
2018-02-02 |
2023-08-13 |
mouse |