| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Terje S Larsen, Kirsten M Janse. Impact of Obesity-Related Inflammation on Cardiac Metabolism and Function. Journal of lipid and atherosclerosis. vol 10. issue 1. 2021-02-06. PMID:33537250. |
this condition, in turn, causes systemic inflammation and elevated fa concentrations in the circulation, which links obesity to several pathologies, including impaired insulin signaling in cardiac muscle and a subsequent shift in myocardial substrate oxidation in favor of fas and reduced cardiac efficiency. |
2021-02-06 |
2023-08-13 |
Not clear |
| Aline Loehfelm, Megan K Elder, Alisa Boucsein, Peter P Jones, Joanna M Williams, Alexander Tup. Docosahexaenoic acid prevents palmitate-induced insulin-dependent impairments of neuronal health. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 34. issue 3. 2021-01-21. PMID:32030816. |
this work provides new insights into how fas can affect the cytoskeletal rearrangements and neuronal function via modulation of insulin signaling. |
2021-01-21 |
2023-08-13 |
rat |
| Hayato Nakagawa, Yuki Hayata, Satoshi Kawamura, Tomoharu Yamada, Naoto Fujiwara, Kazuhiko Koik. Lipid Metabolic Reprogramming in Hepatocellular Carcinoma. Cancers. vol 10. issue 11. 2020-10-01. PMID:30445800. |
obesity and nonalcoholic steatohepatitis (nash) are well-known risk factors of hepatocellular carcinoma (hcc), and individuals with these conditions exhibit an increased intake of dietary fas accompanied by enhanced lipolysis of visceral adipose tissue due to insulin resistance, resulting in enormous exogenous fa supplies to hepatocytes via the portal vein and lymph vessels. |
2020-10-01 |
2023-08-13 |
Not clear |
| Muhammad T Tabiin, Christopher P White, Grant Morahan, Bernard E Tuc. Insulin expressing hepatocytes not destroyed in transgenic NOD mice. Journal of autoimmune diseases. vol 1. issue 1. 2020-09-29. PMID:15679918. |
it is possible that the insulin secreting liver cells will be destroyed by the immune system because hepatocytes express major histocompatibility complex (mhc) class i molecules and exhibit constitutive fas expression; moreover the liver has antigen presenting activity. |
2020-09-29 |
2023-08-12 |
mouse |
| Rodrigo Valenzuela, Macarena Ortiz, María Catalina Hernández-Rodas, Francisca Echeverría, Luis Alberto Videl. Targeting n-3 Polyunsaturated Fatty Acids in Non-Alcoholic Fatty Liver Disease. Current medicinal chemistry. vol 27. issue 31. 2020-09-25. PMID:30968772. |
non-alcoholic fatty liver disease (nafld) is characterized by abnormal hepatic accumulation of triacylglycerides in the absence of alcohol consumption, in association with oxidative stress (os), a pro-inflammatory state and insulin resistance (ir), which are attenuated by n-3 long-chain polyunsaturated fatty acids (fas) c20-c22 (lcpufas) supplementation. |
2020-09-25 |
2023-08-13 |
Not clear |
| Xing Xiao, Pei Qiu, Hui-Zhen Gong, Xue-Ming Chen, Yan Sun, An Hong, Yi M. PACAP ameliorates hepatic metabolism and inflammation through up-regulating FAIM in obesity. Journal of cellular and molecular medicine. vol 23. issue 9. 2020-08-28. PMID:31270932. |
our previous study showed that fas apoptosis inhibitory molecule (faim) is a new mediator of akt2 signalling, increases the insulin signalling pathway and lipid metabolism. |
2020-08-28 |
2023-08-13 |
mouse |
| Chi-Long Hao, Hui-Li Lin, Liang-Yin Ke, Hsueh-Wei Yen, Kuo-Ping She. Pre-germinated brown rice extract ameliorates high-fat diet-induced metabolic syndrome. Journal of food biochemistry. vol 43. issue 3. 2020-06-22. PMID:31353547. |
