| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Stephan Wueest, Rouven Mueller, Matthias Blüher, Flurin Item, Annie S H Chin, Michael S F Wiedemann, Hitoshi Takizawa, Larisa Kovtonyuk, Alexander V Chervonsky, Eugen J Schoenle, Markus G Manz, Daniel Konra. Fas (CD95) expression in myeloid cells promotes obesity‐induced muscle insulin resistance. EMBO molecular medicine. vol 6. issue 1. 2014-07-25. PMID:24203314. |
fas (cd95) expression in myeloid cells promotes obesity‐induced muscle insulin resistance. |
2014-07-25 |
2023-08-12 |
mouse |
| Stephan Wueest, Rouven Mueller, Matthias Blüher, Flurin Item, Annie S H Chin, Michael S F Wiedemann, Hitoshi Takizawa, Larisa Kovtonyuk, Alexander V Chervonsky, Eugen J Schoenle, Markus G Manz, Daniel Konra. Fas (CD95) expression in myeloid cells promotes obesity‐induced muscle insulin resistance. EMBO molecular medicine. vol 6. issue 1. 2014-07-25. PMID:24203314. |
in a large cohort of obese human individuals, blood monocyte fas (cd95) expression correlated with systemic and skeletal muscle insulin resistance. |
2014-07-25 |
2023-08-12 |
mouse |
| Stephan Wueest, Rouven Mueller, Matthias Blüher, Flurin Item, Annie S H Chin, Michael S F Wiedemann, Hitoshi Takizawa, Larisa Kovtonyuk, Alexander V Chervonsky, Eugen J Schoenle, Markus G Manz, Daniel Konra. Fas (CD95) expression in myeloid cells promotes obesity‐induced muscle insulin resistance. EMBO molecular medicine. vol 6. issue 1. 2014-07-25. PMID:24203314. |
to test a causal role for myeloid cell fas expression in the development of skeletal muscle insulin resistance, we generated myeloid/haematopoietic cell-specific fas-depleted mice. |
2014-07-25 |
2023-08-12 |
mouse |
| Stephan Wueest, Rouven Mueller, Matthias Blüher, Flurin Item, Annie S H Chin, Michael S F Wiedemann, Hitoshi Takizawa, Larisa Kovtonyuk, Alexander V Chervonsky, Eugen J Schoenle, Markus G Manz, Daniel Konra. Fas (CD95) expression in myeloid cells promotes obesity‐induced muscle insulin resistance. EMBO molecular medicine. vol 6. issue 1. 2014-07-25. PMID:24203314. |
studies using neutralizing antibodies demonstrated a role for tnfα as mediator between myeloid fas and skeletal muscle insulin resistance, supported by significant correlations between monocyte fas expression and circulating tnfα in humans. |
2014-07-25 |
2023-08-12 |
mouse |
| Anne P L Jensen-Urstad, Haowei Song, Irfan J Lodhi, Katsuhiko Funai, Li Yin, Trey Coleman, Clay F Semenkovic. Nutrient-dependent phosphorylation channels lipid synthesis to regulate PPARα. Journal of lipid research. vol 54. issue 7. 2014-04-25. PMID:23585690. |
cytoplasmic fas was preferentially phosphorylated during feeding or insulin treatment at thr-1029 and thr-1033, which flank a dehydratase domain catalytic residue. |
2014-04-25 |
2023-08-12 |
mouse |
| Matthias Blüher, Nora Klöting, Stephan Wueest, Eugen J Schoenle, Michael R Schön, Arne Dietrich, Mathias Fasshauer, Michael Stumvoll, Daniel Konra. Fas and FasL expression in human adipose tissue is related to obesity, insulin resistance, and type 2 diabetes. The Journal of clinical endocrinology and metabolism. vol 99. issue 1. 2014-03-12. PMID:24178789. |
fas and fasl expression in human adipose tissue is related to obesity, insulin resistance, and type 2 diabetes. |
2014-03-12 |
2023-08-12 |
mouse |
| Matthias Blüher, Nora Klöting, Stephan Wueest, Eugen J Schoenle, Michael R Schön, Arne Dietrich, Mathias Fasshauer, Michael Stumvoll, Daniel Konra. Fas and FasL expression in human adipose tissue is related to obesity, insulin resistance, and type 2 diabetes. The Journal of clinical endocrinology and metabolism. vol 99. issue 1. 2014-03-12. PMID:24178789. |
deletion of the death receptor fas (cd95) in adipocytes of mice is associated with improved insulin sensitivity and reduced adipose tissue (at) inflammation. |
2014-03-12 |
2023-08-12 |
mouse |
| Nigel Turner, Gregory J Cooney, Edward W Kraegen, Clinton R Bruc. Fatty acid metabolism, energy expenditure and insulin resistance in muscle. The Journal of endocrinology. vol 220. issue 2. 2014-03-11. PMID:24323910. |