in the hfd group, higher body and liver weight gain, hyperglycemia, hba1c, and insulin; higher tg, tc, ldl-c, non-hdl, atherosclerosis index, lower hdl, adiponectin in blood; higher tg in the liver; higher tg, bile acid in feces; and lower protein levels of amp-activated protein kinase, insulin receptor, insulin receptor substrate-1, insulin receptor substrate-2, peroxisome proliferator-activated receptor-γ, phosphatidylinositol-3-kinase, akt/pkb, glucose transporter-1, glucose transporter-4, glucokinase in the skeletal muscle; lower glucagon-like peptide 1 (glp-1) in the intestine; higher sterol regulatory element-binding protein-1 (srebp-1), stearoyl-coa desaturase 1 (scd-1), fatty acid synthase (fas), 3-hydroxy-3-methylglutaryl-coa reductase, proprotein convertase subtilisin/kexin type 9 (pcsk9), and lower ppar-α, low-density lipoprotein receptor, cholesterol-7α-hydroxylase in the liver; higher srebp-1, scd-1, fas, and lower ppar-α, adiponectin in the adipose tissue were found. |
2020-06-22 |
2023-08-13 |
mouse |
| Paola Antonia Corsetto, Gigliola Montorfano, Catherine Klersy, Luca Massimino, Vittoria Infantino, Giancarlo Iannello, Milena Anna Faliva, Henry Lukaski, Simone Perna, Tariq A Alalwan, Angela Maria Rizzo, Mariangela Rondanell. Fatty Acid Profile and Antioxidant Status Fingerprint in Sarcopenic Elderly Patients: Role of Diet and Exercise. Nutrients. vol 11. issue 11. 2020-04-08. PMID:31653011. |
plasma fatty acids (fas) and oxidant status contribute to the etiology of sarcopenia in the elderly concurring to age-related muscle loss and elderly frailty through several mechanisms including changes in fa composition within the sarcolemma, promotion of chronic low-grade inflammation, and insulin resistance. |
2020-04-08 |
2023-08-13 |
human |
| Ren Lin, Yue Jia, Fengjuan Wu, Yuan Meng, Qi Sun, Lihong Ji. Combined Exposure to Fructose and Bisphenol A Exacerbates Abnormal Lipid Metabolism in Liver of Developmental Male Rats. International journal of environmental research and public health. vol 16. issue 21. 2020-03-16. PMID:31661889. |
the results showed that the levels of gene and protein catalyzing lipogenesis were increased (srebp1, acc1 and fas), while those catalyzing lipolysis were decreased (atgl, hsl and zag), accompanied by dyslipidemia, insulin resistance and hepatic fat accumulation, and there were higher expression of tlr4 and nf-κb protein and lower expression of erα protein in liver, and increased serum il-17 and tnf-α levels in fructose and/or bpa exposed rats compared with controls. |
2020-03-16 |
2023-08-13 |
rat |
| Rodrigo Martins Pereira, Kellen Cristina da Cruz Rodrigues, Chadi Pellegrini Anaruma, Marcella Ramos Sant'Ana, Thaís Dantis Pereira de Campos, Rodrigo Stellzer Gaspar, Raphael Dos Santos Canciglieri, Diego Gomes de Melo, Rania A Mekary, Adelino Sanchez Ramos da Silva, Dennys Esper Cintra, Eduardo Rochete Ropelle, José Rodrigo Pauli, Leandro Pereira de Mour. Short-term strength training reduces gluconeogenesis and NAFLD in obese mice. The Journal of endocrinology. vol 241. issue 1. 2019-12-16. PMID:30878016. |
key points: (1) short-term strength training (stst) reduced fat accumulation and inflammation in the liver; (2) hepatic insulin sensitivity and hpg control were increased with stst; (3) the content and activity of acc and content of fas were reduced with stst; (4) stst improved hepatic fat accumulation and glycemic homeostasis; (5) stst effects were observed independently of body weight change. |
2019-12-16 |
2023-08-13 |
mouse |
| Z Lu, X F He, B B Ma, L Zhang, J L Li, Y Jiang, G H Zhou, F Ga. Increased fat synthesis and limited apolipoprotein B cause lipid accumulation in the liver of broiler chickens exposed to chronic heat stress. Poultry science. vol 98. issue 9. 2019-12-03. PMID:30809677. |
the 7 d of heat exposure significantly increased the respiratory rate, relative weight of abdominal fat, the levels of glucose, tg, corticosterone, insulin, and vldl in plasma, as well as the levels of tg, total cholesterol, acyl-coa carboxylase (acc), and fatty acid synthase (fas) in the liver, and mrna expression levels of carbohydrate response element-binding protein (chrebp), acc, fas, and microsomal triglyceride transfer protein (mttp) in comparison with the other 2 groups. |
2019-12-03 |
2023-08-13 |
Not clear |
| Wenmin Xia, Ariane R Pessentheiner, Dina C Hofer, Melina Amor, Renate Schreiber, Gabriele Schoiswohl, Thomas O Eichmann, Evelyn Walenta, Bianca Itariu, Gerhard Prager, Hubert Hackl, Thomas Stulnig, Dagmar Kratky, Thomas Rülicke, Juliane G Bogner-Straus. Loss of ABHD15 Impairs the Anti-lipolytic Action of Insulin by Altering PDE3B Stability and Contributes to Insulin Resistance. Cell reports. vol 23. issue 7. 2019-12-02. PMID:29768196. |
elevated circulating fatty acids (fas) contribute to obesity-associated metabolic complications, but the mechanisms by which insulin suppresses lipolysis are poorly understood. |
2019-12-02 |
2023-08-13 |
mouse |
| Giovanni Enrico Lombardo, Saverio Massimo Lepore, Valeria Maria Morittu, Biagio Arcidiacono, Carmela Colica, Antonio Procopio, Valentina Maggisano, Stefania Bulotta, Nicola Costa, Chiara Mignogna, Domenico Britti, Antonio Brunetti, Diego Russo, Marilena Celan. Effects of Oleacein on High-Fat Diet-Dependent Steatosis, Weight Gain, and Insulin Resistance in Mice. Frontiers in endocrinology. vol 9. 2019-11-20. PMID:29615982. |
in addition, protein levels of fas, srebp-1, and phospho-erk in liver were positively modulated by oleacein, indicating an improvement in liver insulin sensitivity. |
2019-11-20 |
2023-08-13 |
mouse |
| Chantal Chudoba, Kristina Wardelmann, André Kleinridder. Molecular effects of dietary fatty acids on brain insulin action and mitochondrial function. Biological chemistry. 2019-11-20. PMID:30730834. |
thus, it seems intuitive that the brain senses elevated amounts of fatty acids (fas) and affects adaptive metabolic response, which is connected to mitochondrial function and insulin signaling. |
2019-11-20 |
2023-08-13 |
Not clear |
| Chantal Chudoba, Kristina Wardelmann, André Kleinridder. Molecular effects of dietary fatty acids on brain insulin action and mitochondrial function. Biological chemistry. 2019-11-20. PMID:30730834. |
this review will address the effect of dietary fas on brain insulin and mitochondrial function with a special emphasis on the impact of different fas on brain function and metabolism. |
2019-11-20 |
2023-08-13 |
Not clear |
| Elaine A Yu, Peter J Hu, Saurabh Meht. Plasma fatty acids in de novo lipogenesis pathway are associated with diabetogenic indicators among adults: NHANES 2003-2004. The American journal of clinical nutrition. vol 108. issue 3. 2019-08-15. PMID:30535092. |
insulin regulates fatty acids (fas) in the blood; conversely, fas may mediate insulin sensitivity and are potentially modifiable risk factors of the diabetogenic state. |
2019-08-15 |
2023-08-13 |
Not clear |
| Lin-Qin Ma, Jing-Chun Zhang, Yue Liu, Yu Qiao, Xin-Li Sun, Shu-Yan Lei, Qiao-Xian Zheng, Ting Ma. [Intervention effects and mechanism of Chinese herbal medicine of supplementing Qi and activating blood circulation on chronic intermittent hypoxia composite insulin resistance ApoE~(-/-) mice model]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 44. issue 1. 2019-08-06. PMID:30868825. |