this review summarises the evidence for these mechanisms in the context of excess dietary fas generating insulin resistance in muscle, the major tissue involved in insulin-stimulated disposal of blood glucose. |
2014-03-11 |
2023-08-12 |
human |
| Nigel Turner, Gregory J Cooney, Edward W Kraegen, Clinton R Bruc. Fatty acid metabolism, energy expenditure and insulin resistance in muscle. The Journal of endocrinology. vol 220. issue 2. 2014-03-11. PMID:24323910. |
it also outlines potential problems with models and measurements that may hinder as well as help improve our understanding of the links between fas and insulin action. |
2014-03-11 |
2023-08-12 |
human |
| Xu Zhao, Yuming Guo, Shuangshuang Guo, Jianzhuang Ta. Effects of Clostridium butyricum and Enterococcus faecium on growth performance, lipid metabolism, and cecal microbiota of broiler chickens. Applied microbiology and biotechnology. vol 97. issue 14. 2014-01-08. PMID:23666481. |
supplementation of c. butyricum improved (p < 0.05) the average daily feed intake and average daily gain, increased (p = 0.016) the serum insulin level at 21 days of age, enhanced (p < 0.05) the content of intramuscular fat, activities of fas in the liver and lipoprotein lipase (lpl) in the breast muscle, mrna expression of fas, me, and acc in the liver and lpl in the breast muscle at 42 days of age, but reduced (p = 0.030) cecal bacteroidetes relative abundance at 21 days of age. |
2014-01-08 |
2023-08-12 |
Not clear |
| Peter Lee, Akihiro Mori, Marcia Coradini, Nobuko Mori, Fumi Sagara, Ichiro Yamamoto, Jacquie S Rand, Toshiro Ara. Potential predictive biomarkers of obesity in Burmese cats. Veterinary journal (London, England : 1997). vol 195. issue 2. 2013-11-25. PMID:22840209. |
expression of genes involved in energy metabolism (glucose-6-phosphate dehydrogenase and malate dehydrogenase), lipogenesis (atp citrate lyase [acl], fatty acid synthase [fas] and sterol regulatory binding protein-1c [srebp-1c]), and insulin signalling (insulin receptor substrates 1 and 2, and phosphatidylinositol-3 kinase), as well as cholesterol lipoprotein subfraction profiling were carried out on pbls from lean burmese cats and compared with similar profiles of age and gender matched lean and obese australian domestic shorthaired cats (dshs) in an attempt to identify possible biomarkers for assessing obesity. |
2013-11-25 |
2023-08-12 |
Not clear |
| Michael S F Wiedemann, Stephan Wueest, Flurin Item, Eugen J Schoenle, Daniel Konra. Adipose tissue inflammation contributes to short-term high-fat diet-induced hepatic insulin resistance. American journal of physiology. Endocrinology and metabolism. vol 305. issue 3. 2013-10-17. PMID:23736545. |
adipocyte-specific depletion of the antiapoptotic/anti-inflammatory factor fas (cd95) attenuated adipose tissue inflammation and improved glucose tolerance as well as hepatic insulin sensitivity without altering the level of hepatic steatosis induced by hfd. |
2013-10-17 |
2023-08-12 |
mouse |
| Ralph Dutt-Ballerstadt, Colton Evans, Arun P Pillai, Ashok Gowda, Roger McNichols, Jesse Rios, William Coh. Acute in vivo performance evaluation of the fluorescence affinity sensor in the intravascular and interstitial space in Swine. Journal of diabetes science and technology. vol 7. issue 1. 2013-08-28. PMID:23439158. |
we assessed and compared the performance levels of a fiber-coupled fluorescence affinity sensor (fas) for glucose detection in the intradermal tissue and intravascular bed during glucose clamping and insulin administration in a large animal model. |
2013-08-28 |
2023-08-12 |
Not clear |
| Amandine Girousse, Geneviève Tavernier, Carine Valle, Cedric Moro, Niklas Mejhert, Anne-Laure Dinel, Marianne Houssier, Balbine Roussel, Aurèle Besse-Patin, Marion Combes, Lucile Mir, Laurent Monbrun, Véronic Bézaire, Bénédicte Prunet-Marcassus, Aurélie Waget, Isabelle Vila, Sylvie Caspar-Bauguil, Katie Louche, Marie-Adeline Marques, Aline Mairal, Marie-Laure Renoud, Jean Galitzky, Cecilia Holm, Etienne Mouisel, Claire Thalamas, Nathalie Viguerie, Thierry Sulpice, Rémy Burcelin, Peter Arner, Dominique Langi. Partial inhibition of adipose tissue lipolysis improves glucose metabolism and insulin sensitivity without alteration of fat mass. PLoS biology. vol 11. issue 2. 2013-08-20. PMID:23431266. |