this study aims to observe the intervention effects of chinese herbal medicine of supplementing qi and activating blood circulation on chronic intermittent hypoxia(cih) composite insulin resistance(ir) mediated atherosclerosis(as) mice model,and to observe the mechanism of srebp-1 c signaling molecule.ir apo e-/-mice model was induced by high-fat diet combined with stz injection.then the mice were treated with hypoxic animal incubator for 8 h per day and 8 weeks to establish a cih+ir-apoe-/-mouse model.model mice were randomly and averagely divided into normoxic control group(nc),model group(cih) and srebps inhibitor group(betulin),atorvastatin group(wm),tcm low-dose group(tcm-l),tcm middle-dose group(tcm-m) and tcm high-dose group(tcm-h) group.chinese herbal medicine of supplementing qi and activating blood circulation including ginsenosides combined with ligustrazine(tmp) were used as intervention drugs.the study observed the effect of drugs on ir,serum lipid,inflammation,stress,as and srebp-1 c related molecules.the results showed that fasting blood glucose in tcm-h group decreased compared with other experimental groups(p<0.05).hdl-c level in betulin group,wm group,tcm-h group was higher than that in cih group(p<0.05).ldl-c level in tcm-m group,tcm-h group is lower than that in cih group(p<0.05).the level of crp in cih group was higher than that in other groups(p<0.05).the level of sod in tcm-h group was higher than that in cih group(p<0.05).nc group and cih group showed obvious as aortic plaque,while betulin group,wm group,tcm-h group showed reduction in as plaque(p<0.05).for descending aorta,as plaque in cih group was multiple and large,while less and smaller in wm group and tcm-h(p<0.05).the expression of srebp-1 c and fas in aorta and skeletal muscle in tcm-h group was lower than that in cih group(p<0.05).in aorta,the expression of tnf-α and cd106(vcam-1) was lower in tcm-h group than that in cih group(p<0.05).in aorta,skeletal muscle and liver,the level of p-irs-1 in tcm-h group was significantly higher than that in cih group(p<0.05).in aorta and liver,the expression of hif-1α in tcm-h group was lower than that in cih group(p<0.05).the study demonstrated that combination ginsenosides with tmp could improve ir and serum lipid level and inhibit inflammation and oxidative stress as well as ultimately alleviate as to some extent.and the mechanism of its interventional effects might be related to the inhibition of cih-induced upregulation of srebp-1 c related molecules. |
2019-08-06 |
2023-08-13 |
mouse |
| Ayodele Olufemi Morakinyo, Titilola Aderonke Samuel, Funmileyi Olubajo Awobajo, Gabriel Olorunleke Oludare, Adekunle Mofoloruns. High-Dose Perinatal Folic-Acid Supplementation Alters Insulin Sensitivity in Sprague-Dawley Rats and Diminishes the Expression of Adiponectin. Journal of dietary supplements. vol 16. issue 1. 2019-05-17. PMID:29451831. |
this study was conducted to investigate the effects of prenatal and postnatal high folic acid supplementation (fas) on glucose tolerance, insulin sensitivity, lipid metabolism, and expression of adiponectin in rats. |
2019-05-17 |
2023-08-13 |
rat |
| Ayodele Olufemi Morakinyo, Titilola Aderonke Samuel, Funmileyi Olubajo Awobajo, Gabriel Olorunleke Oludare, Adekunle Mofoloruns. High-Dose Perinatal Folic-Acid Supplementation Alters Insulin Sensitivity in Sprague-Dawley Rats and Diminishes the Expression of Adiponectin. Journal of dietary supplements. vol 16. issue 1. 2019-05-17. PMID:29451831. |
fas significantly increased the postweaning food, water intake, triglyceride, and insulin levels but diminished insulin sensitivity in adult offspring. |
2019-05-17 |
2023-08-13 |
rat |
| Ayodele Olufemi Morakinyo, Titilola Aderonke Samuel, Funmileyi Olubajo Awobajo, Gabriel Olorunleke Oludare, Adekunle Mofoloruns. High-Dose Perinatal Folic-Acid Supplementation Alters Insulin Sensitivity in Sprague-Dawley Rats and Diminishes the Expression of Adiponectin. Journal of dietary supplements. vol 16. issue 1. 2019-05-17. PMID:29451831. |
the expression of adiponectin in insulin-sensitive tissues was also significantly decreased and these were consistent with insulin resistance of fas offspring. |
2019-05-17 |
2023-08-13 |
rat |