fas have been postulated to play a critical role in the development of obesity-induced insulin resistance, a major risk factor for diabetes and cardiovascular disease. |
2013-08-20 |
2023-08-12 |
mouse |
| Maria R Ferreira, Maria del C Camberos, Dante Selenscig, Lucía C Martucci, Adriana Chicco, Yolanda B Lombardo, Juan C Crest. Changes in hepatic lipogenic and oxidative enzymes and glucose homeostasis induced by an acetyl-L-carnitine and nicotinamide treatment in dyslipidaemic insulin-resistant rats. Clinical and experimental pharmacology & physiology. vol 40. issue 3. 2013-08-16. PMID:23278446. |
the following parameters were determined in all groups: (i) liver activity of fatty acid synthase (fas), acetyl-coa carboxylase (acc) and carnitine-palmitoyl transferase-1 (cpt-1); (ii) hepatic and skeletal muscle triacylglycerol content, plasma glucose, insulin, free fatty acid (ffa) and triacylglycerol levels and pancreatic insulin content; and (iii) glucose tolerance. |
2013-08-16 |
2023-08-12 |
rat |
| Stanley M H Chan, Ruo-Qiong Sun, Xiao-Yi Zeng, Zi-Heng Choong, Hao Wang, Matthew J Watt, Ji-Ming Y. Activation of PPARα ameliorates hepatic insulin resistance and steatosis in high fructose-fed mice despite increased endoplasmic reticulum stress. Diabetes. vol 62. issue 6. 2013-08-02. PMID:23349482. |
while retaining the elevated dnl (indicated by the upregulation of srebp1c, acc, fas, and scd1 and [3h]h2o incorporation into lipids), fb treatment markedly increased fatty acid oxidation (indicated by induction of acox1, p-acc, β-had activity, and [14c]palmitate oxidation) and eliminated the accumulation of diacylglycerols (dags), which is known to have an impact on insulin signaling. |
2013-08-02 |
2023-08-12 |
mouse |
| Yoshinori Nagai, Yasuharu Watanabe, Kiyoshi Takats. The TLR family protein RP105/MD-1 complex: A new player in obesity and adipose tissue inflammation. Adipocyte. vol 2. issue 2. 2013-06-28. PMID:23805400. |
for instance, tlr4/md-2 can be ligated by adipose tissue-derived saturated free fatty acids (fas) and induce adipose tissue inflammation and insulin resistance. |
2013-06-28 |
2023-08-12 |
mouse |
| Reto A Rapold, Stephan Wueest, Adrian Knoepfel, Eugen J Schoenle, Daniel Konra. Fas activates lipolysis in a Ca2+-CaMKII-dependent manner in 3T3-L1 adipocytes. Journal of lipid research. vol 54. issue 1. 2013-05-28. PMID:23089915. |
we previously demonstrated that mice lacking fas specifically in adipocytes are partly protected from diet-induced insulin resistance, potentially via decreased delivery of fas to the liver, as manifested by lower total liver ceramide content. |
2013-05-28 |
2023-08-12 |
mouse |
| Katsuhiko Funai, Haowei Song, Li Yin, Irfan J Lodhi, Xiaochao Wei, Jun Yoshino, Trey Coleman, Clay F Semenkovic. Muscle lipogenesis balances insulin sensitivity and strength through calcium signaling. The Journal of clinical investigation. vol 123. issue 3. 2013-05-13. PMID:23376793. |
unexpectedly, the lipogenic enzyme fatty acid synthase (fas) was increased in the skeletal muscle of mice with diet-induced obesity and insulin resistance. |
2013-05-13 |
2023-08-12 |
mouse |
| Katsuhiko Funai, Haowei Song, Li Yin, Irfan J Lodhi, Xiaochao Wei, Jun Yoshino, Trey Coleman, Clay F Semenkovic. Muscle lipogenesis balances insulin sensitivity and strength through calcium signaling. The Journal of clinical investigation. vol 123. issue 3. 2013-05-13. PMID:23376793. |
skeletal muscle-specific inactivation of fas protected mice from insulin resistance without altering adiposity, specific inflammatory mediators of insulin signaling, or skeletal muscle levels of diacylglycerol or ceramide. |
2013-05-13 |
2023-08-12 |
mouse |